Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications
Abstract
The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12 healthy middle-aged (45.1 +/- 4.9) and 12 healthy young (22.7 +/- 2.8) men by monitoring their sleep by polysomnography for 4 consecutive nights, including in tandem 1 adaptation and 2 baseline nights and a night during which we administered equipotent doses of ovine CRH (1 microg/kg, iv bolus) 10 min after sleep onset. Analyses included comparisons within and between groups using multiple ANOVA and regression analysis. Although both middle-aged and young men responded to CRH with similar elevations of ACTH and cortisol, the former had significantly more wakefulness and suppression of slow wave sleep compared with baseline sleep; in contrast, the latter showed no change. Also, comparison of the change in sleep patterns from baseline to the CRH night in the young men to the respective change observed in middle-aged men showed that middle-age was associated with significantly higher wakefulness and significantly greater decrease in slow wave sleep than in young age. We conclude that middle-aged men show increased vulnerability of sleep to stress hormones, possibly resulting in impairments in the quality of sleep during periods of stress. We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057 · see citing works
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951 · see citing works
Ehlers, C. L., Reed, T. K., & Henriksen, S. J. (2008) · Neuroendocrinology · doi:10.1159/000124489 · Cited by 310 · see citing works
Cortisol Secretion Is Inhibited during Sleep in Normal Man*
WEITZMAN, E. D., ZIMMERMAN, J. C., CZEISLER, C. A., & RONDA, J. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-2-352 · Cited by 265 · see citing works
Holsboer, F., von Bardeleben, U., & Steiger, A. (2008) · Neuroendocrinology · doi:10.1159/000124986 · Cited by 255 · cited 3× · see citing works
“healthy men either resulted in a small decrease in SWS (9) or”
BackgroundResultVgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., & Chrousos, G. P. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00763.x · Cited by 249 · see citing works
Self-citationPAVLOV, E. P., Harman, S. M., Chrousos, G. P., Loriaux, D. L., & Blackman, M. R. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-4-767 · Cited by 188 · see citing works
Jan Born, A., Späth‐Schwalbe, E., SCHWAKENHOFER, H., Kern, W., & Fehm, H. L. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-5-904 · Cited by 171 · see citing works
Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial
Chrousos, G. A. (1993) · JAMA · doi:10.1001/jama.269.16.2110 · Cited by 170 · see citing works
Evaluation and Treatment of Insomnia
Kales, J. D., & Kales, A. (1987) · Psychiatric Annals · doi:10.3928/0048-5713-19870701-08 · Cited by 167 · see citing works
Relationships between sleep quality and glucose regulation in normal humans
Scheen, A. J., Byrne, M. M., Plat, L., Leproult, R., & Cauter, E. V. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e261 · Cited by 141 · see citing works
Acute Effect of a Glucocorticoid on Normal Human Sleep
Gillin, J. C., Jacobs, L. S., Fram, D. H., & Snyder, F. R. (1972) · Nature · doi:10.1038/237398a0 · Cited by 134 · see citing works
Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits
Opp, M. R., Obál, F., & Krueger, J. M. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.3.r528 · Cited by 128 · see citing works
Slow Wave Sleep Drives Inhibition of Pituitary‐AdrenalSecretion in Humans
Bierwolf, C., Struve, K., Marshall, L., Born, J., & Fehm, H. L. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00605.x · Cited by 104 · see citing works
Kellner, M. B., Yassouridis, A., MANZ, B., Steiger, A., Holsboer, F., & Wiedemann, K. (2008) · Neuroendocrinology · doi:10.1159/000127186 · Cited by 87 · see citing works
Vgontzas, A. N., Bixler, E. O., Papanicolaou, D. A., Kales, A., Stratakis, C. A., Vela‐Bueno, A., Gold, P. W., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4307 · Cited by 59 · see citing works
Gillin, J. C., Jacobs, L. S., Snyder, F. R., & Henkin, R. I. (1974) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(74)90170-9 · Cited by 30 · see citing works
Decreased Delta-Sleep and Plasma Delta-Sleep-Inducing Peptide in Patients with Cushing Syndrome
Friedman, T. C., Garcı́a-Borreguero, D., Hardwick, D., Akuete, C. N., Doppman, J. L., Dorn, L. D., Barker, C. N., Yanovski, J. A., & Chrousos, G. P. (2008) · Neuroendocrinology · doi:10.1159/000126806 · Cited by 29 · see citing works
