Cited by 60Polymer Surface Interaction StudiesTissue Engineering and Regenerative MedicineMechanical Circulatory Support Devices

The artificial endothelium

Open access
Reynolds, Melissa M., Annich, Gail M.·2011·Organogenesis

Abstract

As the world of critical care medicine advances, extracorporeal therapies (ECC) have become commonplace in the management of the high risk intensive care patient. ECC encompasses a wide variety of technologies from hemodialysis, continuous renal replacement therapy (CRRT) and plasmapheresis, to cardiopulmonary bypass (CPB), extracorporeal life support (ECLS) and hepatic support. The development of internal man made organs is the next step with ventricular assist devices and artificial lungs. As we advance the technologies with smaller devices, and more intricate circuitry, we lack the keystone necessary to control the blood-biomaterial interface. For the last 50 years much has been learned about surface induced thrombosis and attempts have been made to prevent it with alternative systemic anticoagulation, circuitry surface modifications, or a combination of both. Despite these efforts, systemic or regional anticoagulation remain necessary for both laboratory and clinical application of ECC. As such, the development of an endothelial-like, biomimetic surface to reduce or perhaps even eliminate the blood activation/thrombus formation events that occur upon exposure to artificial surfaces is paramount.

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Crossref · 10.4161/org.7.1.14029

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Research works printed but not linked: 2

  1. Hayashi Y, Sawa Y, Nishimura M, Chang JC, Amemiya A, Kagisaki K, et al. NO gas infusion to the oxygenator enhances the biocompatibility of heparin coated extra- corporeal by pass circuits. ASAIO 1998; 44:456.
  2. Eynden FV, Carrier M, Ouellet S, Demers P, Forcillo J, Perrault LP, et al. AVECOR oxygenator: a randomized study J Card Surg 2008; 23:288-93.

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Authors
Reynolds, M. M., & Annich, G. M.
Affiliations
  • Colorado State University (US)
  • University of Michigan (US)
Corresponding author
Annich, Gail M.
Venue
Organogenesis
Published
2011-01
Volume
7
Issue
1
Pages
42-49
ISSN
  • 1547-6278 (ISSN-L)
  • 1555-8592
OpenAlex
W2054093494
Cited by
60
References
34
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 1
FWCI
0.14
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Organogenesis (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
Keywords
extracorporeal circulation, anticoagulation, biomimetic surfaces, hemocompatibility, cardiopulmonary bypass, extracorporeal membrane oxygenation, ventricular assist devices, artificial lung, continuous renal replacement therapy, plasmapheresis
MeSH terms
Animals, Artificial Organs, Biocompatible Materials, Blood Platelets, Endothelium, Extracorporeal Circulation, Nitric Oxide, Rabbits, Thrombosis

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