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Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
Abstract
Gut microbial-derived short-chain fatty acids (SCFA) are believed to affect host metabolism and cardiometabolic risk factors. The present study aim was to investigate the effects of proximal and distal colonic infusions with the SCFA acetate on fat oxidation and other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight/obese men [body mass index (BMI) 25-35 kg/m 2 ] underwent two experimental periods: one with distal and one with proximal colonic sodium acetate infusions. A feeding catheter was endoscopically positioned at the beginning of each period and remained in the colon for three consecutive test days, enabling colonic acetate (100 or 180 mmol/l) or placebo infusion during fasting conditions and after an oral glucose load (postprandial). Fat oxidation and energy expenditure were measured using an open-circuit ventilated hood system and blood samples were repeatedly collected for 2 h during fasting and postprandial conditions. Distal colonic 180 mmol/l acetate infusions increased fasting fat oxidation (1.78±0.28 compared with -0.78±0.89 g fat 2 h -1 , P=0.015), fasting peptide YY (PYY, P=0.01) and postprandial glucose and insulin concentrations (P<0.05), and tended to increase fasting plasma acetate (P=0.069) compared with placebo. Distal 100 mmol/l acetate administration tended to decrease fasting tumour necrosis factor-α (TNF-α; P=0.067) compared with placebo. In contrast, proximal colonic acetate infusions showed no effects o…
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“Although limited, some of these results were confirmed in human in vivo studies, as showed that acute rectal infusions of sodium acetate and SCFA mixtures increased circulating concentrations of PYY in individuals who were overweight (197–199).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [197]
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Self-citation
Metadata
- Authors
- van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E.
- Affiliations
- Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands
- Maastricht University Medical Centre (NL)
- Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands
- University of Copenhagen (DK)
- Corresponding author
- Lenaerts, Kaatje
- ORCID
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2016-10-11
- Volume
- 130
- Issue
- 22
- Pages
- 2073-2082
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2482094715
- Semantic Scholar
- 6bfc063f788f3c5ab84157b2e19a1bf924a329f3
- Cited by
- 230
- References
- 43
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 28 · 2023: 25 · 2022: 23 · 2021: 37 · 2020: 27 · 2019: 17 · 2018: 12 · 2017: 16 · 2016: 2
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Maastricht Universitair Medisch Centrum
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- short-chain fatty acids, fat oxidation, obesity, overweight men, gut microbiota, peptide YY, TNF-α, energy expenditure, plasma acetate, substrate metabolism
- MeSH terms
- Acetates, Adult, Colon, Energy Metabolism, Fats, Female, Humans, Insulin, Male, Middle Aged, Obesity, Oxidation-Reduction, Peptide YY, Overweight, Young Adult
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