Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity
Open accessAbstract
Scope: To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota, and insulin sensitivity in humans. Methods and results: Gut microbiota composition and gene markers of browning are analyzed in subcutaneous (SAT) and visceral (VAT) adipose tissue from morbidly obese subjects (n = 34). Plasma acetate is measured through 1 H NMR and insulin sensitivity using euglycemic hyperinsulinemic clamp. Subjects with insulin resistance show an increase in the relative abundance (RA) of the phyla Bacteroidetes and Proteobacteria while RA of Firmicutes is decreased. In all subjects, Firmicutes RA is negatively correlated with HbA 1c and fasting triglycerides, whereas Proteobacteria RA was negatively correlated with insulin sensitivity. Firmicutes RA is positively associated with markers of brown adipocytes (PRDM16, UCP1, and DIO2) in SAT, but not in VAT. Multivariate regression analysis indicates that Firmicutes RA contributes significantly to SAT PRDM16, UCP1, and DIO2 mRNA variance after controlling for age, BMI, HbA 1c, or insulin sensitivity. Interestingly, Firmicutes RA, specifically those bacteria belonging to the Ruminococcaceae family, is positively associated with plasma acetate levels, which are also linked to SAT PRDM16 mRNA and insulin sensitivity. Conclusion: Gut microbiota composition is linked to adipose tissue browning and insulin action in morbidly obese subjects, possibly through circulating acetate.
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Gut microbiota seems to play an important role as a regulator of WAT browning.
“In addition, gut microbiota also seems to play an important role as a regulator of WAT browning.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
In some obese insulin-sensitive patients, a decreased level in Firmicutes is associated with downregulation of WAT browning.
“In some obese insulin-sensitive patients, a decreased level in Firmicutes is associated with the downregulation of WAT browning.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
Firmicutes level is directly correlated with PRDM16 mRNA expression and UCP-1 expression in subcutaneous and visceral WAT.
“Interestingly, the Firmicutes level was found to be directly correlated with PRDM16 mRNA expression (a key transcription factor involved in BAT differentiation) and UCP-1 expression in subcutaneous and visceral WAT [247].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [247]
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Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Quality control and preprocessing of metagenomic datasets
Schmieder, R., & Edwards, R. A. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr026 · Cited by 4,989 · see citing works
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232 · see citing works
Microbial community profiling for human microbiome projects: Tools, techniques, and challengesPreprint
Hamady, M., & Knight, R. D. (2009) · Genome Research · doi:10.1101/gr.085464.108 · Cited by 998 · see citing works
Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.021 · Cited by 878 · see citing works
Meta‐analyses of human gut microbes associated with obesity and IBD
Walters, W. A., Xu, Z., & Knight, R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.09.039 · Cited by 836 · see citing works
Gut Microbiota Orchestrates Energy Homeostasis during Cold
Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.004 · Cited by 829 · see citing works
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works
Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.019 · Cited by 667 · see citing works
Exercise Modifies the Gut Microbiota with Positive Health Effects
Monda, V., Villano, I., Messina, A., Valenzano, A., Esposito, T., Moscatelli, F., Viggiano, A., Cibelli, G., Chieffi, S., Monda, M., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3831972 · Cited by 654 · see citing works
Lu, Y., Fan, C., Li, P., Lu, Y., Chang, X., & Qi, K. (2016) · Scientific Reports · doi:10.1038/srep37589 · Cited by 638 · see citing works
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 621 · see citing works
Self-citationThe gut microbiota in human energy homeostasis and obesity
Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450 · see citing works
Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
Korem, T., Zeevi, D., Suez, J., Weinberger, A., Avnit-Sagi, T., Lotan‐Pompan, M., Matot, E., Jona, G., Harmelin, A., Cohen, N., et al. (2015) · Science · doi:10.1126/science.aac4812 · Cited by 437 · see citing works
Responses of gut microbiota to diet composition and weight loss in lean and obese mice
Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity · doi:10.1038/oby.2011.111 · Cited by 406 · see citing works
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
Sommer, F., Ståhlman, M., Ilkayeva, O., Arnemo, J. M., Kindberg, J., Josefsson, J., Newgard, C. B., Fröbert, O., & Bäckhed, F. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.026 · Cited by 370 · see citing works
The Intestinal Metabolome: An Intersection Between Microbiota and Host
Ursell, L. K., Haiser, H. J., Treuren, W. V., Garg, N., Reddivari, L., Vanamala, J., Dorrestein, P. C., Turnbaugh, P. J., & Knight, R. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.001 · Cited by 357 · see citing works
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
Stanford, K. I., Middelbeek, R. J. W., & Goodyear, L. J. (2015) · Diabetes · doi:10.2337/db15-0227 · Cited by 342 · see citing works
Canfora, E. E., van der Beek, C. M., Jocken, J. W. E., Goossens, G. H., Holst, J. J., Olde Damink, S. W. M., Lenaerts, K., Dejong, C. H. C., & Blaak, E. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-02546-x · Cited by 331 · see citing works
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 314 · see citing works
Pallejá, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, T., Liang, S., Feng, Q., Jørgensen, N. B., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0312-1 · Cited by 312 · see citing works
Haro, C., Montes-Borrego, M., Rangel-Zúñiga, O. A., Alcala-Diaz, J. F., Gómez-Delgado, F., Pérez‐Martínez, P., Delgado‐Lista, J., Quintana‐Navarro, G. M., Tinahones, F. J., Landa, B. B., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3351 · Cited by 302 · see citing works
Gut microorganisms as promising targets for the management of type 2 diabetes
Delzenne, N. M., Cani, P. D., Everard, A., Neyrinck, A. M., & Bindels, L. B. (2015) · Diabetologia · doi:10.1007/s00125-015-3712-7 · Cited by 264 · see citing works
Sahuri-Arisoylu, M., Brody, L., Parkinson, J. R. C., Parkes, H. G., Navaratnam, N., Miller, A. D., Thomas, E. L., Frost, G. S., & Bell, J. D. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.23 · Cited by 255 · see citing works
van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E. (2016) · Clinical Science · doi:10.1042/cs20160263 · Cited by 230 · see citing works
IRF3 promotes adipose inflammation and insulin resistance and represses browning
Kumari, M., Wang, X., Lantier, L., Lyubetskaya, A., Eguchi, J., Kang, S., Tenen, D. E., Roh, H. C., Kong, X., Kazak, L., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86080 · Cited by 178 · see citing works
Goffredo, M., Maas, K. R., Parks, E. J., Wagner, D. A., McClure, E. A., Graf, J., Savoye, M., Pierpont, B. M., Cline, G. W., & Santoro, N. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1797 · Cited by 178 · see citing works
YAMASHITA, H., MARUTA, H., JOZUKA, M., KIMURA, R., IWABUCHI, H., YAMATO, M., SAITO, T., FUJISAWA, K., TAKAHASHI, Y., KIMOTO, M., et al. (2009) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.80634 · Cited by 146 · see citing works
Hu, J., Kyrou, I., Tan, B. K., Dimitriadis, G. K., Ramanjaneya, M., Tripathi, G., Patel, V. C., James, S. G., Kawan, M., Chen, J., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1944 · Cited by 138 · see citing works
Fugmann, M., Breier, M., Rottenkolber, M., Banning, F., Ferrari, U., Sacco, V., Grallert, H., Parhofer, K. G., Seissler, J., Clavel, T., et al. (2015) · Scientific Reports · doi:10.1038/srep13212 · Cited by 131 · see citing works
Yamaguchi, Y., Adachi, K., Sugiyama, T., Shimozato, A., Ebi, M., Ogasawara, N., Funaki, Y., Goto, C., Sasaki, M., & Kasugai, K. (2016) · Digestion · doi:10.1159/000447690 · Cited by 119 · see citing works
