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Decreased hepcidin mRNA expression in thalassemic mice
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The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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“We note in this context that thalassaemia not only predisposes towards PE but is known in general to cause hepcidin to decrease and NGAL to increase [352,353,356,535], with consequent and inevitable iron dysregulation.”
In the citing paper
“In addition, the amount of hepcidin mRNA in liver cells is decreased in response to hypoxia and ineffective erythropoiesis (overlapping with the response to iron deficiency) 99,105 and induced in response to treatment with lipopolysaccharide or by inflammation of other etiologies.92,99”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [105]
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Citations
Cites
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
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Heparin‐induced thrombocytopenia: pathogenesis and management
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Successful treatment of murine β-thalassemia intermedia by transfer of the human β-globin gene
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Self-citationBiological and clinical features of low‐molecular‐weight heparin‐induced thrombocytopenia
Gruel, Y., Pouplard, C., Nguyên, P., Borg, J. Y., Derlon, A. B., Juhan-Vague, I., Regnault, V., Samama, M. M., & The French Heparin‐Induced Thrombocytopenia Study Group (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04363.x · Cited by 107
Cited by
Sorted by citations
Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122
“Hepcidin production is inappropriately low in most forms of hereditary hemochromatosis (89, 113, 137, 163, 166, 169, 170, 177, 178, 204, 256, 261) and certain iron-loading anemias, including -thalassemia (2, 21, 85, 160, 174, 178) and congenital dyserythropoietic anemias (32, 125, 236).”
BackgroundPapanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070
“, 2004) and secondary iron overload (Adamsky et al., 2004) and is suppressed in hereditary hemochromatosis (Bridle et al.”
BackgroundRegulation of Iron Metabolism by Hepcidin
Nemeth, E., & Ganz, T. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111303 · Cited by 756
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
“some evidence for their co-regulation [356], they have”
BackgroundHepcidin and disorders of iron metabolism
Ganz, T., & Nemeth, E. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-050109-142444 · Cited by 466
Hepcidin in iron overload disorders
Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood · doi:10.1182/blood-2004-12-4844 · Cited by 445
Liver iron concentrations and urinary hepcidin in -thalassemia
Origa, R., Galanello, R., Ganz, T., Giagu, N., Maccioni, L., Faa, G., & Nemeth, E. (2007) · Haematologica · doi:10.3324/haematol.10842 · Cited by 365
Anemia of inflammation: the cytokine-hepcidin link
Andrews, N. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21441 · Cited by 354
“(13), as occurs in other mouse models with increased erythroid iron demand (7, 8).”
Hepcidin: from discovery to differential diagnosis
Kemna, E., Tjalsma, H., Willems, H. L., & Swinkels, D. W. (2007) · Haematologica · doi:10.3324/haematol.11705 · Cited by 318
Gardenghi, S., Marongiu, M. F., Ramos, P., Guy, E. C., Breda, L., Chadburn, A., Liu, Y.-F., Amariglio, N., Rechavi, G., Rachmilewitz, E. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048868 · Cited by 314
Self-citationKautz, L., Jung, G., Du, X., Gabayan, V., Chapman, J., Nasoff, M., Nemeth, E., & Ganz, T. (2015) · Blood · doi:10.1182/blood-2015-07-658419 · Cited by 306
“The Hbb mouse (Th3/1) recapitulates the features of b-thalassemia intermedia in humans, including lowhemoglobin levels, aberrant erythrocytemorphology, increased reticulocyte count, ineffective and extramedullary erythropoiesis, hepatosplenomegaly, and liver and spleen iron overload.(8,9) In contrast to human patients…”
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
Vokurka, M., Krijt, J., Šulc, K., & Nečas, E. (2006) · Physiological Research · doi:10.33549/physiolres.930841 · Cited by 263
“…DMT1 FPN TfR1 TfR2 ferritin 0.0001 0.001 0.01 0.1 1 10 Control P16 R16 RP16 P48 R48 RP48 relative to beta-actin * *** ** † 672 Vokurka et al. Vol. 55 (hpx/hpx) and in thalassemic mice which are both characterized by decreased hepcidin mRNA expression (Weinstein et al. 2002, Adamsky et al. 2004).”
InfluentialSchmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J., Bumcrot, D., & Fleming, M. D. (2013) · Blood · doi:10.1182/blood-2012-09-453977 · Cited by 204
Anemia of inflammation: the hepcidin link
Roy, C. N., & Andrews, N. C. (2005) · Current Opinion in Hematology · doi:10.1097/00062752-200503000-00001 · Cited by 203
Transferrin therapy ameliorates disease in β-thalassemic mice
Li, H., Rybicki, A. C., Suzuka, S. M., von Bonsdorff, L., Breuer, W., Hall, C. B., Cabantchik, Z. I., Bouhassira, E. E., Fabry, M. E., & Ginzburg, Y. Z. (2010) · Nature Medicine · doi:10.1038/nm.2073 · Cited by 192
“Relatively low levels of hepcidin messenger RNA expression in the liver are also characteristic of mouse models of β-thalassemi”
BackgroundIneffective erythropoiesis and thalassemias
Rivella, S. (2009) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32832990a4 · Cited by 191
Self-citationRegulation of Iron Metabolism by Hepcidin under Conditions of Inflammation
Schmidt, P. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.650150 · Cited by 188
“Hepcidin is only regulated at the transcriptional level, and expression is inhibited by anemia, hypoxia (19), and ineffective erythropoiesis (20), and stimulated by iron loading and inflammation.”
BackgroundOxidative stress in β-thalassaemia and sickle cell disease
Voskou, S., Aslan, M., Fanis, P., Phylactides, M., & Kleanthous, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.018 · Cited by 175
“Its levels are decreased in β-thalasseamia due to the ineffective erythropoiesis and subsequent enhanced erythropoietic activity, which increases iron demand [139,3].”
BackgroundUrinary hepcidin in congenital chronic anemias
Kearney, S. L., Nemeth, E., Neufeld, E. J., Thapa, D., Ganz, T., Weinstein, D. A., & Cunningham, M. J. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.20616 · Cited by 172
“Data from a murine model of thalassemia suggested that hepcidin levels are low [15].”
BackgroundDecreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia
Libani, I. V., Guy, E. C., Melchiori, L., Schirò, R., Ramos, P., Breda, L., Scholzen, T. E., Chadburn, A., Liu, Y., Kernbach, M., et al. (2008) · Blood · doi:10.1182/blood-2007-12-126938 · Cited by 162
Self-citationDeletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia
Nai, A., Pagani, A., Mandelli, G., Lidonnici, M. R., Silvestri, L., Ferrari, G., & Camaschella, C. (2012) · Blood · doi:10.1182/blood-2012-01-401885 · Cited by 161
Kattamis, A., Papassotiriou, I., Palaiologou, D., Apostolakou, F., Galani, A., Ladis, V., Sakellaropoulos, N., & Papanikolaou, G. (2006) · PubMed · Cited by 156
Iron Metabolism: Interactions with Normal and Disordered ErythropoiesisPreprint
Ganz, T., & Nemeth, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011668 · Cited by 163
“…prominent under pathological conditions of expanded but ineffective erythropoiesis, seen in b-thalassemia and congenital dyserythropoietic anemias (Adamsky et al. 2004; Papanikolaou et al. 2005) where the large number of apoptosing erythrocyte precursors could generate additional suppressive…”
BackgroundInfluentialMinihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood · doi:10.1182/blood-2015-10-676742 · Cited by 148
“In b-thalassemia and anemia, increased EPO levels and expanded but ineffective erythropoiesis result in lowered hepcidin levels, increased intestinal iron absorption, and TSAT.3,6,8,21,27 In turn, excess iron contributes to the development and worsening of ineffective erythropoiesis and reduced erythroblast maturation…”
BackgroundPakbaz, Z., Fischer, R., Fung, E. B., Nielsen, P., Harmatz, P., & Vichinsky, E. P. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21275 · Cited by 128
“hypoxia or hyperactive bone marrow due to low hemoglobin observed in our nTx-Thal patients would down regulate hepcidin [14,15] and increase iron absorption and iron accumulation in”
BackgroundRivella, S. (2015) · Haematologica · doi:10.3324/haematol.2014.114827 · Cited by 125
Self-citationHereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches
Swinkels, D. W., Janssen, M. C. H., Bergmans, J., & Marx, J. J. M. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.068684 · Cited by 117
“In pilot-scale studies, hepcidin is found to be suppressed for both disorders, with a median hepcidin/ferritin ratio in thalassemia syndromes that is only 5% of that of controls (176), indicating that the erythroid iron needs appears to be dominant over the inhibitory signals of iron stores (80, 127, 177, 178).”
