Natural deep eutectic solvents-mediated extractions: the way forward for sustainable analytical developments
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The concept of sustainable development has impacted in analytical chemistry changing the way of thinking processes and methods. It is important for analytical chemists to consider how sample preparation can integrate the basic concepts of Green Chemistry. In this sense, the replacement of traditional organic solvents is of utmost importance. Natural Deep Eutectic Solvents (NADES) have come to light as a green alternative. In the last few years, a growing number of contributions have applied these natural solvents proving their efficiency in terms of extraction ability, analyte stabilization capacity and detection compatibility. However, the arising question that has to be answered is: the use of NADES is enough to green an extraction process? This review presents an overview of knowledge regarding sustainability of NADES-based extraction procedures, focused on reported literature within the timeframe spanning from 2011 up to date. The contributions were analyzed from a green perspective in terms of energy, time, sample and solvent consumption. Moreover, we include a critical analysis to clarify whether the use of NADES as extraction media is enough for greening an analytical methodology; strategies to make them even greener are also presented. Finally, recent trends and future perspectives on how NADES-based extraction approaches in combination with computational methodologies can contribute are discussed.
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The main advantages of both DES and NADES are biodegradability, low toxicity, low cost, simple preparation, negligible volatility, and especially their adjustable physicochemical properties (density, viscosity, and polarity).
“The main advantages of both classes of green solvents are biodegradability, low toxicity, low cost, simple preparation, negligible volatility, and especially their adjustable physicochemical properties (density, viscosity, and polarity) [15].”
From Greenness of procedures using NADES in the preparation of vegetal samples: Comparison of five green metrics (2022) · cites this paper as [15]
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- Authors
- Fernández, M. D. L. Á., Boiteux, J., Espino, M., Gomez, F. J. V., & Silva, M. F.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Silva, María Fernanda
- Venue
- Analytica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 1038
- Pages
- 1-10
- ISSN
- 0003-2670 (ISSN-L)
- OpenAlex
- W2883843539
- Cited by
- 307
- References
- 60
- Citations by year
- 2026: 26 · 2025: 44 · 2024: 37 · 2023: 39 · 2022: 51 · 2021: 42 · 2020: 35 · 2019: 33
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Analytica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Conicet (submittedVersion, cc-by-nc-nd)
- Funders
- Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo (06/P31-04)
- Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 11220130100185CO)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Keywords
- natural deep eutectic solvents, solvent extraction, green chemistry, sample preparation, energy consumption, solvent consumption, extraction efficiency
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