Spare respiratory capacity, oxidative stress and excitotoxicity

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

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High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

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Glutamate neurotoxicity in cortical cell culture

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NMDA-dependent superoxide production and neurotoxicity

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Glutamate release in severe brain ischaemia is mainly by reversed uptake

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The release and uptake of excitatory amino acids

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Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

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The mitochondrial permeability transition from<i>in vitro</i>artifact to disease target

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Glutamate-induced neuron death requires mitochondrial calcium uptake

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Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

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Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

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Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

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Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

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Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

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Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons

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Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Ward, M. W., Rego, A. C., Frenguelli, B. G., & Nicholls, D. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07208.2000 · Cited by 306 · see citing works

Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone

Yadava, N., & Nicholls, D. G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0212-07.2007 · Cited by 272 · see citing works

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease

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Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

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‘Mild Uncoupling’ does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

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The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

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Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons

Pivovarova, N. B., Nguyen, H. V., Winters, C. A., Brantner, C. A., Smith, C. L., & Andrews, S. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0531-04.2004 · Cited by 146 · see citing works

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

Jekabsons, M. B., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401540200 · Cited by 140 · see citing works

Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons

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Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

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Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neuronsin vitro: Effect of chemical ischemia

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Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate

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Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

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Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

Rego, A. C., Ward, M. W., & Nicholls, D. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01893.2001 · Cited by 59 · see citing works

Brevetoxins Cause Acute Excitotoxicity in Primary Cultures of Rat Cerebellar Granule Neurons

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Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria

Tretter, L., & Ádám‐Vizi, V. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04891.x · Cited by 50 · see citing works

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Buck, M. D., O’Sullivan, D., Geltink, R. I. K., Curtis, J. D., Chang, C., Sanin, D. E., Qiu, J., Kretz, O., Braas, D., van der Windt, G. J. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.035 · Cited by 1,444 · see citing works

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

Kawalekar, O. U., O’Connor, R. S., Fraietta, J. A., Guo, L., McGettigan, S. E., Posey, A. D., Patel, P. R., Guedan, S., Scholler, J., Keith, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.021 · Cited by 1,234 · see citing works

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Patsoukis, N., Bardhan, K., Chatterjee, P., Sari, D., Liu, B., Bell, L. N., Karoly, E. D., Freeman, G. J., Petkova, V., Seth, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7692 · Cited by 1,210 · see citing works

Mitochondria are the powerhouses of immunity

Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology · doi:10.1038/ni.3704 · Cited by 1,161 · see citing works

Metabolic switching and fuel choice during T‐cell differentiation and memory development

van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563 · see citing works

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

Mookerjee, S. A., Gerencser, A. A., Nicholls, D. G., & Brand, M. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.774471 · Cited by 550 · see citing works

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

van der Windt, G. J. W., O’Sullivan, D., Everts, B., Huang, S. C.-C., Buck, M. D., Curtis, J. D., Chang, C.-H., Smith, A. M., Ai, T., Faubert, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221740110 · Cited by 523 · see citing works

Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data

Divakaruni, A. S., Paradyse, A. R., Ferrick, D. A., Murphy, A. N., & Jastroch, M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801415-8.00016-3 · Cited by 525 · see citing works

The Regulation and Physiology of Mitochondrial Proton Leak

Divakaruni, A. S., & Brand, M. D. (2011) · Physiology · doi:10.1152/physiol.00046.2010 · Cited by 484 · see citing works

Brain lactate metabolism: the discoveries and the controversies

Dienel, G. A. (2012) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479 · see citing works

Calcium‐dependent mitochondrial function and dysfunction in neurons

Pivovarova, N. B., & Andrews, S. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07754.x · Cited by 382 · see citing works

Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells

Marchetti, P., Fovez, Q., Germain, N., Khamari, R., & Kluza, J. (2020) · The FASEB Journal · doi:10.1096/fj.202000767r · Cited by 321 · see citing works

