The role of TNFα and TNF receptors in obesity and insulin resistance

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

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The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

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Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

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Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

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Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

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The expression of TNF alpha by human muscle. Relationship to insulin resistance.

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The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

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Redox Control of Liver Function in Health and Disease

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Resistin and Adiponectin Expression in Visceral Fat of Obese Rats: Effect of Weight Loss

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Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

Rangwala, S. M., Rich, A. S., Rhoades, B., Shapiro, J. S., Obici, S., Rossetti, L., & Lazar, M. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1937 · Cited by 195

Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation

Weiss, R., Dufour, S., Groszmann, A., Petersen, K. F., Dziura, J. D., Taksali, S. E., Shulman, G. I., & Caprio, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021711 · Cited by 193

Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Orthotopic Liver Transplantation

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Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes

van Harmelen, V., Dicker, A., Rydén, M., Hauner, H., Lönnqvist, F., Näslund, E. B., & Arner, P. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2029 · Cited by 188

Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells

Anderson, H. D. I., Rahmutula, D., & Gardner, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309552200 · Cited by 186

Tumor Necrosis Factor-α in Heart Failure: an Updated Review

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Tumour necrosis factor‐alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and cardiovascular risk factors

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Tumor Necrosis Factor-α Inhibits Insulin’s Stimulating Effect on Glucose Uptake and Endothelium-Dependent Vasodilation in Humans

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Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome

Cortón, M., Botella-Carretero, J. I., Benguría, A., Villuendas, G., Zaballos, Á., Millán, J. L. S., Escobar-Morreale, H. F., & Peral, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1665 · Cited by 174

Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers

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Muscle dysfunction in type 2 diabetes: a major threat to patient’s mobility and independence

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Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor

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Stability and reproducibility of proteomic profiles measured with an aptamer-based platform

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Expression of adiponectin and its receptors in swine1,2

Lord, É., Ledoux, S., Murphy, B. D., Beaudry, D., & Palin, M. (2005) · Journal of Animal Science · doi:10.2527/2005.833565x · Cited by 169

Insulin Resistance in Equids: Possible Role in Laminitis

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Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth

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Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999–2004 National Health and Nutrition Examination Survey

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Increased visfatin concentrations in women with gestational diabetes mellitus

Krzyżanowska, K., Krugluger, W., Mittermayer, F., Rahman, R. A., Haider, D. G., Shnawa, N., & Schernthaner, G. (2006) · Clinical Science · doi:10.1042/cs20050363 · Cited by 166

Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers

de Gonzalo‐Calvo, D., Neitzert, K., Fernández, M. F., Vega‐Naredo, I., Caballero, B., Macia, M. G., Suárez, F. M., Rodríguez‐Colunga, M. J., Solano, J. J., & Coto‐Montes, A. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.05.019 · Cited by 165

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

Wong, A., Howie, J., Petrie, J. R., & Lang, C. C. (2009) · Clinical Science · doi:10.1042/cs20080066 · Cited by 170

Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes

Kralisch, S., Klein, J. C., Lössner, U., Blüher, M., Paschke, R., Stümvoll, M., & Faßhauer, M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06211 · Cited by 165

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197

Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

White, M. F. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-008 · Cited by 164

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154

11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Lean and Obese Males with Type 2 Diabetes Mellitus

Valsamakis, G., Anwar, A., Tomlinson, J., Shackleton, C. H. L., McTernan, P. G., Chetty, R., Wood, P. J., Banerjee, A. K., Holder, G., Barnett, A. H., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032240 · Cited by 156

Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes

Fujinami, A., Obayashi, H., Ohta, K., Ichimura, T., Nishimura, M., Matsui, H., Kawahara, Y., Yamazaki, M., Ogata, M., Hasegawa, G., et al. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.009 · Cited by 158

Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice

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Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport

Horita, S., Seki, G., Yamada, H., Suzuki, M., Koike, K., & Fujita, T. (2011) · International Journal of Hypertension · doi:10.4061/2011/391762 · Cited by 158

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00631.x · Cited by 146

The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial

Caballero, A. E., Delgado, A., Aguilar-Salinas, C. A., Herrera, A. N., Castillo, J. L., Cabrera, T., Gomez-Perez, F. J., & Rull, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0019 · Cited by 151

