The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
Open accessAbstract
SUMMARY: To investigate the role of B cells in the development of CIA, a model for rheumatoid arthritis, we investigated susceptibility to CIA in mice lacking B cells due to the deletion of the IgM heavy chain gene (μMT). The μMT deletion was backcrossed into two different CIA-susceptible strains, B10.Q and B10.RIII. Two different variants of the CIA model are inducible in these strains: in B10.Q with rat type II collagen (CII) and in B10.RIII with bovine CII. Homozygous deletion of the IgM gene led to the absence of B cells and dramatically reduced immunoglobulin levels compared with wild-type mice. The deletion of IgM totally abrogated development of CIA in both strains, although the anti-CII T cell response did not differ between the μMT and wild-type controls. We conclude that B cells play a crucial role in the development of CIA.
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Cites
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Cited by
B‐lymphocyte contributions to human autoimmune disease
Yanaba, K., Bouaziz, J., Matsushita, T., Magro, C. M., St.Clair, E. W., & Tedder, T. F. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00646.x · Cited by 326
Young, D. A., Hegen, M., Ma, H. L. M., Whitters, M. J., Albert, L. M., Lowe, L., Senices, M., Wu, P. W., Sibley, B., Leathurby, Y., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22452 · Cited by 275
Induction and Suppression of Collagen-Induced Arthritis Is Dependent on Distinct Fcγ Receptors
Kleinau, S., Martinsson, P., & Heyman, B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.9.1611 · Cited by 255
Takahashi, D., Hoshina, N., Kabumoto, Y., Maeda, Y., Suzuki, A., Tanabe, H., Isobe, J., Yamada, T., Muroi, K., Yanagisawa, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102913 · Cited by 205
Pizzolla, A., Hultqvist, M., Nilson, B., Grimm, M. J., Eneljung, T., Jonsson, I.-M., Verdrengh, M., Kelkka, T., Gjertsson, I., Segal, B. H., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103430 · Cited by 108
Self-citation
Metadata
- Authors
- Svensson, L., Jirholt, J., Holmdahl, R., & Jansson, L.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-03
- Volume
- 111
- Issue
- 3
- Pages
- 521-526
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W2041019072
- Cited by
- 314
- References
- 31
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Svensson, L., Jirholt, J., Holmdahl, R., & Jansson, L. (2001). B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clinical and Experimental Immunology. https://doi.org/10.1046/j.1365-2249.1998.00529.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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