Placental mTOR links maternal nutrient availability to fetal growth

TOR signaling in growth and metabolism

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Living with the Past: Evolution, Development, and Patterns of Disease

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Regulation of TORC1 by Rag GTPases in nutrient response

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Hypothalamic mTOR Signaling Regulates Food Intake

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Mammalian TOR: a homeostatic ATP sensor

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A nutrient sensor mechanism controls Drosophila growth

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

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mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

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Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

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hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

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Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

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A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

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Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation

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The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

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Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

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Starvation Induces Vacuolar Targeting and Degradation of the Tryptophan Permease in Yeast

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Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth

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Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

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Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

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Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis

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Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? – A Review

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Amino Acid (System A) Transporter Activity in Microvillous Membrane Vesicles from the Placentas of Appropriate and Small for Gestational Age Babies

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Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

Jansson, T., Ekstrand, Y., Björn, C., Wennergren, M., & Powell, T. L. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2214 · Cited by 238 · see citing works

Placental Transport of Leucine and Lysine Is Reduced in Intrauterine Growth Restriction1

Jansson, T., Scholtbach, V., & Powell, T. L. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00011 · Cited by 235 · see citing works

L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport.

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Placental Transport of Leucine, Phenylalanine, Glycine, and Proline in Intrauterine Growth-Restricted Pregnancies

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Blood glucose and oxygen tension levels in small-for-gestational-age fetuses

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Intrauterine Growth Restriction Is Associated with a Reduced Activity of Placental Taurine Transporters

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Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation

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Exogenous Amino Acids Regulate Trophectoderm Differentiation in the Mouse Blastocyst through an mTOR-Dependent Pathway

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Management of fetal growth restriction

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Trends in fetal growth among singleton gestations in the United States and Canada, 1985 through 1998

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Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

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Tissue concentrations of free amino acids in term human placentas

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TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

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Regulation of placental amino acid transporter activity by mammalian target of rapamycin

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mTOR: A placental growth signaling sensor

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Intrauterine growth retardation at term: association between anthropometric and endocrine parameters

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An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival

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Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin

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Controlling cell growth and survival through regulated nutrient transporter expression

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Platelet‐derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: Role in cell growth

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Rapamycin regulates the phosphorylation of rictor

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Pathophysiology of placental-derived fetal growth restriction

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Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta

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Regulation of Nutrient Transport across the Placenta

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Placental efficiency and adaptation: endocrine regulation

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The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

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Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

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Review: The Placenta is a Programming Agent for Cardiovascular Disease

Thornburg, K. L. R., O'Tierney, P. F., & Louey, S. (2010) · Placenta · doi:10.1016/j.placenta.2010.01.002 · Cited by 248 · see citing works

Measuring high-altitude adaptation

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Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk

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Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

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The frequency and type of placental histologic lesions in term pregnancies with normal outcome

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Human Genetic Adaptation to High Altitude: Evidence from the Andes

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Nutrition and human health from a sex–gender perspective

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Can We Modify the Intrauterine Environment to Halt the Intergenerational Cycle of Obesity?

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Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply

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Regulation of maternal–fetal metabolic communication

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Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth

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Understanding placental nutrient transfer – why bother? New biomarkers of fetal growth

Sibley, C. P. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172403 · Cited by 92 · see citing works

Review: Placenta, evolution and lifelong health

Lewis, R. M., Cleal, J. K., & Hanson, M. A. (2011) · Placenta · doi:10.1016/j.placenta.2011.12.003 · Cited by 91 · see citing works

Characterization of Neutrophil Subsets in Healthy Human Pregnancies

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Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

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Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction

Curtis, S., Jones, C. J. P., Garrod, A., Hulme, C. H., & Heazell, A. E. P. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.733764 · Cited by 82 · see citing works

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas

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Activation of Placental Insulin and mTOR Signaling in a Mouse Model of Maternal Obesity Associated with Fetal Overgrowth

