AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose

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Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773

AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

Viollet, B., Guigas, B., Leclerc, J., Hébrard, S., Lantier, L., Mounier, R., Andréelli, F., & Foretz, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01970.x · Cited by 498

AMPK: guardian of metabolism and mitochondrial homeostasis

Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,198

Regulation of hepatic glucose metabolism in health and disease

Petersen, M. C., Vatner, D. F., & Shulman, G. I. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.80 · Cited by 1,159

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797

AMP-activated protein kinase: the current landscape for drug development

Steinberg, G. R., & Carling, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0019-2 · Cited by 785

AMPK—Sensing Energy while Talking to Other Signaling Pathways

Hardie, D. G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.013 · Cited by 597

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Yuan, J., Dong, X., Yap, J., & Hu, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00949-4 · Cited by 516

AMP ‐activated protein kinase: a cellular energy sensor that comes in 12 flavours

Ross, F. A., MacKintosh, C., & Hardie, D. G. (2016) · The FEBS Journal · doi:10.1111/febs.13698 · Cited by 381

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.08.019 · Cited by 385

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

Srivastava, R. A. K., Pinkosky, S. L., Filippov, S. I., Hanselman, J. C., Cramer, C. T., & Newton, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r025882 · Cited by 308

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

O'Neill, H. M. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.1 · Cited by 295

AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels

Hardie, D. G. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161148 · Cited by 281

AMPK signaling and its targeting in cancer progression and treatment

Hsu, C.-C., Peng, D., Cai, Z., & Lin, H. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.006 · Cited by 265

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

Tamargo‐Gómez, I., & Mariño, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123812 · Cited by 258

Emerging Role of cAMP/AMPK Signaling

Aslam, M., & Ladilov, Y. (2022) · Cells · doi:10.3390/cells11020308 · Cited by 241

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0774 · Cited by 195

AMP-Activated Protein Kinase

Salt, I. P., & Hardie, D. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309633 · Cited by 190

Disorders of cancer metabolism: The therapeutic potential of cannabinoids

Sun, D., Li, X., Nie, S., Liu, J., & Wang, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113993 · Cited by 195

Regulation of AMP-activated protein kinase by natural and synthetic activators

Hardie, D. G. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.06.002 · Cited by 180

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Kreuzaler, P. A., Panina, Y., Segal, J., & Yuneva, M. O. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.021 · Cited by 170

AMPK in the brain: its roles in glucose and neural metabolism

Muraleedharan, R., & Dasgupta, B. (2021) · FEBS Journal · doi:10.1111/febs.16151 · Cited by 170

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Johanns, M., Lai, Y., Hsu, M. F., Jacobs, R., Vertommen, D., Sande, J. V., Dumont, J. E., Woods, A., Carling, D., Hue, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms10856 · Cited by 146

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Vara‐Ciruelos, D., Russell, F. M., & Hardie, D. G. (2019) · Open Biology · doi:10.1098/rsob.190099 · Cited by 140

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis

Hinson, J. T., Chopra, A., Lowe, A., Sheng, C. C., Gupta, R. M., Rajarajan, K., O’Sullivan, J., Rowe, G. C., Wakimoto, H., Gorham, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.066 · Cited by 97

Interactions between adipose tissue and the immune system in health and malnutrition

Wensveen, F. M., Marinović, S., Šestan, M., Wensveen, T. T., & Polić, B. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.006 · Cited by 103

Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α

Clark, A. J., & Parikh, S. M. (2020) · Kidney International · doi:10.1016/j.kint.2020.09.037 · Cited by 96

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 98

Promise and challenges for direct small molecule AMPK activators

Olivier, S., Foretz, M., & Viollet, B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.049 · Cited by 90

miR‐212 downregulation contributes to the protective effect of exercise against non‐alcoholic fatty liver via targeting FGF ‐21

Xiao, J., Bei, Y., Liu, J., Dimitrova‐Shumkovska, J., Kuang, D., Zhou, Q., Li, J., Yang, Y., Xiang, Y., Wang, F., et al. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12733 · Cited by 75

