Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

Collapse: how societies choose to fail or succeed

Lee, V. (2005) · Choice Reviews Online · doi:10.5860/choice.43-1028 · Cited by 3,081

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Decoding driver and phenotypic genes in cancer: Unveiling the essence behind the phenomenon

Liu, D., Liu, L., Zhang, X., Zhao, X., Li, X., Che, X., & Wu, G. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101358 · Cited by 6

NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer

Xu, W., Fang, H., Cao, X., Xu, M.-Z., Yan, Y., Shen, M., Yang, Y., & Jiang, K. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07638-5 · Cited by 6

Molecular profiling of signaling pathways involved in chicken ovarian follicle development by transcriptome sequencing

Wadood, A. A., Bordbar, F., Safdar, M., & Zhang, X. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1676247 · Cited by 6

Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways

An, P.-P., Huang, H., Ru, S.-J., Gao, Y., Ren, Y., Gao, K., Zhou, H., Zhou, B., & Yue, J. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107619 · Cited by 6

Role of Cathepsin K in bone invasion of pituitary adenomas: A dual mechanism involving cell proliferation and osteoclastogenesis

Liu, H., Wang, P., Li, J., Zhao, J., Mu, Y., & Gu, W. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217443 · Cited by 6

Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

Lane, A. R., Scher, N. E., Bhattacharjee, S., Zlatic, S. A., Roberts, A. M., Gokhale, A., Singleton, K. S., Duong, D. M., McKenna, M., Liu, W. L., et al. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-11-0512 · Cited by 6

The activation mechanism of plant S6 kinase (S6K), a substrate of TOR kinase, is different from that of mammalian S6K

Yaguchi, M., Ikeya, S., & Kozaki, A. (2019) · FEBS Letters · doi:10.1002/1873-3468.13661 · Cited by 6

p70S6K Promotes Acquired Resistance of Erlotinib Through Induction of Epithelial-Mesenchymal Transition in Non-Small Cell Lung Carcinoma

Li, M., Chen, H., Sun, T., Ma, Z., Chen, X., Wu, D., Huang, W., & Wang, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249695 · Cited by 6

Predicting mechanism of action of cellular perturbations with pathway activity signatures

Ren, Y., Sivaganesan, S., Clark, N. A., Zhang, L., Biesiada, J., Niu, W., Plas, D. R., & Medvedovic, M. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa590 · Cited by 6

Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress

Orlik, C., Berschneider, K. M., Jahraus, B., Niesler, B., Balta, E., Schäkel, K., Schröder–Braunstein, J., Souto‐Carneiro, M., & Samstag, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016112 · Cited by 6

Inhibitors of the Mechanistic Target of Rapamycin Can Ameliorate Bortezomib-Induced Peripheral Neuropathy

Suzuki, M., Zhou, Z. J., Nagayasu, K., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00861 · Cited by 7

Computational analysis of regulatory regions in human protein kinases

Pei, J., & Cong, Q. (2023) · Protein Science · doi:10.1002/pro.4764 · Cited by 5

Pharmacological inhibition of S6K1 rescues synaptic deficits and attenuates seizures and depression in chronic epileptic rats

Zhang, Y., Cheng, X., Wu, L., Li, J., Liu, C., Wei, M., Zhu, C., Huang, H., & Lin, W. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14475 · Cited by 5

Attenuation of Replication Stress–Induced Premature Cellular Senescence to Assess Anti‐Aging Modalities

Zhao, H., & Darżynkiewicz, Z. (2014) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy0947s69 · Cited by 6

Locus Mapping, Molecular Cloning, and Expression Analysis of rps6kb2, a Novel Metamorphosis-Related Gene in Chinese Tongue Sole (Cynoglossus semilaevis)

Liu, Y., Wei, M., Guo, H., Shao, C., Liang, M., Xu, W., Wang, N., Wang, L., Power, D. M., Hou, J., et al. (2017) · Marine Biotechnology · doi:10.1007/s10126-017-9769-1 · Cited by 6

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

Junemann, J., Just, I., Gerhard, R., & Pich, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03083 · Cited by 6

Autophagic cell death in viral infection: Do TAM receptors play a role?

