Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D., Tolcher, A., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,505

Cu-free click cycloaddition reactions in chemical biology

Jewett, J. C., & Bertozzi, C. R. (2010) · Chemical Society Reviews · doi:10.1039/b901970g · Cited by 1,684

The development of microgels/nanogels for drug delivery applications

Oh, J. K., Drumright, R., Siegwart, D. J., & Matyjaszewski, K. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.01.002 · Cited by 1,598

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities

Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407

Michael addition reactions in macromolecular design for emerging technologies

Mather, B. D., Viswanathan, K., Miller, K. M., & Long, T. E. (2006) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2006.03.001 · Cited by 1,127

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

Fleige, E., Quadir, M. A., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,111

Glutathione in Cancer Biology and Therapy

Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

Gupte, A., & Mumper, R. J. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.07.004 · Cited by 1,036

Functional soft materials from metallopolymers and metallosupramolecular polymers

Whittell, G. R., Hager, M. D., Schubert, U. S., & Manners, I. (2011) · Nature Materials · doi:10.1038/nmat2966 · Cited by 1,013

Multivalency as a Chemical Organization and Action Principle

Fasting, C., Schalley, C. A., Weber, M., Seitz, O., Hecht, S., Koksch, B., Dernedde, J., Graf, C., Knapp, E., & Haag, R. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201201114 · Cited by 993

Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation

Williams, C. G., Malik, A. N., Kim, T. K., Manson, P. N., & Elisseeff, J. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.024 · Cited by 899

Formation and transfer of disulphide bonds in living cells

Sevier, C. S., & Kaiser, C. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm954 · Cited by 796

Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

Jiang, Y., Chen, J., Deng, C., Suuronen, E. J., & Zhong, Z. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.001 · Cited by 762

Apoptosis and glutathione: beyond an antioxidant

Franco, R., & Cidlowski, J. A. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.107 · Cited by 744

Designing degradable hydrogels for orthogonal control of cell microenvironments

Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

DeForest, C. A., & Anseth, K. S. (2011) · Nature Chemistry · doi:10.1038/nchem.1174 · Cited by 708

Polymer nanogels: A versatile nanoscopic drug delivery platform

Chacko, R. T., Ventura, J., Zhuang, J., & Thayumanavan, S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.02.002 · Cited by 645

Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering

Moreira Teixeira, L. S., Feijen, J., van Blitterswijk, C. A., Dijkstra, P. J., & Karperien, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.067 · Cited by 615

Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles

Akiyoshi, K., Deguchi, S., Moriguchi, N., Yamaguchi, S., & Sunamoto, J. (1993) · Macromolecules · doi:10.1021/ma00064a011 · Cited by 601

Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform

Ryu, J.-H., Chacko, R. T., Jiwpanich, S., Bickerton, S., Babu, R. P., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1069932 · Cited by 553

Biopolymer-based microgels/nanogels for drug delivery applications

Oh, J. K., Lee, D. I., & Park, J. M. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.08.001 · Cited by 542

Photoresponsive hydrogels for biomedical applications

Tomatsu, I., Peng, K., & Kros, A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.009 · Cited by 535

Design and development of polymeric micelles with cleavable links for intracellular drug delivery

Wei, H., Zhuo, R.-X., & Zhang, X.-Z. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.07.002 · Cited by 474

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

Baldwin, A. D., & Kiick, K. L. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200148v · Cited by 470

Biodegradable Nanogels Prepared by Atom Transfer Radical Polymerization as Potential Drug Delivery Carriers: Synthesis, Biodegradation, in Vitro Release, and Bioconjugation

Oh, J. K., Siegwart, D. J., Lee, H.-I., Sherwood, G., Peteanu, L., Hollinger, J. O., Kataoka, K., & Matyjaszewski, K. (2007) · Journal of the American Chemical Society · doi:10.1021/ja069150l · Cited by 467

Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Li, Y., Zhu, L., Liu, Z., Cheng, R., Meng, F., Cui, J., Ji, S., & Zhong, Z. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904260 · Cited by 451

pH responsive self-healing hydrogels formed by boronate–catechol complexation

He, L., Fullenkamp, D. E., Rivera, J. G., & Messersmith, P. B. (2011) · Chemical Communications · doi:10.1039/c1cc11928a · Cited by 450

