Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering
Open accessAbstract
The extracellular matrix (ECM) is a complex and dynamic structural scaffold for cells within tissues and plays an important role in regulating cell function. Recently it has become appreciated that the ECM contains bioactive motifs that can directly modulate immune responses. This review describes strategies for engineering immunomodulatory biomaterials that utilize natural ECM‐derived molecules and have the potential to harness the immune system for applications ranging from tissue regeneration to drug delivery. A top‐down approach utilizes full‐length ECM proteins, including collagen, fibrin, or hyaluronic acid‐based materials, as well as matrices derived from decellularized tissue. These materials have the benefit of maintaining natural conformation and structure but are often heterogeneous and encumber precise control. By contrast, a bottom‐up approach leverages immunomodulatory domains, such as Arg–Gly–Asp (RGD), matrix metalloproteinase (MMP)‐sensitive peptides, or leukocyte‐associated immunoglobulin‐like receptor‐1(LAIR‐1) ligands, by incorporating them into synthetic materials. These materials have tunable control over immune cell functions and allow for combinatorial approaches. However, the synthetic approach lacks the full natural context of the original ECM protein. These two approaches provide a broad range of engineering techniques for immunomodulation through material interactions and hold the potential for the development of future therapeutic applications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The decellularization process may increase the immunogenicity of tissue by exposing hidden immunogenic domains, converting inert molecules into immunogenic particles, or depleting immunomodulatory substances.
“Decellularization process may increase the immunogenicity of the tissue by exposing hidden immunogenic domains, converting inert molecules within the decellularized tissue into immunogenic particles, or depleting immunomodulatory substances [74].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [74]
The Decellularized matrices section (page not provided) says that decellularization methods and post-processing affect immune responses, supporting the general point that processing can change immunogenicity. It does not describe increased immunogenicity through exposed hidden domains, conversion of inert molecules into immunogenic particles, or depletion of immunomodulatory substances; its antigen-removal example instead reports reduced antigen presentation. (LLM, conf=0.79)
Experimental — accuracy not yet measuredLow molecular weight hyaluronic acids are released when ECM undergoes damage or degradation and enhance immune cell chemotaxis, dendritic cell maturation, and macrophage polarization toward the M1 phenotype through CD44 and TLRs.
“Conversely, low molecular weight hyaluronic acids are released when ECM undergoes damage or degradation. They enhance immune cell chemotaxis, dendritic cell maturation, and macrophage polarization toward the M1 phenotype, mediated through the same receptors, CD44 and TLRs [74].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [74]
The Hyaluronic acid section (page unavailable) says lower-molecular-weight HA forms through degradation or damage and induces an inflammatory macrophage phenotype, consistent with the M1 portion of the claim. It does not report enhanced immune-cell chemotaxis or dendritic-cell maturation from low-MW HA, or establish that its effects are mediated through both CD44 and TLRs; its CD44 discussion specifically describes crosslinking by high-MW, not low-MW, HA. (LLM, conf=0.87)
Experimental — accuracy not yet measuredRGD motives of collagen, laminin, and fibronectin interact with integrin receptors of immune cells and exert significant immunomodulatory effects such as dampening adaptive immunity activities, neutrophils chemotaxis and pro-inflammatory cytokine production in macrophages.
“Moreover, three-peptide sequence amino acid (Arg-Gly-Asp) domains (RGD motives) of collagen, laminin, and fibronectin interact with integrin receptors of immune cells and exert significant immunomodulatory effects such as dampening adaptive immunity activities, neutrophils chemotaxis and pro-inflammatory cytokine production in macrophages [63].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds by depleting immunomodulatory moieties.
“ECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds via (i) exposing hidden immunogenic domains to induce immune reactions, (ii) converting inert molecules to immunogen particles, and (iii) depleting immunomodulatory moieties [63].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
The ‘Decellularized matrices’ section (page unavailable) says that decellularization and post-processing methods affect immune responses, supporting the general link between processing and immunomodulation. It does not say that denaturation during decellularization increases scaffold immunogenicity by depleting immunomodulatory moieties; the other mechanisms in the citing sentence are also not established there. (LLM, conf=0.72)
Experimental — accuracy not yet measuredHMWHAs exert anti-inflammatory effects by impeding antigen-antibody interaction and triggering TLRs and CD44 receptors of innate and adaptive immune cells.
“In another example, high molecular weight hyaluronic acids (HMWHAs), well-known GAGs of dECM, exert anti-inflammatory effects by impeding antigen-antibody interaction and triggering toll-like receptors (TLRs), a subgroup of PRRs, and CD44 receptors of innate and adaptive immune cells.”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
The Hyaluronic acid section (page unavailable) says high-molecular-weight HA tends to be immunosuppressive and that its effects are mediated primarily through CD44 receptors on innate and adaptive immune cells. It does not say that HA impedes antigen–antibody interactions or that triggering TLRs produces these anti-inflammatory effects. (LLM, conf=0.88)
Experimental — accuracy not yet measured
ECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds by exposing hidden immunogenic domains to induce immune reactions.
“ECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds via (i) exposing hidden immunogenic domains to induce immune reactions, (ii) converting inert molecules to immunogen particles, and (iii) depleting immunomodulatory moieties [63].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
The Decellularized matrices section (page unavailable) says that decellularization methods and subsequent processing affect immune responses to dECM. It does not say that denaturation exposes hidden immunogenic domains or thereby increases immunogenicity; its specific example concerns antigen removal reducing immune responses. (LLM, conf=0.77)
Experimental — accuracy not yet measuredLMWHAs are released during ECM damage or degradation, act as DAMPs and drive inflammatory responses such as enhancing immune cell chemotaxis, DC maturation, and M1 polarization of macrophages via CD44 and TLRs.
“In contrast to HMWHAs, low molecular weight hyaluronic acids (LMWHAs) are released during ECM damage or degradation, which act as DAMPs and drive inflammatory responses such as enhancing immune cells chemotaxis, DCs maturation, and M1 polarization of macrophages via the same receptors (CD44 and TLRs) [63, 100].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
The Hyaluronic acid section (page unavailable) says lower-molecular-weight HA forms through degradation or damage, provokes inflammation, and induces an inflammatory macrophage phenotype. It does not identify these fragments as DAMPs or say they enhance immune-cell chemotaxis or DC maturation via CD44 and TLRs; its DC-maturation finding concerns high-molecular-weight HA. (LLM, conf=0.88)
Experimental — accuracy not yet measuredActivation of TLRs and CD44 receptors by HMWHAs accompanies a decrease in DC maturation and promotion in the polarization of macrophages toward M2 phenotype besides differentiation of T cells into regulatory phenotype and induction of apoptosis in activated T cells.
“Activation of these receptors accompanies a decrease in DC maturation and promotion in the polarization of macrophages toward M2 phenotype besides differentiation of T cells into regulatory phenotype and induction of apoptosis in activated T cells.”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredPerturbations in ECM integrity may directly increase its immunogenicity.
