Cited by 9443D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

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Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

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Bertassoni, Luiz E., Cecconi, Martina, Manoharan, Vijayan, Nikkhah, Mehdi, Hjortnaes, Jesper, Cristino, Ana Luiza, Barabaschi, Giada, Demarchi, Danilo, Dokmeci, Mehmet R., Yang, Yunzhi, Khademhosseini, Ali·2014·Lab Chip

DOI 10.1039/c4lc00030gPMC PMC4201051

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Abstract

Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel constructs. Using the proposed approach, we were able to successfully embed functional and perfusable microchannels inside methacrylated gelatin (GelMA), star poly(ethylene glycol-co-lactide) acrylate (SPELA), poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels at different concentrations. In particular, GelMA hydrogels were used as a model to demonstrate the functionality of the fabricated vascular networks in improving mass transport, cellular viability and differentiation within the cell-laden tissue constructs. In addition, successful formation of endothelial monolayers within the fabricated channels was confirmed. Overall, our proposed strategy represents an effective technique for vascularization of hydrogel constructs with useful applications in tissue engineering and organs on a chip.

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Self-citation

Authors: Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., & Khademhosseini, A.
Affiliations: Brigham and Women's Hospital (US)
Politecnico di Torino (IT)
Stanford Medicine (US)
Corresponding author: Khademhosseini, Ali
ORCID: Bertassoni, Luiz E.
Manoharan, Vijayan
Nikkhah, Mehdi
Hjortnaes, Jesper
Demarchi, Danilo
Dokmeci, Mehmet R.
Yang, Yunzhi
Khademhosseini, Ali
Venue: Lab Chip
Publisher: Royal Society of Chemistry (RSC)
Published: 2014
Volume: 14
Issue: 13
Pages: 2202-2211
ISSN: 1473-0189 (ISSN-L)
1473-0197
DOI: 10.1039/c4lc00030g
PMC: PMC4201051
OpenAlex: W2129322399
Cited by: 944
References: 50
Citations by year: 2026: 34 · 2025: 53 · 2024: 63 · 2023: 78 · 2022: 55 · 2021: 102 · 2020: 96 · 2019: 129 · 2018: 104 · 2017: 87 · 2016: 76 · 2015: 50 · 2014: 16
FWCI: 39.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Lab on a Chip (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
PORTO@Iris (submittedVersion)
PORTO Publications Open Repository TOrino (Politecnico di Torino) (submittedVersion)
Funders: National Institutes of Health
Defense Threat Reduction Agency
Australian Research Council
National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
National Institute of General Medical Sciences (R01GM095906, GM095906)
National Institute of Allergy and Infectious Diseases (R01AI081534, AI081534)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
National Institute of Biomedical Imaging and Bioengineering (EB02597)
National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: microchannel networks, vascularization, gelatin methacryloyl, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, endothelial monolayer, mass transfer, cell viability, cell differentiation, organ-on-a-chip
MeSH terms: Animals, Blood Vessel Prosthesis, Cell Line, Osteoblasts, Polyethylene Glycols, Sepharose, Hydrogels, Tissue Engineering, Mice

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Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

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