The role of gut microbiota in human obesity: Recent findings and future perspectives
Tagliabue, A., & Elli, M. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.09.002 · Cited by 118 · see citing works
Insulin Resistance Modulates Iron-Related Proteins in Adipose Tissue
Moreno‐Navarrete, J. M., Novelle, M. G., Catalán, V., Ortega, F. J., Moreno, M., Gómez‐Ambrosi, J., Xifra, G., Serrano, M., Guerra, E., Ricart, W., et al. (2014) · Diabetes Care · doi:10.2337/dc13-1602 · Cited by 82 · see citing works
Self-citationGagen, E. J., Padmanabha, J., Denman, S. E., & McSweeney, C. S. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv104 · Cited by 80 · see citing works
Hanatani, S., Motoshima, H., Takaki, Y., Kawasaki, S., Igata, M., Matsumura, T., Kondo, T., Senokuchi, T., Ishii, N., Kawashima, J., et al. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-23 · Cited by 73 · see citing works
Shirouchi, B., Nagao, K., Umegatani, M., Shiraishi, A., Morita, Y., Kai, S., Yanagita, T., Ogawa, A., Kadooka, Y., & Satô, M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002245 · Cited by 61 · see citing works
Gavaldà‐Navarro, A., Moreno‐Navarrete, J. M., Quesada‐López, T., Cairó, M., Giralt, M., Fernández‐Real, J. M., & Villarroya, F. (2016) · Diabetologia · doi:10.1007/s00125-016-4028-y · Cited by 57 · see citing works
Self-citationTransfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism
Nicolas, S., Blasco‐Baqué, V., Fournel, A., Gilleron, J., Klopp, P., Waget, A., Ceppo, F., Marlin, A., Padmanabhan, R., Iacovoni, J. S., et al. (2017) · Molecular Systems Biology · doi:10.15252/msb.20167356 · Cited by 54 · see citing works
Self-citationMoreno‐Navarrete, J. M., Ortega, F. J., Moreno, M., Xifra, G., Ricart, W., & Fernández‐Real, J. M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.042 · Cited by 14 · see citing works
Self-citationMr. A. R. Wallace's “Australasia”
EVERETT, A. H. (1880) · Nature · doi:10.1038/021535a0 · Cited by 1 · see citing works
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- Pedersen, H.K., Gudmundsdottir, V., Nielsen, H.B., Hyotylainen, T., Nielsen, T., Jensen, B.A., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D.R., Pöhö, P., Hellgren, L.I., Arumugam, M., Sunagawa, S., Vieira-Silva, S., Jørgensen, T., Holm, J.B., Trošt, K.; MetaHIT Consortium, Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Oresic, M., Ehrlich, S.D., Pedersen, O., Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 2016, 21, 535:376-381.
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Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 625 · see citing works
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“Interestingly, the Firmicutes level was found to be directly correlated with PRDM16 mRNA expression (a key transcription factor involved in BAT differentiation) and UCP-1 expression in subcutaneous and visceral WAT [247].”
BackgroundMetabolically healthy versus metabolically unhealthy obesity
Iacobini, C., Pugliese, G., Blasetti Fantauzzi, C., Federici, M., & Menini, S. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.009 · Cited by 453 · see citing works
Self-citationAron-Wisnewsky, J., Warmbrunn, M. V., Nieuwdorp, M., & Clément, K. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.057 · Cited by 452 · see citing works
Müller, M., Hernández, M. A. G., Goossens, G. H., Reijnders, D., Holst, J. J., Jocken, J. W. E., van Eijk, H. M. H., Canfora, E. E., & Blaak, E. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-48775-0 · Cited by 333 · see citing works
Vallianou, N. G., Stratigou, T., Christodoulatos, G. S., Tsigalou, C., & Dalamaga, Μ. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00379-w · Cited by 251 · see citing works
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Gérard, C., & Vidal, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00029 · Cited by 209 · see citing works
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Jyoti, & Dey, P. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00066-1 · Cited by 217 · see citing works
Palmnäs, M. S. A., Costabile, G., Vetrani, C., Åberg, S., Hjalmarsson, Y., Dicksved, J., Riccardi, G., & Landberg, R. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac217 · Cited by 192 · see citing works
