Hemocompatibility comparison of biomedical grade polymers using rabbit thrombogenicity model for preparing nonthrombogenic nitric oxide releasing surfaces
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In a polymer comparison, E2As was found to have superior hemocompatibility and then was used to prepare nitric oxide (NOrel) surfaces and tested in a 4 h rabbit model.
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Handa et al. and Cai et al. studied PLGA additives with different hydrolysis rates to slowly generate protons in the organic polymer phase and drive NO release from NONOates.
“Therefore, Handa et al.154,155 as well as Cai et al.156 studied various poly(lactic-co-glycolic acid) (PLGA) additives with different hydrolysis rates as a means to slowly produce protons within the organic polymer phase that can continue to drive NO release reaction from NONOates.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [155]
E2As polymer was the most biocompatible material among the four tested.
“E2As polymer was found to be the most biocompatible material amongst the four tested.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [155]
E2As coated ECC tubing preserved 56% of baseline platelet after 4 h versus 48, 40 and 47% for PVC/DOS, Tecophilic SP-60D-60 and Tecoflex SG 80A, respectively.
“E2As coated ECC tubing can preserve 56% of baseline platelet after 4 h versus 48, 40 and 47 % for PVC/DOS, Tecophilic SP-60D-60 and Tecoflex SG 80A, respectively.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [155]
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Research works printed but not linked: 2
- [18]Wu B PhD Dissertation, University of Michigan, Ann Arbor, MI 2009
- [24]Sivaraman B Latour RA Biomaterials 2011 32 5365 5370 21529934 PMC3104098
Cited by
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Self-citation
- Authors
- Handa, H., Major, T. C., Brisbois, E. J., Amoako, K. A., Meyerhoff, M. E., & Bartlett, R. H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Handa, Hitesh
- Meyerhoff, Mark E.
- Venue
- J. Mater. Chem. B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 2
- Issue
- 8
- Pages
- 1059-1067
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- PMC
- PMC3952273
- OpenAlex
- W2033195427
- Cited by
- 64
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 5
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - New Heaven (University of New Haven) (submittedVersion)
- Funders
- National Institutes of Health (K25HL111213, EB000783, R21EB016236, HL015434)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
- Keywords
- hemocompatibility, thrombogenicity, nitric oxide release, biomedical polymers, extracorporeal circuit, blood-contacting surfaces, polymer coatings, endothelialization
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