BackgroundFrazer, D. M., Inglis, H. R., Wilkins, S. J., Millard, K. N., Steele, T. M., McLaren, G. D., McKie, A. T., Vulpe, C. D., & Anderson, G. J. (2004) · Gut · doi:10.1136/gut.2003.037416 · Cited by 109
Zhu, B., McLaughlin, S. K., Na, R., Liu, J., Cui, Y., Martin, C., Kimura, A., Robinson, G. W., Andrews, N. C., & Hennighausen, L. G. (2008) · Blood · doi:10.1182/blood-2007-12-127480 · Cited by 107
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
Anderson, E. R., Taylor, M. J., Xue, X., Ramakrishnan, S. K., Martin, A. S., Xie, L., Bredell, B. X., Gardenghi, S., Rivella, S., & Shah, Y. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314197110 · Cited by 101
“Hepcidin expression is decreased in several disorders of secondary hemochromatosis (16, 17).”
BackgroundSelf-citationThe Ins and Outs of Iron Homeostasis
Donovan, A., Roy, C. N., & Andrews, N. C. (2006) · Physiology · doi:10.1152/physiol.00052.2005 · Cited by 101
Interacting signals in the control of hepcidin expression
Darshan, D., & Anderson, G. J. (2009) · BioMetals · doi:10.1007/s10534-008-9187-y · Cited by 95
Gardenghi, S., Grady, R. W., & Rivella, S. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.08.003 · Cited by 98
“In the case of mice affected by β-thalassemia intermedia, it has been observed that they exhibit very low hepcidin levels during the first months of life (16,89,91,97-99).”
BackgroundSelf-citationHepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53
Weizer‐Stern, O., Adamsky, K., Margalit, O., Ashur‐Fabian, O., Givol, D., Amariglio, N., & Rechavi, G. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06638.x · Cited by 94
“Hepcidin is upregulated in response to increased body iron levels (Gehrke et al, 2003) or to inflammation (Nemeth et al, 2004b), and is downregulated in response to hypoxia, anaemia (Nicolas et al, 2002; Adamsky et al, 2004) and oxidative stress (Choi et al, 2007).”
BackgroundSelf-citationLow molecular weight heparin in pregnancy: current issues
Greer, I. A., & Hunt, B. J. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05304.x · Cited by 93
Ineffective Erythropoiesis: Anemia and Iron Overload
Gupta, R., Musallam, K. M., Taher, A. T., & Rivella, S. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.11.009 · Cited by 94
Self-citationRachmilewitz, E. A., Weizer‐Stern, O., Adamsky, K., Amariglio, N., Rechavi, G., Breda, L., Rivella, S., & Cabantchik, Z. I. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1345.014 · Cited by 87
Self-citationThe role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia
Fibach, E., & Rachmilewitz, E. A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05577.x · Cited by 85
Self-citationWeizer‐Stern, O., Adamsky, K., Amariglio, N., Levin, C., Koren, A., Breuer, W., Rachmilewitz, E., Breda, L., Rivella, S., Ioav Cabantchik, Z., et al. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06258.x · Cited by 80
“We have previously shown that HAMP mRNA is decreased in the livers of Hbbth3/+ b-thalassaemia intermedia (TI) mice (Adamsky et al, 2004) and even more so in the Hbbth3/th3 TM mouse model (WeizerStern et al, 2006).”
BackgroundResultSelf-citationSchmidt, P. J., Racie, T., Westerman, M., Fitzgerald, K., Butler, J. S., & Fleming, M. D. (2015) · American Journal of Hematology · doi:10.1002/ajh.23934 · Cited by 77
“Similar to their human counterparts, these animals have moderately severe, transfusion-independent hypochromic, microcytic anemia associated and ineffective erythropoeisis resulting in splenomegaly, hepcidin suppression, and secondary iron overload [4–7].”
