Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion
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Several studies have reported a strong association between high plasma level of trimethylamine N-oxide (TMAO) and atherosclerosis development. However, the exact mechanism underlying this correlation is unknown. In the present study, we try to explore the impact of TMAO on endothelial dysfunction. After TMAO treatment, human umbilical vein endothelial cells (HUVECs) showed significant impairment in cellular proliferation and HUVECs-extracellular matrix (ECM) adhesion compared with control. Likewise, TMAO markedly suppressed HUVECs migration in transwell migration assay and wound healing assay. In addition, we found TMAO up-regulated vascular cell adhesion molecule-1 (VCAM-1) expression, promoted monocyte adherence, activated protein kinase C (PKC) and p-NF-κB. Interestingly, TMAO-stimulated VCAM-1 expression and monocyte adherence were diminished by PKC inhibitor. These results demonstrate that TMAO promotes early pathological process of atherosclerosis by accelerating endothelial dysfunction, including decreasing endothelial self-repair and increasing monocyte adhesion. Furthermore, TMAO-induced monocyte adhesion is partly attributable to activation of PKC/NF-κB/VCAM-1.
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TMAO treatment enhances monocyte adhesion through the PKC/NF-κB pathway, increasing expression of VCAM-1 in human monocytic THP-1 cells and human umbilical vein endothelial cells.
“some studies performed on human monocytic THP-1 cells and human umbilical vein endothelial cells (HUVEC) showed that TMAO treatment enhanced monocyte adhesion through the PKC/NF-κB pathway, thus increasing the expression of VCAM-1 [58].”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [58]
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Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Bonetti, P. O., Lerman, L. O., & Lerman, A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051384.43104.fc · Cited by 2,199 · see citing works
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works
Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
Geraldes, P., & King, G. L. (2010) · Circulation Research · doi:10.1161/circresaha.110.217117 · Cited by 993 · see citing works
Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works
Vascular Adhesion Molecules in Atherosclerosis
Galkina, E., & Ley, K. F. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149179 · Cited by 804 · see citing works
Tang, W. H. W., Wang, Z., Fan, Y., Levison, B., Hazen, J. E., Donahue, L. M., Wu, Y., & Hazen, S. L. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.617 · Cited by 681 · see citing works
The contributory role of gut microbiota in cardiovascular disease
Tang, W. H. W., & Hazen, S. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72331 · Cited by 641 · see citing works
Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., & Hazen, S. L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu002 · Cited by 559 · see citing works
Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., & Wang, Y. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.03.001 · Cited by 360 · see citing works
Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches
Park, K., & Park, W. J. (2015) · Journal of Korean Medical Science · doi:10.3346/jkms.2015.30.9.1213 · Cited by 327 · see citing works
Tang, W. H. W., Wang, Z., Shrestha, K., Borowski, A. G., Wu, Y., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.11.006 · Cited by 325 · see citing works
Pathophysiology of Acute Coronary Syndrome
Santos‐Gallego, C. G., Picatoste, B., & Badimón, J. J. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0401-9 · Cited by 254 · see citing works
PKCζ Regulates TNF-α–Induced Activation of NADPH Oxidase in Endothelial Cells
Frey, R. S., Rahman, A., Kefer, J., Minshall, R. D., & Malik, A. B. (2002) · Circulation Research · doi:10.1161/01.res.0000017631.28815.8e · Cited by 225 · see citing works
Min, J., Kim, Y., Kim, S. W., Kwon, M.-C., Kong, Y., Hwang, I. K., Won, M. H., Rho, J., & Kwon, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.531 · Cited by 211 · see citing works