Effects of hCRH on sleep and body temperature rhythms
Tsuchiyama, Y., Uchimura, N., Sakamoto, T., Maeda, H., & Kotorii, T. (1995) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1995.tb01906.x · Cited by 28 · see citing works
Effects of Intravenous Catheter on Sleep in Healthy Men and in Depressed Patients
Kerkhofs, M., Linkowski, P., & Mendlewicz, J. (1989) · SLEEP · doi:10.1093/sleep/12.2.113 · Cited by 21 · see citing works
Effects of corticotropin-releasing hormone on respiratory parameters during sleep in normal men
Mann, K., Roschke, J., Benkert, O., Aldenhoff, J., Nink, M., Beyer, J., & Lehnert, H. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211356 · Cited by 20 · see citing works
Evaluation and Treatment of Insomnia
Berlin, R. M. (1984) · Psychosomatics · doi:10.1016/s0033-3182(84)72936-7 · Cited by 12 · see citing works
Side Effects of Glucocorticoid Treatment
Chrousos, G. A. (1993) · JAMA · doi:10.1001/jama.1993.03500160080036 · Cited by 9 · see citing works
Side effects of glucocorticoid treatment
(1993) · Journal of Emergency Medicine · doi:10.1016/0736-4679(93)90657-s · Cited by 2 · see citing works
Effects of H-CRH on sleep and body temperature rhythms
Hirano, T., Uchimura, N., Tsuchiyama, Y., Sakamoto, T., Hashizume, Y., Nakazawa, Y., & Kotorii, T. (1996) · European Neuropsychopharmacology · doi:10.1016/0924-977x(96)87664-4 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Buckley, T. M., & Schatzberg, A. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1056 · Cited by 964 · see citing works
Kudielka, B. M., Hellhammer, D. H., & Wüst, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.004 · Cited by 963 · see citing works
Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder
Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., & Bixler, E. O. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.005 · Cited by 776 · see citing works
Bixler, E. O., Vgontzas, A. N., Lin, H. ‐., Calhoun, S. L., Vela‐Bueno, A., & Kales, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0035 · Cited by 727 · see citing works
Vgontzas, A. N., & Chrousos, G. P. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00005-6 · Cited by 414 · see citing works
A meta-analysis of cortisol response to challenge in human aging: importance of gender
Otte, C., Hart, S. L., Neylan, T. C., Marmar, C. R., Yaffe, K. S., & Mohr, D. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.06.002 · Cited by 417 · see citing works
Insomnia and its Impact on Physical and Mental Health
Fernández‐Mendoza, J., & Vgontzas, A. N. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0418-8 · Cited by 339 · see citing works
Chronic Insomnia and the Stress System
Basta, M., Chrousos, G. P., Vela‐Bueno, A., & Vgontzas, A. N. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.002 · Cited by 294 · see citing works
Grammatopoulos, D. K., & Chrousos, G. P. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00670-7 · Cited by 277 · see citing works
Risk factors for incident chronic insomnia: A general population prospective study
Singareddy, R., Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., Calhoun, S., Shaffer, M. L., & Bixler, E. O. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2011.10.033 · Cited by 272 · see citing works
Neurochemical regulation of sleep
Steiger, A. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.04.007 · Cited by 262 · see citing works
Lemoine, P., Nir, T., Laudon, M., & Zisapel, N. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00613.x · Cited by 261 · see citing works
Vgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H.-M., Prolo, P., Vela‐Bueno, A., Kales, A., & Chrousos, G. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021176 · Cited by 235 · see citing works
Cognitive-Emotional Hyperarousal as a Premorbid Characteristic of Individuals Vulnerable to Insomnia
Fernández-Mendoza, J., Vela-Bueno, A., Vgontzas, A. N., Ramos-Platón, M. J., Olavarrieta-Bernardino, S., Bixler, E. O., & De la Cruz-Troca, J. J. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d75319 · Cited by 234 · see citing works
Self-citationHyperarousal in insomnia disorder: Current evidence and potential mechanisms
Dressle, R. J., & Riemann, D. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13928 · Cited by 218 · see citing works
Sleep and sleep disturbances: biological basis and clinical implications
Zisapel, N. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6529-9 · Cited by 216 · see citing works
Excessive daytime sleepiness in sleep disorders.