BackgroundHepcidin: A novel peptide hormone regulating iron metabolism
Singh, B., Arora, S., Agrawal, P., & Gupta, S. K. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.02.014 · Cited by 61
-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
Melchiori, L., Gardenghi, S., & Rivella, S. (2010) · Advances in Hematology · doi:10.1155/2010/938640 · Cited by 77
“…one of the first monogenic diseases to be described and represents a global health problem, only recently has the scientific community started to focus on the real molecular mechanisms that underlie this disease, opening new and exciting therapeutic perspectives for thalassemic patients worldwide.”
Self-citationWeizer-Stern, O., Adamsky, K., Amariglio, N., Rachmilewitz, E., Breda, L., Rivella, S., & Rechavi, G. (2006) · American Journal of Hematology · doi:10.1002/ajh.20549 · Cited by 71
“We have shown previously that hepcidin liver mRNA expression is decreased in the liver of Hbbth3/þ b-thalassemia intermedia mouse model [16].”
Self-citationDecreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice
Li, H., Choesang, T., Bao, W., Chen, H., Feola, M., Garcia‐Santos, D., Li, J., Sun, S., Follenzi, A., Pham, P., et al. (2017) · Blood · doi:10.1182/blood-2016-09-742387 · Cited by 72
“Mouse models of b-thalassemia also exhibit relatively low hepcidin.(10) Lack of appropriately increased hepcidin despite increased parenchymal iron stores suggests that a competing signal is counterregulating hepcidin expression,(11-13) establishing b-thalassemia as an important opportunity for evaluating erythroid re…”
BackgroundSelf-citationHepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Jones, E., Pasricha, S.-R., Allen, A., Evans, P., Fisher, C. A., Wray, K., Premawardhena, A., Bandara, D., Perera, A., Webster, C., et al. (2015) · Blood · doi:10.1182/blood-2014-10-606491 · Cited by 68
“Hepcidin concentrations are suppressed in b-thalassemia,(11,12) as is hepatic HAMP mRNA expression in patients with thalassemia major (TM)(13,14) and in the C57Bl/6 Hbb thalassemia mouse model.(15) However, patients with thalassemia intermedia exhibit lower liver HAMP mRNA than those with TM,(14) probably because of t…”
BackgroundArezes, J., Foy, N., McHugh, K., Quinkert, D., Benard, S., Sawant, A., Frost, J. N., Armitage, A. E., Pasricha, S., Lim, P. J., et al. (2020) · Blood · doi:10.1182/blood.2019003140 · Cited by 73
Pietrangelo, A., & Trautwein, C. (2004) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0019 · Cited by 69
Hepcidin: an important new regulator of iron homeostasis
Hugman, A. (2006) · Clinical & Laboratory Haematology · doi:10.1111/j.1365-2257.2006.00768.x · Cited by 62
“Thalassaemic mice with iron overload have significantly lower hepcidin expression compared with controls, supporting the dominant force of anaemia over hepatic iron in hepcidin induction (Adamsky et al., 2004).”
BackgroundLyoumi, S., Abitbol, M., Andrieu, V., Hénin, D., Robert, E., Schmitt, C., Gouya, L., de Verneuil, H., Deybach, J., Montagutelli, X., et al. (2006) · Blood · doi:10.1182/blood-2006-04-014142 · Cited by 63
Survival of the fittest: in vivo selection and stem cell gene therapy
Neff, T., Beard, B. C., & Kiem, H. (2005) · Blood · doi:10.1182/blood-2005-06-2335 · Cited by 63
Mattè, A., Low, P. S., Turrini, F., Bertoldi, M., Campanella, M. E., Spano, D., Pantaleo, A., Siciliano, A., & Franceschi, L. D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.05.003 · Cited by 60
“severe β-thalassemia intermedia (Hbbth3/+) (Table 1) [24,37,38].”
BackgroundLiver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.
Franceschi, L. D., Daraio, F., Filippini, A., Carturan, S., Muchitsch, E. M., Roetto, A., & Camaschella, C. (2006) · PubMed · Cited by 57
Chapter 6 Iron Homeostasis and Erythropoiesis
Wrighting, D. M., & Andrews, N. C. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00006-3 · Cited by 59
Iron dysregulation in beta-thalassemia
Leecharoenkiat, K., Lithanatudom, P., Sornjai, W., & Smith, D. R. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.07.035 · Cited by 52
Beaumont, C., & Canonne‐Hergaux, F. (2005) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2005.04.017 · Cited by 57
Animal models with enhanced erythropoiesis and iron absorption
Latunde-Dada, G. O., McKie, A. T., & Simpson, R. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.12.007 · Cited by 50
“Hepcidin levels are decreased in beta thalassaemic mice [106].”
