Cited by 25Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

Tong, Tao, Kim, Minji, Park, Taesun·2019·Food & Function

Abstract

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.

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Crossref · 10.1039/c8fo01992d

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  • Dietary supplementation of α-ionone improves the loss of skeletal muscle induced by HFD in C57BL/6N mice and prevents C2C12 myotubes from palmitic acid-induced atrophy via cyclic adenosine monophosphate signaling.

    “Dietary supplementation of α-ionone, a naturally occurring flavoring agent in violets and blackberries, improves the loss of skeletal muscle induced by HFD in C57BL/6N mice and prevents C2C12 myotubes from palmitic acid-induced atrophy via cyclic adenosine monophosphate signaling [121].”

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Authors
Tong, T., Kim, M., & Park, T.
Affiliations
Yonsei University (KR)
Corresponding author
Park, Taesun
Venue
Food & Function
Published
2019
Volume
10
Issue
2
Pages
1167-1178
ISSN
  • 2042-6496 (ISSN-L)
  • 2042-650X
OpenAlex
W2914663380
Cited by
23
References
53
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Locations
  • Food & Function (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Research Foundation of Korea (NRF-2016R1A2B4016189)
  • Yonsei University (2018-12-0006)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
α-ionone, skeletal muscle atrophy, high-fat diet, cAMP signaling, PKA/CREB signaling, myogenesis, myotube fusion, palmitic acid, muscle mass, muscle strength
MeSH terms
Animals, Cell Line, Muscle Proteins, Muscular Atrophy, Signal Transduction, Muscle, Skeletal, Norisoprenoids, Mice, Diet, High-Fat

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