“First, as discussed below, perturbations in the ECM integrity may directly increase its immunogenicity [63].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
ECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds by converting inert molecules to immunogen particles.
“ECM denaturation during decellularization may enhance the immunogenicity of dECM scaffolds via (i) exposing hidden immunogenic domains to induce immune reactions, (ii) converting inert molecules to immunogen particles, and (iii) depleting immunomodulatory moieties [63].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [63]
The Decellularized matrices section (page unavailable) says that decellularization methods and post-processing affect immune responses, but it does not address ECM denaturation or the conversion of inert molecules into immunogenic particles. Searches for denaturation, hidden immunogenic domains, and inert molecules found no passage establishing the proposed mechanism. (LLM, conf=0.73)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477 · see citing works
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001294 · Cited by 5,572 · see citing works
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959 · see citing works
Pierschbacher, M. D., & Ruoslahti, E. I. (1984) · Nature · doi:10.1038/309030a0 · Cited by 3,670 · see citing works
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191 · see citing works
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429 · see citing works
Cross-presentation by dendritic cells
Joffre, O. P., Segura, É., Savina, A., & Amigorena, S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3254 · Cited by 1,646 · see citing works
Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
Cui, H., Webber, M. J., & Stupp, S. I. (2010) · Biopolymers · doi:10.1002/bip.21328 · Cited by 1,548 · see citing works
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY
Gross, J., & Lapiere, C. M. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.6.1014 · Cited by 1,314 · see citing works
Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity
Ashkar, S., Weber, G. F., Panoutsakopoulou, V., Sanchirico, M. E., Jansson, M., Zawaideh, S., Rittling, S. R., Denhardt, D. T., Glimcher, M. J., & Cantor, H. (2000) · Science · doi:10.1126/science.287.5454.860 · Cited by 1,125 · see citing works
Collagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041 · see citing works
Tissue repair and the dynamics of the extracellular matrix
Midwood, K. S., Williams, L. V., & Schwarzbauer, J. E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.12.003 · Cited by 919 · see citing works
Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896 · see citing works
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
Jetten, N., Verbruggen, S. E. L., Gijbels, M. J., Post, M. J., de Winther, M. P. J., & Donners, M. M. P. C. (2013) · Angiogenesis · doi:10.1007/s10456-013-9381-6 · Cited by 841 · see citing works
Fibrin Formation, Structure and Properties
Weisel, J. W., & Litvinov, R. I. (2017) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-49674-0_13 · Cited by 739 · see citing works
Fibrin structure and wound healing
LAURENS, N., KOOLWIJK, P., & DE MAAT, M. P. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01861.x · Cited by 724 · see citing works
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 627 · see citing works
Matrix Metalloproteinases as Modulators of Inflammation
MANICONE, A., & MCGUIRE, J. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2007.07.003 · Cited by 617 · see citing works
High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation
Rayahin, J., Buhrman, J. S., Zhang, Y., Koh, T. J., & Gemeinhart, R. A. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00181 · Cited by 615 · see citing works
Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells
Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., et al. (2016) · Science · doi:10.1126/science.aad9272 · Cited by 605 · see citing works
Patterson, J., & Hubbell, J. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.061 · Cited by 536 · see citing works
Fakhari, A., & Berkland, C. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.005 · Cited by 523 · see citing works
Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response
Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., Vrana, N. E., & Khademhosseini, A. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.03.009 · Cited by 516 · see citing works
Clark, R. A. F. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03522.x · Cited by 506 · see citing works
Newby, A. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.173898 · Cited by 496 · see citing works
Application of hyaluronic acid as carriers in drug delivery
Huang, G., & Huang, H. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1450910 · Cited by 478 · see citing works
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 401 · see citing works
Churg, A., Wang, R. D., Tai, H., Wang, X., Xie, C., Dai, J. M., Shapiro, S. D., & Wright, J. L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1396oc · Cited by 366 · see citing works
Haro, H., Crawford, H. C., Fingleton, B., Shinomiya, K., Spengler, D. M., & Matrisian, L. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7091 · Cited by 364 · see citing works
Hydrogels and Scaffolds for Immunomodulation
Singh, A. K., & Peppas, N. A. (2014) · Advanced Materials · doi:10.1002/adma.201402105 · Cited by 358 · see citing works
Hur, E.-M., Youssef, S., Haws, M., Zhang, S. Y., Sobel, R. A., & Steinman, L. (2007) · Nature Immunology · doi:10.1038/ni1415 · Cited by 342 · see citing works
Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1
Lebbink, R. J., Ruiter, T. E.-D., Adelmeijer, J., Brenkman, A. B., van Helvoort, J. M. L. M., Koch, M., Farndale, R. W., Lisman, T., Sonnenberg, A., Lenting, P. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052554 · Cited by 339 · see citing works
Galler, K. M., Aulisa, L., Regan, K. R., D’Souza, R. N., & Hartgerink, J. D. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910481t · Cited by 339 · see citing works
Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair
Webber, M. J., Tongers, J., Newcomb, C. J., Marquardt, K.-T., Bauersachs, J. K., Losordo, D. W., & Stupp, S. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016546108 · Cited by 324 · see citing works
Design, clinical translation and immunological response of biomaterials in regenerative medicine
Sadtler, K., Singh, A., Wolf, M. T., Wang, X., Pardoll, D. M., & Elisseeff, J. H. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.40 · Cited by 323 · see citing works
The inhibitory collagen receptor LAIR-1 (CD305)
Meyaard, L. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907609 · Cited by 290 · see citing works
Vaday, G. G., & Lider, O. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.2.149 · Cited by 281 · see citing works
A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Tissue Engineering
Galler, K. M., Hartgerink, J. D., Cavender, A. C., Schmalz, G., & D’Souza, R. N. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0222 · Cited by 277 · see citing works
Moore, A. N., & Hartgerink, J. D. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00553 · Cited by 272 · see citing works
Therapeutic cancer vaccines: Are we there yet?
Klebanoff, C. A., Acquavella, N., Yu, Z., & Restifo, N. P. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00979.x · Cited by 271 · see citing works
Parmaksiz, M., Dogan, A., Odabas, S., Elçin, A. E., & Elçin, Y. M. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/2/022003 · Cited by 268 · see citing works
Knopf‐Marques, H., Pravda, M., Wolfová, L., Velebný, V., Schaaf, P., Vrana, N. E., & Lavall�e, P. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600316 · Cited by 260 · see citing works
The promotion of a constructive macrophage phenotype by solubilized extracellular matrix
Sicari, B. M., Dziki, J. L., Siu, B. F., Medberry, C. J., Dearth, C. L., & Badylak, S. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.060 · Cited by 255 · see citing works
Integrin‐Mediated Interactions Control Macrophage Polarization in 3D Hydrogels
Cha, B., Shin, S. R., Leijten, J., Li, Y., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700289 · Cited by 251 · see citing works
Robson, S. C., Shephard, E., & Kirsch, R. E. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04733.x · Cited by 235 · see citing works
Artzi, N., Oliva, N., Puron, C., Shitreet, S., Artzi, S., Ramos, A. B., Groothuis, A., Sahagian, G. G., & Edelman, E. R. (2011) · Nature Materials · doi:10.1038/nmat3095 · Cited by 234 · see citing works
Fibroblast migration in fibrin gel matrices.
