SWIR emissive RosIndolizine dyes with nanoencapsulation in water soluble dendrimers
Open accessAbstract
A xanthene–indolizine dye is shown to emit in the shortwave infrared spectral region (∼1100 nm maximum) in water when nanoencapsulated.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RosIndolizine dyes based on xanthene consist of mixed amine (rosamines) or oxygen/nitrogen (Rosol) donor groups to delocalize the positive charge over the entire π-conjugation system.
“The SWIR emitting RosIndolizine dyes based on xanthene consist of mixed amine (rosamines) or oxygen/nitrogen (Rosol) donor groups to delocalize the positive charge over the entire π-conjugation system (tolRosIndz and PhRosIndz).46”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [46]
The Introduction says amine or oxygen/nitrogen mixed donors are common in other xanthene dyes, then distinguishes RosIndz by its carbon-linked indolizine donor. The Results and discussion identifies tolRosIndz and PhRosIndz as bisindolizine dyes. Thus, the cited paper does not describe these RosIndolizine dyes as consisting of the donor groups named in the claim. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredRosIndolizine dyes have similar absorption profiles in an organic solvent with peaks at 930 nm that stretch well into the SWIR region reaching up to 1100 nm.
“They have similar absorption profiles in an organic solvent with peaks at 930 nm that stretch well into the SWIR region reaching up to 1100 nm.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Density-functional thermochemistry. III. The role of exact exchange
Becke, A. D. (1993) · The Journal of Chemical Physics · doi:10.1063/1.464913 · Cited by 103,767 · see citing works
Lee, C., Yang, W., & Parr, R. G. (1988) · Physical Review B · doi:10.1103/physrevb.37.785 · Cited by 100,874 · see citing works
Self‐consistent molecular orbital methods 25. Supplementary functions for Gaussian basis sets
Frisch, M., Pople, J., & Binkley, J. (1984) · The Journal of Chemical Physics · doi:10.1063/1.447079 · Cited by 7,062 · see citing works
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Liu, Z., Davis, C. R., Cai, W., He, L., Chen, X.-Y., & Dai, H. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0707654105 · Cited by 1,097 · see citing works
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582 · see citing works
A general method to fine-tune fluorophores for live-cell and in vivo imaging
Grimm, J., Muthusamy, A. K., Liang, Y.-J., Brown, T., Lemon, W. C., Patel, R., Lu, R., Macklin, J., Keller, P. J., Ji, N., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4403 · Cited by 563 · see citing works
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 540 · see citing works
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide.
Miller, E. W., Albers, A. E., Pralle, A., Isacoff, E., & Chang, C. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054474f · Cited by 530 · see citing works
A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues
Wan, H., Yue, J., Zhu, S., Uno, T., Zhang, X., Yang, Q., Yu, K., Hong, G., Wang, J., Li, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03505-4 · Cited by 450 · see citing works
NIR-I-to-NIR-II fluorescent nanomaterials for biomedical imaging and cancer therapy
Zhao, J., Zhong, D., & Zhou, S. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02573d · Cited by 354 · see citing works
Recent Progress in NIR-II Contrast Agent for Biological Imaging
Cao, J., Zhu, B., Zheng, K., He, S., Liang, M., Song, J., & Yang, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00487 · Cited by 314 · see citing works
Wang, Q., Dai, Y.-N., Xu, J.-Z., Cai, J., Niu, X., Zhang, L., Chen, R.-F., Shen, Q.-M., Huang, W., & Fan, Q.-L. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901480 · Cited by 313 · see citing works
Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy
Wang, R., Li, X., & Yoon, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02019 · Cited by 294 · see citing works
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274 · see citing works
Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
Zhang, Y., Zhang, Y., Hong, G., Wei, H., Zhou, K., Yang, K., Li, F., Chen, G., Liu, Z., Dai, H., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.089 · Cited by 254 · see citing works
Li, M.-L., Long, S.-R., Kang, Y., Guo, L.-Y., Wang, J.-Y., Fan, J.-L., Du, J.-J., & Peng, X.-J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09117 · Cited by 196 · see citing works
Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges
Ilina, K., MacCuaig, W. M., Laramie, M., Jeouty, J. N., McNally, L., & Henary, M. (2019) · Bioconjugate chemistry · doi:10.1021/acs.bioconjchem.9b00482 · Cited by 179 · see citing works
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177 · see citing works
Super-resolution fluorescent materials: an insight into design and bioimaging applications.