Processing, signaling, and physiological function of chemerin

Mattern, A., Zellmann, T., & Beck‐Sickinger, A. G. (2014) · IUBMB Life · doi:10.1002/iub.1242 · Cited by 151

Differential Regulation of Adipocytokine mRNAs by Rosiglitazone in db/db Mice

Moore, G. B. T., Chapman, H., Holder, J. C., Lister, C. A., Piercy, V., Smith, S. A., & Clapham, J. C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5460 · Cited by 150

Moderate alcohol consumption and lower levels of inflammatory markers in US men and women

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Stress-Induced Hyperglycemia: Consequences and Management

Vedantam, D., Poman, D. S., Motwani, L., Asif, N., Patel, A., & Anne, K. K. (2022) · Cureus · doi:10.7759/cureus.26714 · Cited by 175

Tumor Necrosis Factor–α–Induced Insulin Resistance May Mediate The Hepatitis C Virus–Diabetes Association

Knobler, H., Zhornicky, T., Sandler, A., Haran, N., Ashur, Y., & Schattner, A. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08728.x · Cited by 148

Effect of PPAR-α and -γ agonist on the expression of visfatin, adiponectin, and TNF-α in visceral fat of OLETF rats

Choi, K. C., Ryu, O. H., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Choi, D. S., Baik, S. H., & Choi, K. M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.203 · Cited by 147

Metabolic stress drives sympathetic neuropathy within the liver

Liu, K., Yang, L., Wang, G., Liu, J., Zhao, X., Wang, Y., Li, J., & Yang, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.012 · Cited by 146

Obesity as the core of the metabolic syndrome and the management of coronary heart disease

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Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke

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Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus

Worda, C., Leipold, H., Gruber, C. J., Kautzky‐Willer, A., Knöfler, M., & Bancher‐Todesca, D. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.04.038 · Cited by 143

Diabetes and Hepatitis C: A Two-Way Association

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Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Melo, H. M., Seixas da Silva, G. D. S., Sant’Ana, M. R., Teixeira, C. V. L., Clarke, J. R., Miya Coreixas, V. S., de Melo, B. C., Fortuna, J. T. S., Forny-Germano, L., Ledo, J. H., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.072 · Cited by 140

Is Metabolic Syndrome X an Inflammatory Condition?

Das, U. N. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701106 · Cited by 140

Conjugated linoleic acid: a novel therapeutic nutrient?

Roche, H. M., Noone, E., Nugent, A. P., & Gibney, M. J. (2001) · Nutrition Research Reviews · doi:10.1079/095442201108729187 · Cited by 140

Is insulin an antiinflammatory molecule?

Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00518-4 · Cited by 140

Inflamed about obesity

Lehrke, M., & Lazar, M. A. (2004) · Nature Medicine · doi:10.1038/nm0204-126 · Cited by 138

Tumor Necrosis Factor α-Mediated Insulin Resistance, but Not Dedifferentiation, Is Abrogated by MEK1/2 Inhibitors in 3T3-L1 Adipocytes

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Polycystic Ovary Syndrome: The influence of environmental and genetic factors

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Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease

Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 143

Tumor Necrosis Factor α Is a Negative Regulator of Resistin Gene Expression and Secretion in 3T3-L1 Adipocytes

Faßhauer, M., Klein, J. C., Neumann, S., Eszlinger, M., & Paschke, R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5874 · Cited by 137

The influences of hyperprolactinemia and obesity on cardiovascular risk markers: effects of cabergoline therapy

Serri, O., Li, L., Mamputu, J., Beauchamp, M.-C., Maingrette, F., & Renier, G. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02469.x · Cited by 136

A defect in the activity of Δ6 and Δ5 desaturases may be a factor predisposing to the development of insulin resistance syndrome

Das, U. N. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.01.002 · Cited by 137

The metabolic abnormalities associated with non-alcoholic fatty liver disease

Haque, M., & Sanyal, A. J. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0325 · Cited by 136

Possible beneficial role of exercise in modulating low‐grade inflammation in the elderly

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Chronic Hepatitis C Is Associated With Peripheral Rather Than Hepatic Insulin Resistance

Milner, K., van der Poorten, D., Trenell, M. I., Jenkins, A. B., Xu, A., Smythe, G. A., Dore, G. J., Zekry, A., Weltman, M., Fragomeli, V., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.050 · Cited by 132