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

Houddane, A., Bultot, L., Novellasdemunt, L., Johanns, M., Gueuning, M.-A., Vertommen, D., Coulie, P. G., Bartrons, R., Hue, L., & Rider, M. H. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.02.019 · Cited by 76

Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase

Johanns, M., Ruys, S. P. D., Houddane, A., Vertommen, D., Herinckx, G., Hue, L., Proud, C. G., & Rider, M. H. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.05.010 · Cited by 78

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Ratman, D., Mylka, V., Bougarne, N., Pawlak, M., Caron, S., Hennuyer, N., Paumelle, R., Cauwer, L. D., Thommis, J., Rider, M. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw742 · Cited by 73

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions

Ponnusamy, L., Natarajan, S. R., Thangaraj, K., & Manoharan, R. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188379 · Cited by 68

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism

Adachi, Y., Sousa‐Coelho, A. L. D., Harata, I., Aoun, C., Weimer, S., Shi, X. D., Herrera, K. N. G., Takahashi, H., Doherty, C., Noguchi, Y., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.002 · Cited by 64

Small Molecule Adenosine 5′-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

Rana, S., Blowers, E. C., & Natarajan, A. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401994c · Cited by 63

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

Russell, F. M., & Hardie, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010186 · Cited by 57

AMPK Localization: A Key to Differential Energy Regulation

Afinanisa, Q., Cho, M., & Seong, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010921 · Cited by 58

The molecular associations between the SnRK1 complex and carbon/nitrogen metabolism in plants

Han, C., Wang, H., Shi, W., & Bai, M. (2023) · New Crops · doi:10.1016/j.ncrops.2023.12.003 · Cited by 54

LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer

Bonanno, L., Zulato, E., Pavan, A., Attili, I., Pasello, G., Conte, P., & Indraccolo, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081874 · Cited by 53

Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future

Brewer, M. K., & Gentry, M. S. (2019) · Advances in neurobiology · doi:10.1007/978-3-030-27480-1_2 · Cited by 46

Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach

Giansanti, P., Stokes, M. P., Silva, J. C., Scholten, A., & Heck, A. J. R. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o113.028456 · Cited by 47

Exercise training improves liver steatosis in mice

Alex, S., Boss, A., Heerschap, A., & Kersten, S. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0026-1 · Cited by 45

Functional characterization of AMP-activated protein kinase signaling in tumorigenesis

Cheng, J., Zhang, T., Ji, H., Tao, K., Guo, J., & Wei, W. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.09.006 · Cited by 45

AMP-Activated Protein Kinase: Friend or Foe in Cancer?

Vara‐Ciruelos, D., Dandapani, M., & Hardie, D. G. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033619 · Cited by 42

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Yoon, H., Spinelli, J. B., Zaganjor, E., Wong, S. J., German, N. J., Randall, E. C., Dean, A., Clermont, A. C., Paulo, J. A., Garcia, D., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.017 · Cited by 38

AMPK inhibits liver gluconeogenesis: fact or fiction?

Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 46

Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells

Zhdanov, A. V., Dmitriev, R. I., Golubeva, A. V., Gavrilova, S. A., & Papkovsky, D. B. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.02.016 · Cited by 35

Cold stress-induced autophagy and apoptosis disorders are mainly mediated by AMPK/PPAR/PI3K/AKT/mTOR pathways

Wang, D., Tian, Y., Wang, Q., Zhang, Y., Ye, B., Zuo, Z., He, J., Pan, Z., Sun, D., Zou, J., et al. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.740574 · Cited by 36

Metabolomic Analysis of Carbohydrate and Amino Acid Changes Induced by Hypoxia in Naked Mole-Rat Brain and Liver

Cheng, H., Qin, Y., Dhillon, R. S., Dowell, J., Denu, J. M., & Pamenter, M. E. (2022) · Metabolites · doi:10.3390/metabo12010056 · Cited by 33

AMPK in myocardial infarction and diabetes: the yin/yang effect

Moussa, A., & Li, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.001 · Cited by 31

