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Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Open accessAbstract
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel constructs. Using the proposed approach, we were able to successfully embed functional and perfusable microchannels inside methacrylated gelatin (GelMA), star poly(ethylene glycol-co-lactide) acrylate (SPELA), poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels at different concentrations. In particular, GelMA hydrogels were used as a model to demonstrate the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. In addition, successful formation of endothelial monolayers within the fabricated channels was confirmed. Overall, our proposed strategy represents an effective technique for vascularization of hydrogel constructs with useful applications in tissue engineering and organs on a chip.
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“Microfabrication enables the use of biomaterials to 1) support long-lasting open EC lumens for perfusion; 2) define sophisticated capillary networks to mimic the hierarchy of native vasculature; 3) guide and support EC growth and maintain their cellular functions [259–263].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [263]
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Cites
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Self-citationRapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917
Self-healing materials with microvascular networks
Toohey, K. S., Sottos, N. R., Lewis, J. A., Moore, J. S., & White, S. R. (2007) · Nature Materials · doi:10.1038/nmat1934 · Cited by 1,644
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
Self-citationScaffold-free vascular tissue engineering using bioprinting
Norotte, C., Marga, F., Niklason, L. E., & Forgács, G. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.034 · Cited by 1,342
In vitro microvessels for the study of angiogenesis and thrombosis
Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201240109 · Cited by 894
Engineering of functional, perfusable 3D microvascular networks on a chip
Kim, S., Lee, H., Chung, M., & Jeon, N. L. (2013) · Lab on a Chip · doi:10.1039/c3lc41320a · Cited by 872
Omnidirectional Printing of 3D Microvascular Networks
Wu, W., DeConinck, A., & Lewis, J. A. (2011) · Advanced Materials · doi:10.1002/adma.201004625 · Cited by 819
Engineering vascularized tissue
Jain, R. K., Au, P., Tam, J., Duda, D. G., & Fukumura, D. (2005) · Nature Biotechnology · doi:10.1038/nbt0705-821 · Cited by 808
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels
Chen, Y., Lin, R., Qi, H., Yang, Y., Bae, H., Melero‐Martin, J. M., & Khademhosseini, A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101662 · Cited by 802
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Bae, 2012, J. Tissue Eng. Regener. Med., 1
- Hansen, 2011, Adv. Funct. Mater., 1
- Jakab, 2006, Biorheology, 43, 509
Cited by
Sorted by citations
Items 201–300 of 943
Kumar, H., Sakthivel, K., Mohamed, M. G. A., Boras, E., Shin, S. R., & Kim, K. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.202000317 · Cited by 100
A mini-review of embedded 3D printing: supporting media and strategies
Zhao, J., & He, N. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01819h · Cited by 99
Advances in bioprinted cell-laden hydrogels for skin tissue engineering
Pereira, R. F., Sousa, A., Barrias, C. C., Bayat, A., Granja, P. L., & Bártolo, P. (2017) · Biomanufacturing Reviews · doi:10.1007/s40898-017-0003-8 · Cited by 100
The emergence of 3D bioprinting in organ-on-chip systems
Fetah, K., Tebon, P. J., Goudie, M. J., Eichenbaum, J., Ren, L. M., de Barros, N. R., Nasiri, R., Ahadian, S., Ashammakhi, N. A., Dokmeci, M. R., et al. (2019) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ab23df · Cited by 106
Self-citationNegrini, N. C., Celikkin, N., Tarsini, P., Farè, S., & Święszkowski, W. (2019) · Biofabrication · doi:10.1088/1758-5090/ab56f9 · Cited by 98
Engineered assistive materials for 3D bioprinting: support baths and sacrificial inks
Brunel, L. G., Hull, S. M., & Heilshorn, S. C. (2022) · Biofabrication · doi:10.1088/1758-5090/ac6bbe · Cited by 109
Elastomeric free-form blood vessels for interconnecting organs on chip systems
Zhang, W., Zhang, Y. S., Bakht, S. M., Aleman, J., Shin, S. R., Yue, K., Sica, M., Ribas, J., Duchamp, M., Ju, J., et al. (2016) · Lab on a Chip · doi:10.1039/c6lc00001k · Cited by 98
Self-citationPrinting of Three-Dimensional Tissue Analogs for Regenerative Medicine
