Cited by 122Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Open access
Fort, Kyle L., van de Waterbeemd, Michiel, Boll, Dmitriy, Reinhardt-Szyba, Maria, Belov, Mikhail E., Sasaki, Eita, Zschoche, Reinhard, Hilvert, Donald +2 more·2018·The Analyst

Abstract

Native mass spectrometry can provide insight into the structure of macromolecular biological systems.

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Integrity signals

Registry

Crossref · 10.1039/c7an01629h

Cites

16 of 16 references verified0 citation errors · 0 not checkable

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  • Instrument hardware improvements enhanced large ion transmission and detection, especially with UHMR Orbitraps capable of analyzing species at 70,000 m/z and mass as large as 800 kDa.

    “More recently, instrument hardware improvements have led to enhanced large ion transmission and detection, especially with the implementation of ultra-high mass range (UHMR) Orbitraps that are capable of analyzing species at 70,000 m/z and mass as large as 800 kDa [103,104].”

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Cites

Flagged first, then by citations

Research works printed but not linked: 16

  1. M. Wilm and M. Mann, Anal. Chem., 1996, 68, 1-8.
  2. M. S. Wilm and M. Mann, Int. J. Mass Spectrom. Ion Processes, 1994, 136, 167-180.
  3. J. B. Fenn, M. Mann, C. K. Meng, S. F. Wong and C. M. Whitehouse, Science, 1989, 246, 64-71.
  4. H. Hernandez and C. V. Robinson, Nat. Protoc., 2007, 2, 715-726.
  5. B. T. Ruotolo, J. L. P. Benesch, A. M. Sandercock, S.-J. Hyung and C. V. Robinson, Nat. Protocols, 2008, 3, 1139-1152.
  6. V. Katta and B. T. Chait, J. Am. Chem. Soc., 1991, 113, 8534- 8535.
  7. J. Snijder, R. J. Rose, D. Veesler, J. E. Johnson and A. J. R. Heck, Angew. Chem., Int. Ed., 2013, 52, 4020-4023.
  8. R. J. Rose, E. Damoc, E. Denisov, A. Makarov and A. J. R. Heck, Nat. Methods, 2012, 9, 1084-1086.
  9. C. Uetrecht, I. M. Barbu, G. K. Shoemaker, E. van Duijn and A. J. R. Heck, Nat. Chem., 2011, 3, 126-132.
  10. J. Snijder and A. J. R. Heck, Annu. Rev. Anal. Chem., 2014, 7, 43-64.
  11. A. J. R. Heck, Nat. Methods, 2008, 5, 927-933.
  12. J. A. Loo, Mass Spectrom. Rev., 1997, 16, 1-23.
  13. J. Snijder, M. van de Waterbeemd, E. Damoc, E. Denisov, D. Grinfeld, A. Bennett, M. Agbandje-McKenna, A. Makarov and A. J. R. Heck, J. Am. Chem. Soc., 2014, 136, 7295-7299.
  14. M. van de Waterbeemd, K. L. Fort, D. Boll, M. Reinhardt- Szyba, A. Routh, A. Makarov and A. J. R. Heck, Nat. Methods, 2017, 14, 283-286.
  15. E. Sasaki, D. Bohringer, M. van de Waterbeemd, M. Leibundgut, R. Zschoche, A. J. R. Heck, N. Ban and D. Hilvert, Nat. Commun., 2017, 8, 10.
  16. G. Ben-Nissan, M. E. Belov, D. Morgenstern, Y. Levin, O. Dyrn, G. Arkind, G. Lipson, A. A. Makarov and M. Sharon, Anal. Chem., 2017, 89, 4708-4715.

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Authors
Fort, K. L., van de Waterbeemd, M., Boll, D., Reinhardt-Szyba, M., Belov, M. E., Sasaki, E., Zschoche, R., Hilvert, D., Makarov, A. A., & Heck, A. J. R.
Affiliations
  • Utrecht University (NL)
  • Biomolecular Mass Spectrometry and Proteomics
  • Thermo Fisher Scientific (Germany) (DE)
  • ETH Zurich (CH)
Corresponding author
Heck, Albert J. R.
Venue
The Analyst
Published
2018
Volume
143
Issue
1
Pages
100-105
ISSN
  • 0003-2654 (ISSN-L)
  • 1364-5528
OpenAlex
W2767559908
Cited by
122
References
16
Citations by year
2026: 10 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 20 · 2020: 18 · 2019: 18 · 2018: 8
FWCI
5.93
Type
journal article
Language
en
Open access
Locations
  • The Analyst (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
  • Stichting voor Fundamenteel Onderzoek der Materie (12PR3303-2)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (184.032.201, 718.015.003)
  • H2020 Future and Emerging Technologies (686547)
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
  • Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords
native mass spectrometry, macromolecular complexes, signal intensity enhancement, mass resolution

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