Ufnal, M., Jazwiec, R., Dadlez, M., Drapala, A., Sikora, M., & Skrzypecki, J. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.09.010 · Cited by 205 · see citing works
Lim, S., Longley, R. L., Couchman, J., & Woods, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208300200 · Cited by 121 · see citing works
Booth, G., Stalker, T. J., Lefer, A. M., & Scalia, R. G. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1556 · Cited by 102 · see citing works
Majdalawieh, A. F., & Ro, J. (2010) · Mediators of Inflammation · doi:10.1155/2010/823821 · Cited by 101 · see citing works
Kawakami, A., Aikawa, M., Nitta, N., Yoshida, M., Libby, P., & Sacks, F. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249620.68705.0d · Cited by 99 · see citing works
Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis
Zhao, Y., Howatt, D. A., Gizard, F., Nomiyama, T., Findeisen, H. M., Heywood, E. B., Jones, K. L., Conneely, O. M., Daugherty, A., & Bruemmer, D. (2010) · Circulation Research · doi:10.1161/circresaha.110.222083 · Cited by 89 · see citing works
Devlin, G. L., Parfrey, H., Tew, D. J., Lomas, D. A., & Bottomley, S. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4407 · Cited by 88 · see citing works
Worldwide disparities in cardiovascular disease: Challenges and solutions
Okwuosa, I. S., Lewsey, S. C., Adesiyun, T. A., Blumenthal, R. S., & Yancy, C. W. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.172 · Cited by 83 · see citing works
Metaorganismal nutrient metabolism as a basis of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000036 · Cited by 80 · see citing works
Gamble, J. R., & Vadas, M. A. (1988) · Journal of Immunological Methods · doi:10.1016/0022-1759(88)90240-2 · Cited by 78 · see citing works
Durpès, M.-C., Morin, C., Paquin-Veillette, J., Beland, R., Paré, M., Guimond, M., Rekhter, M. D., King, G. L., & Geraldes, P. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv107 · Cited by 75 · see citing works
Wei, C., Zhu, P., Shah, S. J., & Blair, I. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.057489 · Cited by 70 · see citing works
Pan, B., Ren, H., Lv, X., Zhao, Y., Yu, B., He, Y., Ma, Y., Niu, C., Kong, J., Yu, F., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-65 · Cited by 64 · see citing works
Self-citationTreating Coronary Disease and the Impact of Endothelial Dysfunction
Matsuzawa, Y., Guddeti, R. R., Kwon, T., Lerman, L. O., & Lerman, A. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.10.004 · Cited by 59 · see citing works
Song, J., & Chuang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107242200 · Cited by 49 · see citing works
Pan, B., Ma, Y., Ren, H., He, Y., Wang, Y., Lv, X., Liu, D., Liang, J., Yu, B., Wang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048530 · Cited by 49 · see citing works
Self-citationDisturbed Flow-Enhanced Endothelial Turnover in Atherosclerosis
Xu, Q. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2009.12.002 · Cited by 40 · see citing works
Ma, L., Guo, X., & Chen, W. (2015) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Dong, S., Kong, J., Kong, J., Shen, Q., Kong, F., Sun, W., & Zheng, L. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666150209110832 · Cited by 27 · see citing works
Self-citationBodiga, V. L., Kudle, M. R., & Bodiga, S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.101 · Cited by 25 · see citing works
Takahashi, K., Shimokado, K., & Yoshida, M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.028 · Cited by 19 · see citing works
Shi, R., Ré, D., Dudl, E. P., Cuddy, M., Okolotowicz, K. J., Dahl, R. S., Su, Y., Hurder, A., Kitada, S., Peddibhotla, S., et al. (2010) · ACS Chemical Biology · doi:10.1021/cb9003089 · Cited by 15 · see citing works
Jiang, R., Teng, Y., Huang, Y., Gu, J., & Li, M. (2009) · Gynecologic and Obstetric Investigation · doi:10.1159/000261788 · Cited by 11 · see citing works
Mechanism of PKC activity affecting the adhesion reaction of endothelial cells with monocytes
Li, L., Xu, S., Yan, J., Li, Y., Wang, X., Du, R., Zhu, J., Fu, X., Xiao, X., & Wang, Z. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.12.136 · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 46 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789 · see citing works
