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The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Estimating population structure in diploids with multilocus dominant DNA markers

Zhivotovsky, Lev A.·1999·Molecular Ecology

Abstract

Multilocus DNA markers [random amplified polymorphic DNA (RAPDs), amplified fragment length polymorphism (AFLPs)] are important for population studies because they reveal many polymorphic loci distributed over the genome. The markers are dominant, that is two phenotypes are distinguished at each locus, with a band and with no band. The latter one represents null‐homozygotes with unamplified, recessive null‐alleles. The frequency of a null‐allele can be estimated by taking the square root of the fraction of individuals with no band. Lynch and Milligan (1994) have suggested a modified procedure that reduces bias introduced by the square‐root transform. However, the procedure recommends to ignore those samples in which fewer than four null‐homozygotes are observed. This may lead to significant bias in estimates of genetic diversity. In this study, I introduce a Bayesian approach to estimation of null‐allele frequencies for dominant DNA markers. It follows from computer simulations and data on two conifer species that the Bayesian method gives nearly unbiased estimates of heterozygosity, genetic distances and F‐statistics. The influence of a prior distribution and departure from Hardy–Weinberg proportions on the estimates is also considered.

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Metadata

Authors
Zhivotovsky, L. A.
Venue
Molecular Ecology
Publisher
Wiley
Published
1999-06
Volume
8
Issue
6
Pages
907-913
ISSN
  • 0962-1083 (ISSN-L)
  • 1365-294X
OpenAlex
W2149575932
Cited by
720
References
14
FWCI
4.39
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Estimating population structure in diploids with multilocus dominant DNA markers. https://app.cochat.ai/papers/10.1046/j.1365-294x.1999.00620.x
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Zhivotovsky, L. A. (1999). Estimating population structure in diploids with multilocus dominant DNA markers. Molecular Ecology. https://doi.org/10.1046/j.1365-294x.1999.00620.x

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