The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids
Open accessAbstract
This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Remarkably, continuously perfused spheroids exhibited higher chemoresistance to cisplatin, a drug commonly prescribed for MPM patients, when compared with spheroids cultured under static conditions.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
In the citing paper
“These authors trapped cancer spheroids derived from malignant pleural mesothelioma (MPM) cells within a “multi-S-shaped” microfluidic channel (Figure 3a) and perfused culture medium and anticancer drug formulations through this system.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
In the citing paper
“The authors observed that the spheroid morphology was similar in both the perfused and the static conditions and remained essentially unchanged during a 48-h perfusion period.”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [20]
Citations
Cites
El-Ali, J., Sorger, P. K., & Jensen, K. F. (2006) · Nature · doi:10.1038/nature05063 · Cited by 2,105
Modeling Tissue Morphogenesis and Cancer in 3D
Yamada, K. M., & Cukierman, E. (2007) · Cell · doi:10.1016/j.cell.2007.08.006 · Cited by 1,751
Multicellular tumor spheroids: An underestimated tool is catching up again
Hirschhaeuser, F., Menne, H., Dittfeld, C., West, J., Mueller-Klieser, W., & Kunz-Schughart, L. A. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.012 · Cited by 1,674
Cancer stem cell definitions and terminology: the devil is in the details
Valent, P., Bonnet, D. A., Maria, R. D., Lapidot, T., Copland, M., Melo, J. V., Chomienne, C., Ishikawa, F., Schuringa, J. J., Stassi, G., et al. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3368 · Cited by 720
Fundamentals of microfluidic cell culture in controlled microenvironments
Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615
Flores, R. M., Pass, H. I., Seshan, V., Dycoco, J., Zakowski, M. F., Carbone, M., Bains, M. S., & Rusch, V. W. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.10.054 · Cited by 614
A trap-and-release integrated microfluidic system for dynamic microarray applications
Tan, W.-H., & Takeuchi, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606625104 · Cited by 590
Cisplatin and DNA repair in cancer chemotherapy
Zamble, D. B., & Lippard, S. J. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89095-7 · Cited by 533
Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?
Friedrich, J., Ebner, R., & Kunz‐Schughart, L. A. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701727531 · Cited by 460
Paper-supported 3D cell culture for tissue-based bioassays
Derda, R., Laromaine, A., Mammoto, A., Tang, S. K. Y., Mammoto, T., Ingber, D. E., & Whitesides, G. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910666106 · Cited by 434
Riss, T., & Moravec, R. A. (2004) · Assay and Drug Development Technologies · doi:10.1089/154065804322966315 · Cited by 370
Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
Albanese, A., Lam, A. K., Sykes, E. A., Rocheleau, J. V., & Chan, W. C. W. (2013) · Nature Communications · doi:10.1038/ncomms3718 · Cited by 330
Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids
Hsiao, A. Y., Torisawa, Y.-S., Tung, Y.-C., Sud, S., Taichman, R. S., Pienta, K. J., & Takayama, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.047 · Cited by 323
Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
Wu, L. Y., Carlo, D. D., & Lee, L. P. (2007) · Biomedical Microdevices · doi:10.1007/s10544-007-9125-8 · Cited by 277
Yu, L., Chen, M. C. W., & Cheung, K. C. (2010) · Lab on a Chip · doi:10.1039/c004590j · Cited by 249
AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies
Godugu, C., Patel, A. R., Desai, U. S., Andey, T. A., Sams, A., & Singh, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053708 · Cited by 239
Tumors on chips: oncology meets microfluidics
Włodkowic, D., & Cooper, J. M. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.016 · Cited by 183
A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip
Torisawa, Y.-S., Takagi, A., Nashimoto, Y., Yasukawa, T., Shiku, H., & Matsue, T. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.054 · Cited by 176
Levina, V., Marrangoni, A., Wang, T., Parikh, S., Su, Y., Herberman, R., Lokshin, A., & Gorelik, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1102 · Cited by 155
Barbone, D., Yang, T., Morgan, J. R., Gaudino, G., & Broaddus, V. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709698200 · Cited by 149
Malignant Pleural Mesothelioma
Pistolesi, M., & Rusthoven, J. J. (2004) · CHEST Journal · doi:10.1378/chest.126.4.1318 · Cited by 128
Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy
Phung, Y., Barbone, D., Broaddus, V. C., & Ho, M. (2011) · Journal of Cancer · doi:10.7150/jca.2.507 · Cited by 99