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Saavedra-García, P., Nichols, K., Mahmud, Z., Fan, L. Y.-N., & Lam, E. W. ‐. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.012 · Cited by 32

Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase

Kakhlon, O., Glickstein, H., Feinstein, N., Liu, Y., Baba, O., Terashima, T., Akman, H. O., DiMauro, S., & Lossos, A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12277 · Cited by 31

AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy

Konhilas, Y. L. J. P. (2015) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000154 · Cited by 28

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

Ducommun, S., Deák, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, T. E., Viollet, B., Foretz, M., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.02.001 · Cited by 30

Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases

Shukal, D. K., Malaviya, P. B., & Sharma, T. (2022) · Human & Experimental Toxicology · doi:10.1177/09603271211063165 · Cited by 28

From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies

Rey, V., & Tamargo‐Gómez, I. (2023) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases1030012 · Cited by 29

Early Treatment with Metformin Improves Neurological Outcomes in Lafora Disease

Burgos, D. F., Machío-Castello, M., Iglesias‐Cabeza, N., Giráldez, B. G., González‐Fernández, J., Sánchez‐Martín, G., Sánchez, M. P., & Serratosa, J. M. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01304-w · Cited by 26

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

Hasenour, C. M., Ridley, D. E., James, F. D., Hughey, C. C., Donahue, E. P., Viollet, B., Foretz, M., Young, J. D., & Wasserman, D. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170382 · Cited by 26

Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate

Lin, L., Zeng, L., Liu, A., Yuan, D., Peng, Y., Zhang, S., Li, Y., Chen, J., Xiao, W., & Gong, Z. (2021) · Nutrients · doi:10.3390/nu13114120 · Cited by 26

AMP‐activated protein kinase couples 3‐bromopyruvate‐induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl‐2 proteins

Bodur, Ç., Karakaş, B., Timuçin, A. C., Tezil, T., & Başağa, H. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22411 · Cited by 24

Examination of role of the AMP-activated protein kinase (Ampk) signaling pathway during low salinity adaptation in the mud crab, Scylla paramamosain, with reference to glucolipid metabolism

Jin, M., Luo, J., Zhu, T., Fang, F., Xie, S., Lu, J., Betancor, M. B., Tocher, D. R., & Zhou, Q. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741329 · Cited by 23

Insights into Transcriptional Regulation of Hepatic Glucose Production

Anyamaneeratch, K., Rojvirat, P., Sukjoi, W., & Jitrapakdee, S. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.05.004 · Cited by 25

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer

Hasani, S., Young, L. E. A., Nort, W. V., Banerjee, M., Rivas, D. R., Kim, J., Xiong, X., Sun, R. C., Gentry, M. S., Sesaki, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06202-3 · Cited by 19

AMP-Activated Protein Kinase

Hardie, D. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00073-5 · Cited by 19

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

Hasenour, C. M., Wall, M. L., Ridley, D. E., James, F. D., Hughey, C. C., Donahue, E. P., Viollet, B., Foretz, M., Young, J. D., & Wasserman, D. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183601 · Cited by 18

Multifaceted role of AMPK in autophagy: more than a simple trigger?

Mandić, M., Misirkic-Marjanovic, M., Janjetović, K., Bošnjak, M., Harhaji-Trajkovic, L. M., Trajković, V., & Vucicevic, L. M. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.01058.2024 · Cited by 26

Glycogenesis and glyconeogenesis from glutamine, lactate and glycerol support human macrophage functions

Jeroundi, N., Roy, C., Basset, L., Pignon, P., Preisser, L., Blanchard, S., Bocca, C., Abadie, C., Lalande-Martin, J., Guéguen, N., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00278-4 · Cited by 18

Conserved versatile master regulators in signalling pathways in response to stress in plants

Balderas‐Hernández, V. E., Alvarado-Rodríguez, M., & Fraire-Velázquez, S. (2013) · AoB Plants · doi:10.1093/aobpla/plt033 · Cited by 19