Slater, G., & Steier, J. S. (2012) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2012.10.07 · Cited by 205 · see citing works
Nocturnal cortisol and melatonin secretion in primary insomnia
Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A., & Voderholzer, U. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00249-4 · Cited by 202 · see citing works
Increased nocturnal interleukin-6 excretion in patients with primary insomnia: A pilot study
Burgos, I., Richter, L., Klein, T., Fiebich, B., Feige, B., Lieb, K., Voderholzer, U., & Riemann, D. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.06.007 · Cited by 198 · see citing works
Schmid, D. A., Wichniak, A., Uhr, M., Ising, M., Brünner, H., Held, K., Weikel, J. C., Sonntag, A., & Steiger, A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300923 · Cited by 162 · see citing works
Dressle, R. J., Feige, B., Spiegelhalder, K., Schmucker, C., Benz, F., Mey, N. C., & Riemann, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101588 · Cited by 161 · see citing works
BIXLER, E. O., PAPALIAGA, M. N., VGONTZAS, A. N., LIN, H., PEJOVIC, S., KARATARAKI, M., VELA‐BUENO, A., & CHROUSOS, G. P. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00713.x · Cited by 195 · see citing works
Sleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease
Motivala, S. J. (2011) · Annals of Behavioral Medicine · doi:10.1007/s12160-011-9280-2 · Cited by 151 · see citing works
Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147 · see citing works
Steiger, A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01175.x · Cited by 137 · see citing works
Sex differences in age-related changes in the sleep-wake cycle
Carrier, J., Semba, K., Deurveilher, S., Drogos, L. L., Cyr-Cronier, J., Lord, C., & Sekerovick, Z. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.004 · Cited by 130 · see citing works
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Smith, R. G., Betancourt, L., & Sun, Y. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0017 · Cited by 127 · see citing works
Drapeau, C., Hamel-Hébert, I., Robillard, R., Selmaoui, B., Filipini, D., & Carrier, J. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00518.x · Cited by 115 · see citing works
Sullivan, N. R., & de Kar, L. D. V. (2003) · Vitamins and hormones · doi:10.1016/s0083-6729(03)01006-9 · Cited by 106 · see citing works
Refractory Insomnia and Sleep-Disordered Breathing: A Pilot Study
Krakow, B. J., Melendrez, D. C., Lee, S. A., Warner, T. D., Clark, J. O., & Sklar, D. P. (2004) · Sleep And Breathing · doi:10.1007/s11325-004-0015-5 · Cited by 103 · see citing works
Lee, H.-A., Cho, C., & Kim, L. (2014) · Sleep Medicine and Psychophysiology · doi:10.14401/kasmed.2014.21.2.51 · Cited by 86 · see citing works
Aging and the Role of the HPA Axis and Rhythm in Sleep and Memory-Consolidation
Buckley, T. M., & Schatzberg, A. F. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.5.344 · Cited by 84 · see citing works
Middle-Aged Men Secrete Less Testosterone at Night Than Young Healthy Men
Luboshitzky, R., Shen‐Orr, Z., & Herer, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021920 · Cited by 81 · see citing works
Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder
Neylan, T. C., Lenoci, M., Maglione, M. L., Rosenlicht, N. Z., Metzler, T. J., Otte, C., Schoenfeld, F. B., Yehuda, R., & Marmar, C. R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300215 · Cited by 75 · see citing works
Insomnia With Short Sleep Duration
Vgontzas, A. N., & Fernández‐Mendoza, J. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.04.009 · Cited by 73 · see citing works
Reuter, M. (2002) · Neuropsychobiology · doi:10.1159/000063575 · Cited by 69 · see citing works
Sleep Disturbances After Cerebral Infarction: Role of Depression and Fatigue
Suh, M., Choi‐Kwon, S., & Kim, J. S. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.01.029 · Cited by 67 · see citing works
Stress hormones and eating disorders
Chami, R., Monteleone, A. M., Treasure, J., & Monteleone, P. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.009 · Cited by 66 · see citing works
Sleep and endocrine regulation
Steiger, A. (2003) · Frontiers in bioscience · doi:10.2741/1055 · Cited by 65 · see citing works
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63 · see citing works
Kluge, M., Gazea, M., SCHÜSSLER, P., Genzel, L., Dresler, M., Kleyer, S., Uhr, M., Yassouridis, A., & Steiger, A. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.007 · Cited by 64 · see citing works
