Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

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mTOR: from growth signal integration to cancer, diabetes and ageing

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Collapse: how societies choose to fail or succeed

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Extending Healthy Life Span—From Yeast to Humans

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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HSF1 and CPSF1 affect milk fat and protein synthesis by regulating the AKT/mTOR signaling pathway

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Chronic intermittent hypoxia modulates energy metabolic pathways and improves hypoxia tolerance capacity in golden pompano, Trachinotus blochii

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Eukaryotic elongation factor 2 kinase (eEF2K): Mechanisms and pharmacological significance in metabolic diseases

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Holotomography-based, label-free quantification of cellular dry mass as a biophysical indicator of microglial Aβ phagocytosis during senescence

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Ribosomal Proteins in Cell Biology and Cancer

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Repeated competition influences neural response, but not neurogenesis or physiology, in the fighting fish Betta splendens

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Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (Capra hircus)

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The Mammalian Target of Rapamycin–70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma

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A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells

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Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma

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The Central FacilitaTOR: Coordinating Transcription and Translation in Eukaryotes

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Metformin and risk factors for chronic kidney disease in a European population based on Mendelian randomization

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The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Lettau, K., Forchhammer, S., Fehrenbacher, B., Mahmutovic, L., Scharpf, M. O., Blumenstock, G., Schaller, M., Bonzheim, I., Khozooei, S., & Toulany, M. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70060 · Cited by 2

Phosphorylation of Ribosomal Protein S6 Kinase 1 at Thr421/Ser424 and Dephosphorylation at Thr389 Regulates SP600125-Induced Polyploidization of Megakaryocytic Cell Lines

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TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: A cautionary tale of the use of this cell line in studies on dioxin toxicity

Brandner, S., Eberhagen, C., Lichtmannegger, J., Hieber, L., & Andrae, U. (2013) · Toxicology · doi:10.1016/j.tox.2013.04.014 · Cited by 2

An atypical switch for metabolism and ageing

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N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

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Three-dimensional imaging of upper tract urothelial carcinoma improves diagnostic yield and accuracy

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Generation and characterization of the MCF-7 cell line with a knockout of a p85-S6K1 isoform of the ribosomal protein S6 kinase 1

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Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington’s disease

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Protein kinase involvement in wild-type and mutant calcium-sensing receptor signalling

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Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell QuiescencePreprint

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Quantitative proteomics and phosphoproteomics of PPP2R5D variants reveal deregulation of RPS6 phosphorylation through converging signaling cascadesPreprint

Smolen, K. A., Papke, C. M., Swingle, M. R., Musiyenko, A., Li, C., Camp, A., Honkanen, R. E., & Kettenbach, A. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.27.534397 · Cited by 2

The Regulation of Mammalian Target of Rapamycin

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Fibroblasts modulate the tumor cell motility and their mTOR/S6K1 phosphorylation status in vitro

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Protein kinase modulation for anti-aging intervention

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External auditory canal ectopic atypical meningioma: A case report and brief literature review

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Therapies Using Anti-diabetics to Prevent and Manage Progression of Parkinson's Disease

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Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics

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Brain Activation Patterns and Dopaminergic Neuron Activity in Response to Conspecific Advertisement Calls in Reproductive versus Non-Reproductive Male Plainfin Midshipman Fish (Porichthys notatus)

Vetter, B. J., Perelmuter, J. T., Lozier, N. R., Sisneros, J. A., & Forlano, P. M. (2025) · Brain Behavior and Evolution · doi:10.1159/000543759 · Cited by 1

Silencing of RNFT2 suppresses cell proliferation and migration through mTORC1 signaling pathway in gastric cancer

Wang, Y., Ma, Q., Zhu, Z., Sang, H., Fan, H., & Li, Z. (2025) · Amino Acids · doi:10.1007/s00726-025-03449-2 · Cited by 1

Monocatechol metabolites of sesamin and episesamin promote higher autophagy flux compared to their unmetabolized forms by mTORC1-selective inhibition

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Bulk RNA-seq conjoined with ScRNA-seq analysis reveals the molecular characteristics of nucleus pulposus cell ferroptosis in rat aging intervertebral discs

Chen, S., Fu, J., Long, J., Liu, C., Ai, X., Long, D., Leng, X., Zhang, Y., Liao, Z., Li, C., et al. (2025) · Arthritis Research & Therapy · doi:10.1186/s13075-025-03550-7 · Cited by 1

17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway

Liu, T., Li, Z., Zhang, W., Guo, X., Liu, G., Yang, D., & Yang, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1564458 · Cited by 1

Tks5 interactome reveals endoplasmic‐reticulum‐associated translation machinery in invadosomes

