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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Abstract
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating signals derived from diverse environmental cues to promote anabolic and inhibit catabolic cellular functions. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1 and S6K2, whose first identified substrate was rpS6 (ribosomal protein S6), a component of the 40S ribosome. Studies over the past decade have uncovered a number of additional S6K1 substrates, revealing multiple levels at which the mTORC1–S6K1 axis regulates cell physiology. The results thus far indicate that the mTORC1–S6K1 axis controls fundamental cellular processes, including transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. In the present review we summarize the regulation of S6Ks, their cellular substrates and functions, and their integration within rapidly expanding mTOR (mammalian TOR) signalling networks. Although our understanding of the role of mTORC1–S6K1 signalling in physiology remains in its infancy, evidence indicates that this signalling axis controls, at least in part, glucose homoeostasis, insulin sensitivity, adipocyte metabolism, body mass and energy balance, tissue and organ size, learning, memory and aging. As dysregulation of this signalling axis contributes to diverse disease states, improved understanding of S6K regulation and function within mTOR signalling networks may enable the development of novel therapeutics.
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“These hallmarks of suppressed autophagy 11,31,32 indicate that LAP and autophagy may be competing for resources and might not easily co-exist in RPE cells.”
From RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye (2017) · cites this paper as [31]
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“MTOR activation is an indicator of suppressed autophagy 31 as is p-BECN1 at this Ser234 residue where it is targeted by the serine/threonine kinase AKT1 during MTOR activation.32”
From RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye (2017) · cites this paper as [31]
Citations
Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Collapse: how societies choose to fail or succeed
Lee, V. (2005) · Choice Reviews Online · doi:10.5860/choice.43-1028 · Cited by 3,081
Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773
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Items 601–700 of 998
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Xue, H., Zhao, Y., Wang, L., Zhu, X., Zhang, K., Li, D., Ji, J., Niu, L., Cui, J., Luo, J., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1006253 · Cited by 11
Walk, C. L., Mullenix, G. J., Maynard, C. W., Greene, E. S., Maynard, C. J., Ward, N. E., & Dridi, S. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1376628 · Cited by 12
Alshaman, R., Truong, L. D., & Oyekan, A. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12648 · Cited by 11
Zhang, J., Guo, J., Qin, X., Wang, B., Zhang, L., Wang, Y., Gan, W., Pandolfi, P. P., Chen, W., & Wei, W. (2018) · Science Signaling · doi:10.1126/scisignal.aao1052 · Cited by 11
Zaiets, I. V., Holiar, V. V., Sivchenko, A. S., Smialkovska, V. V., & Filonenko, V. V. (2019) · The Ukrainian Biochemical Journal · doi:10.15407/ubj91.04.017 · Cited by 11
Yoshikawa, M., Morifuji, T., Matsumoto, T., Maeshige, N., Tanaka, M., & Fujino, H. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00070.2019 · Cited by 11
A Regulatory Circuit Orchestrated by Novel-miR-3880 Modulates Mammary Gland Development
Zhang, Y., Liu, J., Li, W., Cao, F., Niu, G., Ji, S., Du, X., Cao, B., & An, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00383 · Cited by 11
Freitas, A. E., Heinrich, I. A., Moura, T. D. M., Fraga, D. B., Costa, A. P., Azevedo, D., Brocardo, P. S., Kaster, M. P., Leal, R. B., & Rodrigues, A. L. S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113398 · Cited by 11
Su, Z., Liao, J., Zhang, H., Zhang, T., Wu, F., Tian, X.-H., Zhang, F., Sun, W., & Cui, Q. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.052 · Cited by 11