Brown, L. F., Lanir, N., McDonagh, J., Tognazzi, K., Dvořàk, A. M., & Dvorak, H. F. (1993) · PubMed Central · Cited by 226 · see citing works
The Role of Hyaluronic Acid in Wound Healing
Price, R. D., Myers, S. R., Leigh, I. M., & Navsaria, H. A. (2005) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200506060-00006 · Cited by 215 · see citing works
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Ryu, J. K., Rafalski, V. A., Meyer-Franke, A., Adams, R. A., Poda, S. B., Rios Coronado, P. E., Pedersen, L. Ø., Menon, V., Baeten, K. M., Sikorski, S. L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0232-x · Cited by 213 · see citing works
The CD44‐Mediated Uptake of Hyaluronic Acid‐Based Carriers in Macrophages
Rosa, J. M. R. D. L., Tirella, A., Gennari, A., Stratford, I. J., & Tirelli, N. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201601012 · Cited by 213 · see citing works
Eckhard, U., Huesgen, P. F., Schilling, O., Bellac, C. L., Butler, G. S., Cox, J. H., Dufour, A., Goebeler, V., Kappelhoff, R., Keller, U. A. D., et al. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.09.003 · Cited by 208 · see citing works
Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen
Hsieh, J., Smith, T. D., Meli, V., Trần, T. N. L., Botvinick, E., & Liu, W. F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.024 · Cited by 206 · see citing works
Self-citationDziki, J. L., Wang, D. S., Pineda, C., Sicari, B. M., Rausch, T., & Badylak, S. F. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35894 · Cited by 201 · see citing works
Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity
Shpacovitch, V. M., Feld, M., Hollenberg, M. D., Luger, T. A., & Steinhoff, M. S. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108001 · Cited by 191 · see citing works
Molecular and structural mapping of collagen fibril interactions
Orgel, J. P. R. O., Antonio, J. D. S., & Antipova, O. A. (2010) · Connective Tissue Research · doi:10.3109/03008207.2010.511353 · Cited by 187 · see citing works
Aukhil, I. (2000) · Periodontology 2000 · doi:10.1034/j.1600-0757.2000.2220104.x · Cited by 187 · see citing works
Collagen types. Molecular structure and tissue distribution.
Burgeson, R. E., & Nimni, M. E. (1992) · PubMed · Cited by 177 · see citing works
Pinto, L. A., Edwards, J., Castle, P. E., Harro, C. D., Lowy, D. R., Schiller, J. T., Wallace, D., Kopp, W., Adelsberger, J. W., Baseler, M., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/376505 · Cited by 177 · see citing works
Lynn, A. D., Kyriakides, T. R., & Bryant, S. J. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32595 · Cited by 174 · see citing works
Integrin-directed modulation of macrophage responses to biomaterials
Zaveri, T. D., Lewis, J. S., Dolgova, N. V., Clare-Salzler, M. J., & Keselowsky, B. G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.007 · Cited by 164 · see citing works
Differential functional effects of biomaterials on dendritic cell maturation
Park, J., & Babensee, J. E. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.006 · Cited by 156 · see citing works
Anitua, E., Zalduendo, M., Troya, M., Padilla, S., & Orive, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121713 · Cited by 153 · see citing works
Regulation of T-helper-cell lineage development by osteopontin: the inside story
Cantor, H., & Shinohara, M. L. (2008) · Nature reviews. Immunology · doi:10.1038/nri2460 · Cited by 151 · see citing works
Recognition of Fibrinogen by Leukocyte Integrins
Ugarova, T. P., & Yakubenko, V. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03523.x · Cited by 143 · see citing works
Babensee, J. E., & Paranjpe, A. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30429 · Cited by 143 · see citing works
Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials <sup/>
Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0538 · Cited by 141 · see citing works
Bollyky, P. L., Wu, R. P., Falk, B. A., Lord, J. D., Long, S. A., Preisinger, A., Teng, B. J., Holt, G. E., Standifer, N. E., Braun, K. R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017360108 · Cited by 136 · see citing works
Ex vivo engineered immune organoids for controlled germinal center reactions
Purwada, A., Jaiswal, M. K., Ahn, H., Nojima, T., Kitamura, D., Gaharwar, A. K., Cerchietti, L. C. A., & Singh, A. K. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.06.002 · Cited by 135 · see citing works
Burgeson, R. E., & Nimni, M. E. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199209000-00033 · Cited by 132 · see citing works
Senior, R. M., Gresham, H. D., Griffin, G. L., Brown, E. J., & Chung, A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116111 · Cited by 132 · see citing works
Taraballi, F., Sushnitha, M., Tsao, C., Bauza, G., Liverani, C., Shi, A., & Tasciotti, E. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800490 · Cited by 128 · see citing works
Collagen Type I as a Ligand for Receptor-Mediated Signaling
Boraschi-Diaz, I., Wang, J. P., Mort, J. S., & Komarova, S. V. (2017) · Frontiers in Physics · doi:10.3389/fphy.2017.00012 · Cited by 125 · see citing works
Self-assembling multidomain peptides tailor biological responses through biphasic release
Kumar, V., Taylor, N. L., Shi, S., Wickremasinghe, N. C., D’Souza, R. N., & Hartgerink, J. D. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.079 · Cited by 122 · see citing works
Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials
Jones, J. A., McNally, A. K., Chang, D. T., Qin, L. A., Meyerson, H., Colton, E., Kwon, I. L. K., Matsuda, T., & Anderson, J. M. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31220 · Cited by 121 · see citing works
Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells
Moore, A. N., Lopez‐Silva, T. L., Carrejo, N. C., Marmolejo, C. A. O., Li, I.-C., & Hartgerink, J. D. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.033 · Cited by 120 · see citing works
Güç, E., Briquez, P. S., Foretay, D., Fankhauser, M., Hubbell, J. A., Kilarski, W. W., & Swartz, M. A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.033 · Cited by 119 · see citing works
Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice
Carrejo, N. C., Moore, A. N., Lopez‐Silva, T. L., Leach, D. G., Li, I.-C., Walker, D. R., & Hartgerink, J. D. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00031 · Cited by 119 · see citing works
A Perspective on Immunomodulation and Tissue Repair
Mokarram, N., & Bellamkonda, R. V. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0941-0 · Cited by 114 · see citing works
Kuijper, P. H. M., Torres, H. I. G., Lammers, J. J., Sixma, J. J., Koenderman, L., & Zwaginga, J. J. (1997) · Blood · doi:10.1182/blood.v89.1.166 · Cited by 113 · see citing works
Lanir, N., Ciano, P. S., Water, L. V. D., McDonagh, J., Dvořàk, A. M., & Dvorak, H. F. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2340 · Cited by 113 · see citing works
Wong, M. L., Wong, J. L., Vapniarsky, N., & Griffiths, L. G. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.024 · Cited by 112 · see citing works
Anitua, E., Zalduendo, M., Prado, R., Alkhraisat, M. H., & Orive, G. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35244 · Cited by 108 · see citing works
Injectable MMP-Sensitive Alginate Hydrogels as hMSC Delivery Systems
Fonseca, K. B., Gomes, D. B., Lee, K., Santos, S. G., Sousa, A., Silva, E. A., Mooney, D. J., Granja, P. L., & Barrias, C. C. (2013) · Biomacromolecules · doi:10.1021/bm4016495 · Cited by 108 · see citing works
Treatment of hind limb ischemia using angiogenic peptide nanofibers
Kumar, V., Liu, Q., Wickremasinghe, N. C., Shi, S., Cornwright, T. T., Deng, Y., Azares, A. R., Moore, A. N., Acevedo‐Jake, A. M., Agudo, N. R., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.032 · Cited by 106 · see citing works
Sadtler, K., Sommerfeld, S. D., Wolf, M. T., Wang, X., Majumdar, S., Chung, L., Kelkar, D. S., Pandey, A., & Elisseeff, J. H. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.002 · Cited by 106 · see citing works
Rygiel, T. P., Stolte, E. H., Ruiter, T. E.-D., van de Weijer, M. L., & Meyaard, L. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.09.006 · Cited by 104 · see citing works
Jha, A. K., Yang, W., Kirn‐Safran, C. B., Farach‐Carson, M. C., & Jia, X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.009 · Cited by 104 · see citing works
Purwada, A., & Singh, A. (2016) · Nature Protocols · doi:10.1038/nprot.2016.157 · Cited by 101 · see citing works
Lebbink, R. J., Raynal, N., Ruiter, T. E.-D., Bihan, D. G., Farndale, R. W., & Meyaard, L. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.03.005 · Cited by 97 · see citing works
Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells
Tian, Y. F., Ahn, H., Schneider, R. S., Yang, S. N., Lidia, R.-G., Melnick, A. M., Cerchietti, L. C. A., & Singh, A. K. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.007 · Cited by 93 · see citing works
Osteopontin as two-sided mediator of intestinal inflammation
Heilmann, K., Hoffmann, U., Witte, E., Loddenkemper, C., Sina, C., Schreiber, S., Hayford, C., Holzlbhner, P., Wolk, K., Tchatchou, E., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00428.x · Cited by 92 · see citing works
Meng, F. W., Slivka, P. F., Dearth, C. L., & Badylak, S. F. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.044 · Cited by 87 · see citing works
Sadtler, K., Allen, B. W., Estrellas, K. M., Housseau, F., Pardoll, D. M., & Elisseeff, J. H. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0304 · Cited by 86 · see citing works
Adhesive substrate-modulation of adaptive immune responses
Acharya, A. P., Dolgova, N. V., Clare-Salzler, M. J., & Keselowsky, B. G. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.08.040 · Cited by 85 · see citing works
Stabilized collagen matrix dressing improves wound macrophage function and epithelialization
Masry, M. S. E., Chaffee, S. M., Ghatak, P. D., Mathew‐Steiner, S. S., Das, A., Higuita‐Castro, N., Roy, S., Anani, R. A. E., & Sen, C. K. (2018) · The FASEB Journal · doi:10.1096/fj.201800352r · Cited by 80 · see citing works
McDade, J. K., Brennan-Pierce, E. P., Ariganello, M. B., Labow, R. S., & Michael Lee, J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.02.021 · Cited by 80 · see citing works
Deegan, D. B., Zimmerman, C., Skardal, A., Atala, A., & Shupe, T. D. (2016) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2015.10.016 · Cited by 79 · see citing works
Kambayashi, T., Jacob, C. O., & Strassmann, G. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0186 · Cited by 78 · see citing works
Xu, D., Jiang, L., Singh, A., Dustin, D. J., Yang, M., Liu, L., Lund, R., Sellati, T. J., & Dong, H. (2014) · Chemical Communications · doi:10.1039/c4cc08808e · Cited by 73 · see citing works
Yu, T., Wang, W., Nassiri, S., Kwan, T. D., Dang, C., Liu, W. X., & Spiller, K. L. (2016) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2016.1155881 · Cited by 70 · see citing works
Self-citationSindhu, S. T. A. K., Al-Roub, A., Koshy, M., Thomas, R., & Ahmad, R. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447798 · Cited by 70 · see citing works
Gowen, B. B., Borg, T. K., Ghaffar, A., & Mayer, E. P. (2000) · Matrix Biology · doi:10.1016/s0945-053x(99)00052-9 · Cited by 68 · see citing works
Zhu, Y., Hideyoshi, S., Jiang, H., Matsumura, Y., Dziki, J. L., LoPresti, S. T., Huleihel, L., Faria, G. N. F., Fuhrman, L. C., Lodono, R., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.003 · Cited by 68 · see citing works
Podolnikova, N. P., Yakubenko, V. P., Gl, V., Plow, E. F., & Ugarova, T. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300410200 · Cited by 67 · see citing works
Acharya, A. P., Dolgova, N. V., Moore, N. M., Xia, C., Clare-Salzler, M. J., Becker, M. L., Gallant, N. D., & Keselowsky, B. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.025 · Cited by 66 · see citing works
Response of human macrophages to wound matrices in vitro
Witherel, C. E., Graney, P. L., Freytes, D. O., Weingarten, M. S., & Spiller, K. L. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12423 · Cited by 65 · see citing works
Kudryavtseva, V., Stankevich, K. S., Gudima, A., Kibler, E., Zhukov, Y. M., Больбасов, Е. Н., Malashicheva, A., Zhuravlev, M. V., Riabov, V., Liu, T., et al. (2017) · Materials & Design · doi:10.1016/j.matdes.2017.04.079 · Cited by 63 · see citing works
CD11b/CD18 mediates the neutrophil chemotactic activity of fibrin degradation product D domain.