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Integrative Transcriptomic and Phosphoproteomic Analysis Reveals Key Components of the SnRK1 Signaling Network in Rice

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AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans

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Phosphoproteomics identification of ERK-dependent activation of Rps6kb1 in cardiac hypertrophy

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From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

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Hyodeoxycholic acid attenuates atherosclerosis by antagonizing FXR and modulating the PD-1/mTORC1 signaling axis

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PFOS exposure at environmentally relevant concentrations promote papillary thyroid carcinoma progression through PI3K/AKT/mTOR-mediated epithelial-mesenchymal transition

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Whey protein regulation of muscle protein synthesis: From molecular mechanisms to physiological effects

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TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

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The nuts‐and‐bolts of ribosomal protein s6 kinase 1 regulation: A shared responsibility for mTOR complexes 1 and 2

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Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study

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iTorin1—An Active Site Inhibitor of mTOR, Suppresses Prostate Cancer Cell Growth Induced by Activated α2M-Macroglobulin Ligation of Cell Surface GRP78

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Acute Exposure to Essential Amino Acids (EAA) Activates MTOR/p70 Signaling in Soleus Muscle of Chronically EAA-Treated Aged Rats

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Flow Cytometry Analysis of mTOR Signaling in Antigen-Specific B Cells

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Aging in Complex Multicellular Organisms

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Эффективность применения препарата рацекадотрил в комплексной терапии ротавирусной инфекции у детей

Незгода, І. І., Naumenko, O. M., Asaulenko, A. А., Онофрійчук, О. С., Brovinska, L. M., Kolesnyk, A., Nikulchenko, O. V., & Sinchuk, N. I. (2020) · ACTUAL INFECTOLOGY · doi:10.22141/2312-413x.8.2.2020.199733 · Cited by 1

Inhibition of GH3 and HEK293 pituitary adenoma cell growth byTrigonella foenum-graecumextract (TFGE) via mTORC1 down-regulation

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Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimer's dysmetabolism, neuropathology, and possible therapies

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Quetiapine Shortens the Lifespan of Caenorhabditis elegans through DOP-2, DAF-2 and RSKS-1

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Methionine restriction and cancer treatment: a systems biology study of yeast to investigate the possible key players

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Quantitative proteomics profiling reveals the inhibition of trastuzumab antitumor efficacy by phosphorylated RPS6 in gastric carcinoma

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Crosstalk between metabolites and myeloid cell biology

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Targeting PAK1 suppresses tumor progression by promoting mRNA decay of oncogenic factors and enhancing chemotherapeutic efficacy in colorectal cancer

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Cellular and Molecular Mechanisms of Protein Synthesis Among Tissues

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Genetic Evidence Supporting Causal Roles of mTOR-Dependent Proteins in Rheumatic Fever: A Two-Sample Randomized Mendelian Study

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Effects of P70 S6 kinase on the ageing process and reproduction of Daphnia pulex (Branchiopoda, Anomopoda)

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Regulation of Translation by Essential Amino Acids and Glucose in Mammary Glands and Skeletal Muscle of Lactating Dairy Cows

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USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signalingPreprint

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Exploring the role of PTN1 in ustilago maydis.

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Investigation of polymeric biodegradable-biocompatible Janus particles in drug delivery systems and further augmentation via a facile synthesis method

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Hyperactivation of Torc1 Drives Resistance to the Pan-Her Tyrosine Kinase Inhibitor Neratinib in Her2-Mutant CancersPreprint

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Modelling Parkinson’s Disease Pre-Clinically: A Novel Virus-Fibril Inducible Mouse Model Exploring Disease Characteristics and Therapeutic Intervention via Metabotropic Glutamate Receptor 5 Negative Allosteric Modulation

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Caracterização do papel das diferentes isoformas de S6K em um modelo de câncer de próstata

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The biology of schizophrenia as a neurodevelopmental disorder

van Berlekom, A. B. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1269 · Cited by 1

The Multifaceted Role of S6K1 in Cellular Regulation: Structural Insights, Isoform-Specific Functions, and Therapeutic PotentialPreprint

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mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearancePreprint

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Exploring the multifactorial causes and therapeutic strategies for anabolic resistance in sarcopenia: A systems modeling studyPreprint

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Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8 + T cellsPreprint

Yang, T., Sharma, H., Benson, J. M., Valente, W. J., LaRue, R. S., Webber, B. R., Moriarity, B. S., Pennell, C. A., Jameson, S. C., & Kelekar, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.08.692849 · Cited by 1

Clinical potential of the mTOR effectors S6K1, S6K2 and 4EBP1 in breast cancer

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Role of PKCε in RNA granule formation and protein translation

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Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle

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Effects of Drosophila Ribosomal Protein S6 Kinase on Wing Growth

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Characterizing the Interactions of the mTORC1 Scaffold Protein Raptor with mTOR Substrates

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Isoform specific functions of protein kinase D3 (PKD3) in breast cancer cell proliferation and motility

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Molecular bases of inherited bone marrow failures : Shwachman-Diamond syndrome and Diamond Blackfan anemia.