Gonzalez, A. M., Hoffman, J. R., Jajtner, A. R., Townsend, J. R., Boone, C. H., Beyer, K. S., Baker, K. M., Wells, A. J., Church, D. D., Mangine, G. T., et al. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.09.006 · Cited by 11
The role of mechanistic target of rapamycin in maintenance of glomerular epithelial cells
Yao, Y., & Inoki, K. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000181 · Cited by 11
The Р60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation
Zaiets, I. V., Sivchenko, A. S., Хоруженко, А. І., Savinska, L. O., & Filonenko, V. V. (2018) · The Ukrainian Biochemical Journal · doi:10.15407/ubj90.04.025 · Cited by 11
Horimoto, Y., Terao, T., Tsutsumi, Y., Tanabe, M., Mogushi, K., Hlaing, M. T., Sasaki, R., Saeki, H., Okazaki, M., Sonoue, H., et al. (2019) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001300 · Cited by 11
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Alam, A., Khan, M. S., Mathur, Y., Sulaimani, M. N., Farooqui, N., Ahmad, S. F., Nadeem, A., Yadav, D. K., & Mohammad, T. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2228912 · Cited by 10
Jia, W., Yuan, J., Li, S., & Cheng, B. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189018 · Cited by 9
Li, K., Cao, J., Gong, Y., Li, X., Wu, M., Qi, Y., Ying, X., Liu, D., Ma, X., & Zhang, X. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105746 · Cited by 10
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Beard, D. J., Brown, L. S., Morris, G. P., Couch, Y., Adriaanse, B. A., Karali, C. S., Schneider, A. M., Howells, D. W., Redzic, Z. B., Sutherland, B. A., et al. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01298-x · Cited by 10
Zhang, Z., Cui, M., Wang, H., Yuan, W., Liu, Z., Gao, H., Guan, X., Chen, X., Xie, L., He, Y., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.125771 · Cited by 11
Unraveling the role of proteins in dementia: insights from two UK cohorts with causal evidence
Gong, J., Williams, D. M., Scholes, S., Assaad, S., Bu, F., Hayat, S. A., Zaninotto, P., & Steptoe, A. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf097 · Cited by 17
Zhu, Y., Zhou, X., Lan, C., Wen, Y., Fu, H., Li, Z., Li, Y., Li, S., Huang, F., Wang, L., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12619 · Cited by 11
Zhang, X.-Y., Jiao, X., Wu, D., Chen, F., Ding, Z.-M., Wang, Y.-S., Meng, F., Duan, Z.-Q., Xiong, J., Yang, C.-X., et al. (2021) · Environmental Toxicology · doi:10.1002/tox.23375 · Cited by 9
Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy
Jain, P. K., Jayappa, S., Sairam, T., Mittal, A., Paul, S., Rao, V. J., Chittora, H., Kashyap, D., Palakodeti, D., Kumarasamy Thangaraj, K., et al. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-107866 · Cited by 10
Li, F., Xian, D., Huang, J., Nie, L., Xie, T., Sun, Q., Zhang, X., & Zhou, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713401 · Cited by 12
Alybayev, S., Smekenov, I., Kuanbay, A. K., Sarbassov, D. D., & Bissenbaev, A. K. (2023) · Current Plant Biology · doi:10.1016/j.cpb.2023.100312 · Cited by 10
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Wang, Y., Mei, H., Shao, Q., Wang, J., & Lin, Z. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1294273 · Cited by 10
Nagao, M., Toh, R., Irino, Y., Nakajima, H., Oshita, T., Tsuda, S., Hara, T., Shinohara, M., Ishida, T., & Hirata, K. (2017) · FEBS Open Bio · doi:10.1002/2211-5463.12279 · Cited by 10
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Wang, X., Yue, P., Tao, H., & Sun, S. (2017) · Heliyon · doi:10.1016/j.heliyon.2017.e00378 · Cited by 10
Cruz, R., Pereira‐Castro, I., Almeida, M. T., Moreira, A., Cabanes, D., & Sousa, S. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00146 · Cited by 10
Luo, Q., Kong, L., Dong, J., Zhāng, T., Wang, H., Zhang, R., Lu, Q., Chen, H., Shao, H., & Jin, M. (2019) · Avian Pathology · doi:10.1080/03079457.2019.1568390 · Cited by 10
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Wang, J., Cao, Y., Fu, S., Li, W., Ge, Y., Cheng, J., & Liu, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118415 · Cited by 10