Gross, T. J., Leavell, K. J., & Peterson, M. W. (1997) · PubMed · Cited by 62 · see citing works
CD1lb/CD 18 Mediates the Neutrophil Chemotactic Activity of Fibrin Degradation Product D Domain
Gross, T. J., Leavell, K. J., & Peterson, M. W. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1656074 · Cited by 60 · see citing works
Sequence Effects of Self-Assembling MultiDomain Peptide Hydrogels on Encapsulated SHED Cells
Kang, M. K., Colombo, J. S., D’Souza, R. N., & Hartgerink, J. D. (2014) · Biomacromolecules · doi:10.1021/bm500075r · Cited by 56 · see citing works
Immune responses to coiled coil supramolecular biomaterials
Rudra, J. S., Tripathi, P., Hildeman, D. A., Jung, J. P., & Collier, J. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.068 · Cited by 56 · see citing works
Immunomodulation and matrix metalloproteinases in viral myocarditis
Westermann, D., Savvatis, K., Schultheiß, H., & Tschöpe, C. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.019 · Cited by 55 · see citing works
Donaldson, A. R., Tanase, C. E., Awuah, D., Bathrinarayanan, P. V., Hall, L., Nikkhah, M., Khademhosseini, A., Rose, F. R. A. J., Alexander, C., & Ghaemmaghami, A. M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00116 · Cited by 54 · see citing works
Yakovlev, S., Zhang, L., Ugarova, T. P., & Medved, L. V. (2004) · Biochemistry · doi:10.1021/bi048266w · Cited by 54 · see citing works
Yu, S. P., Duan, Y., Zuo, X., Chen, X., Mao, Z., & Gao, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.022 · Cited by 54 · see citing works
The In Vitro and In Vivo Response to MMP-Sensitive Poly(Ethylene Glycol) Hydrogels
Amer, L. D., & Bryant, S. J. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1608-4 · Cited by 52 · see citing works
Lynn, A. D., & Bryant, S. J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.033 · Cited by 52 · see citing works
Levesque, M. C., & Haynes, B. F. (1999) · Cellular Immunology · doi:10.1006/cimm.1999.1456 · Cited by 50 · see citing works
Liu, L., Du, G., Chen, J., Zhu, Y., Wang, M., & Sun, J. (2008) · Bioresource Technology · doi:10.1016/j.biortech.2008.05.040 · Cited by 49 · see citing works
Ramelli, G., Marraco, S. A. F., Narayan, S., Busso, N., Acha‐Orbea, H., & So, A. K.-L. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03144.x · Cited by 45 · see citing works
Zhang, Y., Lv, K., Zhang, C. M., Jin, B., Zhuang, R., & Ding, Y. (2013) · Cellular Immunology · doi:10.1016/j.cellimm.2013.12.005 · Cited by 43 · see citing works
Interface between hemostasis and adaptive immunity
Qu, Z., & Chaikof, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.08.017 · Cited by 42 · see citing works
Recombinant collagen scaffolds as substrates for human neural stem/progenitor cells
Que, R. A., Arulmoli, J., Silva, N. A. D., Flanagan, L. A., & Wang, S. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36343 · Cited by 42 · see citing works
Self-citationYakovlev, S., & Medved, L. V. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.11.007 · Cited by 42 · see citing works
In Situ Delivery of Fibrin-Based Hydrogels Prevents Contraction and Reduces Inflammation
Burmeister, D. M., Roy, D. C., Becerra, S. C., Natesan, S., & Christy, R. J. (2017) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000576 · Cited by 39 · see citing works
Macrophage-like U937 cells recognize collagen fibrils with strain-induced discrete plasticity damage
Veres, S. P., Brennan-Pierce, E. P., & Lee, J. M. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35156 · Cited by 34 · see citing works
Kazura, J. W., Wenger, J. D., Salata, R. A., Budzynski, A. Z., & Goldsmith, G. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114098 · Cited by 34 · see citing works
Effect of source animal age upon macrophage response to extracellular matrix biomaterials
LoPresti, S. T., & Brown, B. N. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.03.004 · Cited by 33 · see citing works
Tuning cellular response by modular design of bioactive domains in collagen
Que, R. A., Chan, S. W. P., Jabaiah, A. M., Lathrop, R. H., Silva, N. A. D., & Wang, S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.074 · Cited by 28 · see citing works
Self-citationHart, S. P., Rossi, A. G., Haslett, C., & Dransfield, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033142 · Cited by 24 · see citing works
Kim, Y. K., Chu, S., Hsieh, J. Y., Kamoku, C., Tenner, A. J., Liu, W. F., & Wang, S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700707 · Cited by 22 · see citing works
Self-citationBiomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells
Wrobel, M. R., & Sundararaghavan, H. G. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.015 · Cited by 22 · see citing works
Expanding Functionality of Recombinant Human Collagen Through Engineered Non-Native Cysteines
Que, R. A., Mohraz, A., Silva, N. A. D., & Wang, S. (2014) · Biomacromolecules · doi:10.1021/bm500735d · Cited by 15 · see citing works
Self-citationArtzi, N., Oliva, N., Puron, C., Shitreet, S., Artzi, S., Ramos, A. B., Groothuis, A., Sahagian, G. G., & Edelman, E. R. (2011) · Nature Materials · doi:10.1038/nmat3147 · Cited by 12 · see citing works
Dong, S., Xu, T., Zhao, P., Parent, K. N., & Chen, M. (2016) · Theranostics · doi:10.7150/thno.14068 · Cited by 11 · see citing works
Dong, S., Wang, P., Zhao, P., & Chen, M. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00367 · Cited by 7 · see citing works
Targeting fibrin in neurodegeneration
Martinꝉ, R. (2018) · Nature Immunology · doi:10.1038/s41590-018-0241-9 · Cited by 5 · see citing works
Burmeister, D. M., Gómez, B. I., Chao, T., Cancio, L. C., & Dubick, M. A. (2018) · Journal of Burn Care & Research · doi:10.1093/jbcr/iry006.324 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 142 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [131]Yu S, Duan Y, Zuo X, Chen X, Mao Z, Gao C. Mediating the invasion of smooth muscle cells into a cell-responsive hydrogel under the existence of immune cells. Biomaterials. 2018; 180: 193– 205. 30048909
- [139]Moore AN, Lopez Silva TL, Carrejo NC, Origel Marmolejo CA, Li I-C, Hartgerink JD. Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells. Biomaterials. 2018; 161: 154– 163. 29421552 PMC5837816
- [140]Kumar VA, Taylor NL, Shi S, Wickremasinghe NC, D’Souza RN, Hartgerink JD. Self-assembling multidomain peptides tailor biological responses through biphasic release. Biomaterials. 2015; 52: 71– 78. 25818414 PMC4613801
Cited by
Sorted by citations
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680 · see citing works
Tuning immunity through tissue mechanotransduction
Du, H., Bartleson, J. M., Butenko, S., Alonso, V., Liu, W. F., Winer, D. A., & Butte, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00761-w · Cited by 433 · see citing works