Henson, A. L. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/608

mTOR regulates Aurora A via enhancing protein stability

Li, F. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1876

Transcriptional Regulation of the Drosophila Peptidoglycan Sensor PGRP-LC by the Steroid Hormone Ecdysone: A Masters Thesis

Tong, M. (2015) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m29w2n

Effects of Mammalian Target of Rapamycin Inhibition on Circuitry Changes in the Dentate Gyrus of Mice after Focal Brain Injury

Butler, C. R. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.182

Characterization of Nedd4 Function and its Interaction with Angiomotin

Nath, M. (2014) · TSpace (University of Toronto)

Phosphatidylinositol 3-Kinase (PI3K) as a therapeutic target in NSCLC

Stamatkin, C. W. (2014) · UKnowledge (University of Kentucky)

Interaction of type I interferons and mTOR signaling underlying PRRSV infection

Liu, Q. (2016) · K-State Research Exchange (Kansas State University)

Characterisation of Resistance to Everolimus in Acute Lymphoblastic Leukemia

Basnett, J. (2016) · The Sydney eScholarship Repository (The University of Sydney)

Intramuscular Anabolic Signaling and Endocrine Response Following Different Resistance Exercise Protocols In Trained Men

Gonzalez, A. M. (2015) · Journal of International Crisis and Risk Communication Research

Mammary mTOR activity during intravenous glucose infusions into lactating dairy cows

Curtis, R. V. (2013) · The Atrium (University of Guelph)

Computer simulation of a large-scale signalling network regulating translation Initiation in the mammalian cell.

Taylor, D. W. (2017) · Surrey Research Insight Open Access (The University of Surrey)

S6 Kinase- and -TrCP2-Dependent Degradation of p19 Arf Is Required for Cell Proliferation

Nakagawa, T., Araki, T., Nakagawa, M., Hirao, A., Unno, M., & Nakayama, K. (2015)

VIRAL REGULATION OF CAP-DEPENDENT MESSENGER RNA TRANSLATION INHIBITOR 4E-BP1 DURING MITOSIS

Velásquez, C. (2017) · D-Scholarship@Pitt (University of Pittsburgh)

Effects of glucose and acetate infusion on milk protein yield and related gene expression in muscle and mammary glands of lactating dairy cows

Li, B. (2017) · The Atrium (University of Guelph)

Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activityPreprint

Chisnell, P. J., Parenteau, T. R., Tank, E. M. H., Ashrafi, K., & Kenyon, C. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/310086

Insulin Signalling in Human Adipocytes and its Interplay with beta-Adrenergic Control of Lipolysis

Jönsson, C. (2018) · doi:10.3384/diss.diva-147618

A participação da via fosfatidilinositol3-quinase (PI3K)/mTOR no carcinoma epidermoide oral

Duarte, A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-20072018-092758

Predicting Tumor Growth and Ligand Dependence from mRNA by Combining Machine Learning with Mechanistic Modeling

Hass, H., & Raue, A. (2018) · Methods in pharmacology and toxicology · doi:10.1007/7653_2018_29

Could Antibiotics Be Therapeutic Agents in Alzheimer’s Disease?

Gómez, O., Pintado, C., Rodríguez-Pérez, M., & Burgos‐Ramos, E. (2019) · Frontiers in clinical drug research. Alzheimer disorders · doi:10.2174/9789811401893119080005

mTOR under stress

Heberle, A. M. (2019) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Jastrzebski, K., Hannan, K. M., Tchoubrieva, E. B., Hannan, R. D., & Pearson, R. B. (2007) · Growth Factors · doi:10.1080/08977190701779101 · Cited by 240

S6 kinase 1 at the central node of cell size and ageing

Fumagalli, S., & Pende, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.949196 · Cited by 28

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size

Ruvinsky, I., & Meyuhas, O. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.04.003 · Cited by 800

The nuts‐and‐bolts of ribosomal protein s6 kinase 1 regulation: A shared responsibility for mTOR complexes 1 and 2

Majeed, S. T., Majeed, R., & Andrabi, K. I. (2026) · FEBS Journal · doi:10.1111/febs.70612 · Cited by 1

Ribosomal Protein S6 and S6 Kinases

Pende, M., & Treins, C. (2014) · Springer eBooks · doi:10.1007/978-94-017-9078-9_16