α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts
Open accessAbstract
Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced photoaging in human Hs68 dermal fibroblasts and identified the mechanisms involved. We found that in human dermal fibroblasts, α-ionone inhibited UVB-induced loss of collagen. α-Ionone upregulated the molecules participating in the TGF-β–SMAD pathway (TGF-β1, phospho-SMAD2/3, Col1A1, and Col1A2), but downregulated the molecules involved in the MAPK–AP-1 signaling pathway (phospho-p38, phospho-JNK, phospho-ERK, phospho-c-Fos, phospho-c-Jun, MMP1, MMP3, and MMP9), in human dermal fibroblasts. α-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Thus, α-ionone is effective in the prevention of UVB-induced decrease of collagen and hyaluronic acid in human dermal fibroblasts. We propose that α-ionone may prove beneficial for the prevention of UV-induced wrinkle formation and skin damage.
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There is increasing animal and clinical evidence that dietary supplementation of functional components can protect skin from photoaging damage.
“There is increasing animal and clinical evidence that dietary supplementation of functional components can protect skin from photoaging damage.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [8]
Mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging.
“mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [8]
Phytochemicals, functional proteins and peptides, functional sugars, functional oils, probiotics, vitamins, and minerals improve photoaging-associated morphological abnormalities and functional decline.
“Phytochemicals [8], functional proteins [9] and peptides [10], functional sugars [11,12], functional oils [13], probiotics [14,15], vitamins [16,17], and minerals [18,19] are well-known to improve the photoaging-associated morphological abnormalities and functional decline.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [8]
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Cites
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959 · see citing works
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
Angel, P. E., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 3,390 · see citing works
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · cited 1× · see citing works
“On the other hand, it is also known that AP-1 [a menagerie of dimers of basic region-leucine zipper (bZIP) proteins that are typically composed of c-Jun and c-Fos] regulates collagen homeostasis via modulation of both collagen synthesis and degradation [25].”
BackgroundPathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472 · see citing works
Ricard-Blum, S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004978 · Cited by 2,305 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works
Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis
Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., & Ohtsuki, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060868 · Cited by 1,099 · see citing works
Hyaluronic acid: A key molecule in skin aging
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031 · see citing works
Ichihashi, M., Ueda, M., Budiyanto, A., Bito, T., Oka, M., Fukunaga, M., Tsuru, K., & Horikawa, T. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00150-1 · Cited by 970 · see citing works
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
Piek, E., HELDIN, C., & ten Dijke, P. (1999) · PubMed · Cited by 783 · see citing works
Matrix-Degrading Metalloproteinases in Photoaging
Quan, T., Qin, Z., Xia, W., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.8 · Cited by 740 · see citing works
Specificity, diversity, and regulation in TGF‐β superfamily signaling
Piek, E., Heldin, C., & ten Dijke, P. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2105 · Cited by 658 · see citing works
The regulation of matrix metalloproteinases and their inhibitors
Clark, I. M., Swingler, T. E., Sampieri, C. L., & Edwards, D. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.006 · Cited by 555 · see citing works
Schiller, M., Javelaud, D., & Mauviel, A. (2004) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2003.12.006 · Cited by 468 · see citing works
Quan, T., & Fisher, G. J. (2015) · Gerontology · doi:10.1159/000371708 · Cited by 464 · see citing works
Cavinato, M., & Jansen-Dürr, P. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.009 · Cited by 284 · see citing works
Connective Tissue Biochemistry of the Aging Dermis
Uitto, J. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30806-4 · Cited by 276 · see citing works
Matsumura, Y., & Ananthaswamy, H. N. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940200532x · Cited by 163 · see citing works