The Gut Microbiota and Inflammation: An Overview
Bander, Z. A., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207618 · Cited by 783 · see citing works
Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
Liu, J., Tan, Y., Cheng, H., Zhang, D., Feng, W., & Peng, C. (2022) · Aging and disease · doi:10.14336/ad.2022.0104 · Cited by 529 · see citing works
Gut microbiota and cardiovascular disease: opportunities and challenges
Kazemian, N., Mahmoudi, M., Halperin, F. A., Wu, J. C., & Pakpour, S. (2020) · Microbiome · doi:10.1186/s40168-020-00821-0 · Cited by 392 · see citing works
Lim, Y. J., Sidor, N. A., Tonial, N. C., Che, A., & Urquhart, B. L. (2021) · Toxins · doi:10.3390/toxins13020142 · Cited by 381 · see citing works
Yang, S., Li, X., Yang, F., Zhao, R., Pan, X., Liang, J., Tian, L., Li, X., Liu, L., Xing, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01360 · Cited by 347 · see citing works
TMAO: how gut microbiota contributes to heart failure
Zhang, Y., Wang, Y., Ke, B., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.007 · Cited by 306 · see citing works
Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway
Geng, J., Yang, C., Wang, B., Zhang, X., Hu, T., Gu, Y., & Li, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.016 · Cited by 297 · see citing works
Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.007 · Cited by 285 · see citing works
Self-citationvan den Munckhof, I., Kurilshikov, A., ter Horst, R., Riksen, N. P., Joosten, L. A. B., Zhernakova, A., Fu, J., Keating, S. T., Netea, M. G., Graaf, J. D., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12750 · Cited by 275 · see citing works
The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
Zhen, J., Zhou, Z., He, M., Han, H.-X., Lv, E., Wen, P., Liu, X., Wang, Y., Cai, X., Tian, J., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1085041 · Cited by 240 · see citing works
Liu, Y., & Dai, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/4634172 · Cited by 231 · see citing works
Duttaroy, A. K. (2021) · Nutrients · doi:10.3390/nu13010144 · Cited by 232 · see citing works
The Role of Gut Microbiota in Atherosclerosis and Hypertension
Ma, J., & Li, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01082 · Cited by 226 · see citing works
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
Canyelles, M., Borràs, C., Rotllán, N., Tondo, M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031940 · Cited by 211 · see citing works
Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide
Zhu, Y., Li, Q., & Jiang, H. (2020) · Apmis · doi:10.1111/apm.13038 · Cited by 204 · see citing works
Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020) · Nutrients · doi:10.3390/nu12082340 · Cited by 200 · see citing works
Al-Obaide, M. A. I., Singh, R., Datta, P., Rewers-Felkins, K., Salguero, M. V., Al‐Obaidi, I., Kottapalli, K. R., & Vasylyeva, T. L. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6090086 · Cited by 200 · see citing works
Lyu, M., Wang, Y., Fan, G., Wang, X., Xu, S.-Y., & Zhu, Y. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02146 · Cited by 193 · see citing works
Host-microbiome interactions: Gut-Liver axis and its connection with other organs
Anand, S., & Mande, S. S. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00352-6 · Cited by 196 · see citing works
The gut microbiota and its interactions with cardiovascular disease
Xu, H., Wang, X., Feng, W., Liu, Q., Zhou, S., Liu, Q., & Cai, L. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13524 · Cited by 192 · see citing works
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 185 · see citing works
Trimethylamine N‐oxide: breathe new life
Subramaniam, S., & Fletcher, C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13959 · Cited by 171 · see citing works
Interaction between gut microbiome and cardiovascular disease
Peng, J., Xiao, X., Hu, M., & Zhang, X. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.063 · Cited by 175 · see citing works
Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome
Li, X., Geng, J., Zhao, J., Ni, Q., Zhao, C., Zheng, Y., Chen, X., & Wang, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00866 · Cited by 161 · see citing works
The gut microbiome and cardiovascular disease: current knowledge and clinical potential
Ahmad, A. F., Dwivedi, G., O’Gara, F., Caparros-Martin, J. A., & Ward, N. C. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2019 · Cited by 153 · see citing works
Chou, R., Chen, C., Chen, I., Huang, H.-L., Lu, Y., Kuo, C., Chang, C., Huang, P., Chen, J., & Lin, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40638-y · Cited by 135 · see citing works
The role of the gut microbiota in health and cardiovascular diseases
Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 124 · see citing works
Extracellular Vesicles: Mechanisms in Human Health and Disease
Malloci, M., Perdomo, L., Veerasamy, M., Andriantsitohaina, R., Simard, G., & Martínez, M. C. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7265 · Cited by 122 · see citing works
Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Jia, Q., Li, H., Zhou, H., Zhang, X., Zhang, A., Xie, Y., Li, Y., Lv, S., & Zhang, J. (2019) · Cardiovascular Therapeutics · doi:10.1155/2019/5164298 · Cited by 118 · see citing works
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
Chakaroun, R., Olsson, L. M., & Bäckhed, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00771-0 · Cited by 122 · see citing works
Inflammation in Coronary Microvascular Dysfunction
Sagris, M., Theofilis, P., Antonopoulos, A. S., Oikonomou, E., Paschaliori, C., Galiatsatos, N., Tsioufis, K., & Tousoulis, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413471 · Cited by 115 · see citing works
Witkowski, M., Witkowski, M., Friebel, J., Buffa, J. A., Li, X. S., Wang, Z., Sangwan, N., Li, L., DiDonato, J. A., Tizian, C., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab263 · Cited by 116 · see citing works
Savi, M., Bocchi, L., Bresciani, L., Falco, A., Quaini, F., Mena, P. R., Brighenti, F., Crozier, A., Stilli, D., & Rio, D. D. (2018) · Molecules · doi:10.3390/molecules23030549 · Cited by 111 · see citing works
Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice
Shi, Y., Hu, J., Geng, J., Hu, T., Wang, B., Yan, W., Jiang, Y., Li, J., & Liu, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.148 · Cited by 111 · see citing works
Simó, C., & García‐Cañas, V. (2020) · Food & Function · doi:10.1039/d0fo01237h · Cited by 110 · see citing works
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 111 · see citing works
High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction
Singh, G. B., Zhang, Y., Boini, K. M., & Koka, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143570 · Cited by 102 · see citing works
The Role of the Oral Microbiome in the Development of Diseases
Kozak, M., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065231 · Cited by 99 · see citing works
Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease
Glorieux, G., Gryp, T., & Perna, A. F. (2020) · Toxins · doi:10.3390/toxins12040245 · Cited by 95 · see citing works
Shanmugham, M., Bellanger, S., & Leo, C. H. (2023) · Pharmaceuticals · doi:10.3390/ph16040504 · Cited by 96 · see citing works
Yao, M., Liao, P., Zhao, X., & Wang, L. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-01310-5 · Cited by 89 · see citing works
Gut Microbiota and Atherosclerosis
Li, D. Y., & Tang, W. H. W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0675-9 · Cited by 88 · see citing works
The gut microbiome and thromboembolism
Hasan, R. A., Koh, A. Y., & Zia, A. N. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.03.003 · Cited by 84 · see citing works
Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease
Kondapalli, N. B., Katari, V., Dalal, K. K., Paruchuri, S. M., & Thodeti, C. K. (2025) · Comprehensive physiology · doi:10.1002/cph4.70024 · Cited by 93 · see citing works
Circulating Metabolites Originating from Gut Microbiota Control Endothelial Cell Function
Amedei, A., & Morbidelli, L. (2019) · Molecules · doi:10.3390/molecules24213992 · Cited by 82 · see citing works
Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
