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Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Open accessAbstract
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel constructs. Using the proposed approach, we were able to successfully embed functional and perfusable microchannels inside methacrylated gelatin (GelMA), star poly(ethylene glycol-co-lactide) acrylate (SPELA), poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels at different concentrations. In particular, GelMA hydrogels were used as a model to demonstrate the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. In addition, successful formation of endothelial monolayers within the fabricated channels was confirmed. Overall, our proposed strategy represents an effective technique for vascularization of hydrogel constructs with useful applications in tissue engineering and organs on a chip.
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“Microfabrication enables the use of biomaterials to 1) support long-lasting open EC lumens for perfusion; 2) define sophisticated capillary networks to mimic the hierarchy of native vasculature; 3) guide and support EC growth and maintain their cellular functions [259–263].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [263]
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Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Self-citationRapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917
Self-healing materials with microvascular networks
Toohey, K. S., Sottos, N. R., Lewis, J. A., Moore, J. S., & White, S. R. (2007) · Nature Materials · doi:10.1038/nmat1934 · Cited by 1,644
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
Self-citationScaffold-free vascular tissue engineering using bioprinting
Norotte, C., Marga, F., Niklason, L. E., & Forgács, G. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.034 · Cited by 1,342
In vitro microvessels for the study of angiogenesis and thrombosis
Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201240109 · Cited by 894
Engineering of functional, perfusable 3D microvascular networks on a chip
Kim, S., Lee, H., Chung, M., & Jeon, N. L. (2013) · Lab on a Chip · doi:10.1039/c3lc41320a · Cited by 872
Omnidirectional Printing of 3D Microvascular Networks
Wu, W., DeConinck, A., & Lewis, J. A. (2011) · Advanced Materials · doi:10.1002/adma.201004625 · Cited by 819
Engineering vascularized tissue
Jain, R. K., Au, P., Tam, J., Duda, D. G., & Fukumura, D. (2005) · Nature Biotechnology · doi:10.1038/nbt0705-821 · Cited by 808
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels
Chen, Y., Lin, R., Qi, H., Yang, Y., Bae, H., Melero‐Martin, J. M., & Khademhosseini, A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101662 · Cited by 802
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Bae, 2012, J. Tissue Eng. Regener. Med., 1
- Hansen, 2011, Adv. Funct. Mater., 1
- Jakab, 2006, Biorheology, 43, 509
Cited by
Sorted by citations
Items 301–400 of 943
Wang, Y., He, C. H., Feng, Y., Yang, Y., Wei, Z., Zhao, W., & Zhao, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01755k · Cited by 61
Self-citationExperimental approaches to vascularisation within tissue engineering constructs
Sarker, M. D., Chen, D., & Schreyer, D. J. (2015) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2015.1059018 · Cited by 64
Li, S., Liu, Y.-Y., Liu, L., & Hu, Q. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b07725 · Cited by 63
Vascularized microfluidic platforms to mimic the tumor microenvironment
Michna, R. J., Gadde, M., Özkan, A., DeWitt, M. R., & Rylander, M. N. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26778 · Cited by 62
Clark, C., Aleman, J., Mutkus, L. A., & Skardal, A. (2019) · Bioprinting · doi:10.1016/j.bprint.2019.e00058 · Cited by 60
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Pradhan, S., Banda, O. A., Farino, C. J., Sperduto, J. L., Keller, K. A., Taitano, R. A., & Slater, J. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901255 · Cited by 63
Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials
Zhang, P., Shao, N., & Qin, L. (2021) · Advanced Materials · doi:10.1002/adma.202005944 · Cited by 61
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Kong, Z., & Wang, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010891 · Cited by 66
Rutz, A. L., Lewis, P. L., & Shah, R. N. (2017) · MRS Bulletin · doi:10.1557/mrs.2017.162 · Cited by 60
Bioprinting and Cellular Therapies for Type 1 Diabetes
Ravnic, D. J., Leberfinger, A. N., & Ozbolat, I. T. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.07.006 · Cited by 60
Stabilization strategies in extrusion-based 3D bioprinting for tissue engineering
Shapira, A., Noor, N., Asulin, M., & Dvir, T. (2018) · Applied Physics Reviews · doi:10.1063/1.5055659 · Cited by 62
Bioprinting a Synthetic Smectic Clay for Orthopedic Applications
Afewerki, S., Magalhães, L. S. S. M., Silva, A. D. R., Stocco, T. D., Silva-Filho, E. C., Marciano, F. R., & Lobo, A. O. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900158 · Cited by 61
Fabrication and Biomedical Applications of Heart-on-a-chip
Yang, Q., Xiao, Z., Lv, X., Zhang, T., & Liu, H. (2021) · International Journal of Bioprinting · doi:10.18063/ijb.v7i3.370 · Cited by 65
Synthesis and High-Throughput Processing of Polymeric Hydrogels for 3D Cell Culture
Lowe, S. B., Tan, V. T. G., Soeriyadi, A. H., Davis, T. P., & Gooding, J. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500310v · Cited by 60
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Suntornnond, R., An, J., & Chua, C. K. (2017) · International Journal of Bioprinting · doi:10.18063/ijb.2017.01.006 · Cited by 59
Li, Y., Zhang, T., Pang, Y., Li, L., Chen, Z., & Sun, W. (2019) · Biofabrication · doi:10.1088/1758-5090/ab256c · Cited by 60
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Bian, F., Sun, L., Cai, L., Wang, Y., Wang, Y., & Zhao, Y. (2019) · Small · doi:10.1002/smll.201903931 · Cited by 59
Cell-microenvironment interactions and architectures in microvascular systems