Dai, G., Freudenberger, T., Zipper, P., Melchior, A., Grether‐Beck, S., Rabausch, B., de Groot, J., Twarock, S., Hanenberg, H., Homey, B., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070136 · Cited by 162 · see citing works
HYALURONIC ACID AND SKIN: WOUND HEALING AND AGING
Manuskiatti, W., & Maibach, H. I. (1996) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1996.tb03650.x · Cited by 161 · see citing works
Quan, T., He, T., Shao, Y., Lin, L., Kang, S., Voorhees, J. J., & Fisher, G. J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060128 · Cited by 130 · see citing works
Molecular Cloning of Human Hyaluronan Synthase
Itano, N., & Kimata, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0827 · Cited by 112 · see citing works
Molecular Mechanisms andIn VivoMouse Models of Skin Aging Associated with Dermal Matrix Alterations
Hwang, K., Yi, B.-R., & Choi, K. (2011) · Laboratory Animal Research · doi:10.5625/lar.2011.27.1.1 · Cited by 108 · see citing works
Dermal Transforming Growth Factor-β Responsiveness Mediates Wound Contraction and Epithelial Closure
Martínez‐Ferrer, M., Sharif‐Afshar, A., Uwamariya, C., Crombrugghe, B. D., Davidson, J. M., & Bhowmick, N. A. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090283 · Cited by 96 · see citing works
Photosensitized DNA Damage and its Protection via a Novel Mechanism†
Hiraku, Y., Ito, K., Hirakawa, K., & Kawanishi, S. (2007) · Photochemistry and Photobiology · doi:10.1562/2006-03-09-ir-840 · Cited by 91 · see citing works
Roeck, K., Grandoch, M., Majora, M., Krutmann, J., & Fischer, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.201665 · Cited by 90 · see citing works
Gao, W., Wang, Y., Hwang, E., Lin, P., Bae, J., Seo, S. A., Yan, Z., & Yi, T. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.06.007 · Cited by 85 · see citing works
Modulation of Collagen Metabolism by the Topical Application of Dehydroepiandrosterone to Human Skin
Shin, M. H., Rhie, G., Park, C., Kim, K. H., Cho, K. H., Eun, H. C., & Chung, J. H. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23588.x · Cited by 78 · see citing works
A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
Belsito, D. V., Bickers, D. R., Bruze, M., Calow, P., Greim, H. A., Hanifin, J. M., Rogers, A. E., Saurat, J. ‐., Sipes, I. G., & Tagami, H. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.067 · Cited by 67 · see citing works
Margelin, D., Medaisko, C., Lombard, D., Picard, J., & Fourtanier, A. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343819 · Cited by 57 · see citing works
α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3
Tong, T., Yu, R., & Park, T. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0176-0 · Cited by 34 · see citing works
Self-citationKim, H. N., Gil, C. H., Kim, Y. R., Shin, H. K., & Choi, B. T. (2016) · Scientific Reports · doi:10.1038/srep31169 · Cited by 32 · see citing works
Tong, T., Kim, M., & Park, T. (2019) · Food & Function · doi:10.1039/c8fo01992d · Cited by 23 · see citing works
Self-citationHuang, C., Lin, Y.-T., Kuo, H.-C., Chiou, W.-F., & Lee, M. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.08.042 · Cited by 21 · see citing works
Li, L., Hwang, E., Ngo, H. T. T., et al. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12894 · Cited by 21 · see citing works
Takahashi, Y., Ishikawa, O., Okada, K., et al. (1995) · Journal of Dermatological Science · doi:10.1016/0923-1811(95)00396-a · Cited by 19 · see citing works
RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3
Api, A. M., Belsito, D. V., Bhatia, S. P., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., Cava, S. L., et al. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.12.010 · Cited by 11 · see citing works
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Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works
Self-citation
- Authors
- Tong, T., Park, J., Moon, Y., Kang, W., & Park, T.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Park, Taesun
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2019-05-09
- Volume
- 24
- Issue
- 9
- Pages
- 1804
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6539661
- OpenAlex
- W2943937274
- Cited by
- 28
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2018: 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2019R1A2C2003340)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- α-ionone, UVB-induced photoaging, human dermal fibroblasts, collagen loss, TGF-β/Smad signaling, MAPK/AP-1 signaling, hyaluronan synthesis, HAS1, HAS2, MMPs, wrinkle formation, skin damage
- MeSH terms
- Collagen, Fibroblasts, Humans, Hyaluronic Acid, Models, Biological, Ultraviolet Rays, Skin Aging, Up-Regulation, Dermis, Norisoprenoids
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