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

Nimmo, C. M., Owen, S. C., & Shoichet, M. S. (2011) · Biomacromolecules · doi:10.1021/bm101446k · Cited by 436

Nanogel engineering for new nanobiomaterials: from chaperoning engineering to biomedical applications

Sasaki, Y., & Akiyoshi, K. (2010) · The Chemical Record · doi:10.1002/tcr.201000008 · Cited by 412

A Novel Strategy for Encapsulation and Release of Proteins: Hydrogels and Microgels with Acid-Labile Acetal Cross-Linkers

Murthy, N., Thng, Y. X., Schuck, S., Xu, M. C., & Fréchet, J. M. J. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026925r · Cited by 407

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.

Russo, A., DeGraff, W., Friedman, N., & Mitchell, J. B. (1986) · PubMed · Cited by 384

Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram

Duan, X., Xiao, J., Yin, Q., Zhang, Z., Yu, H., Mao, S., & Li, Y. (2013) · ACS Nano · doi:10.1021/nn4010796 · Cited by 379

Self‐Healing Polymer Coatings Based on Crosslinked Metallosupramolecular Copolymers

Bode, S., Zedler, L., Schacher, F. H., Dietzek, B., Schmitt, M., Popp, J., Hager, M. D., & Schubert, U. S. (2013) · Advanced Materials · doi:10.1002/adma.201203865 · Cited by 364

Well‐Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis ‐Diols

Li, Y., Xiao, W., Xiao, K., Berti, L., Luo, J., Tseng, H. P., Fung, G., & Lam, K. S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107144 · Cited by 360

α-Lipoic Acid in Liver Metabolism and Disease

Bustamante, J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00371-7 · Cited by 349

Click chemistry: function follows form

Finn, M. G., & Fokin, V. V. (2010) · Chemical Society Reviews · doi:10.1039/c003740k · Cited by 328

Multifunctional Hybrid Nanogel for Integration of Optical Glucose Sensing and Self-Regulated Insulin Release at Physiological pH

Wu, W., Mitra, N., Yan, E. C. Y., & Zhou, S. (2010) · ACS Nano · doi:10.1021/nn1008319 · Cited by 309

Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202847 · Cited by 299

Toward an enhanced understanding and implementation of photopolymerization reactions

Bowman, C. N., & Kloxin, C. J. (2008) · AIChE Journal · doi:10.1002/aic.11678 · Cited by 280

Synthesis of nanogels/microgels by conventional and controlled radical crosslinking copolymerization

Sanson, N., & Rieger, J. (2010) · Polymer Chemistry · doi:10.1039/c0py00010h · Cited by 251

A Nanogel for Ratiometric Fluorescent Sensing of Intracellular pH Values

Peng, H., Stolwijk, J. A., Sun, L., Wegener, J., & Wolfbeis, O. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906926 · Cited by 246

Human Plasma ATP Concentration

Gorman, M. W., Feigl, E. O., & Buffington, C. W. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.076364 · Cited by 244

Core–shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment

Wu, W., Shen, J., Banerjee, P., & Zhou, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.030 · Cited by 236

Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks

Roberts, M. C., Hanson, M. C., Massey, A. P., Karren, E. A., & Kiser, P. F. (2007) · Advanced Materials · doi:10.1002/adma.200602649 · Cited by 236

Controlled Synthesis of Cell-Laden Microgels by Radical-Free Gelation in Droplet Microfluidics

Rossow, T., Heyman, J. A., Ehrlicher, A. J., Langhoff, A., Weitz, D. A., Haag, R., & Seiffert, S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300460p · Cited by 233

Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs

Qiao, Z.-Y., Zhang, R., Du, F.-S., Liang, D.-H., & Li, Z.-C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.029 · Cited by 225

Chitosan-based responsive hybrid nanogels for integration of optical pH-sensing, tumor cell imaging and controlled drug delivery

Wu, W., Shen, J., Banerjee, P., & Zhou, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.061 · Cited by 222