Minireview: Serine Phosphorylation of Insulin Receptor Substrate-1: A Novel Target for the Reversal of Insulin Resistance

Sykiotis, G. P., & Papavassiliou, A. G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.11.0725 · Cited by 134

Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-α, and FFAs to low-dose endotoxemia in humans

Krogh‐Madsen, R., Møller, K., Dela, F., Kronborg, G., Jauffred, S., & Pedersen, B. K. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00468.2003 · Cited by 129

Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus

Shim, K., Begum, R., Yang, C. F., & Wang, H. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v11.i1.1 · Cited by 128

Interleukin 6, soluble tumor necrosis factor receptor I and red blood cell distribution width as biological markers of functional dependence in an elderly population: A translational approach

de Gonzalo‐Calvo, D., de Luxán‐Delgado, B., Rodríguez‐González, S., Macia, M. G., Suárez, F. M., Solano, J. J., Rodríguez‐Colunga, M. J., & Coto‐Montes, A. M. (2012) · Cytokine · doi:10.1016/j.cyto.2012.01.005 · Cited by 129

Isoproterenol, TNFα, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes

Kralisch, S., Klein, J. C., Lössner, U., Blüher, M., Paschke, R., Stümvoll, M., & Faßhauer, M. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.06.002 · Cited by 128

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

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Involvement of the PA28γ-Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core Protein

Miyamoto, H., Moriishi, K., Moriya, K., Murata, S., Tanaka, K., Suzuki, T., Miyamura, T., Koike, K., & Matsuura, Y. (2006) · Journal of Virology · doi:10.1128/jvi.01683-06 · Cited by 124

Insulin resistance – a common link between type 2 diabetes and cardiovascular disease

Lebovitz, H. E. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00521.x · Cited by 125

Cardiovascular risk associated with the metabolic syndrome

Lindsay, R. S., & Howard, B. V. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0013-9 · Cited by 119

Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study

Derosa, G., Fogari, E., D’Angelo, A., Bianchi, L., Bonaventura, A., Romano, D., & Maffioli, P. (2013) · Inflammation · doi:10.1007/s10753-013-9620-4 · Cited by 119

Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia

Λεωνίδου, Λ., Mouzaki, A., Michalaki, M. A., Delastic, A., Kyriazopoulou, V. E., Bassaris, H. P., & Gogos, C. A. (2007) · Journal of Infection · doi:10.1016/j.jinf.2007.05.177 · Cited by 116

Serum TNF-α concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis

Chen, Y.-L., Qiao, Y.-C., Xu, Y., Ling, W., Pan, Y.-H., Huang, Y., Geng, L.-J., Zhao, H., & Zhang, X. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.04.003 · Cited by 114

Endothelial dysfunction, inflammation, and insulin resistance: A focus on subjects at risk for type 2 diabetes

Caballero, A. E. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0074-9 · Cited by 114

Fatty acids and the metabolic syndrome

Roche, H. M. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004405 · Cited by 113

Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients

Derosa, G., Maffioli, P., SALVADEO, S. A. T., Ferrari, I., Ragonesi, P. D., Querci, F., Franzetti, I., Gadaleta, G., Ciccarelli, L., Piccinni, M. N., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.007 · Cited by 113

Fibrosis progression in chronic hepatitis C virus infection

McCaughan, G. W., & George, J. (2004) · Gut · doi:10.1136/gut.2003.026393 · Cited by 112

AICAR stimulates adiponectin and inhibits cytokines in adipose tissue

Lihn, A. S., Jessen, N., Pedersen, S. B., Lund, S. A., & Richelsen, B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.139 · Cited by 111

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032938 · Cited by 152

Adipocyte-selective Reduction of the Leptin Receptors Induced by Antisense RNA Leads to Increased Adiposity, Dyslipidemia, and Insulin Resistance

Huan, J., Li, J., Han, Y., Chen, K., Wu, N. L., & Zhao, A. Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304165200 · Cited by 112

Adiponectin and its association with insulin resistance and type 2 diabetes

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Influence of Acute and Chronic Exercise on Glucose Uptake

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Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

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Control of pyruvate dehydrogenase kinase gene expression

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Relationship between body mass index and periodontitis in young Japanese adults

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Chronic TNF-α Neutralization Does Not Improve Insulin Resistance or Endothelial Function in “Healthy” Men with Metabolic Syndrome

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