Spaan, I., Timmerman, L. M., Kimman, T., Slomp, A., Cuenca, M., van Nieuwenhuijzen, N., Moesbergen, L. M., Minnema, M. C., Raymakers, R. A. P., & Peperzak, V. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003624 · Cited by 10
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Chantarasrivong, C., Higuchi, Y., Tsuda, M., Yamane, Y., Hashida, M., Konishi, M., Komura, N., Ando, H., & Yamashita, F. (2019) · RSC Advances · doi:10.1039/c9ra01943j · Cited by 10
Zhao, Y., Castro, L. F. C., Monroig, Ó., Cao, X., Sun, Y., & Gao, J. (2022) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00839-7 · Cited by 9
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Kemmer, S., Berdiel‐Acer, M., Reinz, E., Sonntag, J., Tarade, N., Bernhardt, S., Fehling-Kaschek, M., Hasmann, M., Korf, U., Wiemann, S., et al. (2022) · Cancers · doi:10.3390/cancers14102379 · Cited by 11
Lehrer, M., Rao, A., Bhadra, A., Ravikumar, V., Chen, J. Y., Wintermark, M., Hwang, S. N., Holder, C. A., Huang, E. P., Fevrier-Sullivan, B., et al. (2017) · Oncoscience · doi:10.18632/oncoscience.353 · Cited by 9
Uppala, J. K., Bhattacharjee, S., & Dey, M. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00662-20 · Cited by 9
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Golberg, N. D., Druzhevskaya, A. M., Rogozkin, V. A., & Ahmetov, I. I. (2014) · Human Physiology · doi:10.1134/s0362119714040070 · Cited by 9
Okazaki, M., Horimoto, Y., Tanabe, M., Ichikawa, Y., Tokuda, E., Arakawa, A., Kobayashi, T., & Saito, M. (2018) · Medical Oncology · doi:10.1007/s12032-018-1112-9 · Cited by 9
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Shane, H. L., Reagin, K. L., & Klonowski, K. D. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701268 · Cited by 9
Liu, X.-W., Zhang, J., Feng, L., Jiang, W., Wu, P., Kuang, S., Tang, L. Y., Shi, H.-Q., Zhou, X., & Liu, Y. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.07.033 · Cited by 9
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Abrisqueta, M., Süren‐Castillo, S., & Maestro, J. L. (2016) · Physiological Entomology · doi:10.1111/phen.12156 · Cited by 9
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Rieder, F. J. J., Kastner, M.-T., Hartl, M., Puchinger, M. G., Schneider, M., Majdic, O., Britt, W. J., Djinović‐Carugo, K., & Steininger, C. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000675 · Cited by 9
Cajas, Y. N., Cañón-Beltrán, K., Núñez-Puente, C., Gutiérrez‐Adán, A., González, E. M., Agirregoitia, E., & Rizos, D. V. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab184 · Cited by 8
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Bokov, R. O., Sharlo, K. A., Vilchinskaya, N. A., Tyganov, S. A., Turtikova, O. V., Rozhkov, S. V., Deviatiiarov, R. M., Gusev, O., Tomilovskaya, E., Shenkman, B. S., et al. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00196.2024 · Cited by 10
Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation
White, B., Wang, Z., Dean, M., Michl, J., Nieora, N., Flannery, S. E., Vendrell, I., Fischer, R., Hulı́ková, A., & Swietach, P. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202409103 · Cited by 8
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Abshire, E. T., & Maquat, L. E. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01724-0 · Cited by 8
Tian, Z., Lin, G., & Jiao, C. (2019) · Fisheries Science · doi:10.1007/s12562-019-01326-y · Cited by 8
Devilliers, M., Garrido, D., Poidevin, M., Rubin, T., Rouzic, A. L., & Montagne, J. (2020) · Genetics · doi:10.1093/genetics/iyaa010 · Cited by 9
Xie, L., Song, X., Lei, L., Chen, C., Zhao, H., Hu, J., Yu, Y., Bai, X., Wu, X., Li, X., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117480 · Cited by 8
Acharya, K. D., & Veney, S. L. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22085 · Cited by 8
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Brooks, D. L. P., Garza, A., Katayama, I. A., Romero, J. R., Adler, G. K., Pojoga, L. H., & Williams, G. H. (2019) · Endocrinology · doi:10.1210/en.2018-00989 · Cited by 8
Corona-Sánchez, I., Peña-Uribe, C. A., González-López, O., Villegas, J., Campos‐García, J., & de la Cruz, H. R. (2019) · PeerJ · doi:10.7717/peerj.7494 · Cited by 8