Xu, Y., Wang, N., Tan, H., Li, S., Zhang, C., Zhang, Z., & Feng, Y. (2020) · Theranostics · doi:10.7150/thno.47746 · Cited by 173 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Naya, I., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., Asúnsolo, Á., & de la Torre, B. (2020) · Nutrients · doi:10.3390/nu12092749 · Cited by 117 · see citing works
Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09523-x · Cited by 106 · see citing works
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Liu, Y. S., Li, S., Wang, X., Xing, T., Li, J. L., Zhu, X. D., Zhang, L., & Gao, F. (2020) · Poultry Science · doi:10.1016/j.psj.2020.09.089 · Cited by 83 · see citing works
Hernández-Baixauli, J., Quesada‐Vázquez, S., Mariné-Casadó, R., Cardoso, K. G., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Baselga‐Escudero, L. (2020) · Nutrients · doi:10.3390/nu12030806 · Cited by 73 · see citing works
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Wang, Y., Ouyang, M., Gao, X., Wang, S., Fu, C., Zeng, J., & He, X. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s240728 · Cited by 66 · see citing works
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Wang, S., Pan, M., Hung, W., Tung, Y., & Ho, C. (2019) · Food & Function · doi:10.1039/c8fo02154f · Cited by 61 · see citing works
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Self-citationBeige Adipocyte as the Flame of White Adipose Tissue: Regulation of Browning and Impact of Obesity
Altınova, A. E. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab921 · Cited by 39 · see citing works
Yu, Q., Yu, F. S., Li, Q., Zhang, J., Peng, Y., Wang, X., Li, T., Yin, N., Sun, G., Ouyang, H., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02696 · Cited by 37 · see citing works
Gong, D., Lei, J., He, X., Hao, J., Zhang, F., Huang, X., Gu, W., Yang, X., & Yu, J. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02300-z · Cited by 36 · see citing works
The concept of probiotics, prebiotics, postbiotics, synbiotics, nutribiotics, and pharmabiotics
Chaudhari, A., & Dwivedi, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00013-1 · Cited by 35 · see citing works
Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health
Diab, R., Dimachkie, L., Zein, O., Dakroub, A. H., & Eid, A. H. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01314-9 · Cited by 38 · see citing works
Li, L., Shuo, L. I. U., Tang, H., Song, S.-Q., Lu, L., Zhang, P., & Li, X. (2020) · Journal of Veterinary Medical Science · doi:10.1292/jvms.20-0245 · Cited by 34 · see citing works
Molina, J. D. D., Avila, S., Rubio, G., & Lopez-Munoz, F. J. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210804110139 · Cited by 34 · see citing works
Xie, J., Liu, M., Liu, H., Jin, Z., Guan, F., Ge, S., Yan, J., Zheng, M., Cai, D., & Liu, J. (2021) · Food & Function · doi:10.1039/d1fo02863d · Cited by 34 · see citing works
Fuemmeler, B. F., Dozmorov, M. G., Do, E. K., Zhang, J. J., Grenier, C., Huang, Z., Maguire, R. L., Kollins, S. H., Hoyo, C., & Murphy, S. K. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8099 · Cited by 30 · see citing works
The Impact of a Very-Low-Calorie Ketogenic Diet in the Gut Microbiota Composition in Obesity
Zambrano, A. K., Cadena-Ullauri, S., Guevara‐Ramírez, P., Frías-Toral, E., Ruiz‐Pozo, V. A., Paz‐Cruz, E., Tamayo‐Trujillo, R., Chapela, S. P., Montalván, M., Sarno, G., et al. (2023) · Nutrients · doi:10.3390/nu15122728 · Cited by 30 · see citing works
Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome
Renson, A., Herd, P., & Dowd, J. B. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094423 · Cited by 28 · see citing works
Modulation of adipose tissue metabolism by microbial-derived metabolites
Liu, W., Ge, Y., Liu, P., Jiang, X. M., & Xin, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1031498 · Cited by 30 · see citing works
Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review
Martínez‐Montoro, J. I., Damas-Fuentes, M., Fernández‐García, J. C., & Tinahones, F. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.869951 · Cited by 28 · see citing works
Exercise-Induced Adipose Tissue Thermogenesis and Browning: How to Explain the Conflicting Findings?