Bersini, S., Yazdi, I. K., Talò, G., Shin, S. R., Moretti, M., & Khademhosseini, A. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.07.002 · Cited by 60
Self-citationMa, Z., He, H., Deng, C., Ya, R., Lu, D., Li, W., Sun, X., Wang, W., Zhang, Y., Xu, Y., et al. (2021) · Composites Part B Engineering · doi:10.1016/j.compositesb.2021.109399 · Cited by 59
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Kreuder, A.-E., Bolaños-Rosales, A., Palmer, C. P., Thomas, A., Geiger, M., Lam, T., Amler, A.-K., Markert, U. R., Lauster, R., & Kloke, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-72559-6 · Cited by 58
Muthusamy, S., Kannan, S., Lee, M., Vijayavenkataraman, S., Lu, W. F., Fuh, J. Y. H., Sriram, G., & Cao, T. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27838 · Cited by 61
Zhao, T., Liu, Y., Wu, Y., Zhao, M., & Zhao, Y. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108243 · Cited by 60
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Li, C., Kuss, M. A., Kong, Y., Nie, F., Liu, X., Liu, B., Dunaevsky, A., Fayad, P. B., Duan, B., & Li, X. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01619 · Cited by 56
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Vetter, J., Palagi, I., Waisman, A., & Blaeser, A. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.041 · Cited by 58
Houben, A., Hoorick, J. V., Erps, J. V., Hugo Thienpont, A., Vlierberghe, S. V., & Dubruel, P. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1610-x · Cited by 57
Qi, D., Wu, S., Kuss, M. A., Shi, W., Chung, S., Deegan, P. T., Kamenskiy, A. V., He, Y., & Duan, B. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.05.044 · Cited by 55
Fabrication of biomimetic vascular scaffolds for 3D tissue constructs using vascular corrosion casts
Huling, J. C., Ko, I. K., Atala, A., & Yoo, J. J. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.01.005 · Cited by 54
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Huang, Y., Segall, J. E., & Wu, M. (2017) · Lab on a Chip · doi:10.1039/c7lc00623c · Cited by 58
Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F. R. A. J., Alexander, C., & Ghaemmaghami, A. M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00116 · Cited by 54
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Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach
Kang, Y., Mochizuki, N., Khademhosseini, A., Fukuda, J., & Yang, Y. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.09.035 · Cited by 53
Self-citationKageyama, T., Osaki, T., Enomoto, J., Myasnikova, D. A., Nittami, T., Hozumi, T., Ito, T., & Fukuda, J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00203 · Cited by 53
Wang, Z., Jin, X., Tian, Z., Ménard, F., Holzman, J. F., & Kim, K. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701249 · Cited by 55
Im, G., & Lin, R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1053491 · Cited by 55
Sun, J., Li, G., Wu, S., Zou, Y., Weng, W., Gai, T., Chen, X., Zhang, K., Zhou, F., Wang, X., et al. (2023) · Composites Part B Engineering · doi:10.1016/j.compositesb.2023.110803 · Cited by 53
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Wu, C., Wang, B., Zhang, C., Wysk, R. A., & Chen, Y. (2016) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2016.1163321 · Cited by 52
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Roy, A., Saxena, V., & Pandey, L. M. (2018) · Materials Technology · doi:10.1080/10667857.2018.1456616 · Cited by 54
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Velasco‐Mallorquí, F., Fernández‐Costa, J. M., Neves, L. A., & Ramón‐Azcón, J. (2020) · Nanoscale Advances · doi:10.1039/d0na00268b · Cited by 52
Appelt‐Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., & Pleß, O. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.122 · Cited by 56
Vrana, N. E., Gupta, S., Mitra, K., Rizvanov, A. A., Solovyeva, V. V., Antmen, E., Salehi, M., Ehterami, A., Pourchet, L., Barthès, J., et al. (2022) · Cell and Tissue Banking · doi:10.1007/s10561-021-09975-z · Cited by 56
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Parthiban, S. P., Athirasala, A., Tahayeri, A., Abdelmoniem, R., George, A., & Bertassoni, L. E. (2021) · Biofabrication · doi:10.1088/1758-5090/abb11f · Cited by 49
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Luo, J., Zhu, J., Wang, L., Kang, J. L., Wang, X., & Xiong, J. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111622 · Cited by 47
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Metadata
- Authors
- Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., & Khademhosseini, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Politecnico di Torino (IT)
- Stanford Medicine (US)
- Corresponding author
- Khademhosseini, Ali
- ORCID
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 13
- Pages
- 2202-2211
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC4201051
- OpenAlex
- W2129322399
- Cited by
- 944
- References
- 50
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 63 · 2023: 78 · 2022: 55 · 2021: 102 · 2020: 96 · 2019: 129 · 2018: 104 · 2017: 87 · 2016: 76 · 2015: 50 · 2014: 16
- FWCI
- 39.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- PORTO@Iris (submittedVersion)
- PORTO Publications Open Repository TOrino (Politecnico di Torino) (submittedVersion)
- Funders
- National Institutes of Health
- Defense Threat Reduction Agency
- Australian Research Council
- National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
- National Institute of General Medical Sciences (R01GM095906, GM095906)
- National Institute of Allergy and Infectious Diseases (R01AI081534, AI081534)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
- National Institute of Biomedical Imaging and Bioengineering (EB02597)
- National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- microchannel networks, vascularization, gelatin methacryloyl, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, endothelial monolayer, mass transfer, cell viability, cell differentiation, organ-on-a-chip
- MeSH terms
- Animals, Blood Vessel Prosthesis, Cell Line, Osteoblasts, Polyethylene Glycols, Sepharose, Hydrogels, Tissue Engineering, Mice
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