Lee, V. K., & Dai, G. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1613-7 · Cited by 99
Zhang, Y., Ge, S., & Yu, J. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.09.008 · Cited by 101
Carletto, R. P., Ko, S. K., Caviglia, C., Wolff, A., Emnéus, J., Keller, S. S., & Dufva, M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.10.047 · Cited by 98
Grafting of 3D Bioprinting to In Vitro Drug Screening: A Review
Nie, J., Gao, Q., Fu, J., & He, Y. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901773 · Cited by 100
3D printing in tissue engineering: a state of the art review of technologies and biomaterials
Poomathi, N., Singh, S., Prakash, C., Subramanian, A., Sahay, R., Chinnappan, A., & Ramakrishna, S. (2020) · Rapid Prototyping Journal · doi:10.1108/rpj-08-2018-0217 · Cited by 98
Fast Stereolithography Printing of Large‐Scale Biocompatible Hydrogel Models
Anandakrishnan, N., Ye, H., Guo, Z., Chen, Z., Mentkowski, K. I., Lang, J. K., Rajabian, N., Andreadis, S. T., Ma, Z., Spernyak, J. A., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002103 · Cited by 107
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Liu, X., Wang, X., Zhang, L., Sun, L., Wang, H., Zhao, H., Zhang, Z., Li, W., Huang, Y., Ji, S., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101405 · Cited by 103
1D, 2D, and 3D scaffolds promoting angiogenesis for enhanced wound healing
Guo, Y., Huang, J. C., Fang, Y., Huang, H. W., & Wu, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134690 · Cited by 98
Yue, L., Qi, C., & Tang, M. (2024) · Applied Thermal Engineering · doi:10.1016/j.applthermaleng.2024.123716 · Cited by 97
Valentin, T. M., Leggett, S. E., Chen, P., Sodhi, J., Stephens, L. H., McClintock, H. D., Sim, J. Y., & Wong, I. Y. (2017) · Lab on a Chip · doi:10.1039/c7lc00694b · Cited by 96
The biophysics and mechanics of blood from a materials perspective
Qiu, Y., Myers, D. R., & Lam, W. A. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0099-y · Cited by 98
Three-Dimensional Bioprinting Strategies for Tissue EngineeringPreprint
Zhang, Y. S., Öklü, R., Dokmeci, M. R., & Khademhosseini, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025718 · Cited by 97
Self-citationShahbazi, M., Jäger, H., Ettelaie, R., Mohammadi, A., & Kashi, P. A. (2023) · Additive manufacturing · doi:10.1016/j.addma.2023.103598 · Cited by 103
A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds
Zhang, L., Xiang, Y., Zhang, H., Cheng, L., Mao, X., An, N., Zhang, L., Zhou, J., Deng, L., Zhang, Y., et al. (2020) · Advanced Science · doi:10.1002/advs.201903553 · Cited by 94
Das, S., Jegadeesan, J. T., & Basu, B. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c01271 · Cited by 104
Tsvirkun, D., Grichine, A., Alain Duperray, B., Misbah, C., & Bureau, L. (2017) · Scientific Reports · doi:10.1038/srep45036 · Cited by 94
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Ji, S., & Güvendiren, M. (2021) · APL Bioengineering · doi:10.1063/5.0034901 · Cited by 95
Bertassoni, L. E. (2021) · Advanced Materials · doi:10.1002/adma.202101321 · Cited by 98
Self-citationMimicking corneal stroma using keratocyte‐loaded photopolymerizable methacrylated gelatin hydrogels
Bektas, C. K., & Hasırcı, V. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2621 · Cited by 92
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Williams, I. M., & Wu, J. C. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312265 · Cited by 96
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V. R., & Moretti, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.057 · Cited by 93
3D bioprinting of soft materials-based regenerative vascular structures and tissues
Zhang, Z., Wang, B., Hui, D., Qiu, J., & Wang, S. (2017) · Composites Part B Engineering · doi:10.1016/j.compositesb.2017.05.011 · Cited by 93
Freeform 3D printing using a continuous viscoelastic supporting matrix
Patrício, S. G., Sousa, L. R., Correia, T. R., Gaspar, V. M., Pires, L. S. O., Luís, J. L., Oliveira, J. M., & Mano, J. F. (2020) · Biofabrication · doi:10.1088/1758-5090/ab8bc3 · Cited by 91
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Kinstlinger, I. S., Andreas, B., Paulsen, S. J., Hwang, D. H., Ta, A. H., Yalacki, D. R., Schmidt, T., & Miller, J. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147399 · Cited by 95
Biopolymer-based strategies in the design of smart medical devices and artificial organs
Altomare, L., Bonetti, L., Campiglio, C. E., Nardo, L. D., Draghi, L., Tana, F., & Farè, S. (2018) · The International Journal of Artificial Organs · doi:10.1177/0391398818765323 · Cited by 95
