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Cited by 97Fatty Acid Research and HealthAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers

Seljeflot, Arnesen, Brude, Nenseter, Drevon, Hjermann·1998·European Journal of Clinical Investigation
DOI 10.1046/j.1365-2362.1998.00336.x
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Abstract

BACKGROUND: Increased expression of cell adhesion molecules and increased procoagulant activity of the vascular endothelium have been postulated to characterize dysfunctional endothelium. The cellular effects of n-3 fatty acids (n-3 FAs) and antioxidants are still not clarified. METHODS: In a randomized, factorial two-by-two design study, we have investigated 41 male smokers with hyperlipidaemia before and after 6 weeks of supplementation with either n-3 FAs (4.8 g daily) or placebo with the addition of antioxidants (150 mg of vitamin C, 75 mg of vitamin E and 15 mg of beta-carotene daily) or placebo with regard to the effects on some endothelial cell markers: thrombomodulin (sTM), von Willebrand factor (vWF), tissue plasminogen activator antigen (tPAag) and soluble forms of the cell adhesion molecules E-selectin, P-selectin and vascular cell adhesion molecule 1 (VCAM-1). RESULTS: In the n-3 FA group, significant reductions in the plasma levels of vWF (P = 0.034) and sTM (P < 0.001) were demonstrated compared with placebo, whereas increased levels were found for E-selectin (P = 0.001) and VCAM-1 (P = 0.010). In the antioxidant group, no differences in changes were noted for any of the variables. CONCLUSION: The reduction in the levels of sTM and vWF with n-3 FA supplementation could indicate an improvement with regard to the haemostatic markers of endothelial dysfunction, whereas the simultaneous increase in the soluble forms of E-selectin and VCAM-1 may suggest an adverse effect on the inflammatory system. The antioxidants seem to be neutral in their effect on these endothelial cell markers in our study population of smokers. The interpretation of the soluble forms of these molecules are, however, still debatable.

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Crossref · 10.1046/j.1365-2362.1998.00336.x

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  • In 39 patients with intermittent claudication, supervised exercise significantly reduced serum CRP and SAA at 3 and 6 months compared with controls.

    “A randomised trial of thirty-nine patients with intermittent claudication demonstrated that both serum CRP and SAA concentrations were significantly reduced after 3 and 6 months of supervised exercise compared with controls (235) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [235]

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Authors
Seljeflot, Arnesen, Brude, Nenseter, Drevon, & Hjermann
Affiliations
  • Oslo University Hospital (NO)
  • University of Oslo (NO)
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1998-08
Volume
28
Issue
8
Pages
629-635
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1046/j.1365-2362.1998.00336.x
OpenAlex
W1995072729
Cited by
97
References
52
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
5.75
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1242 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
omega-3 fatty acids, antioxidants, endothelial dysfunction, adhesion molecules, von Willebrand factor, thrombomodulin, E-selectin, VCAM-1, P-selectin, tissue plasminogen activator, smokers, hyperlipidemia, vitamin C, vitamin E, beta-carotene, hemostasis, inflammation
MeSH terms
Adult, Antioxidants, Cholesterol, Double-Blind Method, Endothelium, Vascular, Fatty Acids, Humans, Hyperlipidemias, Lipoproteins, Male, Middle Aged, Tissue Plasminogen Activator, Smoking, Triglycerides, Vitamin E, von Willebrand Factor, Biomarkers, Fatty Acids, Omega-3, Thrombomodulin, P-Selectin, Vascular Cell Adhesion Molecule-1, E-Selectin

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