Neuronal vulnerability, pathogenesis, and Parkinson's disease

Sulzer, D. L., & Surmeier, D. J. (2012) · Movement Disorders · doi:10.1002/mds.25095 · Cited by 315 · see citing works

Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α

Faubert, B., Vincent, E. E., Griss, T., Samborska, B., Izreig, S., Svensson, R. U., Mamer, O. A., Avizonis, D., Shackelford, D. B., Shaw, R. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312570111 · Cited by 278 · see citing works

Mitochondrial Dysfunction in Airway Disease

Prakash, Y. S., Pabelick, C. M., & Sieck, G. C. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.03.020 · Cited by 259 · see citing works

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

Pfleger, J. M., He, M., & Abdellatif, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.202 · Cited by 251 · see citing works

Role of sigma-1 receptors in neurodegenerative diseases

Nguyen, L., Lucke-Wold, B. P., Mookerjee, S. A., Cavendish, J. Z., Robson, M. J., Scandinaro, A. L., & Matsumoto, R. R. (2014) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2014.12.005 · Cited by 231 · see citing works

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

Rose, S., Niyazov, D. M., Rossignol, D. A., Goldenthal, M. J., Kahler, S. G., & Frye, R. E. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0352-x · Cited by 235 · see citing works

Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer

van der Windt, G. J. W., Chang, C., & Pearce, E. L. (2016) · Current Protocols in Immunology · doi:10.1002/0471142735.im0316bs113 · Cited by 186 · see citing works

Neuronal vulnerability, pathogenesis, and Parkinson's disease

Sulzer, D., & Surmeier, D. J. (2013) · Movement Disorders · doi:10.1002/mds.25187 · Cited by 184 · see citing works

Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

Rose, S., Frye, R. E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., & James, S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085436 · Cited by 168 · see citing works

Fueling and Imaging Brain Activation

Dienel, G. A. (2012) · ASN NEURO · doi:10.1042/an20120021 · Cited by 175 · see citing works

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

Buskiewicz, I. A., Montgomery, T. L., Yasewicz, E. C., Huber, S. A., Murphy, M. P., Hartley, R. C., Kelly, R., Crow, M. K., Perl, A., Budd, R. C., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aaf1933 · Cited by 177 · see citing works

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

Mookerjee, S. A., Nicholls, D. G., & Brand, M. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152016 · Cited by 167 · see citing works

Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

Li, W., Qiu, S., Chen, J., Jiang, S., Chen, W., Jiang, J., Wang, F., Si, W., Shu, Y., Wei, P., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.011 · Cited by 160 · see citing works

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Divakaruni, A. S., Wallace, M., Buren, C., Martyniuk, K. M., Andreyev, A. Y., Li, E., Fields, J. A., Cordes, T., Reynolds, I. J., Bloodgood, B. L., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612067 · Cited by 157 · see citing works

Differential effects of AMPK agonists on cell growth and metabolism

Vincent, E. E., Coelho, P. P., Blagih, J., Griss, T., Viollet, B., & Jones, R. G. (2014) · Oncogene · doi:10.1038/onc.2014.301 · Cited by 155 · see citing works

Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

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A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements

Divakaruni, A. S., & Jastroch, M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00619-4 · Cited by 150 · see citing works

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172168 · Cited by 131 · see citing works

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines

Frye, R. E., Rose, S., Chacko, J., Wynne, R., Bennuri, S. C., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.189 · Cited by 130 · see citing works

Imaging of neurosphere oxygenation with phosphorescent probes

Dmitriev, R. I., Zhdanov, A. V., Nolan, Y. M., & Papkovsky, D. B. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.065 · Cited by 117 · see citing works

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Vasconcelos, A. R., dos Santos, N. B., Scavone, C., & Munhoz, C. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00033 · Cited by 112 · see citing works

Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes

Dhingra, A., Jayas, R., Afshar, P., Guberman, M., Maddaford, G. G., Gerstein, J., Lieberman, B., Nepon, H., Margulets, V., Dhingra, R., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.010 · Cited by 108 · see citing works