Krakow, B. J., Melendrez, D. C., Warner, T. D., Dorin, R. I., Harper, R. M., & Hollifield, M. A. (2002) · Sleep And Breathing · doi:10.1007/s11325-002-0189-7 · Cited by 71 · see citing works
Caska, C. M., Hendrickson, B. E., Wong, M. H., Ali, S., Neylan, T. C., & Whooley, M. A. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819b6a08 · Cited by 64 · see citing works
Kluge, M., SCHÜSSLER, P., Bleninger, P., Kleyer, S., Uhr, M., Weikel, J. C., Yassouridis, A., Zuber, V., & Steiger, A. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.008 · Cited by 56 · see citing works
Fernández‐Mendoza, J., Shaffer, M. L., Olavarrieta‐Bernardino, S., Vgontzas, A. N., Calhoun, S. L., Bixler, E. O., & Vela‐Bueno, A. (2014) · Journal of Sleep Research · doi:10.1111/jsr.12168 · Cited by 56 · see citing works
Sleep disturbances in patients with Addison's disease
Løvås, K., Husebye, E., Holsten, F., & Bjorvatn, B. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480449 · Cited by 55 · see citing works
Vgontzas, A. N., Puzino, K., Fernández‐Mendoza, J., Krishnamurthy, V., Basta, M., & Bixler, E. O. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8740 · Cited by 54 · see citing works
Sleep is more sensitive to high doses of caffeine in the middle years of life
Robillard, R., Bouchard, M., Cartier, A., Nicolau, L., & Carrier, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115575535 · Cited by 53 · see citing works
Restless legs syndrome: Evidence for nocturnal hypothalamic‐pituitary‐adrenal system activation
Schilling, C., Schredl, M., Strobl, P., & Deuschle, M. (2010) · Movement Disorders · doi:10.1002/mds.23026 · Cited by 53 · see citing works
Kok, S. W., Roelfsema, F., Overeem, S., Lammers, G. J., STRIJERS, R. L. M., Frölich, M. A., Meinders, A. E., & Pijl, H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020638 · Cited by 52 · see citing works
Palma, B. D., Tiba, P. A., Machado, R. B., Tufik, S., & Suchecki, D. (2007) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462007000500007 · Cited by 51 · see citing works
Predisposition in the Evolution of Insomnia: Evidence, Potential Mechanisms, and Future Directions
Drake, C. L., & Roth, T. G. (2006) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.06.005 · Cited by 51 · see citing works
Bliwise, D. L. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50010-0 · Cited by 48 · see citing works
Miller, C. M., Rindflesch, T. C., Marcelo Fiszman, B., Hristovski, D., Shin, D., Rosemblat, G., Zhang, H., & Strohl, K. P. (2012) · SLEEP · doi:10.5665/sleep.1640 · Cited by 47 · see citing works
Daytime dynamic of spontaneous expressions of pedestrians in an urban forest park
Wei, H., Hauer, R. J., & Guo, S. (2021) · Urban forestry & urban greening · doi:10.1016/j.ufug.2021.127326 · Cited by 46 · see citing works
Sleep and Hormonal Changes in Aging
Copinschi, G., & Caufriez, A. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.009 · Cited by 43 · see citing works
Kluge, M., SCHÜSSLER, P., Zuber, V., Yassouridis, A., & Steiger, A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.015 · Cited by 42 · see citing works
SCHÜSSLER, P., Yassouridis, A., Uhr, M., Kluge, M., Weikel, J., Holsboer, F., & Steiger, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00641.2005 · Cited by 41 · see citing works
Chapter, M. C., White, C. M., DeRidder, A. M., Chadwick, W., Martin, B., & Maudsley, S. R. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.006 · Cited by 40 · see citing works
Neuroendocrine Regulation of Sleep Disturbances in PTSD
Neylan, T. C., Otte, C., Yehuda, R., & Marmar, C. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.015 · Cited by 39 · see citing works
The relationship between melatonin and cortisol rhythms: clinical implications of melatonin therapy
Zisapel, N., Tarrasch, R., & Laudon, M. (2005) · Drug Development Research · doi:10.1002/ddr.20014 · Cited by 39 · see citing works
Moraes, M. M., Bruzzi, R. S., Martins, Y. A. T., Mendes, T. T., Maluf, C. B., Ladeira, R. V. P., Núñez-Espinosa, C. A., Soares, D. D., Wanner, S. P., & Arantes, R. M. E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113069 · Cited by 39 · see citing works
Tozawa, T., Mishima, K., Satoh, K., Echizenya, M., Shimizu, T., & Hishikawa, Y. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030147 · Cited by 38 · see citing works
Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men
Guyon, A., Morselli, L. L., Balbo, M. L., Tasali, E., Leproult, R., L’Hermite-Balériaux, M., Van Cauter, E., & Spiegel, K. (2017) · SLEEP · doi:10.1093/sleep/zsx064 · Cited by 35 · see citing works
Effects of sleep fragmentation on sleep and markers of inflammation in mice.