Photoresponsive Nanogels Based on Photocontrollable Cross-Links

He, J., Tong, X., & Zhao, Y. (2009) · Macromolecules · doi:10.1021/ma900665v · Cited by 220

In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery

Wu, W., Aiello, M., Zhou, T., Berliner, A., Banerjee, P., & Zhou, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.011 · Cited by 218

Nanogel-quantum dot hybrid nanoparticles for live cell imaging

Hasegawa, U., Nomura, S.-I. M., Kaul, S. C., Hirano, T., & Akiyoshi, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.228 · Cited by 216

Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities

Ryu, J.-H., Jiwpanich, S., Chacko, R., Bickerton, S., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102316a · Cited by 211

Cationic Polymer Nanoparticles and Nanogels: From Synthesis to Biotechnological Applications

Ramos, J., Forcada, J., & Hidalgo-Alvarez, R. (2014) · Chemical Reviews · doi:10.1021/cr3002643 · Cited by 202

Peptide-Functionalized Nanogels for Targeted siRNA Delivery

Blackburn, W. H., Dickerson, E. B., Smith, M. H., McDonald, J. F., & Lyon, L. A. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800547c · Cited by 196

Protein refolding assisted by self‐assembled nanogels as novel artificial molecular chaperone

Nomura, Y., Ikeda, M., Yamaguchi, N., Aoyama, Y., & Akiyoshi, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01028-7 · Cited by 186

Molecular Chaperone-Like Activity of Hydrogel Nanoparticles of Hydrophobized Pullulan: Thermal Stabilization with Refolding of Carbonic Anhydrase B

Akiyoshi, K., Sasaki, Y., & Sunamoto, J. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801272 · Cited by 179

Reversible maleimide–thiol adducts yield glutathione-sensitive poly(ethylene glycol)–heparin hydrogels

Baldwin, A. D., & Kiick, K. L. (2013) · Polym. Chem. · doi:10.1039/c2py20576a · Cited by 177

Smart Core−Shell Hybrid Nanogels with Ag Nanoparticle Core for Cancer Cell Imaging and Gel Shell for pH-Regulated Drug Delivery

Wu, W., Zhou, T., Berliner, A., Banerjee, P., & Zhou, S. (2010) · Chemistry of Materials · doi:10.1021/cm903357q · Cited by 175

Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering

Fujioka-Kobayashi, M., Ota, M. S., Shimoda, A., Nakahama, K.-I., Akiyoshi, K., Miyamoto, Y., & Iseki, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.075 · Cited by 173

Injectable, Mixed Natural-Synthetic Polymer Hydrogels with Modular Properties

Patenaude, M., & Hoare, T. (2012) · Biomacromolecules · doi:10.1021/bm2013982 · Cited by 173

A Microgel Construction Kit for Bioorthogonal Encapsulation and pH‐Controlled Release of Living Cells

Steinhilber, D., Rossow, T., Wedepohl, S., Paulus, F., Seiffert, S., & Haag, R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201308005 · Cited by 164

Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules

Steinhilber, D., Witting, M., Zhang, X., Staegemann, M., Paulus, F., Friess, W., Küchler, S., & Haag, R. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.008 · Cited by 161

New self-assembled nanogels based on host–guest interactions: Characterization and drug loading

Gref, R., Amiel, C., Molinard, K., Daoud-Mahammed, S., Sébille, B., Gillet, B., Belœil, J., Ringard-Lefebvre, C., Rosilio, V., Poupaert, J., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.025 · Cited by 160

A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching

Zhang, X., Achazi, K., Steinhilber, D., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.005 · Cited by 150

Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy

Xiong, W., Wang, W., Wang, Y., Zhao, Y., Chen, H., Xu, H., & Yang, X. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.01.040 · Cited by 148

Atom transfer radical polymerization in inverse miniemulsion: A versatile route toward preparation and functionalization of microgels/nanogels for targeted drug delivery applications

Oh, J. K., Bencherif, S. A., & Matyjaszewski, K. A. (2009) · Polymer · doi:10.1016/j.polymer.2009.06.045 · Cited by 148