BackgroundHoofnagle, M. H., Wamhoff, B. R., & Owens, G. K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21761 · Cited by 47
“reduced cholesteryl ester transfer protein– mediated transfer of triglyceride to LDLs and subsequent lipolysis (10, 13).”
BackgroundInfluentialFrazer, D. M., Wilkins, S. J., Darshan, D., Badrick, A. C., McLaren, G. D., & Anderson, G. J. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09104.x · Cited by 43
“Hepatic Hamp expression was decreased, as shown previously (Adamsky et al, 2004), however, in agreement with our PHZ model, Bmp6 expression was significantly increased (Fig 6C).”
ResultModulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders
Schmidt, P. J., & Fleming, M. D. (2014) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2013.11.004 · Cited by 43
“roblasts) seem to uniquely potently suppress hepcidin production even in the presence of systemic iron overload.(7) The factor or factors that communicate this signal from the bonemarrow to the liver to suppress hepcidin have been termed the erythroid regulator of iron metabolism.”
BackgroundIron overload in myelodysplastic syndromes
Mahesh, S. A., Ginzburg, Y. Z., & Verma, A. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701843221 · Cited by 40
“A mouse model of b-thalassemia also indicates that hepcidin mRNA expression is decreased [18].”
BackgroundHAMP promoter hypomethylation and increased hepcidin levels as biomarkers for Kawasaki disease
Huang, Y., Kuo, H., Li, S.-C., Cai, X.-Y., Liu, S., & Kuo, H. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.017 · Cited by 34
Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis
Winder, A., Lefkowitz, R., Ghoti, H., Leiba, M., Ganz, T., Nemeth, E., & Rachmilewitz, E. A. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07225.x · Cited by 33
“Hepcidin is increased in response to increased body iron levels, transferrin saturation (Ganz & Nemeth, 2006) or inflammation, and is decreased in response to hypoxia, (Nicolas et al, 2002) erythropoietic activity (Adamsky et al, 2004) and oxidative stress (Choi et al, 2007).”
BackgroundSelf-citationRegulation of Iron Absorption in Hemoglobinopathies
Rechavi, G., & Rivella, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408786241401 · Cited by 32
Self-citationExogenous iron increases hemoglobin in β–thalassemic mice
Ginzburg, Y. Z., Rybicki, A. C., Suzuka, S. M., Hall, C. B., Breuer, W. V., Cabantchik, Z. I., Bouhassira, E. E., Fabry, M. E., & Nagel, R. L. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.10.004 · Cited by 33
Schmidt, P. J., Liu, K., Visner, G. A., Fitzgerald, K. J., Fishman, S., Racie, T., Hettinger, J. L., Butler, J. S., & Fleming, M. D. (2018) · American Journal of Hematology · doi:10.1002/ajh.25079 · Cited by 31
Hepcidin and Hfe in iron overload in β‐thalassemia
Gardenghi, S., Ramos, P., Follenzi, A., Rao, N., Rachmilewitz, E. A., Giardina, P. J., Grady, R. W., & Rivella, S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05595.x · Cited by 27
Self-citationLiver-gut axis in the regulation of iron homeostasis
Darshan, D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4737 · Cited by 31
Pathophysiology and therapy for haemoglobinopathies; Part II: thalassaemias
Urbinati, F., Madigan, C., & Malik, P. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406010805 · Cited by 26
Liu, J., Liu, W., Liu, Y., Miao, Y., Guo, Y., Song, H., Wang, F., Zhou, H., Ganz, T., Yan, B., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.209874 · Cited by 30
“The common mechanism is lower level of hepcidin compared to that in Wt mice, giving rise to enhanced dietary iron uptake and iron egress out of macrophages and consequently iron deposition in various organs, especially the liver.(36,43) However in β-thalassemias, unlike in HH, ineffective erythropoiesis and hemolysis…”
BackgroundBeta‐thalassemia and the advent of new interventions beyond transfusion and iron chelation
Chauhan, W., Shoaib, S., Fatma, R., Zaka‐ur‐Rab, Z., & Afzal, M. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15343 · Cited by 27
“ship between relatively reduced hepcidin mRNA levels in the liver and iron overload in this disorder (Table 1).(56,57) IE can be therapeutically targeted at different sites as follows:”
BackgroundOlivera, J. D., Zhang, V., Nemeth, E., & Ganz, T. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022009307 · Cited by 25
“Studies in human subjects and mice have documented that augmented erythropoietic activity, whether in response to blood loss, EPO, or ineffective erythropoiesis, generates 1 or more signals that suppress the production of the iron-regulatory hormone hepcidin.(3,4,7,8,12,25,26) ERFE, a glycoprotein erythrokine produced…”
BackgroundFuture alternative therapies for β-thalassemia
Rivella, S., & Rachmilewitz, E. A. (2009) · Expert Review of Hematology · doi:10.1586/ehm.09.56 · Cited by 23
Self-citationClinical Perspectives on Hereditary Hemochromatosis
Ayonrinde, O. T., Milward, E. A., Chua, A. C. G., Trinder, D., & Olynyk, J. K. (2008) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360802335716 · Cited by 23
Where do we go now with low molecular weight heparin use in obstetric care?