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Vera, D., García-Díaz, M., Torras, N., Álvarez, M., Villa, R., & Martínez, E. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c21573 · Cited by 90
Zheng, F., Xiao, Y., Liu, H., Fan, Y., & Dao, M. (2021) · Advanced Biology · doi:10.1002/adbi.202000024 · Cited by 96
Sun, H. R., Yuan, J. Y., Dong, H., Dong, D., & Zheng, J. (2019) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2019.10.006 · Cited by 90
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Roudsari, L. C., & West, J. L. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.004 · Cited by 89
Iranmanesh, P., Ehsani, A., Khademi, A., Asefnejad, A., Shahriari, S., Soleimani, M., Nejad, M. G., Saber‐Samandari, S., & Khandan, A. (2021) · Transport in Porous Media · doi:10.1007/s11242-021-01618-x · Cited by 87
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Potyondy, T., Uquillas, J. A., Tebon, P. J., Byambaa, B., Hasan, A., Tavafoghi, M., Mary, H., Aninwene, G. E., Pountos, I., Khademhosseini, A., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/abc8de · Cited by 92
Self-citationAttalla, R., Puersten, E., Jain, N., & Selvaganapathy, P. R. (2018) · Biofabrication · doi:10.1088/1758-5090/aaf7c7 · Cited by 87
Bai, Z., Wang, T., Zheng, X. H., Huang, Y., Chen, Y., & Dan, W. (2020) · Polymer Engineering and Science · doi:10.1002/pen.25574 · Cited by 85
Monolithic multilayer microfluidics via sacrificial molding of 3D-printed isomalt
Gelber, M. K., & Bhargava, R. (2015) · Lab on a Chip · doi:10.1039/c4lc01392a · Cited by 91
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Wang, K., Hao, Y., Wang, Y., Chen, J., Mao, L., Deng, Y., Chen, J., Yuan, S., Zhang, T., Ren, J., et al. (2019) · International Journal of Polymer Science · doi:10.1155/2019/3160732 · Cited by 86
On-chip high-definition bioprinting of microvascular structures
Dobos, A., Chalupa‐Gantner, F., Marković, M., Hoorick, J. V., Tytgat, L., Vlierberghe, S. V., & Ovsianikov, A. (2020) · Biofabrication · doi:10.1088/1758-5090/abb063 · Cited by 87
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Loukelis, K., Koutsomarkos, N., Mikos, A. G., & Chatzinikolaidou, Μ. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae033 · Cited by 94
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Huang, M. S., Christakopoulos, F., Roth, J. G., & Heilshorn, S. C. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00268-0 · Cited by 99
Mirdamadi, E., Muselimyan, N., Koti, P., Asfour, H., & Sarvazyan, N. A. (2019) · 3D Printing and Additive Manufacturing · doi:10.1089/3dp.2018.0175 · Cited by 89
Synchronous 3D Bioprinting of Large‐Scale Cell‐Laden Constructs with Nutrient Networks
Shao, L., Gao, Q., Xie, C., Fu, J., Xiang, M., & He, Y. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901142 · Cited by 83
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Goto, R., Nishida, E., Kobayashi, S., Aino, M., Ohno, T., Iwamura, Y., Kikuchi, T., Hayashi, J., Yamamoto, G., Asakura, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041635 · Cited by 82
3D bioprinting for modelling vasculature
Sasmal, P. K., Datta, P., Wu, Y. B., & Ozbolat, I. T. (2018) · Microphysiological Systems · doi:10.21037/mps.2018.10.02 · Cited by 85
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Jian, H., Wang, M., Wang, S., Wang, A., & Bai, S. (2018) · Bio-Design and Manufacturing · doi:10.1007/s42242-018-0006-1 · Cited by 82
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Shahabipour, F., Ashammakhi, N. A., Oskuee, R. K., Bonakdar, S., Hoffman, T., Shokrgozar, M. A., & Khademhosseini, A. (2019) · Translational research · doi:10.1016/j.trsl.2019.08.010 · Cited by 84
Self-citationAdditive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs
Elomaa, L., & Yang, Y. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0348 · Cited by 82
Self-citationLim, K. S., Baptista, M., Moon, S., Woodfield, T. B. F., & Rnjak‐Kovacina, J. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.04.004 · Cited by 82
Nasello, G., Alamán‐Díez, P., Schiavi, J., Pérez, M. Á., McNamara, L. M., & García‐Aznar, J. M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00336 · Cited by 80
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Perfusion and endothelialization of engineered tissues with patterned vascular networks
Kinstlinger, I. S., Calderon, G. A., Royse, M. K., Means, A. K., Grigoryan, B., & Miller, J. S. (2021) · Nature Protocols · doi:10.1038/s41596-021-00533-1 · Cited by 88
