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Cited by 137Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuropeptides and Animal Physiology

Sleep and endocrinology

Steiger, A.·2003·Journal of Internal Medicine
DOI 10.1046/j.1365-2796.2003.01175.x
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Abstract

Abstract.: Steiger A (Max Planck Institute of Psychiatry, Munich, Germany). Sleep and endocrinology (Minisymposium). J Intern Med 2003; 254: 13–22. A bidirectional interaction between sleep electroencephalogram and endocrine activity is well established in various species including humans. Various hormones (peptides and steroids) participate in sleep regulation. A keyrole was shown for the reciprocal interaction between sleep‐promoting growth hormone‐releasing hormone (GHRH) and sleep‐impairing corticotropin‐releasing hormone (CRH). Changes in the GHRH : CRH ratio result in changes of sleep‐endocrine activity. It is thought that the change of this ratio in favour of CRH contributes to aberrances of sleep during ageing and depression (shallow sleep, blunted GH and elevated cortisol). Besides GHRH, ghrelin and galanin enhance slow wave sleep. Somatostatin is another sleep‐impairing factor. Neuropeptide Y acts as a CRH antagonist and induces sleep onset. There are hints that CRH promotes rapid eye movement sleep (REMS). In animals prolactin enhances REMS. In humans vasocactive intestinal polypeptide (VIP) appears to play a role in the temporal organization of sleep as, after VIP, the non‐REMS–REMS cycle decelerated. Cortisol appears to enhance REMS. Finally, gonadal hormones participate in sleep regulation. Oestrogen replacement therapy and CRH‐1 receptor antagonism in depression are beneficial clinical applications of sleep‐endocrine research.

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Crossref · 10.1046/j.1365-2796.2003.01175.x

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  • Sleep timing, duration, and quality partly determine glucose tolerance, the 24-hour insulin release pattern, growth hormone and cortisol, and the appetite hormones leptin and ghrelin.

    “glucose tolerance, the 24-h pattern of release of insulin, and the counterregulatory hormones growth hormone (GH) and cortisol, as well as of hormones involved in the regulation of appetite, such as leptin and ghrelin, are partly dependent on sleep timing, duration, and quality [59, 168, 186].”

    From Sleep and metabolic function (2012) · cites this paper as [168]

  • Sleep-wake homeostasis is a major determinant of growth hormone secretion.

    “Taken together, these results indicate that sleep–wake homeostasis is a major determinant of GH secretion [59, 168, 186].”

    From Sleep and metabolic function (2012) · cites this paper as [168]

  • Wake-sleep transitions inhibit cortisol levels, and sleep-wake transitions stimulate them.

    “wake–sleep and sleep–wake transitions are associated with inhibition and stimulation of cortisol levels, respectively [59, 168, 186].”

    From Sleep and metabolic function (2012) · cites this paper as [168]

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Authors
Steiger, A.
Affiliations
Max Planck Society (DE)
Corresponding author
Steiger, A.
ORCID
Steiger, A.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2003-06-16
Volume
254
Issue
1
Pages
13-22
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
DOI
10.1046/j.1365-2796.2003.01175.x
OpenAlex
W2131637342
Cited by
137
References
76
Citations by year
2026: 3 · 2025: 1 · 2024: 10 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 21 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 7
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
sleep regulation, sleep hormones, growth hormone-releasing hormone, corticotropin-releasing factor, ghrelin, galanin, somatostatin, neuropeptide Y, vasoactive intestinal peptide, prolactin, REM sleep, slow-wave sleep, cortisol, gonadal hormones, estrogen replacement therapy, depression, aging, sleep-wake cycle
MeSH terms
Aging, Depressive Disorder, Endocrine System, Humans, Peptides, Sleep, Steroids

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