The artificial endothelium
Open accessAbstract
As the world of critical care medicine advances, extracorporeal therapies (ECC) have become commonplace in the management of the high risk intensive care patient. ECC encompasses a wide variety of technologies from hemodialysis, continuous renal replacement therapy (CRRT) and plasmapheresis, to cardiopulmonary bypass (CPB), extracorporeal life support (ECLS) and hepatic support. The development of internal man made organs is the next step with ventricular assist devices and artificial lungs. As we advance the technologies with smaller devices, and more intricate circuitry, we lack the keystone necessary to control the blood-biomaterial interface. For the last 50 years much has been learned about surface induced thrombosis and attempts have been made to prevent it with alternative systemic anticoagulation, circuitry surface modifications, or a combination of both. Despite these efforts, systemic or regional anticoagulation remain necessary for both laboratory and clinical application of ECC. As such, the development of an endothelial-like, biomimetic surface to reduce or perhaps even eliminate the blood activation/thrombus formation events that occur upon exposure to artificial surfaces is paramount.
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Pinon, V. D., Kumar, S., Crutchfield, N., Sapkota, A., Shorter, T. N., Brisbois, E. J., & Handa, H. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.140836
- Authors
- Reynolds, M. M., & Annich, G. M.
- Affiliations
- Colorado State University (US)
- University of Michigan (US)
- Corresponding author
- Annich, Gail M.
- Venue
- Organogenesis
- Publisher
- Informa UK Limited
- Published
- 2011-01
- Volume
- 7
- Issue
- 1
- Pages
- 42-49
- ISSN
- 1547-6278 (ISSN-L)
- 1555-8592
- PMC
- PMC3082033
- OpenAlex
- W2054093494
- Cited by
- 60
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Organogenesis (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Keywords
- extracorporeal circulation, anticoagulation, biomimetic surfaces, hemocompatibility, cardiopulmonary bypass, extracorporeal membrane oxygenation, ventricular assist devices, artificial lung, continuous renal replacement therapy, plasmapheresis
- MeSH terms
- Animals, Artificial Organs, Biocompatible Materials, Blood Platelets, Endothelium, Extracorporeal Circulation, Nitric Oxide, Rabbits, Thrombosis
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