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

Raemdonck, K., Naeye, B., Buyens, K., Vandenbroucke, R. E., Høgset, A., Demeester, J., & Smedt, S. C. D. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200801795 · Cited by 147

Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle

Morimoto, N., Hirano, S., Takahashi, H., Loethen, S., Thompson, D. H., & Akiyoshi, K. (2012) · Biomacromolecules · doi:10.1021/bm301286h · Cited by 145

Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

Zhan, F., Chen, W., Wang, Z., Lu, W., Cheng, R., Deng, C., Meng, F., Liu, H., & Zhong, Z. (2011) · Biomacromolecules · doi:10.1021/bm200876x · Cited by 136

Reduced acute inflammatory responses to microgel conformal coatings

Bridges, A. W., Singh, N., Burns, K. L., Babensee, J. E., Lyon, L. A., & García, A. J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.08.015 · Cited by 134

Synthesis, characterization, and intracellular delivery of reducible heparin nanogels for apoptotic cell death

Bae, K. H., Mok, H., & Park, T. G. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.035 · Cited by 134

Thermosensitive hydrogels synthesized by fast Diels–Alder reaction in water

Wei, H., Yang, Z., Zheng, L., & Shen, Y. (2009) · Polymer · doi:10.1016/j.polymer.2009.04.032 · Cited by 129

Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function

Hirakura, T., Yasugi, K., Nemoto, T., Sato, M., Shimoboji, T., Aso, Y., Morimoto, N., & Akiyoshi, K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.023 · Cited by 128

In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins

Chen, W., Zheng, M., Meng, F., Cheng, R., Deng, C., Feijén, J., & Zhong, Z. (2013) · Biomacromolecules · doi:10.1021/bm400206m · Cited by 125

Temperature, pH, and Glucose Responsive Gels via Simple Mixing of Boroxole- and Glyco-Based Polymers

Kotsuchibashi, Y., Agustin, R. V. C., Lu, J., Hall, D. G., & Narain, R. (2013) · ACS Macro Letters · doi:10.1021/mz400076p · Cited by 122

Raspberry-like assembly of cross-linked nanogels for protein delivery

Hasegawa, U., Sawada, S., Shimizu, T., Kishida, T., Otsuji, E., Mazda, O., & Akiyoshi, K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.06.025 · Cited by 120

Investigation of the Diels–Alder reaction as a cross-linking mechanism for degradable poly(ethylene glycol) based hydrogels

Kirchhof, S., Brandl, F., Hammer, N., & Göpferich, A. M. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20831a · Cited by 120

Specific glucose-to-SPR signal transduction at physiological pH by molecularly imprinted responsive hybrid microgels

Wu, W., Shen, J., Li, Y., Zhu, H., Banerjee, P., & Zhou, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.031 · Cited by 115

Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell

Calderón, M., Welker, P., Licha, K., Fichtner, I., Graeser, R., Haag, R., & Kratz, F. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.017 · Cited by 114

Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery

Wu, W., Shen, J., Gai, Z., Hong, K., Banerjee, P., & Zhou, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.082 · Cited by 114

Synthesis by AGET ATRP of Degradable Nanogel Precursors for In Situ Formation of Nanostructured Hyaluronic Acid Hydrogel

Bencherif, S. A., Washburn, N. R., & Matyjaszewski, K. A. (2009) · Biomacromolecules · doi:10.1021/bm9004639 · Cited by 111

Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties

Sisson, A. L., Steinhilber, D., Rossow, T., Welker, P., Licha, K., & Haag, R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901583 · Cited by 108

Cellular Uptake of Functional Nanogels Prepared by Inverse Miniemulsion ATRP with Encapsulated Proteins, Carbohydrates, and Gold Nanoparticles

Siegwart, D. J., Srinivasan, A., Bencherif, S. A., Karunanidhi, A., Oh, J. K., Vaidya, S., Jin, R. M., Hollinger, J. O., & Matyjaszewski, K. A. (2009) · Biomacromolecules · doi:10.1021/bm9004904 · Cited by 106

Degradable Thermoresponsive Nanogels for Protein Encapsulation and Controlled Release