Trammell, R. A., Verhulst, S., & Toth, L. A. (2014) · PubMed Central · Cited by 33 · see citing works
Kotronoulas, G., Stamatakis, A., & Stylianopoulou, F. (2009) · HORMONES · doi:10.14310/horm.2002.1239 · Cited by 33 · see citing works
Acute cortisol administration reduces subjective fatigue in healthy women
Mattie Tops, A., van Peer, J. M., Wijers, A. A., & Korf, J. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00458.x · Cited by 33 · see citing works
Edéll‐Gustafsson, U., Gustavsson, G., & Uhlin, P. Y. (2003) · International Journal of Nursing Practice · doi:10.1046/j.1440-172x.2003.00402.x · Cited by 32 · see citing works
El síndrome de apneas-hipopneas durante el sueño en edades avanzadas
Martínez‐García, M. Á., Durán‐Cantolla, J., & Montserrat, J. M. (2010) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(10)70116-6 · Cited by 37 · see citing works
Fatigue and Disrupted Sleep-Wake Patterns in Patients With Cancer: A Shared Mechanism
Wu, H.-S., Davis, J. E., & Natavio, T. (2012) · Clinical journal of oncology nursing · doi:10.1188/12.cjon.e56-e68 · Cited by 29 · see citing works
The Molecular Basis of Insomnia: Implication for Therapeutic Approaches
Wang, Z., & Liu, J. (2016) · Drug Development Research · doi:10.1002/ddr.21338 · Cited by 29 · see citing works
Sex and Sleep Disruption as Contributing Factors in Alzheimer’s Disease
Johnson, C. E., Duncan, M. J., & Murphy, M. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230527 · Cited by 34 · see citing works
Sgro, M., Kodila, Z. N., Brady, R. D., Reichelt, A. C., Mychasiuk, R., & Yamakawa, G. R. (2021) · SLEEP · doi:10.1093/sleep/zsab268 · Cited by 25 · see citing works
Contemporary work characteristics, stress, and ill health
Jamison, C. S., Wallace, M., & Jamison, P. L. (2003) · American Journal of Human Biology · doi:10.1002/ajhb.10237 · Cited by 25 · see citing works
Mehta, R., Giri, S., & Mallick, B. N. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00222-1 · Cited by 24 · see citing works
Sleep and circadian rhythms in normal aging
Carrier, J., & Bliwise, D. L. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0217-3_24 · Cited by 24 · see citing works
Nicolaides, N. C., Vgontzas, A. N., Kritikou, I., & Chrousos, G. P. (2016) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Human basal cortisol levels are increased in hospital compared to home setting
Scheer, F. A. J. L., van Paassen, B. W., van Montfrans, G. A., Fliers, E., Someren, E. J. W. V., van Heerikhuize, J. J., & Buijs, R. M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00988-6 · Cited by 22 · see citing works
Endocrine and metabolic changes during sleep.