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Ma, Y., Li, X., Yang, B., & Tian, W. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26882 · Cited by 82
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Leijten, J., Rouwkema, J., Zhang, Y. S., Nasajpour, A., Dokmeci, M. R., & Khademhosseini, A. (2015) · Small · doi:10.1002/smll.201501798 · Cited by 76
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Kang, Y., & Chang, J. (2018) · Regenerative Medicine · doi:10.2217/rme-2018-0022 · Cited by 75
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Hwang, D. G., Choi, Y., & Jang, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.685507 · Cited by 74
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Wu, J., Yun, Z., Song, W., Yu, T., Xue, W., Liu, Q., & Sun, X. (2024) · Theranostics · doi:10.7150/thno.89493 · Cited by 76
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Zou, Q., Grottkau, B. E., He, Z., Shu, L., Yang, L., Ma, M., & Ye, C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110205 · Cited by 74
Tenje, M., Cantoni, F., Hernández, A. M. P., Searle, S. S., Johansson, S., Barbe, L., Antfolk, M., & Pohlit, H. (2020) · Organs-on-a-Chip · doi:10.1016/j.ooc.2020.100003 · Cited by 79
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Sun, M., Liu, A., Yang, X., Gong, J., Yu, M., Yao, X., Wang, H., & He, Y. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000066 · Cited by 75
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Park, J. Y., Jang, J., & Kang, H. (2018) · Microelectronic Engineering · doi:10.1016/j.mee.2018.08.004 · Cited by 73
Zhang, Y. S., & Khademhosseini, A. (2015) · Nanomedicine · doi:10.2217/nnm.15.18 · Cited by 71
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Yeo, M., Sarkar, A., Singh, Y. P., Derman, İ. D., Datta, P., & Ozbolat, I. T. (2023) · Biofabrication · doi:10.1088/1758-5090/ad0b3f · Cited by 75
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Jongprasitkul, H., Turunen, S., Parihar, V. S., & Kellomäki, M. (2021) · Bioprinting · doi:10.1016/j.bprint.2021.e00185 · Cited by 69
Silva, A. C., Rodrigues, S. C., Caldeira, J., Nunes, A. M., Sampaio‐Pinto, V., Resende, T. P., Oliveira, M. J., Barbosa, M. A., Þorsteinsdóttir, S., Nascimento, D. S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.062 · Cited by 69
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Mohamed, M. G. A., Ambhorkar, P., Samanipour, R., Yang, A., Ghafoor, A., & Kim, K. (2020) · Biomicrofluidics · doi:10.1063/1.5134060 · Cited by 68
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Bégin‐Drolet, A., Dussault, M.-A., Fernandez, S. A., Larose-Dutil, J., Leask, R. L., Hoesli, C. A., & Ruel, J. (2017) · Additive manufacturing · doi:10.1016/j.addma.2017.03.006 · Cited by 66
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Metadata
- Authors
- Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., & Khademhosseini, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Politecnico di Torino (IT)
- Stanford Medicine (US)
- Corresponding author
- Khademhosseini, Ali
- ORCID
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 13
- Pages
- 2202-2211
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC4201051
- OpenAlex
- W2129322399
- Cited by
- 944
- References
- 50
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 63 · 2023: 78 · 2022: 55 · 2021: 102 · 2020: 96 · 2019: 129 · 2018: 104 · 2017: 87 · 2016: 76 · 2015: 50 · 2014: 16
- FWCI
- 39.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- PORTO@Iris (submittedVersion)
- PORTO Publications Open Repository TOrino (Politecnico di Torino) (submittedVersion)
- Funders
- National Institutes of Health
- Defense Threat Reduction Agency
- Australian Research Council
- National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
- National Institute of General Medical Sciences (R01GM095906, GM095906)
- National Institute of Allergy and Infectious Diseases (R01AI081534, AI081534)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
- National Institute of Biomedical Imaging and Bioengineering (EB02597)
- National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- microchannel networks, vascularization, gelatin methacryloyl, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, endothelial monolayer, mass transfer, cell viability, cell differentiation, organ-on-a-chip
- MeSH terms
- Animals, Blood Vessel Prosthesis, Cell Line, Osteoblasts, Polyethylene Glycols, Sepharose, Hydrogels, Tissue Engineering, Mice
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