The pericyte–glia interface at the blood–brain barrier
Open accessAbstract
The cerebrovasculature is a multicellular structure with varying rheological and permeability properties. The outer wall of the brain capillary endothelium is enclosed by pericytes and astrocyte end feet, anatomically assembled to guarantee barrier functions. We, here, focus on the pericyte modifications occurring in disease conditions, reviewing evidence supporting the interplay amongst pericytes, the endothelium, and glial cells in health and pathology. Deconstruction and reactivity of pericytes and glial cells around the capillary endothelium occur in response to traumatic brain injury, epilepsy, and neurodegenerative disorders, impacting vascular permeability and participating in neuroinflammation. As this represents a growing field of research, addressing the multicellular reorganization occurring at the outer wall of the blood-brain barrier (BBB) in response to an acute insult or a chronic disease could disclose novel disease mechanisms and therapeutic targets.
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A breakdown of the blood brain barrier has been shown in neurodegenerative diseases.
“Furthermore, a breakdown of the blood brain barrier has been shown in neurodegenerative diseases [81, 82].”
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- Authors
- Giannoni, P., Badaut, J., Dargazanli, C., De Maudave, A. F., Klement, W., Costalat, V., & Marchi, N.
- Affiliations
- Université de Nîmes (FR)
- Laboratory of Brain Molecular Imaging, CNRS UMR5287, University of Bordeaux, France
- Centre National de la Recherche Scientifique (FR)
- Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
- Corresponding author
- Marchi, Nicola
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2018-02-08
- Volume
- 132
- Issue
- 3
- Pages
- 361-374
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2786513893
- Cited by
- 81
- References
- 25
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 6
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-16-CE37-0013)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- pericytes, blood-brain barrier, cerebrovascular endothelium, vascular permeability, traumatic brain injury, epilepsy, neurodegenerative diseases, neuroinflammation
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Brain, Capillary Permeability, Humans, Neuroglia, Pericytes
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