Cited by 410Mitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism, Diabetes, and Cancer

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The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

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Brand, Martin D., Pakay, Julian L., Ocloo, Augustine, Kokoszka, Jason, Wallace, Douglas C., Brookes, Paul S., Cornwall, Emma J.·2005·Biochemical Journal

DOI 10.1042/bj20050890PMC PMC1316271

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Abstract

The basal proton conductance of mitochondria causes mild uncoupling and may be an important contributor to metabolic rate. The molecular nature of the proton-conductance pathway is unknown. We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls. Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila mitochondria increases proton conductance, and underexpression decreases it, even when the carrier is fully inhibited using carboxyatractylate. We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions.

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Authors: Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J.
Affiliations: MRC Mitochondrial Biology Unit (GB)
Emory University (US)
Department of Molecular and Cellular Pathology, University of Birmingham, Birmingham, AL 35294, U.S.A.
Corresponding author: Ocloo, Augustine
ORCID: Brand, Martin D.
Ocloo, Augustine
Wallace, Douglas C.
Brookes, Paul S.
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 2005-11-22
Volume: 392
Issue: 2
Pages: 353-362
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj20050890
PMC: PMC1316271
OpenAlex: W1996324277
Cited by: 410
References: 52
Citations by year: 2026: 6 · 2025: 20 · 2024: 13 · 2023: 23 · 2022: 25 · 2021: 20 · 2020: 25 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 14 · 2015: 18 · 2014: 23 · 2013: 21 · 2012: 23
FWCI: 6.60
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cambridge Commonwealth Trust
National Institutes of Health
Medical Research Council
National Institute of Neurological Disorders and Stroke (NS 41850, R01NS041850)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: adenine nucleotide translocase, adenine nucleotide carrier, mitochondrial uncoupling, muscle mitochondria, B gene, carboxyatractylate, ADP/ATP exchange, metabolic rate
MeSH terms: Mitochondrial ADP, ATP Translocases, Animals, Cattle, Drosophila melanogaster, Female, Horses, Male, Membrane Potentials, Mitochondria, Phospholipids, Protein Binding, Protons, Rabbits, Swine, Gene Expression Regulation, Enzymologic, Mice, Knockout, Cell Respiration, Drosophila Proteins, Mice, Rats

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The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

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