Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions
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1. In hepatocytes from starved rats, vasopressin, angiotensin (angiotensin II) and oxytocin stimulated gluconeogenesis from lactate by 25–50%; minimal effective concentrations were about 0.02pM, 1 nM and 0.2 nM respectively. 2. Vasopressin and angiotensin also stimulated gluconeogenesis from alanine, pyruvate, serine and glycerol. EGTA decreased gluconeogenesis from these substrates. 3. Hormonal stimulation of gluconeogenesis from lactate was abolished in the absence of extracellular Ca2+. 4. Insulin did not prevent stimulation of gluconeogenesis by vasopressin or angiotensin. 5. The potency of the stimulatory effects of vasopressin and angiotensin on hepatic gluconeogenesis suggests they are operative in vivo. Also, the data suggest that Ca2+ plays a role in the stimulation by these hormones.
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Vasopressin induces gluconeogenesis in the rat liver.
“A causal link between vasopressin and glucose homeostasis is plausible because vasopressin induces gluconeogenesis in the rat liver and transiently increases glycemia in healthy humans and because vasopressin receptors are expressed in hepatocytes and pancreatic islets (2–9).”
From Low Water Intake and Risk for New-Onset Hyperglycemia (2011) · cites this paper as [4]
A causal link between vasopressin and glucose homeostasis is plausible.
“A causal link between vasopressin and glucose homeostasis is plausible because vasopressin induces gluconeogenesis in the rat liver and transiently increases glycemia in healthy humans and because vasopressin receptors are expressed in hepatocytes and pancreatic islets (2–9).”
From Low Water Intake and Risk for New-Onset Hyperglycemia (2011) · cites this paper as [4]
Vasopressin receptors are expressed in hepatocytes and pancreatic islets.
“A causal link between vasopressin and glucose homeostasis is plausible because vasopressin induces gluconeogenesis in the rat liver and transiently increases glycemia in healthy humans and because vasopressin receptors are expressed in hepatocytes and pancreatic islets (2–9).”
From Low Water Intake and Risk for New-Onset Hyperglycemia (2011) · cites this paper as [4]
Vasopressin transiently increases glycemia in healthy humans.
“A causal link between vasopressin and glucose homeostasis is plausible because vasopressin induces gluconeogenesis in the rat liver and transiently increases glycemia in healthy humans and because vasopressin receptors are expressed in hepatocytes and pancreatic islets (2–9).”
From Low Water Intake and Risk for New-Onset Hyperglycemia (2011) · cites this paper as [4]
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- Authors
- Whitton, P. D., Rodrigues, L. M., & Hems, D. A.
- Affiliations
- St George's, University of London (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1978-12-15
- Volume
- 176
- Issue
- 3
- Pages
- 893-898
- ISSN
- 0264-6021 (ISSN-L)
- PMC
- PMC1186313
- OpenAlex
- W98167733
- Cited by
- 123
- References
- 24
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- gluconeogenesis, vasopressin, angiotensin II, oxytocin, hepatocytes, lactate, calcium, insulin, starved rats, hepatic glucose metabolism
- MeSH terms
- Angiotensin II, Animals, Calcium, Gluconeogenesis, Insulin, Lactates, Liver, Male, Oxytocin, Substrate Specificity, Vasopressins, Rats, In Vitro Techniques
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