Datan, E., & Salman, S. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.10.001 · Cited by 5

Porcine Plasmacytoid Dendritic Cells Are Unique in Their Expression of a Functional NKp46 Receptor

Mair, K. H., Stadler, M., Razavi, M. A., Saalmüller, A., & Gerner, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.822258 · Cited by 6

Two novel STK11 missense mutations induce phosphorylation of S6K and promote cell proliferation in Peutz‑Jeghers syndrome

Li, R., Wang, Z., Liu, S., Wu, B., Zeng, D., Zhang, Y., Gong, L., Deng, F., Zheng, H., Wang, Y., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.7436 · Cited by 6

Single-cell transcriptome analysis reveals heterogeneity and a dynamic regenerative response of quiescent radial glia in adult zebrafish brainPreprint

Kutsia, M., Takeuchi, Y., Ranawat, N., & Masai, I. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.27.501663 · Cited by 5

Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis

Wilkes, M., Shibuya, A., Liu, Y., Mark, K., Mercado, J., Saxena, M., Sathianathen, R. S., Kim, H., Glader, B., Kenny, P., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107542 · Cited by 7

Role of the p38/AKT Pathway in the Promotion of Cell Proliferation by Serum Heat Inactivation

Geng, H., Li, R., Feng, D., Zhu, Y., & Deng, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216538 · Cited by 5

Role and targeting of the AGC kinase family in pulmonary fibrosis (Review)

Mei, C., Chen, T., Huang, X., Xiong, C., Chen, S. R. W., & Li, Y. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12478 · Cited by 5

Aloe vera Gel Extract Prolongs Lifespan in Caenorhabditis elegans

Berk, Ş. (2024) · Cumhuriyet Science Journal · doi:10.17776/csj.1400264 · Cited by 5

Timing of TORC1 inhibition dictates Pol III involvement in Caenorhabditis elegans longevity

Malik, Y., Silva, I. G., Diazgranados, R. R., Selman, C., Alic, N., & Tullet, J. M. A. (2024) · Life Science Alliance · doi:10.26508/lsa.202402735 · Cited by 5

Embryonic Leucine Promotes Early Postnatal Growth via mTOR Signalling in Japanese Quails

Ndunguru, S. F., Reda, G. K., Csernus, B., Knop, R., Lugata, J. K., Szabó, C., Lendvai, Á. Z., & Czeglédi, L. (2024) · Animals · doi:10.3390/ani14172596 · Cited by 5

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat

Yu, J. P., Gu, X., Guo, Y., Gao, M., Cheng, S., Meng, M., Cui, X., Zhang, Z., Guo, W., Yan, D., et al. (2025) · EMBO Reports · doi:10.1038/s44319-024-00337-w · Cited by 7

Abiotic stress-related genes governing signal transduction cascades in wild plants with emphasis to those in Hordeum spontaneum

Abulfaraj, A. A., Qari, S. H., Abuljadayel, D. A., & Hassoubah, S. A. (2021) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/s13562-021-00660-6 · Cited by 5

Tceal7 Regulates Skeletal Muscle Development through Its Interaction with Cdk1

Xiong, Z., Wang, M., Wu, J., & Shi, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076264 · Cited by 5

Quantifying the Neural and Behavioral Correlates of Repeated Social Competition in the Fighting Fish Betta splendens

Dupeyron, S., & Wallace, K. J. (2023) · Fishes · doi:10.3390/fishes8080384 · Cited by 5

Human cytomegalovirus modulates mTORC1 to redirect mRNA translation within quiescently infected monocytes

Miller, M. J., Akter, D., Mahmud, J., & Chan, G. C. T. (2024) · Journal of Virology · doi:10.1128/jvi.01888-23 · Cited by 5

Feed restriction of lactating cows triggers acute downregulation of mammary mammalian target of rapamycin signaling and chronic reduction of mammary epithelial mass

Seymour, D. J., Kim, J. J. M., Doelman, J., & Cant, J. P. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24478 · Cited by 4

