Cited by 783Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

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The role of TNFα and TNF receptors in obesity and insulin resistance

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Hotamisligil, G. S.·1999·Journal of Internal Medicine

DOI 10.1046/j.1365-2796.1999.00490.x

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Abstract

Abstract. Hotamisligil GS (Harvard University, Boston, Massachusetts, USA). The role of TNFα and TNF receptors in obesity and insulin resistance. (Minisymposium: Genes & Obesity). J Intern Med 1999; 245: 621–625. Insulin resistance, a smaller than expected response to a given dose of insulin, is associated with many common diseases including, ageing, polycystic ovarian disease, syndrome X, cancer, infections, trauma and, most significantly, obesity and type 2 diabetes mellitus. The biochemical basis of insulin resistance in type 2 diabetes has been the subject of many studies. Earlier studies have indicated that quantitative regulation of the insulin sensitive glucose transporters (Glut‐4) and insulin receptors themselves may contribute to this disorder, however, these two factors are probably inadequate to explain the extent of insulin resistance. This point also became apparent by the development of only mild hyperinsulinaemia in mice with a targeted mutation in the Glut‐4 gene. Studies on postreceptor defects in type 2 diabetes has recently focused on the intrinsic catalytic activity of the insulin receptor and downstream signalling events. A reduction in tyrosine phosphorylation of both the insulin receptor (IR) and the insulin receptor substrate‐1 (IRS‐1) has been noted in both animal and human type 2 diabetes. Importantly, this appears to occur in all of the major insulin‐sensitive tissues, namely the muscle, fat and liver. It is now clear that decreased signalling capacity of the insulin receptor is an important component of this disease. I will review some of the potential mechanisms underlying this deficiency.

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Self-citation
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein
Hotamışlıgil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5291.1377 · Cited by 915
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
The expression of TNF alpha by human muscle. Relationship to insulin resistance.
Saghizadeh, M., Ong, J. M., Garvey, W. T., Henry, R. R., & Kern, P. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118504 · Cited by 717

Show all 41 references

Research works printed but not linked: 5

Olefsky JM, 1990, Diabetes Mellitus. 4th edn., 121
Moller DE., 1993, Insulin Resistance.
10.1210/en.134.1.264 · DOI
10.1210/en.139.12.4928 · DOI
10.1210/en.139.12.4832 · DOI

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Harwood, H. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.010 · Cited by 282
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Rana, J. S., Mittleman, M. A., Sheikh, J. K., Hu, F. B., Manson, J. E., Colditz, G. A., Speizer, F. E., Barr, R. G., & Camargo, C. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2478 · Cited by 265
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Faßhauer, M., Klein, J. C., Neumann, S., Eszlinger, M., & Paschke, R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02960-x · Cited by 263
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Kobashi, C., Urakaze, M., Kishida, M., Kibayashi, E., Kobayashi, H., Kihara, S., Funahashi, T., Takata, M., Temaru, R., Sato, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000194328.57164.36 · Cited by 252
Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue
Lin, Y., Rajala, M. W., Berger, J. P., Moller, D. E., Barzilai, N., & Scherer, P. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107101200 · Cited by 255
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High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
Zou, Y., Li, J., Lü, C., Wang, J., Ge, J., Huang, Y., Zhang, L., & Wang, Y. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.021 · Cited by 246
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Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?
Das, U. N. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0226 · Cited by 244
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Pérez‐Matute, P., Pérez-Echarri, N., Martínez, J. A., Martí, A., & Moreno-Aliaga, M. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507207627 · Cited by 227
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Authors: Hotamisligil, G. S.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 1999-06
Volume: 245
Issue: 6
Pages: 621-625
ISSN: 0954-6820 (ISSN-L)
1365-2796
DOI: 10.1046/j.1365-2796.1999.00490.x
OpenAlex: W2009818179
Cited by: 780
References: 41
Citations by year: 2026: 5 · 2025: 14 · 2024: 13 · 2023: 9 · 2022: 15 · 2021: 24 · 2020: 7 · 2019: 16 · 2018: 23 · 2017: 25 · 2016: 24 · 2015: 19 · 2014: 25 · 2013: 34 · 2012: 31
FWCI: 6.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 938 d)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: TNF-α, TNF receptor, obesity, insulin resistance, type 2 diabetes, insulin receptor signaling, tyrosine phosphorylation, IRS-1, GLUT4, postreceptor defect
MeSH terms: Animals, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Mice, Transgenic, Obesity, Tumor Necrosis Factor-alpha, Receptors, Tumor Necrosis Factor, Mice

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The role of TNFα and TNF receptors in obesity and insulin resistance

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