Central Circadian Clock Regulates Energy Metabolism

Ding, Guolian; Gong, Yingyun; Eckel-Mahan, Kristin L.; Sun, Zheng

doi:10.1007/978-981-13-1286-1_5

Cited by 33Circadian rhythm and melatoninSleep and Wakefulness ResearchHypothalamic control of reproductive hormones

Central Circadian Clock Regulates Energy Metabolism

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Ding, Guolian, Gong, Yingyun, Eckel-Mahan, Kristin L., Sun, Zheng·2018·Advances in Experimental Medicine and Biology

DOI 10.1007/978-981-13-1286-1_5PMC PMC6324174

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Abstract

Our body not only responds to environmental changes but also anticipates them. The light and dark cycle with the period of about 24 h is a recurring environmental change that determines the diurnal variation in food availability and safety from predators in nature. As a result, the circadian clock is evolved in most animals to align locomotor behaviors and energy metabolism with the light cue. The central circadian clock in mammals is located at the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain. We here review the molecular and anatomic architecture of the central circadian clock in mammals, describe the experimental and observational evidence that suggests a critical role of the central circadian clock in shaping systemic energy metabolism, and discuss the involvement of endocrine factors, neuropeptides, and the autonomic nervous system in the metabolic functions of the central circadian clock.

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Eating late can cause circadian disruption, resulting in production of free cortisol, changes in daily rhythms of body temperature, decreased resting energy expenditure, and decreased glucose tolerance.
“Eating late can cause circadian disruption, resulting in production of free cortisol, changes in daily rhythms of body temperature, decreased resting energy expenditure, and decreased glucose tolerance.”
From Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance (2021) · cites this paper as [92]
The Introduction and “Light and feeding” section (pages not provided) report that feeding during the normal sleep phase disturbed metabolism in animals. “Intrinsic rhythm of energy metabolism” reports lower glucose tolerance in humans at evening or night, but does not establish that late eating causes it. The cited passages do not link late eating to free cortisol production, changes in body-temperature rhythms, or decreased resting energy expenditure. (LLM, conf=0.87)
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Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance
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Authors: Ding, G., Gong, Y., Eckel-Mahan, K. L., & Sun, Z.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Sun, Zheng
ORCID: Ding, Guolian
Gong, Yingyun
Sun, Zheng
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer Singapore
Published: 2018
Volume: 1090
Pages: 79-103
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-981-13-1286-1_5
PMC: PMC6324174
OpenAlex: W2898863223
Cited by: 33
References: 191
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 1 · 2016: 1
FWCI: 5.33
Type: book chapter
Language: en
Update notices: correction (2019-07-02)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Natural Science Foundation of China
National Institutes of Health
National Institutes of Natural Sciences
National Cancer Institute (R21CA215591)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK111436)
National Institute of Environmental Health Sciences (R01ES027544)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: circadian clock, suprachiasmatic nucleus, energy metabolism, diurnal cycle, light-dark cycle, hormonal regulation, neuropeptides, autonomic nervous system
MeSH terms: Animals, Autonomic Nervous System, Circadian Rhythm, Endocrine System, Energy Metabolism, Suprachiasmatic Nucleus, Circadian Clocks

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