Steiger, A. (2011) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52006-7.00016-2 · Cited by 11 · see citing works
Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women
Mathias, S., Held, K., Ising, M., Weikel, J. C., Yassouridis, A., & Steiger, A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.008 · Cited by 18 · see citing works
SCHÜSSLER, P., Kluge, M., Gamringer, W., Wetter, T. C., Yassouridis, A., Uhr, M., Rupprecht, R., & Steiger, A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.015 · Cited by 18 · see citing works
Mukherjee, D., Weissenkampen, J. D., Wasserman, E. J., Krishnamurthy, V., Millett, C. E., Conway, S., & Saunders, E. F. H. (2021) · Neuropsychobiology · doi:10.1159/000517343 · Cited by 17 · see citing works
Zisapel, N. (2010) · The Open Neuroendocrinology Journal · Cited by 16 · see citing works
Hypothalamic stress systems in mood disorders
(2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-819973-2.00003-4 · Cited by 15 · see citing works
Effect of paradoxical sleep deprivation and stress on passive avoidance behavior
HONGWANG, J., van den Buuse, M., WENTIAN, S., & YEMA, Y. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00142-2 · Cited by 15 · see citing works
The Diagnosis and Treatment of Chronic Insomnia in Adults
Vgontzas, A. N. (2005) · SLEEP · doi:10.1093/sleep/28.9.1047 · Cited by 14 · see citing works
Kristiansen, J., Persson, R., Björk, J., Albin, M. C., Jakobsson, K., Östergren, P.-O., & Ardö, J. (2010) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-010-0557-8 · Cited by 12 · see citing works
Sleep at the helm: A case study of how a head coach sleeps compared to his team
Lastella, M., Roach, G., Halson, S. L., Gore, C., Garvican‐Lewis, L. A., & Sargent, C. (2017) · International Journal of Sports Science & Coaching · doi:10.1177/1747954117738882 · Cited by 11 · see citing works
Park, I., Kokudo, C., Seol, J., Ishihara, A., Zhang, S., Uchizawa, A., Osumi, H., Miyamoto, R., Horie, K., Suzuki, C., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1050648 · Cited by 9 · see citing works
Selvı, Y., Kandeğer, A., & Sayin, A. A. (2016) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.10797 · Cited by 9 · see citing works
Alpha-Helical CRH Exerts CRH Agonistic Effects on Sleep-Endocrine Activity in Humans
Held, K., Antonijevic, I. A., Murck, H., Kunzel, H. E., & Steiger, A. (2005) · Neuropsychobiology · doi:10.1159/000086606 · Cited by 9 · see citing works
Cognitive benefits of sleep: a narrative review to explore the relevance of glucose regulation
Longis, E. D., Kassis, A. N., Rémond-Derbez, N., Thota, R. N., Darimont, C., Donato, L., & Hudry, J. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae095 · Cited by 10 · see citing works
Holsboer, F., & Ising, M. (2024) · Pharmacopsychiatry · doi:10.1055/a-2372-3549 · Cited by 8 · see citing works
Neurological perspectives in insomnia and hyperarousal syndromes
Terzano, M. G., & Parrino, L. (2010) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52007-4.00003-5 · Cited by 8 · see citing works
Yu, K., Xia, L., Chen, H.-H., Zou, T.-T., Zhang, Y., Zhang, P., Yang, Y., Wei, R.-M., Su, Z.-F., & Chen, G.-H. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s491040 · Cited by 7 · see citing works
Stapel, B., Alvarenga, M. E., & Kahl, K. G. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1490585 · Cited by 7 · see citing works
Neurobiological Disturbances in Insomnia: Clinical Utility of Objective Measures of Sleep
Pejovic, S., & Vgontzas, A. N. (2010) · Medical psychiatry · doi:10.3109/9781420080803.007 · Cited by 7 · see citing works
Steiger, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_25 · Cited by 3 · see citing works
Sleep quality of middle‐aged T ai C hi practitioners
Lee, L. Y. K., Tam, K. W., Lee, M. L., Lau, N. Y., Lau, J. C. Y., Lam, Y. M., Lam, C. H. W., Kwan, W. K., Chan, D., Chan, B., et al. (2014) · Japan Journal of Nursing Science · doi:10.1111/jjns.12045 · Cited by 6 · see citing works
Steiger, A. (2006) · Elsevier eBooks · doi:10.1016/b978-012369442-3/50215-4 · Cited by 6 · see citing works
- Authors
- Vgontzas, A. N., Bixler, E. O., Wittman, A. M., Zachman, K., Lin, H.-M., Vela-Bueno, A., Kales, A., & Chrousos, G. P.
- Affiliations
- Pennsylvania State University (US)
- National Institutes of Health (US)
- Corresponding author
- Vgontzas, Alexandros N.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-03
- Volume
- 86
- Issue
- 4
- Pages
- 1489-1495
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2071937025
- Cited by
- 134
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 8 · 2012: 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticotropin-releasing factor, middle age (human life stage), age-related sleep changes, wakefulness, hypothalamic-pituitary-adrenal axis, ACTH, cortisol, stress hormones, insomnia, sleep quality, older men
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Aging, Animals, Arousal, Corticotropin-Releasing Hormone, Electroencephalography, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Sheep, Sleep, Sleep Wake Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review