The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids
Open accessAbstract
This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.
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In the citing paper
“Remarkably, continuously perfused spheroids exhibited higher chemoresistance to cisplatin, a drug commonly prescribed for MPM patients, when compared with spheroids cultured under static conditions.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
In the citing paper
“These authors trapped cancer spheroids derived from malignant pleural mesothelioma (MPM) cells within a “multi-S-shaped” microfluidic channel (Figure 3a) and perfused culture medium and anticancer drug formulations through this system.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
In the citing paper
“The authors observed that the spheroid morphology was similar in both the perfused and the static conditions and remained essentially unchanged during a 48-h perfusion period.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
Citations
Cites
El-Ali, J., Sorger, P. K., & Jensen, K. F. (2006) · Nature · doi:10.1038/nature05063 · Cited by 2,105
Modeling Tissue Morphogenesis and Cancer in 3D
Yamada, K. M., & Cukierman, E. (2007) · Cell · doi:10.1016/j.cell.2007.08.006 · Cited by 1,751
Multicellular tumor spheroids: An underestimated tool is catching up again
Hirschhaeuser, F., Menne, H., Dittfeld, C., West, J., Mueller-Klieser, W., & Kunz-Schughart, L. A. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.012 · Cited by 1,674
Cancer stem cell definitions and terminology: the devil is in the details
Valent, P., Bonnet, D. A., Maria, R. D., Lapidot, T., Copland, M., Melo, J. V., Chomienne, C., Ishikawa, F., Schuringa, J. J., Stassi, G., et al. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3368 · Cited by 720
Fundamentals of microfluidic cell culture in controlled microenvironments
Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615
Flores, R. M., Pass, H. I., Seshan, V., Dycoco, J., Zakowski, M. F., Carbone, M., Bains, M. S., & Rusch, V. W. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.10.054 · Cited by 614
A trap-and-release integrated microfluidic system for dynamic microarray applications
Tan, W.-H., & Takeuchi, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606625104 · Cited by 590
Cisplatin and DNA repair in cancer chemotherapy
Zamble, D. B., & Lippard, S. J. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89095-7 · Cited by 533
Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?
Friedrich, J., Ebner, R., & Kunz‐Schughart, L. A. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701727531 · Cited by 460
Paper-supported 3D cell culture for tissue-based bioassays
Derda, R., Laromaine, A., Mammoto, A., Tang, S. K. Y., Mammoto, T., Ingber, D. E., & Whitesides, G. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910666106 · Cited by 434
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Research works printed but not linked: 1
- Cortes-Dericks, 2010, Gene Expression, 437
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Matrigel: From discovery and ECM mimicry to assays and models for cancer research
Benton, G., Arnaoutova, I., George, J., Kleinman, H. K., & Koblinski, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.005 · Cited by 477
Challenges of applying multicellular tumor spheroids in preclinical phase
Han, S. J., Kwon, S., & Kim, K. S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01853-8 · Cited by 428
Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
Frey, O., Misun, P. M., Fluri, D. A., Hengstler, J. G., & Hierlemann, A. R. (2014) · Nature Communications · doi:10.1038/ncomms5250 · Cited by 389
Białkowska, K., Komorowski, P., Bryszewska, M. J., & Miłowska, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176225 · Cited by 416
Vascularized cancer on a chip: the effect of perfusion on growth and drug delivery of tumor spheroid
Nashimoto, Y., Okada, R., Hanada, S., Arima, Y., Nishiyama, K., Miura, T., & Yokokawa, R. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119547 · Cited by 332
Metadata
- Authors
- Ruppen, J., Cortes-Dericks, L., Marconi, E., Karoubi, G., Schmid, R. A., Peng, R., Marti, T. M., & Guenat, O. T.
- Affiliations
- University of Bern (CH)
- Division of General Thoracic Surgery
- Corresponding author
- Guenat, Olivier T.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 6
- Pages
- 1198-1205
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2079761432
- Cited by
- 105
- References
- 36
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 18 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 3
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- Novartis Foundation
- École Polytechnique Fédérale de Lausanne
- Novartis Stiftung für Medizinisch-Biologische Forschung
- Bernische Krebsliga
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- malignant pleural mesothelioma, tumor spheroids, chemoresistance, cisplatin, microfluidic perfusion, caspase activity, spheroid viability, drug susceptibility testing, personalized medicine, continuous perfusion
- MeSH terms
- Drug Screening Assays, Antitumor, Humans, Mesothelioma, Pleural Neoplasms, Spheroids, Cellular, Cell Line, Tumor, Microfluidic Analytical Techniques
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