Caradonna, E., Abate, F., Schiano, E., Paparella, F., Ferrara, F., Vanoli, E., Difruscolo, R., Goffredo, V. M., Amato, B., Setacci, C., et al. (2025) · Metabolites · doi:10.3390/metabo15040220 · Cited by 88 · see citing works
Oktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 87 · see citing works
Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease
Samarraie, A. A., Pichette, M., & Rousseau, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065420 · Cited by 76 · see citing works
Chan, M. M.-Y., Yang, X., Wang, H., Saaoud, F., Sun, Y., & Fong, D. (2019) · Nutrients · doi:10.3390/nu11081821 · Cited by 68 · see citing works
Roles of Gut Microbial Metabolites in Diabetic Kidney Disease
Fang, Q., Liu, N., Zheng, B., Guo, F., Zeng, X., Huang, X., & Ouyang, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636175 · Cited by 69 · see citing works
Ilyas, A., Wijayasinghe, Y. S., Khan, I., Samaloty, N. M. E., Adnan, M., Dar, T. A., Poddar, N. K., Singh, L. R., Sharma, H., & Khan, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.964624 · Cited by 71 · see citing works
Chen, P., Li, S., Koh, Y., Wu, J.-C., Yang, M., Ho, C., & Pan, M. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03092 · Cited by 69 · see citing works
Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
Querio, G., Antoniotti, S., Geddo, F., Levi, R. C., & Gallo, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065806 · Cited by 70 · see citing works
Chamieh, C. E., Liabeuf, S., & Massy, Z. A. (2022) · Toxins · doi:10.3390/toxins14040280 · Cited by 69 · see citing works
Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis
Jing, L., Zhang, H., Xiang, Q., Shen, L., Guo, X., Zhai, C., & Hu, H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.864600 · Cited by 66 · see citing works
From obesity through gut microbiota to cardiovascular diseases: a dangerous journey
Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64 · see citing works
The role of trimethylamine‐N‐Oxide in the development of Alzheimer's disease
Buawangpong, N., Pinyopornpanish, K., Siri‐Angkul, N., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30646 · Cited by 58 · see citing works
Tacconi, E., Palma, G., Biase, D. D., Luciano, A., Barbieri, M., de Nigris, F., & Bruzzese, F. (2023) · Nutrients · doi:10.3390/nu15030563 · Cited by 62 · see citing works
Gut microbiota metabolites as integral mediators in cardiovascular diseases (Review)
Zhu, Y., Shui, X., Liang, Z., Huang, Z., Qi, Y., He, Y., Chen, C., Luo, H., & Lei, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4674 · Cited by 60 · see citing works
TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies
Zhang, W., Wang, Y., Zhang, A., Ding, Y., Zhang, X., Jia, Q.-J., Zhu, Y., Li, Y., Lv, S., & Zhang, J. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-021-10115-x · Cited by 59 · see citing works
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works
Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity
Bu, J., & Wang, Z. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/6458094 · Cited by 59 · see citing works
Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
Puccetti, M., Xiroudaki, S., Ricci, M., & Giovagnoli, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070624 · Cited by 70 · see citing works
DiNicolantonio, J. J., McCarty, M. F., & O’Keefe, J. H. (2019) · Open Heart · doi:10.1136/openhrt-2018-000890 · Cited by 56 · see citing works
Yamagata, K., Hashiguchi, K., Yamamoto, H., & Tagami, M. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000747 · Cited by 57 · see citing works
Samulak, J. J., Sawicka, A. K., Hartmane, D., Grı̄nberga, S., Pugovičs, O., Łysiak−Szydłowska, W., & Olek, R. A. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000495037 · Cited by 54 · see citing works
Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats
Li, H., Qi, T., Huang, Z., Ying, Y., Zhang, Y., Wang, B., Ye, L., Zhang, B., Chen, D., & Chen, J. (2017) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-017-1767-z · Cited by 52 · see citing works
Li, Y., Lü, H., Guo, J., Zhang, M., Zheng, H., Liu, Y., & Liu, W. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2215542 · Cited by 53 · see citing works
Microbiota of the gastrointestinal tract: Friend or foe?
