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Cited by 152Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesMetabolism, Diabetes, and Cancer

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

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Steensberg, A., Fischer, C. P, Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A +1 more·2003·The Journal of Physiology
DOI 10.1113/jphysiol.2002.032938PMC PMC2342867
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Abstract

The cytokine interleukin (IL)-6 has recently been linked with type 2 diabetes mellitus and has been suggested to affect glucose metabolism. To determine whether acute IL-6 administration affects whole-body glucose kinetics or muscle glucose uptake, 18 healthy young men were assigned to one of three groups receiving a high dose of recombinant human IL-6 (HiIL-6; n = 6), a low dose of IL-6 (LoIL-6; n = 6) or saline (Con; n = 6) infused into one femoral artery for 3 h. The stable isotope [6,6-(2)H(2)] glucose was infused into a forearm vein throughout the 3 h infusion period and for a further 3 h after the cessation of infusion (recovery) to determine endogenous glucose production and whole-body glucose disposal. Infusion with HiIL-6 and LoIL-6 resulted in a marked (P < 0.05) increase in systemic IL-6 concentration throughout the 3 h of infusion (mean arterial plasma [IL-6]s of 319 and 143 pg ml(−1) for HiIL-6 and LoIL-6, respectively), followed by a rapid decline (P < 0.05) during the recovery period. Subjects experienced clinical symptoms such as shivering and discomfort during HiIL-6 administration, but were asymptomatic during LoIL-6 administration. In addition, only HiIL-6 elevated (P < 0.05) plasma adrenaline (epinephrine). IL-6 infusion, irrespective of dose, did not result in any changes to endogenous glucose production, whole-body glucose disposal or leg- glucose uptake. These data demonstrate that acute IL-6 administration does not impair whole-body glucose disposal, net leg-glucose uptake, or increase endogenous glucose production at rest in healthy young humans.

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  • IL6 does not appear to increase gluconeogenesis at rest.

    “While IL6 does not appear to increase gluconeogenesis at rest (Steensberg et al., 2003), our studies resonate well with other studies demonstrating STAT3 regulation of the same gluconeogenic genes such as Pck1 and G6pc and by studies demonstrating a role for IL6 in exercise-mediated hepatic gluconeogenesis (Banzet et al., 2009).”

    From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Steensberg et al., 2003

  • Infusion of recombinant human IL-6 into resting healthy humans does not impair whole body, lower limb, or subcutaneous adipose tissue glucose uptake or endogenous glucose production.

    “Infusion of recombinant human (rh) IL-6 into resting healthy humans does not impair whole body, lower limb, or subcutaneous adipose tissue glucose uptake or endogenous glucose production [48, 49].”

    From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [48]

  • The exercise-induced increase in plasma IL-6 levels is followed by increased circulating levels of anti-inflammatory cytokines IL-1ra and IL-10.

    “The exercise-induced increase in plasma IL-6 levels is followed by increased circulating levels of well-known anti-inflammatory cytokines such as IL-1ra and IL-10 [28, 48].”

    From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [48]

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Authors
Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2003-03-14
Volume
548
Issue
2
Pages
631-638
ISSN
0022-3751 (ISSN-L)
DOI
10.1113/jphysiol.2002.032938
PMC
PMC2342867
OpenAlex
W2130620882
Cited by
152
References
29
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 10 · 2012: 7
FWCI
9.63
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1 (tdm, 4554 d)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Figshare (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
interleukin-6, muscle glucose uptake, endogenous glucose production, type 2 diabetes, epinephrine, glucose kinetics, healthy young men
MeSH terms
Adult, Blood Pressure, Energy Metabolism, Epinephrine, Glucose, Glycogen, Heart Rate, Humans, Infusions, Intravenous, Male, Monosaccharide Transport Proteins, Muscle Proteins, Norepinephrine, Recombinant Proteins, Regional Blood Flow, RNA, Messenger, Exercise, Interleukin-6, Muscle, Skeletal, Glucose Transporter Type 4

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