High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation
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Mitochondria generate reactive oxygen species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the uncoupling proteins and adenine nucleotide translocase. Using mitochondria from rat liver, which lack uncoupling proteins, in the present study we show that energization (specifically, high membrane potential) is required for 4-hydroxynonenal to activate proton conductance mediated by adenine nucleotide translocase. Prolonging the time at high membrane potential promotes greater uncoupling. 4-Hydroxynonenal-induced uncoupling via adenine nucleotide translocase is prevented but not readily reversed by addition of carboxyatractylate, suggesting a permanent change (such as adduct formation) that renders the translocase leaky to protons. In contrast with the irreversibility of proton conductance, carboxyatractylate added after 4-hydroxynonenal still inhibits nucleotide translocation, implying that the proton conductance and nucleotide translocation pathways are different. We propose a model to relate adenine nucleotide translocase conformation to proton conductance in the presence or absence of 4-hydroxynonenal and/or carboxyatractylate.
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Synchronized oscillations in ΔΨm, the redox states of NADH, GSH/GSSG and other redox pairs, and ROS can occur across isolated cardiomyocytes.
“Synchronized oscillations in ΔΨm, the redox states of NADH, GSH/GSSG and other redox pairs, and ROS can occur across isolated cardiomyocytes (11)”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [11]
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Schiffer, T. A., Löf, L., Gallini, R., Kamali‐Moghaddam, M., Carlström, M., & Palm, F. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.866590 · Cited by 9 · see citing works
Woyda-Ploszczyca, A. M., & Jarmuszkiewicz, W. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9456-x · Cited by 7 · see citing works
Samartsev, V. N., & Kozhina, O. V. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910050093 · Cited by 5 · see citing works
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Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury
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Systems biology of energy metabolism in skeletal muscle
Schmitz, J. J. (2012) · TU/e Research Portal · doi:10.6100/ir739234
- Authors
- Azzu, V., Parker, N., & Brand, M. D.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Corresponding author
- Azzu, Vian
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2008-06-26
- Volume
- 413
- Issue
- 2
- Pages
- 323-332
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC2474560
- OpenAlex
- W1976727447
- Cited by
- 52
- References
- 54
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochemical Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (066750, 065326)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- mitochondrial membrane potential, 4-hydroxynonenal, alkenals, mitochondrial uncoupling, adenine nucleotide translocase, proton leak, oxidative phosphorylation, carboxyatractylate, protein conformation, lipid peroxidation, rat liver mitochondria
- MeSH terms
- Mitochondrial ADP, ATP Translocases, Aldehydes, Animals, Biological Transport, Female, Kinetics, Membrane Potentials, Mitochondria, Mitochondria, Liver, Nucleotides, Oxidative Phosphorylation, Oxygen Consumption, Protein Conformation, Protons, Rats
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