Kwapiszewska, K., Stelmachowska, A., Kwapiszewski, R., Chudy, M., Dybko, A., & Brzózka, Z. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.06.017 · Cited by 98
Continuously perfused microbubble array for 3D tumor spheroid model
Agastin, S., Giang, U.-B. T., Geng, Y., DeLouise, L. A., & King, M. R. (2011) · Biomicrofluidics · doi:10.1063/1.3596530 · Cited by 86
Kim, C., Bang, J. H., Kim, Y. E., Lee, S. H., & Kang, J. Y. (2012) · Lab on a Chip · doi:10.1039/c2lc40570a · Cited by 84
Surgical management of malignant pleural mesothelioma: a systematic review and evidence summary
Maziak, D. E., Gagliardi, A. R., Haynes, A. E., Mackay, J. A., & Evans, W. K. (2005) · Lung Cancer · doi:10.1016/j.lungcan.2004.11.003 · Cited by 78
Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells
Morrison, B. J., Steel, J. C., & Morris, J. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049752 · Cited by 59
Das, T., Meunier, L., Barbe, L., Provencher, D. M., Guenat, O. T., Gervais, T., & Mes‐Masson, A. (2013) · Biomicrofluidics · doi:10.1063/1.4774309 · Cited by 59
Self-citationThree-dimensional cell culture based on microfluidic techniques to mimic living tissues
Morimoto, Y., & Takeuchi, S. (2012) · Biomaterials Science · doi:10.1039/c2bm00117a · Cited by 51
Goudar, R. K. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1603 · Cited by 51
The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance
Barbone, D., Ryan, J. A., Kolhatkar, N. S., Chacko, A., Jablons, D. M., Sugarbaker, D. J., Bueno, R., Letai, A. G., Coussens, L. M., Fennell, D. A., et al. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.58 · Cited by 51
Hepatocyte spheroid arrays inside microwells connected with microchannels
Fukuda, J., & Nakazawa, K. (2011) · Biomicrofluidics · doi:10.1063/1.3576905 · Cited by 50
Hu, G., & Li, D. (2007) · Biomedical Microdevices · doi:10.1007/s10544-006-9035-1 · Cited by 46
Microfluidic experimental platform for producing size-controlled three-dimensional spheroids
Ota, H., & Miki, N. (2011) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2011.03.051 · Cited by 43
Cytokinetic analysis of lung cancer by in vivo bromodeoxyuridine labelling
Tinnemans, M. M. F. J., Schütte, B., Lenders, M. ‐., ten Velde, G. P. M., Ramaekers, F. C. S., & Blijham, G. H. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.228 · Cited by 38
Microfluidic Systems for Live Cell Imaging
Lee, P., Gaige, T. A., & Hung, P. J. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-374912-3.00004-3 · Cited by 16
Flagged first, then by citations
Research works printed but not linked: 1
- Cortes-Dericks, 2010, Gene Expression, 437
Cited by
Sorted by citations
Matrigel: From discovery and ECM mimicry to assays and models for cancer research
Benton, G., Arnaoutova, I., George, J., Kleinman, H. K., & Koblinski, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.005 · Cited by 477
Challenges of applying multicellular tumor spheroids in preclinical phase
Han, S. J., Kwon, S., & Kim, K. S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01853-8 · Cited by 428
Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
Frey, O., Misun, P. M., Fluri, D. A., Hengstler, J. G., & Hierlemann, A. R. (2014) · Nature Communications · doi:10.1038/ncomms5250 · Cited by 389
Białkowska, K., Komorowski, P., Bryszewska, M. J., & Miłowska, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176225 · Cited by 416
Vascularized cancer on a chip: the effect of perfusion on growth and drug delivery of tumor spheroid
Nashimoto, Y., Okada, R., Hanada, S., Arima, Y., Nishiyama, K., Miura, T., & Yokokawa, R. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119547 · Cited by 332
Metadata
- Authors
- Ruppen, J., Cortes-Dericks, L., Marconi, E., Karoubi, G., Schmid, R. A., Peng, R., Marti, T. M., & Guenat, O. T.
- Affiliations
- University of Bern (CH)
- Division of General Thoracic Surgery
- Corresponding author
- Guenat, Olivier T.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 6
- Pages
- 1198-1205
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2079761432
- Cited by
- 105
- References
- 36
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 18 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 3
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- Novartis Foundation
- École Polytechnique Fédérale de Lausanne
- Novartis Stiftung für Medizinisch-Biologische Forschung
- Bernische Krebsliga
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- malignant pleural mesothelioma, tumor spheroids, chemoresistance, cisplatin, microfluidic perfusion, caspase activity, spheroid viability, drug susceptibility testing, personalized medicine, continuous perfusion
- MeSH terms
- Drug Screening Assays, Antitumor, Humans, Mesothelioma, Pleural Neoplasms, Spheroids, Cellular, Cell Line, Tumor, Microfluidic Analytical Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