Yang, Z.-G., Sharma, A., Qi, J., Peng, X., Lee, D. Y., Hu, R., Lin, D.-Y., Qu, J.-L., & Kim, J. S. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00875a · Cited by 150 · see citing works
Wang, W., Ma, Z., Zhu, S., Wan, H., Yue, J., Ma, H., Ma, R., Yang, Q., Wang, Z., Li, Q., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800106 · Cited by 148 · see citing works
Small Molecular NIR-II Fluorophores for Cancer Phototheranostics
Dai, H., Shen, Q., Shao, J.-J., Wang, W.-J., Gao, F., & Dong, X.-C. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100082 · Cited by 128 · see citing works
A short review on NIR-II organic small molecule dyes
Li, L., Dong, X., Li, J., & Wei, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108756 · Cited by 113 · see citing works
Chemistry Is Dead. Long Live Chemistry!
Lavis, L. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00529 · Cited by 105 · see citing works
Indolizine‐Based Donors as Organic Sensitizer Components for Dye‐Sensitized Solar Cells
Huckaba, A., Giordano, F., McNamara, L. E., Dreux, K. M., Hammer, N. I., Tschumper, G. S., Zakeeruddin, S., Grätzel, M., Nazeeruddin, M., & Delcamp, J. H. (2015) · doi:10.1002/aenm.201401629 · Cited by 86
Self-citationPhotophysical Properties of Indocyanine Green in the Shortwave Infrared Region
Cosco, E. D., Lim, I., & Sletten, E. M. (2021) · ChemPhotoChem · doi:10.1002/cptc.202100045 · Cited by 79 · see citing works
Hows and Whys of Tumor-Seeking Dyes.
Usama, S., & Burgess, K. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00733 · Cited by 62 · see citing works
Indolizine-Cyanine Dyes: Near Infrared Emissive Cyanine Dyes with Increased Stokes Shifts.
Gayton, J., Autry, S. A., Meador, W. E., Parkin, S., Hill, G., Hammer, N., & Delcamp, J. (2018) · Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02521 · Cited by 60 · see citing works
Self-citationShen, Q., Wang, S., Yang, N., Zhang, C., Wu, Q., & Yu, C. (2020) · Journal of Luminescence · doi:10.1016/j.jlumin.2020.117338 · Cited by 60 · see citing works
Donor-Acceptor-Donor NIR II Emissive Rhodindolizine Dye Synthesized by C-H Bond Functionalization.
Rathnamalala, C., Gayton, J., Dorris, A. L., Autry, S. A., Meador, W. E., Hammer, N., Delcamp, J., & Scott, C. (2019) · Journal of Organic Chemistry · doi:10.1021/acs.joc.9b01860 · Cited by 54 · see citing works
Self-citationMeador, W. E., Autry, S. A., Bessetti, R. N., Gayton, J., Flynt, A., Hammer, N., & Delcamp, J. (2020) · Journal of Organic Chemistry · doi:10.1021/acs.joc.9b03108 · Cited by 53 · see citing works
Self-citationPhotophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement
Pengshung, M., Li, J., Mukadum, F., Lopez, S. A., & Sletten, E. M. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02213 · Cited by 42 · see citing works
Multimodal Imaging Probe Development for Pancreatic β Cells: From Fluorescence to PET.
Kang, N.-Y., Lee, J. Y., Lee, S. H., Song, I., Hwang, Y. H., Kim, M. J., Phue, W., Agrawalla, B., Wan, S. Y. D., Lalic, J., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b11173 · Cited by 34
Indolizine-Squaraines: NIR Fluorescent Materials with Molecularly Engineered Stokes Shifts.