Adiponectin regulates glycogen metabolism at the human fetal–maternal interface

Duval, F., Santos, E. D., Maury, B., Serazin-Leroy, V., Fathallah, K., Vialard, F., & Dieudonné, M. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0013 · Cited by 18

Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress

Pham, T. N. M., Perumal, N., Manicam, C., Başoğlu, M., Eimer, S., Fuhrmann, D. C., Pietrzik, C. U., Clement, A. M., Körschgen, H., Schepers, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102943 · Cited by 16

Protein restriction reprograms the multi-organ proteomic landscape of mouse aging

Lu, T., Xie, Y., Wang, Y., Lin, X., Cai, X., Zhang, Y., Nie, Z., Su, C., Gou, W., Zhang, H., et al. (2025) · Cell · doi:10.1016/j.cell.2025.10.004 · Cited by 19

Impact of Metabolic disrupting chemicals on redox homeostasis, energy sensors, receptor modulation, and hormone metabolism: A comparative account in Teleost and mammalian model organisms

Mukherjee, U., & Maitra, S. (2023) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2023.05.004 · Cited by 15

AMPK activity is required for the induction of anhydrobiosis in a tardigrade Hypsibius exemplaris, and its potential up‐regulator is PP2A

Kondo, K., Mori, M., Tomita, M., & Arakawa, K. (2019) · Genes to Cells · doi:10.1111/gtc.12726 · Cited by 16

Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner

Trefts, E., Hughey, C. C., Lantier, L., Lark, D. S., Boyd, K. L., Pozzi, A., Zent, R., & Wasserman, D. H. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00496.2018 · Cited by 14

Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in mice

Müller, M., Schubert, T., Welke, C., Maske, T., Patschkowski, T., Donhauser, E., Heinen‐Weiler, J., Hormann, F.-L., Heiles, S., Schulz, T. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59192-5 · Cited by 14

AMPK is involved in the differential neonatal performance of chicks hatching at different time

Wang, Y., Buyse, J. G., Song, Z., Decuypere, E. M. P., & Everaert, N. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.02.008 · Cited by 13

Effects of Whey Proteins on Glucose Metabolism in Normal Wistar Rats and Zucker Diabetic Fatty (ZDF) Rats

Gregersen, S., Bystrup, S., Overgaard, A., Jeppesen, P. B., Thorup, A. C. S., Jensen, E., & Hermansen, K. (2013) · The Review of Diabetic Studies · doi:10.1900/rds.2013.10.252 · Cited by 13

New Insight into Metformin Mechanism of Action and Clinical Application

Yan, Y., Kover, K. L., & Moore, W. V. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91148 · Cited by 13

Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling

Saks, V. A., Schlattner, U., Tokarska-Schlattner, M., Wallimann, T., Bagur, R., Zorman, S., Pelosse, M., Santos, P. D. D., Boucher, F. R., Käämbre, T., et al. (2013) · Springer series in biophysics · doi:10.1007/978-3-642-38505-6_11 · Cited by 13

Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

Hunter, R. W., Zeqiraj, E., Morrice, N. A., Sicheri, F., & Sakamoto, K. (2014) · Protein Expression and Purification · doi:10.1016/j.pep.2014.12.007 · Cited by 12

Regulation of glycogen synthase in muscle and its role in Type 2 diabetes

Kleinert, M., Sylow, L., & Richter, E. A. (2012) · Diabetes Management · doi:10.2217/dmt.12.54 · Cited by 11

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Johanns, M., Corbet, C., Jacobs, R., Drappier, M., Bommer, G. T., Herinckx, G., Vertommen, D., Tajeddine, N., Young, D., Messens, J., et al. (2022) · Biochemical Journal · doi:10.1042/bcj20220170 · Cited by 9

Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane

Bizerra, P. F. V., Gilglioni, E. H., Li, H. L., Go, S., Elferink, R. P. J. O., Verhoeven, A. J., & Chang, J. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119585 · Cited by 9

Kinase Inhibitors Involved in the Regulation of Autophagy: Molecular Concepts and Clinical Implications

