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Cited by 230Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

The DOI matches its Crossref record; 40 of the 44 references it cites were found in a registry or an index, and 4 are not checked yet.

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

van der Beek, Christina M., Canfora, Emanuel E., Lenaerts, Kaatje, Troost, Freddy J., Olde Damink, Steven W.M., Holst, Jens J., Masclee, Ad A.M., Dejong, Cornelis H.C., Blaak, Ellen E.·2016·Clinical Science
DOI 10.1042/cs20160263
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Abstract

Gut microbial-derived short-chain fatty acids (SCFA) are believed to affect host metabolism and cardiometabolic risk factors. The present study aim was to investigate the effects of proximal and distal colonic infusions with the SCFA acetate on fat oxidation and other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight/obese men [body mass index (BMI) 25-35 kg/m 2 ] underwent two experimental periods: one with distal and one with proximal colonic sodium acetate infusions. A feeding catheter was endoscopically positioned at the beginning of each period and remained in the colon for three consecutive test days, enabling colonic acetate (100 or 180 mmol/l) or placebo infusion during fasting conditions and after an oral glucose load (postprandial). Fat oxidation and energy expenditure were measured using an open-circuit ventilated hood system and blood samples were repeatedly collected for 2 h during fasting and postprandial conditions. Distal colonic 180 mmol/l acetate infusions increased fasting fat oxidation (1.78±0.28 compared with -0.78±0.89 g fat 2 h -1 , P=0.015), fasting peptide YY (PYY, P=0.01) and postprandial glucose and insulin concentrations (P<0.05), and tended to increase fasting plasma acetate (P=0.069) compared with placebo. Distal 100 mmol/l acetate administration tended to decrease fasting tumour necrosis factor-α (TNF-α; P=0.067) compared with placebo. In contrast, proximal colonic acetate infusions showed no effects o…

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Metadata

Authors
van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E.
Affiliations
  • Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands
  • Maastricht University Medical Centre (NL)
  • Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands
  • University of Copenhagen (DK)
Corresponding author
Lenaerts, Kaatje
ORCID
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
2016-10-11
Volume
130
Issue
22
Pages
2073-2082
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs20160263
OpenAlex
W2482094715
Semantic Scholar
6bfc063f788f3c5ab84157b2e19a1bf924a329f3
Cited by
230
References
43
Citations by year
2026: 19 · 2025: 22 · 2024: 28 · 2023: 25 · 2022: 23 · 2021: 37 · 2020: 27 · 2019: 17 · 2018: 12 · 2017: 16 · 2016: 2
FWCI
6.14
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Science (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Maastricht Universitair Medisch Centrum
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
short-chain fatty acids, fat oxidation, obesity, overweight men, gut microbiota, peptide YY, TNF-α, energy expenditure, plasma acetate, substrate metabolism
MeSH terms
Acetates, Adult, Colon, Energy Metabolism, Fats, Female, Humans, Insulin, Male, Middle Aged, Obesity, Oxidation-Reduction, Peptide YY, Overweight, Young Adult

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