Self-citationQiu, P., Li, M.-B., Chen, K., Fang, B., Chen, P.-F., Tang, Z., Lin, X.-F., & Fan, S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119552 · Cited by 298 · see citing works
Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316 · see citing works
Zhang, D., Chen, Q., Shi, C., Chen, M., Ma, K., Wan, J., & Liu, R. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007226 · Cited by 304 · see citing works
A Dual‐Cross‐Linked Hydrogel Patch for Promoting Diabetic Wound Healing
Liu, J., Qu, M., Wang, C., Xue, Y., Huang, H., Chen, Q., Sun, W., Zhou, X., Xu, G., & Jiang, X. (2022) · Small · doi:10.1002/smll.202106172 · Cited by 287 · see citing works
Revete, A., Aparicio, A., Cisterna, B. A., Revete, J., Luis, L., Ibarra, E., González, E. A. S., Molino, J. J., & Reginensi, D. (2022) · International Journal of Biomaterials · doi:10.1155/2022/3606765 · Cited by 235 · see citing works
Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity
Wang, Z., Chai, C., Wang, R., Feng, Y., Huang, L., Zhang, Y., Xiao, X., Yang, S., Zhang, Y., & Zhang, X. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.650 · Cited by 158 · see citing works
Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment
McQuitty, C. E., Williams, R., Chokshi, S., & Urbani, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574276 · Cited by 146 · see citing works
Liu, Y., Niu, R., Zhao, H. Q., Wang, Y., Song, S., Zhang, H., & Zhao, Y. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c08622 · Cited by 145 · see citing works
Regulation of decellularized matrix mediated immune response
Chakraborty, J., Roy, S., & Ghosh, S. (2020) · Biomaterials Science · doi:10.1039/c9bm01780a · Cited by 130 · see citing works
Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone
Williams, D. F. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.08.014 · Cited by 128 · see citing works
Progress in biomaterials inspired by the extracellular matrix
Chen, Z., Du, C., Liu, S., Liu, J., Yang, Y., Dong, L., Zhao, W., Huang, W., & Lei, Y. (2024) · Giant · doi:10.1016/j.giant.2024.100323 · Cited by 132 · see citing works
Fang, B., Qiu, P., Xia, C., Cai, D., Zhao, C., Chen, Y., Wang, H., Liu, S., Cheng, H., Tang, Z., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120603 · Cited by 109 · see citing works
Tian, G., Jiang, S., Li, J.-Q., Wei, F., Li, X., Ding, Y., Yang, Z., Sun, Z., Zha, K.-K., Wang, F., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.054 · Cited by 96 · see citing works
Cell–scaffold interactions in tissue engineering for oral and craniofacial reconstruction
Wang, F., Cai, X., Shen, Y., & Meng, L. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.029 · Cited by 106 · see citing works
Rational design of hydrogels for immunomodulation
Bu, W., Wu, Y., Ghaemmaghami, A. M., Sun, H., & Mata, Á. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac009 · Cited by 106 · see citing works
Li, W., Dai, F., Zhang, S., Xu, F., Xu, Z., Liao, S., Zeng, L., Li, S., & Ai, F. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02001 · Cited by 92 · see citing works
Antmen, E., Vrana, N. E., & Hasırcı, V. (2021) · Biomaterials Science · doi:10.1039/d1bm00840d · Cited by 89 · see citing works
Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine
Zhang, Z., He, C., & Chen, X. (2023) · Advanced Materials · doi:10.1002/adma.202308894 · Cited by 84 · see citing works
Tiskratok, W., Chuinsiri, N., Limraksasin, P., Kyawsoewin, M., & Jitprasertwong, P. (2025) · Polymers · doi:10.3390/polym17060822 · Cited by 88 · see citing works
Nizioł, M., Paleczny, J., Junka, A., Shavandi, A., Dawiec‐Liśniewska, A., & Podstawczyk, D. A. (2021) · Bioengineering · doi:10.3390/bioengineering8060079 · Cited by 77 · see citing works
Wang, C., Li, G., Cui, K., Chai, Z., Huang, Z., Liu, Y., Chen, S., Huang, H., Zhang, K., Han, Z., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.12.055 · Cited by 72 · see citing works
Hydrogel Drug Delivery Systems for Bone Regeneration
Bai, L., Tao, G., Feng, M., Xie, Y., Cai, S., Peng, S., & Xiao, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051334 · Cited by 70 · see citing works
Yu, Y., Jin, H., Li, L., Zhang, X., Zheng, C., Gao, X., Yang, Y., & Sun, B. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02073-0 · Cited by 68 · see citing works
Extracellular matrix scaffold-immune microenvironment modulates tissue regeneration
Yu, Y., Zhang, W., Liu, X., Wang, H., Shen, J., Xiao, H., Mei, J., Chai, Y., & Wen, G. (2021) · Composites Part B Engineering · doi:10.1016/j.compositesb.2021.109524 · Cited by 63 · see citing works
Harnessing Biomaterials for Immunomodulatory-Driven Tissue Engineering
Zhong, J. X., Raghavan, P., & Desai, T. A. (2022) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-022-00279-6 · Cited by 65 · see citing works
Dewey, H. M., Lamb, A., & Budhathoki-Uprety, J. (2024) · Nanoscale · doi:10.1039/d4nr01892c · Cited by 63 · see citing works
Biomaterials in tissue repair and regeneration: key insights from extracellular matrix biology
Abolhasani, S., Ahmadi, Y., Rostami, Y., Baravar, E., & Fattahi, D. (2025) · Frontiers in Medical Technology · doi:10.3389/fmedt.2025.1565810 · Cited by 60 · see citing works
An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases
Qasim, S. S. B., Alotaibi, D. H., Jasser, R. A., Gul, S. S., & Zafar, M. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113829 · Cited by 64 · see citing works
Tan, J., Zhang, Q.-Y., Huang, L.-P., Huang, K., & Xie, H.-Q. (2021) · Biomaterials Science · doi:10.1039/d1bm00470k · Cited by 57 · see citing works
Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Zhou, S., Zhu, J., Zhou, P., & Gu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999600 · Cited by 57 · see citing works
Bio-based composite hydrogels for biomedical applications
Buwalda, S. J. (2020) · Multifunctional Materials · doi:10.1088/2399-7532/ab80d6 · Cited by 56 · see citing works
Xu, J., Duan, Z., Qi, X., Ou, Y., Guo, X., Zi, L., Yang, W., Liu, H., Ma, L., Li, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00785 · Cited by 55 · see citing works
A Polymeric Extracellular Matrix Nanoremodeler for Activatable Cancer Photo‐Immunotherapy
Zhang, C., Xu, M., Zeng, Z., Wei, X., He, S., Huang, J., & Pu, K. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202217339 · Cited by 52 · see citing works
Wulf, V., & Bisker, G. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01587 · Cited by 51 · see citing works
Hyaluronan in the Tumor Microenvironment
Spinelli, F. M., Vitale, D. L., Sevic, I., & Alaniz, L. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-40146-7_3 · Cited by 50 · see citing works
Current knowledge of immunomodulation strategies for chronic skin wound repair
Heydari, P., Kharaziha, M., Varshosaz, J., & Javanmard, S. H. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34921 · Cited by 49 · see citing works