Al‐Huseini, I., Sirasanagandla, S. R., Babu, K. S., Sofin, R. G. S., & Das, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220117114306 · Cited by 8

Cell-specific regulation of iNOS by AMP-activated protein kinase in primary rat hepatocytes

Zhang, B., Lakshmanan, J., Du, Y., Smith, J. W., & Harbrecht, B. G. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.08.028 · Cited by 9

M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress

Elbæk, C. R., Gradinaru, S., Dahlström, A. M., Frueh, A., Jahan, A. S., Cuenco, J., Aalto, A. L., Rizk, J., Hawley, S. A., Franks, S. N. J., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01675-z · Cited by 8

AMPK Promotes Larval Metamorphosis of Mytilus coruscus

Zhang, W., Wang, Y., Hu, X., Zhou, Z., Zhu, Y.-T., Xiao, L., & Yang, J.-L. (2022) · Genes · doi:10.3390/genes13122384 · Cited by 6

Autophagy as a therapeutic linchpin in metabolic diseases and obesity-associated diabetes

Vakili, O., Klionsky, D. J., Reiter, R. J., Ren, J., Deshpande, A., Ahn, K. S., Cho, W., Hushmandi, K., & Kumar, A. P. (2026) · Autophagy · doi:10.1080/15548627.2026.2636096 · Cited by 7

AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart

Pelosse, M., Tokarska-Schlattner, M., & Schlattner, U. (2015) · Springer eBooks · doi:10.1007/978-3-319-15263-9_10 · Cited by 4

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model

Theodoulou, A., Speckmann, T., Potamiti, L., Baba, O., Morita, T., Drousiotou, A., Panayiotidis, M. I., Schürmann, A., & Petrou, P. (2025) · FEBS Journal · doi:10.1111/febs.70040 · Cited by 4

Metabolism-associated protein network constructing and host-directed anti-influenza drug repurposing

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miR-141/200c contributes to ethanol-mediated hepatic glycogen metabolism

Tran, M., Gilling, S., Wu, J., Wang, L., & Shin, D. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101942 · Cited by 3

AMPK signaling in cancer: dual roles, molecular mechanisms, and therapeutic potential

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Exploration of glycogen deposition disorders in low-body-weight fetuses in a pig model

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How mass spectrometry can be exploited to study AMPK

Rider, M. H., Vertommen, D., & Johanns, M. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240009 · Cited by 2

LKB1/AMPK pathway in the control of hepatic energy metabolism

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Laforin: Function and Action of a Glucan Phosphatase

Sherwood, A., Dukhande, V. V., & Gentry, M. S. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_603 · Cited by 1

Integrin Linked Kinase is Critical for Hepatic Cellular Organization, Metabolism, and Glucoregulation

Trefts, E. (2019) · Cited by 1

Metabolic and cellular effects of calorie restriction and whey proteins in experimental obesity

Kurki, E. (2013) · Työväentutkimus Vuosikirja

AMPK phosphorylates and inactivates liver glycogen synthase but does not phosphorylate myosin regulatory light chains

Bultot, L. (2012) · Digital Access to Libraries

The 2–5AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

Richter, E. A., & Wojtaszewski, J. F. P. (2016)

Phosphorylation and inactivation of rat liver glycogen synthase by cAMP-dependent protein kinase and cAMP-independent synthase (casein) kinase-1.

Huang, K., Akatsuka, A., Singh, T. J., & Blake, K. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32337-8 · Cited by 41

The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

Jørgensen, S. B., Nielsen, J. N., Birk, J. B., Olsen, G. S., Viollet, B., Andreelli, F., Schjerling, P., Vaulont, S., Hardie, D. G., Hansen, B. F., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3074 · Cited by 241

Inactivation of glycogen synthase by the catalytic subunit of cyclic AMP-dependent protein kinase. Kinetics of inactivated forms

Brown, D. F., Reimann, E. M., & Schlender, K. K. (1980) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(80)90118-7 · Cited by 13