Cited by 143Angiogenesis and VEGF in Cancer3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

Open access
Kim, Choong, Kasuya, Junichi, Jeon, Jessie, Chung, Seok, Kamm, Roger D.·2015·Lab on a Chip

Abstract

Anti-angiogenic therapy is now widely accepted as a treatment for cancer. We introduce a new microfluidic platform that can monitor and quantify cellular behaviors, such as morphological changes, endothelial cell viability, and formation of angiogenic sprouts, depending on the various concentrations of drug applied (i.e., bortezomib, a selective 26S proteasome inhibitor).

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Crossref · 10.1039/c4lc00866a

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  • Fibroblasts can boost angiogenesis in in vitro assays.

    “fibroblasts can boost angiogenesis in in vitro assays, with exciting advances in the development of microfluidic angiogenesis models, and an increasing number of studies have shown how they can alter T cell functionality118,161,162.”

    From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [161]

    The Results and Discussion section (‘High throughput angiogenesis assay’; page unavailable) reports increased endothelial migration and lumen-like growth in response to VEGF, not fibroblasts. Searches for ‘fibroblast’ and fibroblast-conditioned media found no passage in our copy addressing whether fibroblasts boost angiogenesis in vitro. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Kim, C., Kasuya, J., Jeon, J., Chung, S., & Kamm, R. D.
Affiliations
  • Kyungil University (KR)
  • Massachusetts Institute of Technology (US)
  • Korea University (KR)
  • Singapore-MIT Alliance for Research and Technology (SG)
Corresponding author
Kamm, Roger D.
Venue
Lab on a Chip
Published
2015
Volume
15
Issue
1
Pages
301-310
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2083166046
Cited by
143
References
39
Citations by year
2026: 3 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 20 · 2020: 21 · 2019: 18 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 9 · 2014: 1
FWCI
4.38
Type
journal article
Language
en
Open access
Locations
  • Lab on a Chip (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
  • PMC
Funders
National Cancer Institute (R33CA174550)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
angiogenesis inhibitors, angiogenesis, high-throughput screening, human umbilical vein endothelial cells, bortezomib, proteasome inhibitors, endothelial cell death, tumor hypoxia
MeSH terms
Bortezomib, Boronic Acids, Cell Movement, Cell Survival, Humans, Neovascularization, Pathologic, Pyrazines, Cell Culture Techniques, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Microfluidic Analytical Techniques, Cell Proliferation, Human Umbilical Vein Endothelial Cells

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