Cited by 226Cellular transport and secretionProtein Kinase Regulation and GTPase SignalingCalcium signaling and nucleotide metabolism

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TBC proteins: GAPs for mammalian small GTPase Rab?

Fukuda, Mitsunori·2011·Bioscience Reports

DOI 10.1042/bsr20100112

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Abstract

The TBC (Tre-2/Bub2/Cdc16) domain was originally identified as a conserved domain among the tre-2 oncogene product and the yeast cell cycle regulators Bub2 and Cdc16, and it is now widely recognized as a conserved protein motif that consists of approx. 200 amino acids in all eukaryotes. Since the TBC domain of yeast Gyps [GAP (GTPase-activating protein) for Ypt proteins] has been shown to function as a GAP domain for small GTPase Ypt/Rab, TBC domain-containing proteins (TBC proteins) in other species are also expected to function as a certain Rab-GAP. More than 40 different TBC proteins are present in humans and mice, and recent accumulating evidence has indicated that certain mammalian TBC proteins actually function as a specific Rab-GAP. Some mammalian TBC proteins {e.g. TBC1D1 [TBC (Tre-2/Bub2/Cdc16) domain family, member 1] and TBC1D4/AS160 (Akt substrate of 160 kDa)} play an important role in homoeostasis in mammals, and defects in them are directly associated with mouse and human diseases (e.g. leanness in mice and insulin resistance in humans). The present study reviews the structure and function of mammalian TBC proteins, especially in relation to Rab small GTPases.

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Authors: Fukuda, M.
Affiliations: Tohoku University (JP)
Corresponding author: Fukuda, Mitsunori
ORCID: Fukuda, Mitsunori
Venue: Bioscience Reports
Publisher: Portland Press Ltd.
Published: 2011-01-14
Volume: 31
Issue: 3
Pages: 159-168
ISSN: 0144-8463 (ISSN-L)
1573-4935
DOI: 10.1042/bsr20100112
OpenAlex: W2070101581
Cited by: 207
References: 70
Citations by year: 2026: 8 · 2025: 6 · 2024: 16 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 22 · 2019: 11 · 2018: 12 · 2017: 17 · 2016: 19 · 2015: 9 · 2014: 14 · 2013: 13 · 2012: 18
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Locations: Bioscience Reports (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: TBC domain, Rab GTPases, GTPase-activating protein, TBC1D1, small GTPases, Bub2, CDC16, insulin resistance, leanness, protein structure-function relationship
MeSH terms: Animals, Humans, Protein Structure, Tertiary, Monomeric GTP-Binding Proteins, rab GTP-Binding Proteins

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TBC proteins: GAPs for mammalian small GTPase Rab?

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