Zhu, Y., Qi, Z., & Ding, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113142 · Cited by 26 · see citing works
Ma, X., Yan, H., Hong, S., Yu, S., Gong, Y., Wu, D., Li, Y., & Xiao, H. (2023) · Nutrients · doi:10.3390/nu15020456 · Cited by 23 · see citing works
Control of Adipose Cell Browning and Its Therapeutic Potential
Lizcano, F., & Arroyave, F. (2020) · Metabolites · doi:10.3390/metabo10110471 · Cited by 23 · see citing works
Food phenolics stimulate adipocyte browning via regulating gut microecology
Wang, Z., Zeng, M., Wang, Z., Qin, F., Wang, Y., Chen, J., Christian, M., & He, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1997905 · Cited by 22 · see citing works
Du, H., Shi, L. S., Yan, T., Wang, Q., Wang, Y., Zhao, Y., & Yang, X. (2022) · Food & Function · doi:10.1039/d2fo02063g · Cited by 20 · see citing works
Liu, J., Tan, Y., Ao, H., Feng, W., & Peng, C. Y. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00437-y · Cited by 20 · see citing works
Dini, I., & Mancusi, A. (2023) · Molecules · doi:10.3390/molecules28145357 · Cited by 19 · see citing works
Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review
Verduci, E., Calcaterra, V., Profio, E. D., Fiore, G., Rey, F., Magenes, V. C., Todisco, C. F., Carelli, S., & Zuccotti, G. (2021) · Nutrients · doi:10.3390/nu13051450 · Cited by 20 · see citing works
Anthropometric and DXA-derived measures of body composition in relation to pre-diabetes among adults
Mohammad, A., Ziyab, A. H., & Mohammad, T. (2023) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2023-003412 · Cited by 18 · see citing works
Fang, X., Wu, H., Wang, X., Lian, F., Li, M., Miao, R., Wei, J., & Tian, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.870407 · Cited by 18 · see citing works
Wu, H., Ding, L., Wang, H., Man, S., Kim, J., Qiu, L., & Yan, Q. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152563 · Cited by 14 · see citing works
The Role of Leptin Levels in Adaptation to Cold Climates
Никанорова, А. А., Алексеевич, Б. Н., Сергеевич, Н. С., Пшенникова, В. Г., Solovyev, A. V., Romanov, G. P., Семеновна, К. С., Sazonov, N. N., Бурцева, Т. Е., Odland, J. Ø., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17061854 · Cited by 14 · see citing works
JACOB, T. K., Sindhu, S. T. A. K., Hasan, A., Malik, M. Z., Arefanian, H., Al‐Rashed, F., Nizam, R., Kochumon, S., Thomas, R., Bahman, F., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1407258 · Cited by 14 · see citing works
Common traits between the beige fat-inducing stimuli
Stojanović, O., Kieser, S., & Trajkovski, M. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.05.011 · Cited by 13 · see citing works
Gutiérrez‐Repiso, C., Moreno‐Indias, I., Martín‐Núñez, G. M., Ho‐Plagaro, A., Rodríguez‐Cañete, A., Gonzalo, M., García‐Fuentes, E., & Tinahones, F. J. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.04.008 · Cited by 14 · see citing works
Hernández, M. A. G., Canfora, E. E., Pasmans, K., Astrup, A. V., Saris, W. H. M., & Blaak, E. E. (2020) · Nutrients · doi:10.3390/nu12020339 · Cited by 13 · see citing works
Antibiotic Treatment Reduces the Health Benefits of Soy Protein
Sánchez‐Tapia, M., Moreno-Vicencio, D., Ordáz‐Nava, G., Guevara‐Cruz, M., Granados‐Portillo, O., Vargas‐Castillo, A., Torres, N., & Tovar, A. R. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000532 · Cited by 13 · see citing works
Urinary Microbiota and Serum Metabolite Analysis in Patients with Diabetic Kidney Disease
Yang, Y. H., Ma, C., Li, S., Cai, W., Dai, W., Zhang, X., Yin, L., Tang, D., Liu, F., & Dai, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e17040 · Cited by 12 · see citing works
New Mediators in the Crosstalk between Different Adipose Tissues
Gómez‐Hernández, A., Heras, N. D. L., Gálvez, B. G., Fernández‐Marcelo, T., Fernández‐Millán, E., & Escribano, Ó. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094659 · Cited by 12 · see citing works