Senchukova, M. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.19 · Cited by 55 · see citing works
Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease
Wang, Y., Bai, M., Peng, Q., Li, L., Tian, F., Guo, Y., & Jing, C. (2024) · European journal of medical research · doi:10.1186/s40001-024-02224-5 · Cited by 49 · see citing works
Farhangi, M. A., & Vajdi, M. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa111 · Cited by 46 · see citing works
Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
Li, X., Fan, Z., Cui, J., Li, D., Lu, J., Cui, X., Xie, L., Wu, Y., Lin, Q., & Li, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.817396 · Cited by 47 · see citing works
Lim, T., Ryu, J., Lee, K., Park, S. Y., & Hwang, K. T. (2020) · Nutrients · doi:10.3390/nu12082448 · Cited by 46 · see citing works
Therapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota
Zhao, X., Oduro, P. K., Tong, W., Wang, Y., Gao, X., & Wang, Q. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105362 · Cited by 47 · see citing works
PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells
Liu, H., Jia, K., Ren, Z., Sun, J. T., & Pan, L. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04719-7 · Cited by 48 · see citing works
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases
He, S., Jiang, H., Zhuo, C., & Jiang, W. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09656-z · Cited by 45 · see citing works
Cimmino, G., Muscoli, S., Rosa, S. D., Cesaro, A., Perrone, M. A., Selvaggio, S., Selvaggio, G., Aimo, A., Pedrinelli, R., Mercuro, G., et al. (2023) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001450 · Cited by 45 · see citing works
Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide
Miyake, T., Mizuno, T., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Ieiri, I., Maeda, K., & Kusuhara, H. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.04.067 · Cited by 44 · see citing works
Liu, S., He, F., Zheng, T., Wan, S., Chen, J., Yang, F., Xu, X., & Pei, X. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100014 · Cited by 45 · see citing works
Gut Microbiota: Critical Controller and Intervention Target in Brain Aging and Cognitive Impairment
Li, H., Ni, J., & Qing, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.671142 · Cited by 43 · see citing works
Pathogenic Mechanisms of Trimethylamine N-Oxide-induced Atherosclerosis and Cardiomyopathy
Zheng, Y., & He, J. (2021) · Current Vascular Pharmacology · doi:10.2174/1570161119666210812152802 · Cited by 44 · see citing works
Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation
Iglesias‐Carres, L., Hughes, M. D., Steele, C. N., Ponder, M. A., Davy, K. P., & Neilson, A. P. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108600 · Cited by 42 · see citing works
Ji, C., Yin, L., Mo, Y., Lu, Z., Lu, F., Lin, Q., Liu, X., Zou, C., & Wu, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780924 · Cited by 41 · see citing works
Querio, G., Antoniotti, S., Geddo, F., Levi, R. C., & Gallo, M. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073982 · Cited by 42 · see citing works
Wu, Y., Rong, X., Pan, M., Wang, T., Yang, H., Chen, X., Xiao, Z., & Zhao, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.840171 · Cited by 42 · see citing works
Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
Belli, M., Barone, L., Longo, S., Prandi, F. R., Lecis, D., Mollace, R., Margonato, D., Muscoli, S., Sergi, D., Federici, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511971 · Cited by 43 · see citing works
Luo, Z., Yu, X., Wang, C., Zhao, H., Wang, X., & Guan, X. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00984-y · Cited by 41 · see citing works
Effects of gut microbiota on atherosclerosis through hydrogen sulfide
