Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

Stephens, Francis B.; Mendis, Buddhike; Shannon, Chris E.; Cooper, Scott; Ortori, Catharine A.; Barrett, David A.; Mansell, Peter; Tsintzas, Kostas

doi:10.1042/cs20140031

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced insulin resistance. The present study tested the…