Никанорова, А. А., Алексеевич, Б. Н., Геннадиевна, П. В., Gotovtsev, N. N., Romanov, G. P., Solovyev, A. V., Семеновна, К. С., Sazonov, N. N., & Федорова, С. А. (2022) · Genes · doi:10.3390/genes13091612 · Cited by 11 · see citing works
Zhang, Y., Zhao, Y., Li, C., Wang, L., Tian, F., Erdene, K., Ao, C., & Hai, J. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103386 · Cited by 12 · see citing works
Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota
Baranowska‐Wójcik, E., Winiarska‐Mieczan, A., Olcha, P., Kwiecień, M., Jachimowicz-Rogowska, K., Nowakowski, Ł., Miturski, A., & Gałczyński, K. (2024) · Nutrients · doi:10.3390/nu16050681 · Cited by 12 · see citing works
Ortiz-Alvarez, L., Acosta, F. M., Xu, H., Sánchez‐Delgado, G., Vilchez‐Vargas, R., Link, A., Plaza‐Díaz, J., Elvira, J. M. L., Gil, Á., Labayen, I., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01936-x · Cited by 12 · see citing works
Distinct Gut Microbiome Induced by Different Feeding Regimes in Weaned Piglets
Zhang, J., Long, X., Liao, Q., Chai, J., Zhang, T., Chen, L., He, H., Yuan, Y., Wan, K., Wang, J., et al. (2022) · Genes · doi:10.3390/genes14010049 · Cited by 9 · see citing works
Cui, F., Mi, H., Wang, R., Du, Y., Li, F., Chang, S., Su, Y., Liu, A., & Shi, M. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02860-6 · Cited by 7 · see citing works
Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue
Ruswandi, Y. A. R., Lesmana, R., Rosdianto, A. M., Gunadi, J. W., Goenawan, H., & Zulhendri, F. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03854-2 · Cited by 7 · see citing works
Habe, B., Črešnovar, T., Hladnik, M., Pražnikar, J., Kenig, S., Bandelj, D., Mohorko, N., Petelin, A., & Pražnikar, Z. J. (2025) · Nutrients · doi:10.3390/nu17142284 · Cited by 6 · see citing works
Dagbasi, A., Cai, M., Hirdaramani, A., Hanyaloglu, A. C., Morrison, D. J., & Frost, G. S. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01579-9 · Cited by 6 · see citing works
Mihálik, D., Lančaričová, A., Mrkvová, M., Kaňuková, Š., Moravčíková, J., Glasa, M., Šubr, Z., Predajňa, L., Hančinský, R., Grešíková, S., et al. (2020) · Life · doi:10.3390/life10090205 · Cited by 6 · see citing works
Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update
D’Archivio, M., Scazzocchio, B., Silenzi, A., Giovannini, C., & Masella, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813006-3.00014-3 · Cited by 6 · see citing works
Multiomics strategy-based obesity biomarkers discovery for precision medicine
Ye, Z.-W., Yang, Q.-Y., Xu, W., Li, F., Luo, P., Qin, S., & Wang, F. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01906-2 · Cited by 5 · see citing works
Dong, H., Zhu, F., Yang, M., Zhang, L., Liu, X., Zhang, H., Huang, Y., Zhu, W., & Xie, L. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151338 · Cited by 5 · see citing works
Liu, X., Wang, H., Lu, Y., Jin, G., Fu, L., Mao, H., Wu, Y., & Liu, P. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71007 · Cited by 4 · see citing works
Мельник, Т., & Pivtorak, K. V. (2024) · ГРААЛЬ НАУКИ · doi:10.36074/grail-of-science.12.04.2024.065 · Cited by 3 · see citing works
Vratarić, M., Teofilović, A., Milutinović, D. V., Veličković, N. A., Đmura, G., & Djordjevic, A. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-20768-2 · Cited by 2 · see citing works
Pillay, D., Kuppusamy, U. R., & Arumugam, B. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107113 · Cited by 2 · see citing works
Chen, H.-Y., Sun, X., Huang, H., Huang, W.-Q., Liu, C., & Liu, S. (2026) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2026.126696 · Cited by 2 · see citing works
A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass
Hankir, M. K. (2020) · Cell Stress · doi:10.15698/cst2020.12.236 · Cited by 2 · see citing works
The Emerging Role of Gut Microbiota in Metabolic Diseases
Safi, S. Z. (2024) · Premier journal of science. · doi:10.70389/pjs.100020 · Cited by 1 · see citing works
Gut Microbiota Dynamics in Obesity and Metabolic Regulation
Farhood, A. H., & Shalal, S. H. (2025) · Academia Open · doi:10.21070/acopen.10.2025.12579 · Cited by 1 · see citing works
