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Cited by 129Fatty Acid Research and HealthNutritional Studies and DietEdible Oils Quality and Analysis

Mediterranean-inspired diet lowers the ratio of serum phospholipid n–6 to n–3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects

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Ambring, Anneli, Johansson, Mats, Axelsen, Mette, Gan, LiMing, Strandvik, Birgitta, Friberg, Peter·2006·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn.83.3.575
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Abstract

Background Reduced cardiovascular mortality and morbidity have been shown in persons adhering to Mediterranean-inspired diets (MIDs). Although the underlying mechanisms of this association are poorly understood, the importance of increasing dietary amounts of polyunsaturated fatty acids of the n-3 series has been emphasized.Objective We investigated whether a MID provided to healthy subjects would affect 1) the inflammatory process and endothelial indexes such as vasoregulation and vascular endothelial growth factor (VEGF) and 2) serum phospholipid fatty acid composition.Design A total of 22 subjects (10 women) received a MID or an ordinary Swedish diet (OSD) for 4 wk in a crossover fashion. Concentrations of lipids and fatty acids, high-sensitivity C-reactive protein, and interleukin 6, both before and after lipopolysaccharide stimulation; the number of leukocytes and platelets; and VEGF and monocyte chemoattractant protein 1 were analyzed.Results The plasma ratio of n-6 to n-3 fatty acids was substantially lower after the MID than after the OSD (x +/- SEM: 4.72 +/- 0.19 and 2.60 +/- 0.17, respectively; P < 0.0001). Neither C-reactive protein nor interleukin 6 concentrations changed significantly after the MID compared with the OSD. The total number of leukocytes and platelets was 10% (P < 0.05) and 15% (P < 0.001) lower, respectively, after the MID than after the OSD. Serum VEGF concentrations were lower after the MID than after the OSD (237 +/- 30 and 206 +/- 25 pg/mL, respectively; P = 0.0014).Conclusions A MID reduces the number of platelets and leukocytes and VEGF concentrations in healthy subjects. This may be linked to higher serum concentrations of n-3 fatty acids, which promote a favorable composition of phospholipids.

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  • Several training interventions did not change basal IL-6 or CRP concentrations.

    “Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [214]

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Authors
Ambring, A., Johansson, M., Axelsen, M., Gan, L., Strandvik, B., & Friberg, P.
Affiliations
University of Gothenburg (SE)
Corresponding author
Friberg, Peter
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2006-03
Volume
83
Issue
3
Pages
575-581
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn.83.3.575
OpenAlex
W2098993721
Cited by
129
References
30
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 11 · 2015: 5 · 2014: 9 · 2013: 3 · 2012: 11
FWCI
9.10
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords
serum phospholipid fatty acids, omega-3 fatty acids, vascular endothelial growth factor, platelets, leukocytes, inflammation, C-reactive protein, interleukin-6, MCP-1, lipopolysaccharide stimulation, cardiovascular risk, healthy volunteers
MeSH terms
Adult, C-Reactive Protein, Female, Humans, Leukocyte Count, Male, Middle Aged, Phospholipids, Platelet Count, Fatty Acids, Omega-3, Interleukin-6, Cross-Over Studies, Chemokine CCL2, Diet, Mediterranean, Vascular Endothelial Growth Factor A, Fatty Acids, Omega-6

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