α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling
Abstract
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.
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Dietary supplementation of α-ionone improves the loss of skeletal muscle induced by HFD in C57BL/6N mice and prevents C2C12 myotubes from palmitic acid-induced atrophy via cyclic adenosine monophosphate signaling.
“Dietary supplementation of α-ionone, a naturally occurring flavoring agent in violets and blackberries, improves the loss of skeletal muscle induced by HFD in C57BL/6N mice and prevents C2C12 myotubes from palmitic acid-induced atrophy via cyclic adenosine monophosphate signaling [121].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [121]
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Traditional Chinese Medicine for Diabetic Sarcopenia: A Review and Its Related Mechanisms
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- Authors
- Tong, T., Kim, M., & Park, T.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Park, Taesun
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 10
- Issue
- 2
- Pages
- 1167-1178
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2914663380
- Cited by
- 23
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2016R1A2B4016189)
- Yonsei University (2018-12-0006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- α-ionone, skeletal muscle atrophy, high-fat diet, cAMP signaling, PKA/CREB signaling, myogenesis, myotube fusion, palmitic acid, muscle mass, muscle strength
- MeSH terms
- Animals, Cell Line, Muscle Proteins, Muscular Atrophy, Signal Transduction, Muscle, Skeletal, Norisoprenoids, Mice, Diet, High-Fat
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