Cited by 301Adipokines, Inflammation, and Metabolic DiseasesInflammatory Biomarkers in Disease PrognosisGenetics, Aging, and Longevity in Model Organisms

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Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

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BRUUNSGAARD, H, LADELUND, S, PEDERSEN, A N, SCHROLL, M, JØRGENSEN, T, PEDERSEN, B K·2003·Clinical and Experimental Immunology

DOI 10.1046/j.1365-2249.2003.02137.xPMC PMC1808682

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Abstract

SUMMARY: Ageing is associated with low-grade inflammation and markers such as IL-6 possess prognostic value. Tumour necrosis-alpha (TNF-α) initiates the inflammatory cascade and has been linked to several age-associated disorders. It remains, however, unknown if TNF-α is associated with mortality in old populations. The aim of the present study was to investigate if serum levels of TNF-α were associated with all-cause mortality independently of interleukin (IL)-6 in a prospective study of 333 relatively healthy 80-year-old people. A Cox regression model was used to explore effects of TNF-α and IL-6 on survival in the following 6 years. A total of 133 participants died during this follow-up period. TNF-α was associated with mortality in men, but not in women, whereas low-grade elevations in IL-6 were associated strongly with mortality in both sexes. TNF-α explained only 7% of the variability in IL-6 and effects of the two cytokines were independent of each other as well as of other traditional risk factors for death [smoking, blood pressure, physical exercise, total cholesterol, co-morbidity, body mass index (BMI) and intake of anti-inflammatory drugs]. These findings indicate that at least in old populations chronic elevated levels of TNF-α and IL-6 have different biological functions that trigger age-associated pathology and cause mortality.

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Authors: BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K.
Affiliations: Department of Infectious Diseases, H:S, Rigshospitalet, University of Copenhagen
Glostrup Hospital (DK)
Center for Preventive Medicine, Glostrup University Hospital
Bispebjerg Hospital (DK)
ORCID: LADELUND, S
JØRGENSEN, T
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 2003-03-24
Volume: 132
Issue: 1
Pages: 24-31
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1046/j.1365-2249.2003.02137.x
PMC: PMC1808682
OpenAlex: W1983973676
Cited by: 300
References: 45
Citations by year: 2026: 4 · 2025: 10 · 2024: 12 · 2023: 18 · 2022: 27 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 14 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 17
FWCI: 7.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: TNF-α, interleukin-6, all-cause mortality, low-grade inflammation, aging, older adults, serum cytokines, sex differences, prognostic factors, age-related diseases
MeSH terms: Aged, Aged, 80 and over, Cause of Death, Death, Female, Humans, Male, Predictive Value of Tests, Prospective Studies, Regression Analysis, Risk Factors, Sex Factors, Tumor Necrosis Factor-alpha, Interleukin-6, Comorbidity, Survival Rate

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Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

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