Bordini, E. A. F., Ferreira, J. A., Dubey, N., Ribeiro, J. S., Costa, C. A. D. S., Soares, D. G., & Bottino, M. C. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00620 · Cited by 47 · see citing works
Early osteoimmunomodulatory effects of magnesium–calcium–zinc alloys
Rahmati, M., Stötzel, S., Khassawna, T. E., Iskhahova, K., Wieland, D. C. F., Zeller‐Plumhoff, B., & Haugen, H. J. (2021) · Journal of Tissue Engineering · doi:10.1177/20417314211047100 · Cited by 47 · see citing works
The role of dendritic cells in the immunomodulation to implanted biomaterials
Wang, S., Chen, Y., Ling, Z., Li, J., Hu, J., He, F., & Chen, Q. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00203-2 · Cited by 45 · see citing works
Self-citationMeniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications
Li, H., Li, P., Yang, Z., Gao, C., Fu, L., Liao, Z., Zhao, T., Cao, F., Chen, W., Peng, Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661802 · Cited by 46 · see citing works
Jin, J., Saiding, Q., Wang, X., Qin, M., Xiang, Y., Cheng, R., Cui, W., & Chen, X. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009879 · Cited by 44 · see citing works
Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing
Wang, X., Chung, L., Hooks, J. S. T., Maestas, D. R., Lebid, A., Andorko, J. I., Huleihel, L., Chin, A. F., Wolf, M. T., Remlinger, N. T., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe2635 · Cited by 44 · see citing works
Dervan, A. G., Franchi, A., Almeida-González, F. R., Dowling, J. K., Kwakyi, O., McCoy, C. E., O’Brien, F. J., & Hibbitts, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122161 · Cited by 44 · see citing works
Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
García-García, A., & Martin, I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02256 · Cited by 43 · see citing works
Jiang, Y., Liao, H., Yan, L., Jiang, S., Zheng, Y., Zhang, X., Wang, K., Wang, Q., Han, L., & Lu, X. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c06706 · Cited by 42 · see citing works
Understanding the contextual functions of C1q and LAIR-1 and their applications
Son, M. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00774-4 · Cited by 42 · see citing works
Immunomodulatory role of metalloproteases in cancers: Current progress and future trends
Wang, Q., Wang, K., Tan, X., Li, Z., & Wang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1064033 · Cited by 42 · see citing works
Kumar, M., Kumar, D., Kumar, D., Garg, Y., Chopra, S., & Bhatia, A. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02827-5 · Cited by 42 · see citing works
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 41 · see citing works
Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications
Rezaei, Z., Yilmaz‐Aykut, D., Tourk, F. M., Bassous, N. J., Barroso‐Zuppa, M., Shawl, A. I., Ashraf, S. M., Avcı, H., & Hassan, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102244 · Cited by 39 · see citing works
Cicuéndez, M., Casarrubios, L., Feito, M. J., Madarieta, I., Garcia-Urkia, N., Murua, O., Olalde, B., Briz, N., Diez-Orejas, R., & Portolés, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083847 · Cited by 39 · see citing works
Antimicrobial and enzyme-responsive multi-peptide surfaces for bone-anchored devices
Fischer, N. G., Chen, X., Astleford, K., He, J., Mullikin, A. F., Mansky, K. C., & Aparicio, C. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112108 · Cited by 39 · see citing works
Tavakoli, S., Kisiel, M., Biedermann, T., & Klar, A. S. (2022) · Biomedicines · doi:10.3390/biomedicines10010118 · Cited by 35 · see citing works
Bian, N., Chu, C., Rung, S., Huangphattarakul, V., Man, Y., Lin, J., & Hu, C. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00491-z · Cited by 38 · see citing works
Mechanical forces amplify TCR mechanotransduction in T cell activation and function
Jeffreys, N. C., Brockman, J. M., Zhai, Y., Ingber, D. E., & Mooney, D. J. (2024) · Applied Physics Reviews · doi:10.1063/5.0166848 · Cited by 37 · see citing works
Smith, M. J., Dempsey, S. G., Veale, R. W. F., Duston-Fursman, C. G., Rayner, C. A. F., Javanapong, C., Gerneke, D., Dowling, S. G., Bosque, B. A., Karnik, T., et al. (2021) · Journal of Biomaterials Applications · doi:10.1177/08853282211045770 · Cited by 36 · see citing works
Lee, C. Y., Chooi, W. H., Ng, S., & Chew, S. Y. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10389 · Cited by 37 · see citing works
Long, J., Qin, Z., Chen, G., Song, B., & Zhang, Z. (2022) · Biomaterials Science · doi:10.1039/d2bm01204a · Cited by 35 · see citing works
3D Multispheroid Assembly Strategies towards Tissue Engineering and Disease Modeling
Zhu, T., Hu, Y., Cui, H., & Cui, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400957 · Cited by 36 · see citing works
Biological characteristics of tissue engineered-nerve grafts enhancing peripheral nerve regeneration
Li, X., Xu, H., Li, C., Guan, Y., Liu, Y., Zhang, T., Meng, F., Cheng, H., Song, X., Jia, Z., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03827-9 · Cited by 34 · see citing works
Immuno-modulatory biomaterials as anti-inflammatory therapeutics
Lynch, R. I., & Lavelle, E. C. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114890 · Cited by 37 · see citing works
Convergence of tissue engineering and sustainable development goals
Kasoju, N., & Sunilkumar, A. (2024) · Biotechnology for Sustainable Materials · doi:10.1186/s44316-024-00021-y · Cited by 31 · see citing works
Advanced biomaterials in immune modulation: The future of regenerative therapies
Biglari, N., Razzaghi, M., Afkham, Y., Azimi, G., Gross, J. D., & Samadi, A. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125972 · Cited by 31 · see citing works
Tavakoli, S., Kisiel, M. A., Biedermann, T., & Klar, A. S. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-213624 · Cited by 31 · see citing works
Poulis, N., Martin, M., Hoerstrup, S. P., Emmert, M. Y., & Fioretta, E. S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.952178 · Cited by 30 · see citing works
Wang, Y., Lu, F., Hu, E., Yu, K., Li, J., Bao, R., Dai, F., Lan, G., & Xie, R. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00420 · Cited by 29 · see citing works
Immunomodulatory hydrogels for tissue repair and regeneration
Liu, X., Hu, Y., Ju, Y., Yang, P. S., Shen, N., Yang, A., Wu, R., Fang, B., & Liu, L. (2024) · APL Materials · doi:10.1063/5.0228692 · Cited by 32 · see citing works
Hussein, K. H., Ahmadzada, B., Correa, J. C., Sultan, A., Wilken, S., Amiot, B., & Nyberg, S. L. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.001 · Cited by 28 · see citing works
“Decellularization process may increase the immunogenicity of the tissue by exposing hidden immunogenic domains, converting inert molecules within the decellularized tissue into immunogenic particles, or depleting immunomodulatory substances [74].”