Rosario, F. J., Powell, T. L., & Jansson, T. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00356.2015 · Cited by 77 · see citing works

Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1

Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76 · see citing works

Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: Role of obesity and sex

Mina, T. H., Räikkönen, K., Riley, S. C., Norman, J. E., & Reynolds, R. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.05.004 · Cited by 76 · see citing works

Maternal amino acid supplementation for intrauterine growth restriction

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Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR

Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works

Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight

Batistel, F., Alharthi, A. S., Wang, L., Parys, C., Pan, Y., Cardoso, F. C., & Loor, J. J. (2017) · Journal of Nutrition · doi:10.3945/jn.117.251876 · Cited by 66 · see citing works

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

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A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone, but not placental labyrinth zone growth

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Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4

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A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth

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Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans

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The Amniotic Fluid Transcriptome

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Placental Glucose and Amino Acid Transport in Calorie-Restricted Wild-Type and Glut3 Null Heterozygous Mice

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Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity

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Environmental regulation of placental phenotype: implications for fetal growth

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Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR

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Weekly Intra-Amniotic IGF-1 Treatment Increases Growth of Growth-Restricted Ovine Fetuses and Up-Regulates Placental Amino Acid Transporters

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Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice

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Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants

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Polychlorinated biphenyls (PCBs) decrease the placental syncytiotrophoblast volume and increase Placental Growth Factor (PlGF) in the placenta of normal pregnancy

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Leucine-Rich Diet Improves the Serum Amino Acid Profile and Body Composition of Fetuses from Tumor-Bearing Pregnant Mice1

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Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome

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Human placental androgen receptor variants: Potential regulators of male fetal growth

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Placental pathology in cancer during pregnancy and after cancer treatment exposure

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Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse

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Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific

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Immune Response Gene Profiles in the Term Placenta Depend Upon Maternal Muscle Mass

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Placental DEPTOR as a stress sensor during pregnancy

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Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity

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Epidemiology and Therapeutic Strategies for Women With Preexisting Diabetes in Pregnancy: How Far Have We Come? The 2021 Norbert Freinkel Award Lecture

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Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring

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Maternal High-Fat Diet Consumption and Chronic Hyperandrogenemia Are Associated With Placental Dysfunction in Female Rhesus Macaques

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Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

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Characterization of the insulin-like growth factor axis in term pregnancies complicated by maternal obesity

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Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status

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A Leucine-Rich Diet Modulates the Tumor-Induced Down-Regulation of the MAPK/ERK and PI3K/Akt/mTOR Signaling Pathways and Maintains the Expression of the Ubiquitin-Proteasome Pathway in the Placental Tissue of NMRI Mice1

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Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats

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Placental Endocrine Function and Hormone Action

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Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport

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Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort

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A role for maternally derived myokines to optimize placental function and fetal growth across gestation

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Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation

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Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

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A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome

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Pregnancy and Cancer: Cellular Biology and Mechanisms Affecting the Placenta

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Maternal Undernutrition Induces the Expression of Hypoxia-Related Genes in the Fetal Brain

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Supplementing N-carbamoylglutamate in late gestation increases newborn calf weight by enhanced placental expression of mTOR and angiogenesis factor genes in dairy cows

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N-Acetylcysteine Resolves Placental Inflammatory-Vasculopathic Changes in Mice Consuming a High-Fat Diet

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Fetal Requirements and Placental Transfer of Nitrogenous Compounds

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The human myometrium differentially expresses mTOR signalling components before and during pregnancy: Evidence for regulation by progesterone

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Intravenous maternal L-arginine administration to twin-bearing ewes during late pregnancy enhances placental growth and development

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The increased expression of glucose transporters in human full-term placentas from assisted reproductive technology without changes of mTOR signaling

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IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway

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Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism

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Expressional regulation of genes linked to immunity & programmed development in human early placental villi.

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Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth

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The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta

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Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

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The emerging role of mTORC1 signaling in placental nutrient-sensing

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Down‐regulation of placental mTOR, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

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