Gui, D.-D., Luo, W., Yan, B., Ren, Z., Tang, Z., Liu, L.-S., Zhang, J., & Jiang, Z.-S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173916 · Cited by 40 · see citing works
Krueger, E. S., Lloyd, T. S., & Tessem, J. S. (2021) · Nutrients · doi:10.3390/nu13082873 · Cited by 40 · see citing works
Role of Gut Microbial Metabolites in Cardiovascular Diseases—Current Insights and the Road Ahead
Datta, S., Pasham, S., Sandeep, I. S., Boini, K. M., & Koka, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810208 · Cited by 42 · see citing works
Chen, C., Leu, H., Wang, S., Tsai, S., Chou, R., Lu, Y., Tsai, Y., Kuo, C., Huang, P., Chen, J., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0115 · Cited by 41 · see citing works
Further insight into systemic sclerosis from the vasculopathy perspective
Ren, H., Liu, L., Xiao, Y., Shi, Y., Zeng, Z., Ding, Y. P., Zou, P., & Xiao, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115282 · Cited by 41 · see citing works
Vascular Cognitive Impairment and the Gut Microbiota
Li, S., Shao, Y., Li, K., HuangFu, C., Wang, W., Liu, Z., Cai, Z., & Zhao, B. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171103 · Cited by 38 · see citing works
Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function
Matsumoto, T., Kojima, M., Takayanagi, K., Taguchi, K., & Kobayashi, T. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa053 · Cited by 37 · see citing works
Wang, A., Dongcheng, C., Zhang, H., Li, Q., Yan, Z., Qiu, Y., Xu, H., & Keji, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.018 · Cited by 37 · see citing works
Gut Microbiota and Cardiovascular Diseases
Anselmi, G., Gagliardi, L., Egidi, G., Leone, S., Gasbarrini, A., Miggiano, G. A. D., & Galiuto, L. (2020) · Cardiology in Review · doi:10.1097/crd.0000000000000327 · Cited by 37 · see citing works
Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis
Zhang, L., She, Z., Li, H., & Zhang, X. (2020) · Clinical Science · doi:10.1042/cs20200446 · Cited by 39 · see citing works
Ding, H., Liu, J., Chen, Z., Huang, S., Yan, C., Kwek, E., He, Z., Zhu, H., & Chen, Z. (2023) · Food & Function · doi:10.1039/d3fo04396g · Cited by 36 · see citing works
- Authors
- Ma, G., Pan, B., Chen, Y., Guo, C., Zhao, M., Zheng, L., & Chen, B.
- Affiliations
- Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China
- Peking University (CN)
- Capital Medical University (CN)
- Corresponding author
- Zheng, LeMin
- Chen, BuXing
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2017-03-02
- Volume
- 37
- Issue
- 2
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- PMC
- PMC5333780
- OpenAlex
- W2583372114
- Cited by
- 267
- References
- 46
- Citations by year
- 2026: 14 · 2025: 35 · 2024: 29 · 2023: 45 · 2022: 36 · 2021: 31 · 2020: 35 · 2019: 18 · 2018: 16 · 2017: 8
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioscience Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greater South Information System
- Funders
- Academy of Medical Sciences
- National Natural Science Foundation of China (81172500, 81170101, 81570321, 81370235)
- Chinese Academy of Sciences
- Chinese Academy of Medical Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- trimethylamine N-oxide, atherosclerosis, endothelial dysfunction, monocyte adhesion, VCAM-1, protein kinase C, NF-κB, endothelial cell migration, endothelial cell proliferation, extracellular matrix adhesion, human umbilical vein endothelial cells
- MeSH terms
- Cell Adhesion, Cells, Cultured, Humans, Methylamines, Monocytes, Protein Kinase C, Signal Transduction, NF-kappa B, Vascular Cell Adhesion Molecule-1, Atherosclerosis, Human Umbilical Vein Endothelial Cells
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