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

Rojas, F., González, D., Cortés, N., Ampuero, E., Hernández, D. E., Fritz, E., Abarzúa, S., Martinez, A. N., Elorza, Á. A., Alvarez, A. R., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00203 · Cited by 95 · see citing works

Roles of Glucose in Photoreceptor Survival

Chertov, A. O., Holzhausen, L. C., Kuok, I. T., Couron, D., Parker, E., Linton, J. D., Sadı́lek, M., Sweet, I. R., & Hurley, J. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279752 · Cited by 93 · see citing works

Preexisting High Frequencies of Memory CD8+ T Cells Favor Rapid Memory Differentiation and Preservation of Proliferative Potential upon Boosting

Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V., & Masopust, D. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.003 · Cited by 89 · see citing works

Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets

Norberg, E., Lako, A., Chen, P.-H., Stanley, I. A., Zhou, F., Ficarro, S. B., Chapuy, B., Chen, L., Rodig, S. J., Shin, D. H., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.116 · Cited by 87 · see citing works

Changing the energy of an immune response.

Delmastro-Greenwood, M. M., & Piganelli, J. D. (2013) · Europe PMC (PubMed Central) · Cited by 84 · see citing works

Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer's disease

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Erratum: Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

Rose, S., Frye, R. E., Slattery, J., Wynne, R. A., Tippett, M., Melnyk, S., & James, S. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.29 · Cited by 78 · see citing works

The pathology roadmap in Parkinson disease

Surmeier, D. J., & Sulzer, D. (2013) · Prion · doi:10.4161/pri.23582 · Cited by 74 · see citing works

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

Keuper, M., Jastroch, M., Yi, C., Fischer‐Posovszky, P., Wabitsch, M., Tschöp, M. H., & Hofmann, S. M. (2013) · The FASEB Journal · doi:10.1096/fj.13-238725 · Cited by 75 · see citing works

Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity

Corrado, M., Edwards-Hicks, J., Villa, M., Flachsmann, L. J., Sanin, D. E., Jacobs, M. M. E., Baixauli, F., Stanczak, M. A., Anderson, E., Azuma, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.003 · Cited by 68 · see citing works

Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines

Rose, S., Frye, R. E., Slattery, J. M., Wynne, R. A., Tippett, M., Melnyk, S., & James, S. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.15 · Cited by 69 · see citing works

Mitochondria: key players in the neurotoxic effects of amphetamines

Barbosa, D. J., Capela, J. P., Feio‐Azevedo, R., Gomes, A., Bastos, M. D. L., & Carvalho, F. D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1478-9 · Cited by 69 · see citing works

Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes

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Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

Kolesar, J. E., Safdar, A., Abadi, A., MacNeil, L., Crane, J. D., Tarnopolsky, M. A., & Kaufman, B. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.038 · Cited by 63 · see citing works

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Golomb, B. A., Allison, M., Koperski, S., Koslik, H. J., Devaraj, S., & Ritchie, J. B. (2014) · Neural Computation · doi:10.1162/neco_a_00659 · Cited by 63 · see citing works

The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation

Yang, C., Wong, C.-M., Wei, J., Chung, A. C. K., & Cai, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.087 · Cited by 62 · see citing works

Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

Clerc, P., & Polster, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034465 · Cited by 59 · see citing works

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

Polster, B. M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.002 · Cited by 58 · see citing works

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

Maeda, A., Palczewska, G., Golczak, M., Kohno, H., Dong, Z., Maeda, T., & Palczewski, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317986111 · Cited by 57 · see citing works

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease

Mancini, Ö. K., Lora, M., Cuillerier, A., Tim, D. S., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U., & Colmegna, I. (2017) · Circulation Research · doi:10.1161/circresaha.117.311400 · Cited by 54 · see citing works

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance

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A High Fat/Cholesterol Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction

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