The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
The basal proton conductance of mitochondria depends on adenine nucleotide translocase content
Open accessAbstract
The basal proton conductance of mitochondria causes mild uncoupling and may be an important contributor to metabolic rate. The molecular nature of the proton-conductance pathway is unknown. We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls. Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila mitochondria increases proton conductance, and underexpression decreases it, even when the carrier is fully inhibited using carboxyatractylate. We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Underlining their importance, ANTs can account for up to 50% of basal mitochondrial membrane proton conductance [25].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION
Gornall, A. G., Bardawill, C. J., & David, M. M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57021-6 · Cited by 16,164
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins
Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032
Uncoupling: new approaches to an old problem of bioenergetics
Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893
Skulachev, V. P. (1996) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005795 · Cited by 703
A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling
Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597
Graham, B. H., Waymire, K. G., Cottrell, B. A., Trounce, I. A., MacGregor, G. R., & Wallace, D. C. (1997) · Nature Genetics · doi:10.1038/ng0797-226 · Cited by 556
Pecqueur, C., Alves‐Guerra, M., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., & Miroux, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006938200 · Cited by 483
The causes and functions of mitochondrial proton leak
Brand, M. D., Chien, L.-F., Ainscow, E. K., Rolfe, D. F. S., & Porter, R. K. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90099-x · Cited by 466
Pande, S. V., & Blanchaer, M. C. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62505-0 · Cited by 355
Mitochondrial carrier proteins
Palmieri, F. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00329-7 · Cited by 341
Flagged first, then by citations
1 of the 52 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Cornwall E. The role of the adenine nucleotide translocase in mitochondrial proton leak 2004 Cambridge University of Cambridge 197 PhD thesis
Cited by
Sorted by citations
Items 401–408 of 408
Laplante, A., & Bergdahl, A. (2026) · Journal of Experimental Pharmacology · doi:10.2147/jep.s598396
Ahmadi, M., Seaman, C., Marchant, E. D., Bartling, J., Kofoed, D., Coombs, K., Hancock, C. R., & Hyldahl, R. D. (2026) · Function · doi:10.1152/function.109.2025
Kinjo, K., Takamatsu, G., Toyama, K., Takayama, C., Akamine, Y., Kuniyoshi, R., Otsuka, N., Manome, Y., Okano, H. J., Katagiri, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.16.732339
Wei, C., Vanhatalo, A., Blackwell, J. R., Black, M. I., Rajaram, R., & Jones, A. M. (2026) · Nitric Oxide · doi:10.1016/j.niox.2026.07.001
Computational modelling of brain energy metabolism and circulation in the neonatal animal model
Moroz, T. (2014) · UCL Discovery (University College London)
Metadata
- Authors
- Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Emory University (US)
- Department of Molecular and Cellular Pathology, University of Birmingham, Birmingham, AL 35294, U.S.A.
- Corresponding author
- Ocloo, Augustine
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2005-11-22
- Volume
- 392
- Issue
- 2
- Pages
- 353-362
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1316271
- OpenAlex
- W1996324277
- Cited by
- 410
- References
- 52
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 13 · 2023: 23 · 2022: 25 · 2021: 20 · 2020: 25 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 14 · 2015: 18 · 2014: 23 · 2013: 21 · 2012: 23
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cambridge Commonwealth Trust
- National Institutes of Health
- Medical Research Council
- National Institute of Neurological Disorders and Stroke (NS 41850, R01NS041850)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- adenine nucleotide translocase, adenine nucleotide carrier, mitochondrial uncoupling, muscle mitochondria, B gene, carboxyatractylate, ADP/ATP exchange, metabolic rate
- MeSH terms
- Mitochondrial ADP, ATP Translocases, Animals, Cattle, Drosophila melanogaster, Female, Horses, Male, Membrane Potentials, Mitochondria, Phospholipids, Protein Binding, Protons, Rabbits, Swine, Gene Expression Regulation, Enzymologic, Mice, Knockout, Cell Respiration, Drosophila Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
