Recapitulating the vasculature using ORGAN-ON-CHIP technology
Open accessAbstract
The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods.
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Gradients (e.g., oxygen, other chemical factors) establish around blood vessels, which can influence the behavior of nearby tumor cells.
“factors) establish around blood vessels, which can influence the behavior of nearby tumor cells [47].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [47]
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- Authors
- Pollet, A. M. A. O., & den Toonder, J. M. J.
- Affiliations
- Eindhoven University of Technology (NL)
- Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands
- Venue
- Bioengineering
- Publisher
- MDPI AG
- Published
- 2020-02-18
- Volume
- 7
- Issue
- 1
- Pages
- 17
- ISSN
- 2306-5354 (ISSN-L)
- PMC
- PMC7175276
- OpenAlex
- W3007625035
- Cited by
- 73
- References
- 84
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 14 · 2022: 13 · 2021: 13 · 2020: 3 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Bioengineering (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- TU/e Research Portal (publishedVersion, other-oa)
- TU/e Research Portal (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- TU/e Research Portal (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (15282)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- organ-on-a-chip, vascular tissue engineering, vascular biology
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