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Timmerman, L. M., de Graaf, J. F., Satravelas, N., Keşmir, C., Meyaard, L., & van der Vlist, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244770 · Cited by 8
Li, Z., Qi, H.-Y., Wang, J., Zhao, Z., Tan, F.-Q., & Yang, W.-X. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03795-1 · Cited by 8
Garifulin, O. M., Zaiets, I. V., Kosach, V., Horak, I. R., Хоруженко, А. І., Gotsulyak, N. Y., Savinska, L. O., Kroupskaya, I. V., Martsynyuk, M. Y., Дробот, Л. Б., et al. (2023) · Biopolymers and Cell · doi:10.7124/bc.000a9d · Cited by 8
Brown, R. W., & Peterson, D. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_394 · Cited by 8
Antignani, A., Griner, L. A. M., Guha, R., Simon, N. C., Pasetto, M., Keller, J. M., Huang, M., Angelus, E., Pastan, I. H., Ferrer, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161415 · Cited by 8
Yang, X. Y., Zhao, Y., Sun, Q., Yang, Y., Gao, Y., Ge, W., Liu, J., Xu, X., & Zhang, J. (2020) · Molecular Reproduction and Development · doi:10.1002/mrd.23321 · Cited by 8
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Li, C., Ma, B., Chen, J., Jeong, Y., & Xu, X. (2020) · Marine Drugs · doi:10.3390/md18100495 · Cited by 8
Leipert, J., Kaßner, F., Schuster, S., Händel, N., Körner, A., Kieß, W., & Garten, A. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1145244 · Cited by 8
Bianchi, A., Lipchick, B. C., & Nikiforov, M. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_1 · Cited by 8
Gong, J., Williams, D. M., Scholes, S., Assaad, S., Bu, F., Hayat, S. A., Zaninotto, P., & Steptoe, A. (2024) · medRxiv · doi:10.1101/2024.06.04.24308415 · Cited by 8
Noori, T., Sahebgharani, M., Sureda, A., Sobarzo-Sanchez, E., Fakhri, S., & Shirooie, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220119125040 · Cited by 7
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Jain, A., Singh, S., Yadav, S., Dubey, A., Awasthi, Y., Tiwari, V., Kumar, V., Dubey, I., Trivedi, S. P., & Kumar, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-85555-5 · Cited by 7
Lipchick, B. C., Guterres, A. N., Chen, H.-Y., Zundell, D. M., Aguila, S. W. D., Reyes-Uribe, P. I., Tirado, Y., Basu, S., Yin, X., Kossenkov, A. V., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp8913 · Cited by 8
He, T., Chen, Q., Li, H., Mao, J., Luo, J., Ma, D., & Yang, Z. (2025) · BMC Genomics · doi:10.1186/s12864-025-11424-0 · Cited by 7
Stavrides, P. H., Goulbourne, C. N., Peddy, J., Huo, C., Rao, M. V., Khetarpal, V. K., Marchionini, D. M., Nixon, R. A., & Yang, D. (2025) · eLife · doi:10.7554/elife.104979.3 · Cited by 8
Li, Y.-C., Wu, S.-X., Zou, Q.-Y., Zheng, Y., Wu, Z., Zhao, X., Gao, X., Yang, Y., & Du, L. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117086 · Cited by 7
Zhang, X.-Z., Sun, Y., Zhang, M.-H., & Jin, Z. (2022) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2022.0005 · Cited by 7
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Metadata
- Authors
- Magnuson, B., Ekim, B., & Fingar, D. C.
- Affiliations
- University of Michigan (US)
- Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, U.S.A.
- Corresponding author
- Magnuson, Brian
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-12-14
- Volume
- 441
- Issue
- 1
- Pages
- 1-21
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2312282875
- Cited by
- 1,015
- References
- 241
- Citations by year
- 2026: 52 · 2025: 57 · 2024: 63 · 2023: 67 · 2022: 57 · 2021: 72 · 2020: 69 · 2019: 82 · 2018: 87 · 2017: 85 · 2016: 73 · 2015: 84 · 2014: 68 · 2013: 64 · 2012: 34
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk078135-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-078135, R01DK100722)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- S6K, S6K1, S6K2, mTORC1, TOR signaling, ribosomal protein S6, translational regulation, glucose homeostasis, insulin sensitivity, adipocyte metabolism, energy balance, organ size, learning and memory, aging, disease therapeutics
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Signal Transduction, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases
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