McNamara, L. E., Rill, T. A., Huckaba, A., Ganeshraj, V., Gayton, J., Nelson, R. A., Sharpe, E. A., Dass, A., Hammer, N., & Delcamp, J. (2017) · Chemistry · doi:10.1002/chem.201702209 · Cited by 33
Self-citationChandrasiri, I., Abebe, D. G., Yaddehige, M. L., Williams, J. S. D., Zia, M. F., Dorris, A. L., Barker, A., Simms, B. L., Parker, A., Vinjamuri, B. P., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00432 · Cited by 33 · see citing works
Self-citationPhotophysical tuning of shortwave infrared flavylium heptamethine dyes via substituent placement
Pengshung, M., Li, J.-B., Mukadum, F., Lopez, S. A., & Sletten, E. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02213.s001 · Cited by 30
Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging
Jin, T. (2019) · ECS Journal of Solid State Science and Technology · doi:10.1149/2.0111901jss · Cited by 25 · see citing works
Bucevičius, J., Kostiuk, G., Gerasimaitė, R., Gilat, T., & Lukinavičius, G. (2020) · Chemical Science · doi:10.1039/d0sc02154g · Cited by 24
Dai, M.-C., Reo, Y., Song, C., Yang, Y. J., & Ahn, K. (2020) · Chemical Science · doi:10.1039/d0sc03314f · Cited by 9
Flavylium‐ and Silylrhodapolymethines In Excitation Multiplexing
Tian, C., & Burgess, K. (2021) · ChemPhotoChem · doi:10.1002/cptc.202000287 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Meador, W. E., Lin, E. Y., Lim, I., Friedman, H. C., Ndaleh, D., Shaik, A. K., Hammer, N., Yang, B., Caram, J., Sletten, E., et al. (2024) · Nature Chemistry · doi:10.1038/s41557-024-01464-6 · Cited by 73 · see citing works
“This approach has led to several reports on SWIR-emitting xanthene-type fluorophores, including the discovery of a 1,256-nm-emitting fluorophore made possible by indolizine-donor-group tuning via the addition of N,N -dimethylaniline (DMA) groups to the heterocycle periphery 22,23 .”
InfluentialSelf-citationPiwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
“46 The spectral properties of these systems fall short on the SWIR spectral region for absorption and emit primarily above 1000 nm.”
Far-red to NIR emitting xanthene-based fluorophores
Khan, Z., & Sekar, N. (2022) · Dyes and pigments · doi:10.1016/j.dyepig.2022.110735 · Cited by 25 · see citing works
Gao, X., Wang, J.-Y., Qin, Y., Zhu, Y., Liu, Y.-J., Zhou, K., & Cui, M. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05794 · Cited by 20 · see citing works
Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging
East, A. K., Lee, M. C., Smaga, L. P., Jiang, C., Mallojjala, S. C., Hirschi, J. S., & Chan, J. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c03382 · Cited by 16 · see citing works
Dorris, A. L., Umar, A. R., & Grieco, C. (2024) · Applied Spectroscopy · doi:10.1177/00037028241247072 · Cited by 7
“1,2 TA spectroscopy is readily used to observe ultrafast processes such as photochemistry, 3 charge photogeneration and polaron dynamics, 4,5 charge transfer in small molecule organic dyes, 6,7 among many other dynamics.”
InfluentialSelf-citationSaucier, M. A., Smith, C. L., Kruse, N. A., Hammer, N., & Delcamp, J. (2023) · Molecules · doi:10.3390/molecules28031287 · Cited by 3 · see citing works
“[23,24], cyanines [25,26], and xanthenes [18,27] equipped with indolizine donors to replace”
BackgroundSelf-citationChatterjee, S., Manna, S., Venkatesan, I., Banerjee, S., Chakraborty, D., Mondal, S., Das, A. K., Ghosh, A., & Samanta, J. (2026) · ChemPhotoChem · doi:10.1002/cptc.202600015
Self-citationBudnikova, Y., Dudkina, Y. B., Kalinin, A., Fazleeva, G., Islamova, L., Levitskaya, A. I., Fominykh, O., & Balakina, M. (2023) · Electrochimica Acta · doi:10.1016/j.electacta.2023.142547
- Authors
- Chatterjee, S., Meador, W. E., Smith, C., Chandrasiri, I., Zia, M. F., Nguyen, J., Dorris, A., Flynt, A., Watkins, D. L., Hammer, N. I., & Delcamp, J. H.
- Affiliations
- University of Mississippi (US)
- University of Southern Mississippi (US)
- Corresponding author
- Delcamp, Jared H.
- ORCID
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 11
- Issue
- 45
- Pages
- 27832-27836
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC9037842
- OpenAlex
- W3195455419
- Cited by
- 20
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 5
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Aquila Digital Community (University of Southern Mississippi) (submittedVersion)
- Funders
- National Science Foundation (1757220)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- nanoencapsulation, water-soluble dendrimers, biocompatibility, cytotoxicity, HEK cells, cell viability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