METTL3 alters capping enzyme expression and its activity on ribosomal proteins

Morales, D. D. V., Romano, G., Nigita, G., Saviana, M., Ferlita, A. L., Le, P., Brown, R., Micalo, L., Li, H. Y., Nana-Sinkam, P. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78152-5 · Cited by 5

Effects of L-amino Acids on Human Peripheral Neutrophil Granulocyte Activation

Sipka, S., Keresztes, T., Kovács, I., Sipka, S., Baráth, S., Szegedi, G., Zeher, M., & Bruckner, G. G. (2014) · The Open Nutrition Journal · doi:10.2174/1874288201408010001 · Cited by 5

A disputed evidence on obesity: comparison of the effects of Rcan2−/− and Rps6kb1−/− mutations on growth and body weight in C57BL/6J mice

Zhao, J., Li, S., Gong, Q.-Q., Ding, L.-C., Jin, Y., Zhang, J., Gao, J., & Sun, X. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1600276 · Cited by 5

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet–Induced Obese Rats

Estridge, T. B., Dey, A., Reidy, C. A., Yu, X., Zhang, Y., Hartley, M., Milligan, P. L., Jin, N., Kowala, M. C., Leohr, J. K., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240242 · Cited by 5

The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired

Chisnell, P. J., Parenteau, T. R., Tank, E. M. H., Ashrafi, K., & Kenyon, C. J. (2018) · Genetics · doi:10.1534/genetics.118.301533 · Cited by 6

Nucleocytoplasmic distribution of S6K1 depends on the density and motility of MCF-7 cells in vitro

Kosach, V., Shkarina, K., Kravchenko, A., Tereshchenko, Y., Kovalchuk, E., Skoroda, L., Krotevych, M. S., & Хоруженко, А. І. (2018) · F1000Research · doi:10.12688/f1000research.15447.1 · Cited by 5

Discovery of novel S6K1 inhibitors by an ensemble-based virtual screening method and molecular dynamics simulation

Zhang, H., Zhang, J., Zhang, J., Hu, M.-L., Ren, L., Luo, Q.-Q., & Qi, H.-Z. (2023) · Journal of Molecular Modeling · doi:10.1007/s00894-023-05504-9 · Cited by 5

Osteoclast microRNA Profiling in Rheumatoid Arthritis to Capture the Erosive Factor

Nguyen, H. D., Lortie, A., Nguimbus, L. M., Marrugo, J., Allard‐Chamard, H., Bouchard, L., Boire, G., Scott, M. S., & Roux, S. (2023) · JBMR Plus · doi:10.1002/jbm4.10776 · Cited by 6

S6 Kinase: A Compelling Prospect for Therapeutic Interventions

Majeed, S. T., Majeed, R., Shah, G., & Andrabi, K. I. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.75209 · Cited by 5

Effects of rapamycin on life span and on expression of TOR and S6K in Brachionus calyciflorus (Rotifera)

Xu, H., Liu, L., Su, Y., Liang, Y., & Yang, J. (2017) · Aquatic Biology · doi:10.3354/ab00673 · Cited by 5

Extension of Life Span in Laboratory Mice

Unnikrishnan, A., Deepa, S. S., Herd, H. R., & Richardson, A. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00019-1 · Cited by 7

mTOR suppresses macroautophagy during postnatal development of the striatumPreprint

Lieberman, O. J., Pigulevskiy, I., Post, M. R., Sulzer, D. L., & Santini, E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/536680 · Cited by 5

Diet-induced impairment of skeletal muscle and adipose tissue metabolic homeostasis and its prevention by probiotic administration

Porzio, A. D., Barrella, V., Cigliano, L., Mauriello, G., Troise, A. D., Scaloni, A., Iossa, S., & Mazzoli, A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03041-9 · Cited by 4

ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis

Zhou, R., Wu, H., You, H., Wang, X., Yuan, X., Sun, Z., Zhou, D. F., Jiang, Y., & Shen, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06500-8 · Cited by 4

Roles and potential mechanisms of hepatic stellate cells activation mediated by epigenetics through insulin like growth factor 1 and receptor: A review

Chen, S., Gao, J., Chen, J., Huang, Y., Wang, L., Lin, J., Zhao, M., Shen, Y., Zhao, G., & Cheng, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147642 · Cited by 4

Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

Li, L., Xia, X., Luo, Y., Zhu, Y., Luo, X., Yang, B., & Shang, L. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.940265 · Cited by 4

Chemical synthesis as a discovery platform in immunosuppression and determination of mode of action

Schupp, M., Saridakis, I., Kaiser, D., & Maulide, N. (2024) · Nature Synthesis · doi:10.1038/s44160-023-00423-2 · Cited by 4

Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation

Malanchuk, O., Bdzhola, A. V., Palchevskyy, S. S., Bdzhola, V. G., Chai, P., Pardo, O. E., Seckl, M. J., Banerjee, A., Peak‐Chew, S., Skehel, M. J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168747 · Cited by 4

mTOR and Regulation of Translation

Tsukumo, Y., Laplante, M., Parsyan, A. E., Ruggero, D., & Fonseca, B. D. (2014) · Springer eBooks · doi:10.1007/978-94-017-9078-9_15 · Cited by 5

Downregulation of RelA (p65) by Rapamycin Inhibits Murine Adipocyte Differentiation and Reduces Fat Mass of C57BL/6J Mice despite High Fat Diet

Ray, P. D., Maclellan, R. A., He, J., Liu, Z., & Wu, J. (2014) · ISRN Obesity · doi:10.1155/2014/540582 · Cited by 4

m-TOR Inhibitors in the Current Practice

Alalawi, F. J. A., Sharma, A., & Halawa, A. M. (2017) · Journal of Clinical & Experimental Nephrology · doi:10.21767/2472-5056.100026 · Cited by 4

Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_13 · Cited by 4

Targeting RPS6K1 for Refractory Breast Cancer Therapy

Sridhar, J., Komati, R., & Kumar, S. (2022) · Exon Publications eBooks · doi:10.36255/exon-publications-breast-cancer-rps6k1 · Cited by 6

Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice

Shi, X., Endicott, S. J., & Miller, R. A. (2022) · Aging · doi:10.18632/aging.203959 · Cited by 4

S6K1 acts through FOXO to regulate juvenile hormone biosynthesis in the red flour beetle, Tribolium castaneum

Jiang, H., Zhang, N., Ge, H., Wei, J., Xu, X., Meng, X., Qian, K., Yang, Z., & Wang, J. (2022) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2022.104405 · Cited by 4

Mealtime alcohol consumption suppresses skeletal muscle mTORC1 signaling in female mice

Bridges, B. O., Tice, A. L., Laudato, J. A., Gordon, B. S., & Steiner, J. L. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111914 · Cited by 4

TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth

Zhang, Y., Fang, X., Wang, J., & Nie, D. (2023) · Cancers · doi:10.3390/cancers15235691 · Cited by 4

Proxies introduce bias in decoding TORC1 activity

Caligaris, M., & VIRGILIO, C. D. (2024) · PubMed Central · doi:10.17912/micropub.biology.001170 · Cited by 4

Role of angiomotin family members in human diseases (Review)

Wang, H., Meng, Y., & Jin, X. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12546 · Cited by 5

mTORC1 and BMP-Smad1/5 regulation of serum-stimulated myotube hypertrophy: a role for autophagy

Zhang, Q., Halle, J. L., Counts, B. R., Pi, M., & Carson, J. A. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00237.2024 · Cited by 4

Generation of HEK-293 stable cell lines with disrupted expression of ribosomal protein S6 kinase (S6K1) isoforms using the CRISPR/Cas9 genome editing system

Zaiets, I. V., Sivchenko, A. S., Хоруженко, А. І., & Filonenko, V. V. (2017) · Biopolymers and Cell · doi:10.7124/bc.00095f · Cited by 4

Association of HSP 22 with mTOR in osteoblasts: regulation of TNF ‐α‐stimulated IL ‐6 synthesis

Sakai, G., Tokuda, H., Yamamoto, N., Matsushima‐Nishiwaki, R., Fujita, K., Kawabata, T., Kozawa, O., & Otsuka, T. (2018) · FEBS Letters · doi:10.1002/1873-3468.13028 · Cited by 4