He, Y., Liu, L., Liu, Y., Jia, J., Chen, Y., Zhang, X., & Liu, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1747767 · Cited by 1 · see citing works
Tung, C.-Y., Lin, Y., Chang, Y.-Y., Ruan, J., Chen, P.-C., Chen, C., Yeh, H., Shen, H., Tsai, H., Li, T.-H., et al. (2026) · Gene · doi:10.1016/j.gene.2026.150292 · Cited by 1 · see citing works
Сучасні підходи до терапії синдрому подразненого кишечника через призму осі «кишечник — мозок»
Sirchak, Y. S. (2018) · GASTROENTEROLOGY · doi:10.22141/2308-2097.52.3.2018.141845 · Cited by 1 · see citing works
Implications of microbiota in the pathogenesis of diabetes mellitus and cardiovascular disease
Tănase, D. M., Leustean, A. M., & Gosav, E. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00005-8
Diet-Induced Adipocyte Browning
Wiśniewski, O. W., Rajczewski, A., Szumigała, A., & Gibas-Dorna, M. (2021) · Polish Journal of Food and Nutrition Sciences · doi:10.31883/pjfns/143164
Yang, Y. H., Li, S., Ma, C., Cai, W., Dai, W., Zhang, X., Yin, L., Tang, D., Liu, F., & Dai, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1543293/v1
Impact of gut-derived metabollites on substrate metabolism and metabolic health
Gonzalez Hernandez Manuel, A. (2020) · doi:10.26481/dis.20201027mgh
Microbiota intestinal y modulación del tejido adiposo en la patogénesis de la obesidad
Leonario-Rodriguez, M., & Saavedra, N. (2022) · Archivos Latinoamericanos de Nutrición · doi:10.37527/2022.72.2.004
Gut Microbiome and Brown Adipose Tissue
Moreno‐Navarrete, J. M. (2023) · Endocrinology · doi:10.1007/978-3-031-08115-6_6-1
Self-citationGut Microbiome and Brown Adipose Tissue
Moreno‐Navarrete, J. M. (2024) · Endocrinology · doi:10.1007/978-3-031-35064-1_6
Self-citationWeight management: functional foods for a balanced body
Emam‐Djomeh, Z., Samieitousi, S., Gashtasbi, S., Behmadi, H., Azarpazhooh, E., & Ramaswamy, H. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-28862-3.00006-6
Wu, Y.-Z., Wang, L., Sun, Y.-X., Yang, W., Wei, X., Tao, Q., Liang, Q., Min, H.-Y., & Gao, Q. (2025) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-025-3831-z
- Authors
- Moreno‐Navarrete, J. M., Serino, M., Blasco‐Baque, V., Azalbert, V., Barton, R. H., Cardellini, M., Latorre, J., Ortega, F., Sabater‐Masdeu, M., Burcelin, R., Dumas, M., Ricart, W., Federici, M., & Fernández‐Real, J. M.
- Affiliations
- Universitat de Girona (ES)
- Institut National de la Santé et de la Recherche Médicale (Inserm) Toulouse France
- Inserm (FR)
- Imperial College London (GB)
- University of Rome Tor Vergata (IT)
- Instituto de Salud Carlos III (ES)
- Department of Diabetes, Endocrinology and Nutrition Institut d'Investigació Biomèdica de Girona (IdIBGi) CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII) Girona Spain
- Corresponding author
- Moreno‐Navarrete, José María
- Fernández‐Real, José Manuel
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-12-29
- Volume
- 62
- Issue
- 3
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2766183128
- Cited by
- 106
- References
- 45
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 12 · 2018: 5
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- green
- hal.inrae.fr
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Instituto de Salud Carlos III (PI15/01934)
- European Regional Development Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, adipose tissue browning, brown adipocytes, insulin sensitivity, insulin resistance, morbid obesity, subcutaneous adipose tissue, visceral adipose tissue, plasma acetate, Firmicutes, Ruminococcaceae, PRDM16, UCP1, DIO2, Bacteroidetes, Proteobacteria, HbA1c, fasting triglycerides
- MeSH terms
- Gastrointestinal Microbiome, Uncoupling Protein 1, Acetates, Iodothyronine Deiodinase Type II, Adipose Tissue, Adult, DNA-Binding Proteins, Female, Humans, Insulin Resistance, Iodide Peroxidase, Male, Middle Aged, Obesity, Morbid, Transcription Factors, Biomarkers, Glucose Transporter Type 4, Adipose Tissue, White, Insulin Receptor Substrate Proteins
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