Bhuchar, N., Sunasee, R., Ishihara, K., Thundat, T. G., & Narain, R. (2011) · Bioconjugate Chemistry · doi:10.1021/bc2003814 · Cited by 105

Embedding of Active Proteins and Living Cells in Redox‐Sensitive Hydrogels and Nanogels through Enzymatic Cross‐Linking

Singh, S., Topuz, F., Hahn, K., Albrecht, K., & Gröll, J. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201206266 · Cited by 104

Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and efficient intracellular doxorubicin release

Chen, W., Achazi, K., Schade, B., & Haag, R. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.012 · Cited by 102

Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure

Tamura, A., Oishi, M., & Nagasaki, Y. (2009) · Biomacromolecules · doi:10.1021/bm900252d · Cited by 102

Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel

Nakai, T., Hirakura, T., Sakurai, Y., Shimoboji, T., Ishigai, M., & Akiyoshi, K. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100352 · Cited by 100

Synthesis and characterization of pH-sensitive poly(N-2-hydroxyethyl acrylamide)–acrylic acid (poly(HEAA/AA)) nanogels with antifouling protection for controlled release

Zhao, C., Chen, Q., Patel, K., Li, L., Li, X., Wang, Q., Zhang, G., & Zheng, J. (2012) · Soft Matter · doi:10.1039/c2sm25861g · Cited by 99

Dual Stimuli-Responsive Poly(2-hydroxyethyl methacrylate- co -methacrylic acid) Microgels Based on Photo-Cleavable Cross-Linkers: pH-Dependent Swelling and Light-Induced Degradation

Klinger, D., & Landfester, K. (2011) · Macromolecules · doi:10.1021/ma201706r · Cited by 99

Cytocompatible Poly(ethylene glycol)‐co‐polycarbonate Hydrogels Cross‐Linked by Copper‐Free, Strain‐Promoted Click Chemistry

Xu, J., Filion, T. M., Prifti, F., & Song, J. (2011) · Chemistry - An Asian Journal · doi:10.1002/asia.201100411 · Cited by 99

Near-Infrared Emitting Polymer Nanogels for Efficient Sentinel Lymph Node Mapping

Noh, Y., Kong, S., Choi, D., Park, H. S., Yang, H., Lee, H.-J., Kim, H. C., Kang, K. W., Sung, M., & Lim, Y. T. (2012) · ACS Nano · doi:10.1021/nn301949y · Cited by 97

Supramolecular polymer gels with potential model-network structure

Rossow, T., & Seiffert, S. (2014) · Polymer Chemistry · doi:10.1039/c3py01692g · Cited by 94

In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

Truong, V. X., Ablett, M. P., Gilbert, H. T. J., Bowen, J., Richardson, S. M., Hoyland, J. A., & Dove, A. P. (2013) · Biomaterials Science · doi:10.1039/c3bm60159e · Cited by 94

Responsive fluorescent Bi2O3@PVA hybrid nanogels for temperature-sensing, dual-modal imaging, and drug delivery

Zhu, H., Li, Y., Qiu, R., Shi, L., Wu, W., & Zhou, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.003 · Cited by 93

Synthesis and Characterization of Degradable p(HEMA) Microgels: Use of Acid‐Labile Crosslinkers

Bulmuş, V., Chan, Y., Nguyen, Q., & Tran, H. L. (2007) · Macromolecular Bioscience · doi:10.1002/mabi.200600258 · Cited by 92

Novel self-assembling nanogels: Stability and lyophilisation studies

Daoud-Mahammed, S., Couvreur, P., & Gref, R. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.09.052 · Cited by 90

Boronate–dextran: An acid-responsive biodegradable polymer for drug delivery

Li, L. X., Bai, Z., & Levkin, P. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.053 · Cited by 88

Responsive nanogel-based dual fluorescent sensors for temperature and Hg2+ ions with enhanced detection sensitivity

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A Smart Nanoprobe Based On Fluorescence‐Quenching PEGylated Nanogels Containing Gold Nanoparticles for Monitoring the Response to Cancer Therapy

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Untitled work

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