Acute alcohol prevents the refeeding-induced decrease in autophagy but does not alter the increased protein synthetic response in heart

Mekheal, M., Steiner, J. L., & Lang, C. H. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.04.005 · Cited by 4

JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways

Li, J., & Huang, F. (2018) · médecine/sciences · doi:10.1051/medsci/201834f102 · Cited by 4

A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7

Zahoor, M. K., Poidevin, M., Lecerf, C., Garrido, D., & Montagne, J. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-018-01529-5 · Cited by 4

Production, characterization, and cross-reactivity of a polyclonal antibody against Arabidopsis TARGET OF RAPAMYCIN

Shin, G., Moon, S. Y., Jeong, S. Y., Ji, M. G., Cha, J., & Kim, W. (2019) · Applied Biological Chemistry · doi:10.1186/s13765-019-0475-8 · Cited by 4

p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells

Xiao, L., & Kan, W.-M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.004 · Cited by 4

Proteomic Profiling of Iron‐Treated Ovarian Cells Identifies AKT Activation that Modulates the CLEAR Network

Rockfield, S., Guergues, J., Rehman, N., Smith, A., Bauckman, K., Stevens, S. M., & Nanjundan, M. (2018) · PROTEOMICS · doi:10.1002/pmic.201800244 · Cited by 5

Altered mTORC1 signalling may contribute to macrophage dysregulation in hidradenitis suppurativa

Vita, V. D. (2017) · Inflammation Research · doi:10.1007/s00011-017-1115-6 · Cited by 4

Regulation of Protein Synthesis

Clark, D. P., Pazdernik, N. J., & McGehee, M. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813288-3.00018-5 · Cited by 4

On the appropriateness of antibody selection to estimate mTORC1 activity

Figueiredo, V. C., Dungan, C. M., Peterson, C. A., & McCarthy, J. J. (2019) · Acta Physiologica · doi:10.1111/apha.13354 · Cited by 4

Correction: Contribution of S6K1/MAPK Signaling Pathways in the Response to Oxidative Stress: Activation of RSK and MSK by Hydrogen Peroxide

Siebel, A. M., Cubillos‐Rojas, M., Santos, R. C. V., Schneider, T., Bonan, C. D., Bartrons, R., Ventura, F., de Oliveira, J. R., & Rosa, J. L. (2013) · PLoS ONE · doi:10.1371/annotation/0b485bd9-b1b2-4c60-ab22-3ac5d271dc59 · Cited by 4

Connecting chemical structure to single cell signaling profiles

Thirman, H. L., Hayes, M., Geben, L. C., Ihrie, R. A., Brown, L. E., Porco, J. A. J., & Irish, J. M. (2025) · Communications Biology · doi:10.1038/s42003-025-08545-3 · Cited by 3

Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster

Umekar, M. J., Qutub, M., Premchandani, T., Tatode, A., Taksansde, J., Singanwad, P., Kale, M. B., Maniyar, M. G., & Hussain, U. (2025) · Precision medication. · doi:10.1016/j.prmedi.2025.100051 · Cited by 4

Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder

Ojha, S. K., Kartawy, M., Hamoudi, W., Tripathi, M. K., Aran, A. A., & Amal, H. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03514-6 · Cited by 4

Potential inhibitors of RPS6KB2 and NRF2 in head and neck squamous cell carcinoma

Madhukar, G., & Subbarao, N. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2205946 · Cited by 3

Autosomal Dominant Polycystic Kidney Disease: From Pathogenesis to Organoid Disease Models

Scarlat, A., Tomasoni, S., & Trionfini, P. (2025) · Biomedicines · doi:10.3390/biomedicines13071766 · Cited by 3

Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone

Pascual-Carreras, E., Garschall, K., & Steinmetz, P. R. H. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003525 · Cited by 4

Running m(o)TOR with the brakes on leads to catastrophe at mitosis

Darżynkiewicz, Z. (2012) · Cell Cycle · doi:10.4161/cc.22932 · Cited by 3

S6 Kinase 2 Deficiency Improves Glucose Disposal in Mice Fed a High Fat Diet

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