BackgroundRegenerative Potential of A Bovine ECM-Derived Hydrogel for Biomedical Applications
Francesco, D. D., Bertani, F., Fusaro, L., Clemente, N., Carton, F., Talmon, M., Fresu, L. G., & Boccafoschi, F. (2022) · Biomolecules · doi:10.3390/biom12091222 · Cited by 28 · see citing works
Liu, X.-Q., Chen, X.-T., Liu, Z.-Z., Gu, S.-S., He, L.-J., Wang, K.-P., & Tang, R.-Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00669 · Cited by 26 · see citing works
Neves, M. I., Magalhães, M. V., Bidarra, S. J., Moroni, L., & Barrias, C. C. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121226 · Cited by 26 · see citing works
Powell, R., Eleftheriadou, D., Kellaway, S. C., & Phillips, J. B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.674473 · Cited by 27 · see citing works
Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning
Потекаев, Н. Н., Borzykh, O. B., Medvedev, G. V., Петрова, М. М., Gavrilyuk, O. A., Karpova, E. I., Trefilova, V. V., Demina, O. M., Popova, T. E., & Shnayder, N. A. (2021) · Cosmetics · doi:10.3390/cosmetics8040092 · Cited by 26 · see citing works
Modulation of Stiffness-Dependent Macrophage Inflammatory Responses by Collagen Deposition
Meli, V. S., Rowley, A. T., Veerasubramanian, P. K., Heedy, S., Liu, W. F., & Wang, S. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01892 · Cited by 24 · see citing works
Self-citationYu, Y., Cui, H., Zhang, C., Zhang, D., Yin, J., Wen, G., & Chai, Y. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02910a · Cited by 24 · see citing works
Heterochiral tetrapeptide self‐assembly into hydrogel biomaterials for hydrolase mimicry
Kurbasic, M., Garcia, A. M., Viada, S., & Marchesan, S. (2021) · Journal of Peptide Science · doi:10.1002/psc.3304 · Cited by 24 · see citing works
Manipulating immune activity of macrophages: a materials and mechanics perspective
Clevenger, A. J., Jha, A., Moore, E., & Raghavan, S. A. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.07.009 · Cited by 21 · see citing works
Makkar, H., Atkuru, S., Tang, Y. L., Sethi, T., Lim, C. T., Tan, K. S., & Sriram, G. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221111650 · Cited by 22 · see citing works
Meganathan, I., Ashokraj, S., Aarthy, M., Shanmugam, G., Ponesakki, G., Ramudu, K. N., & Ayyadurai, N. (2020) · Biomaterials Science · doi:10.1039/d0bm01379j · Cited by 21 · see citing works
Zhang, X., Wang, B., Hong, H., Wang, Y., Liu, J., Liu, C., & Chen, X. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.08.028 · Cited by 21 · see citing works
Kasravi, M., Yaghoobi, A., Tayebi, T., Hojabri, M., Taheri, A. T., Shirzad, F., Nooshin, B. J., Mazloomnejad, R., Ahmadi, A., Tehrani, F. A., et al. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213710 · Cited by 20 · see citing works
Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation
Rowley, A. T., Meli, V. S., Wu-Woods, N. J., Chen, E. Y., Liu, W. F., & Wang, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00747 · Cited by 20 · see citing works
Self-citationThe Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation
Sousa, A. B., & Barbosa, J. N. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14040223 · Cited by 19 · see citing works
Samani, F. S., Kazemi-Ashtiani, M., Karimi, H., Shiravandi, A., Baharvand, H., & Daemi, H. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213020 · Cited by 18 · see citing works
Kafili, G., Kabir, H., Kandeloos, A. J., Golafshan, E., Ghasemi, S., Mashayekhan, S., & Taebnia, N. (2023) · Journal of Biomaterials Applications · doi:10.1177/08853282231207216 · Cited by 21 · see citing works
dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing
Ju, Z., Si, R., Gao, Y., Shan, H., Su, Q., Feng, Z., Huang, P., Kong, D., & Wang, W. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbad118 · Cited by 19 · see citing works
Biomimetic Polymer-Based Engineered Scaffolds for Improved Stem Cell Function
Patel, D. K., & Lim, K. (2019) · Materials · doi:10.3390/ma12182950 · Cited by 19 · see citing works
Rahaman, J., & Mukherjee, D. (2025) · Applied Materials Today · doi:10.1016/j.apmt.2025.102753 · Cited by 19 · see citing works
Prospective of extracellular matrix and drug correlations in disease management
Ahmad, V. (2020) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.06.007 · Cited by 18 · see citing works
Luo, Y., Yuan, P., Hu, S., Wang, H., Zhang, H., & Ma, L. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.09.055 · Cited by 18 · see citing works
Bhar, B., Ranta, P., Samudrala, P. K., & Mandal, B. B. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01877 · Cited by 18 · see citing works
Deng, M., Tan, J., Dai, Q., Luo, F., & Xu, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714011 · Cited by 17 · see citing works
Immunomodulatory PEG-CRGD Hydrogels Promote Chondrogenic Differentiation of PBMSCs
Yang, M., Deng, R., Yuan, F., Zhang, J., Zhang, Z., Chen, Y., & Yu, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122622 · Cited by 17 · see citing works
Differential Activation of Immune Cells for Genetically Different Decellularized Cardiac Tissues
Methe, K., Nayakawde, N. B., Banerjee, D., Sihlbom, C., Agbajogu, C., Travnikova, G., & Olausson, M. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0055 · Cited by 17 · see citing works
Rather, H., Varghese, J. F., Dhimmar, B., Yadav, U. C. S., & Vasita, R. (2022) · Biomaterials and Biosystems · doi:10.1016/j.bbiosy.2022.100064 · Cited by 16 · see citing works
Fang, W., Yang, M., Jin, Y., Zhang, K., Wang, Y., Liu, M., Wang, Y., Yang, R., & Fu, Q. (2023) · Gels · doi:10.3390/gels9110913 · Cited by 16 · see citing works
Matrix‐Bound Hyaluronan Molecular Weight as a Regulator of Dendritic Cell Immune Potency
Quartey, B. C., Sapudom, J., ElGindi, M., Alatoom, A., & Teo, J. C. M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303125 · Cited by 16 · see citing works
Synthesis, characterization and application of hydrogel for cancer treatment
Jain, N., Kejariwal, M., Chowdhury, F. I., Noor, I. M., Savilov, S. V., Yahya, M. Z. A., Diantoro, M., & Singh, P. K. (2024) · Chemical Physics Impact · doi:10.1016/j.chphi.2024.100737 · Cited by 16 · see citing works
- Authors
- Rowley, A. T., Nagalla, R. R., Wang, S., & Liu, W. F.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Wang, Szu‐Wen
- Liu, Wendy F.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2019-02-04
- Volume
- 8
- Issue
- 8
- Pages
- e1801578-e1801578
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC7568845
- OpenAlex
- W2914156600
- Cited by
- 193
- References
- 142
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 29 · 2023: 23 · 2022: 38 · 2021: 29 · 2020: 19 · 2019: 3 · 2018: 1
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI128519‐01)
- National Institute of Biomedical Imaging and Bioengineering (R21EB022240)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- extracellular matrix, immunomodulatory biomaterials, biomaterials engineering, decellularized tissue, collagen, fibrin, hyaluronic acid, RGD peptide, top-down and bottom-up approaches, tissue regeneration, drug delivery, immune cell modulation
- MeSH terms
- Animals, Biocompatible Materials, Cell Line, Extracellular Matrix, Humans, Tissue Engineering, Mice, Immunomodulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