Patel, J. P., & Hunt, B. J. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03048.x · Cited by 20
What regulates hepcidin in poly-transfused β-Thalassemia Major: Erythroid drive or store drive?
Chauhan, R., Sharma, S., & Chandra, J. (2014) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.130891 · Cited by 20
Saad, H. K. M., Rahman, A. A. A., Ghani, A. S. A., Taib, W. R. W., Ismail, I., Johan, M. F., Al-wajeeh, A. S., & Al‐Jamal, H. A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10010189 · Cited by 22
“Hepcidin expression in thalassemia was first reported in a mouse model of severe anemia (C57BI/6 Hbbth3/+) [38].”
BackgroundInfluentialBreda, L., Gardenghi, S., Guy, E. C., Rachmilewitz, E. A., Weizer‐Stern, O., Adamsky, K., Amariglio, N., Rechavi, G., Giardina, P. J., Grady, R. W., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1345.069 · Cited by 19
Self-citationHepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes
Andriopoulos, B., & Pantopoulos, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.025 · Cited by 18
“mouse models of hemochromatosis [17–23] and thalassemia [24].”
BackgroundCampos‐Sánchez, J. C., Serna-Duque, J. A., Alburquerque, C., Guardiola, F. A., & Esteban, M. Á. (2024) · Marine Biotechnology · doi:10.1007/s10126-024-10293-0 · Cited by 15
“On the other hand, since hepcidins seem to be regulated only at the transcriptional level (Nicolas et al. 2002; Adamsky et al. 2004), the overrepresented presence of various inflammatory TFBS such as STAT3 or NF-κB (REL and RELA) located in their promoter regions could be a very relevant data in…”
BackgroundRosato, B. E., Marra, R., D’Onofrio, V., Giudice, F. D., Monica, S. D., Iolascon, A., Andolfo, I., & Russo, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031304 · Cited by 13
“It is now clear that stimulated erythrocyte precursors produce one or more hepcidin-suppressive factors [31,32].”
BackgroundPathogenic Mechanisms in Thalassemia II
Ganz, T., & Nemeth, E. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.12.006 · Cited by 17
Fan, Q., Zhou, Y., Yu, C., Chen, J., Shi, X., Zhang, Y., & Zheng, W. (2016) · PeerJ · doi:10.7717/peerj.2413 · Cited by 11
“The response of these Fe regulatory proteins to variations of systemic Fe status has been established in literature (Adamsky et al., 2004; Gehrke et al., 2003; Theurl et al., 2008); however their expression at the translational level in the human body as affected by Mn exposure has never been investigated.”
BackgroundZaman, B. A., & Ibrahim, S. (2022) · Hemoglobin · doi:10.1080/03630269.2022.2083969 · Cited by 9
Saad, H., Taib, W. R. W., Ismail, I., Johan, M. F., Al-wajeeh, A. S., & Al‐Jamal, H. A. N. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10838 · Cited by 8
“These findings were similar to previous studies reporting that HEPC expression in β‐thalassemia is downregulated in β‐thalassemia mice (36,37).”
ResultHepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8
Upanan, S., McKie, A. T., Latunde-Dada, G. O., Roytrakul, S., Uthaipibull, C., Pothacharoen, P., Kongtawelert, P., Fucharoen, S., & Srichairatanakool, S. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2231-3 · Cited by 5
Métabolisme du fer : physiologie et pathologie
Beaumont, C., & Girot, R. (2010) · Encyclopédie médico-chirurgicale. Hématologie · doi:10.1016/s1155-1984(10)49948-3 · Cited by 7
Troadec, M., Loréal, O., & Brissot, P. (2006) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(06)40611-9 · Cited by 5
Fetal Factors Disrupt Placental and Maternal Iron Homeostasis in Murine β-Thalassemia
Yang, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Zhu, S., Nemeth, E., Garrick, L. M., Garrick, M. D., & Collins, J. F. (2023) · Blood · doi:10.1182/blood.2022018839 · Cited by 4
Duca, L., Delbini, P., Nava, I., Cappellini, M. D., & Meo, A. (2009) · Internal and Emergency Medicine · doi:10.1007/s11739-009-0306-8 · Cited by 4
“thalassemia major) and in patients with thalassemia major urinary hepcidin was disproportionately suppressed in regard to iron burden [ 2 ].”
BackgroundKobayashi, Y., Wakasugi, E., Ohbuchi, T., YOKOYAMA, M., Yasui, R., Kuwahata, M., Nakabou, Y., & Kido, Y. (2011) · Biomedical Research-tokyo · Cited by 4
Yu, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Shine, J. S., Zhu, S., He, Y., & Collins, J. F. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013333 · Cited by 4
“39,40 Low hepcidin in young Th3/+ mice may increase iron absorption and precipitate iron loading; however, unlike the situation in humans, 41-43 hepcidin levels normalize in Th3/+ mice as they approach adulthood.”
ДОНАЦІЇ КРОВІ І МЕТАБОЛІЗМ ЗАЛІЗА
Видиборець, С. В., & Дерпак, Ю. (2022) · Іnternational Science Group eBooks · doi:10.46299/979-8-88831-933-8 · Cited by 3
Molecular Regulation of Systemic Iron Metabolism
Ganz, T., & Vaulont, S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_9 · Cited by 4
The Role of Hepcidin in Iron Homeostasis
Ganz, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_3 · Cited by 3
“, 2007) and in the mouse models of b-thalassemia (Adamsky et al., 2004; Breda et al., 2005; Gardenghi et al., 2007).”
BackgroundDisorders of Red Cell Production and the Iron-Loading Anemias
Rivella, S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_16 · Cited by 2
Self-citationNormal iron absorption and metabolism
Barton, J. C., Edwards, C. Q., Phatak, P. D., Britton, R. S., & Bacon, B. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777035.004 · Cited by 1
Role of Hepcidin in Dysregulation of Iron Metabolism and Anemia of Chronic Diseases
Singh, B. M., Arora, S., Gupta, S., & Saxena, A. (2012) · BiblioBoard Library Catalog (Open Research Library) · doi:10.5772/27286 · Cited by 1
“Murine models of human thalassemia, have also demonstrated decreased hepcidin mRNA expression [84].”
BackgroundMécanismes impliqués dans la régulation de l’absorption intestinale du fer
Nicolas, G., Vaulont, S., & Beaumont, C. (2004) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(04)94453-7 · Cited by 1
Metadata
- Authors
- Adamsky, K., Weizer, O., Amariglio, N., Breda, L., Harmelin, A., Rivella, S., Rachmilewitz, E., & Rechavi, G.
- Affiliations
- Tel Aviv University (IL)
- Cornell University (US)
- Weizmann Institute of Science (IL)
- Wolfson Medical Center (IL)
- Corresponding author
- Rachmilewitz, Eliezer
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2003-12-11
- Volume
- 124
- Issue
- 1
- Pages
- 123-124
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W1983551732
- Cited by
- 108
- References
- 9
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Hospitals of Leicester NHS Trust
- Strong
- British Society for Haematology
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- hepcidin, mRNA expression, thalassemia, iron metabolism
- MeSH terms
- Animals, Mice, Inbred C57BL, RNA, Messenger, Thalassemia, Antimicrobial Cationic Peptides, Mice, Hepcidins
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