The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays
Open accessAbstract
Whole‐genome comparisons of the tubercle bacilli were undertaken using ordered bacterial artificial chromosome (BAC) libraries of Mycobacterium tuberculosis and the vaccine strain, Mycobacterium bovis BCG‐Pasteur, together with the complete genome sequence of M. tuberculosis H37Rv. Restriction‐digested BAC arrays of M. tuberculosis H37Rv were used in hybridization experiments with radiolabelled M. bovis BCG genomic DNA to reveal the presence of 10 deletions (RD1–RD10) relative to M. tuberculosis. Seven of these regions, RD4–RD10, were also found to be deleted from M. bovis, with the three M. bovis BCG‐specific deletions being identical to the RD1–RD3 loci described previously. The distribution of RD4–RD10 in Mycobacterium africanum resembles that of M. tuberculosis more closely than that of M. bovis, whereas an intermediate arrangement was found in Mycobacterium microti, suggesting that the corresponding genes may affect host range and virulence of the various tubercle bacilli. Among the known products encoded by these loci are a copy of the proposed mycobacterial invasin Mce, three phospholipases, several PE, PPE and ESAT‐6 proteins, epoxide hydrolase and an insertion sequence. In a complementary approach, direct comparison of BACs uncovered a third class of deletions consisting of two M. tuberculosis H37Rv loci, RvD1 and RvD2, deleted from the genome relative to M. bovis BCG and M. bovis. These deletions affect a further seven genes, including a fourth phospholipase, plcD. In summary, the insertions and deletions described here have important implications for our understanding of the evolution of the tubercle complex.
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citationExploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
DeRisi, J. L., Iyer, V. R., & Brown, P. O. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,456
Accessing Genetic Information with High-Density DNA Arrays
Chee, M., Yang, R., Hubbell, E., Berno, A., Huang, X. C., Stern, D., Winkler, J., Lockhart, D. J., Morris, M. S., & Fodor, S. P. A. (1996) · Science · doi:10.1126/science.274.5287.610 · Cited by 1,489
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C., & Stover, C. K. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1274-1282.1996 · Cited by 1,103
Sreevatsan, S., Pan, X., Stockbauer, K. E., Connell, N. D., Kreiswirth, B. N., Whittam, T. S., & Musser, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9869 · Cited by 1,024
Tuberculosis: Pathogenesis, Protection and Control
(1996) · Nature Medicine · doi:10.1038/nm0296-244b · Cited by 977
Harboe, M., Oettinger, T., Wiker, H. G., Rosenkrands, I., & Andersen, P. (1996) · Infection and Immunity · doi:10.1128/iai.64.1.16-22.1996 · Cited by 465
Construction and Characterization of a Human Bacterial Artificial Chromosome Library
Kim, U.-J., Birren, B. W., Slepak, T., Mancino, V., Boysen, C., Kang, H.-L., Simon, M. I., & Shizuya, H. (1996) · Genomics · doi:10.1006/geno.1996.0268 · Cited by 454
Titball, R. W. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.2.347-366.1993 · Cited by 453
Horwitz, M. A., Lee, B. W., Dillon, B. J., & Harth, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1530 · Cited by 432
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Type VII secretion — mycobacteria show the way
Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1773 · Cited by 763
Pym, A. S., Brodin, P., Brosch, R., Huerre, M., & Cole, S. T. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03237.x · Cited by 729
Self-citationRecombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Pym, A. S., Brodin, P., Majlessi, L., Brosch, R., Demangel, C., Williams, A., Griffiths, K. E., Marchal, G., Leclerc, C., & Cole, S. T. (2003) · Nature Medicine · doi:10.1038/nm859 · Cited by 644
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Metadata
- Authors
- Gordon, S. V., Brosch, R., Billault, A., Garnier, T., Eiglmeier, K., & Cole, S. T.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1999-05
- Volume
- 32
- Issue
- 3
- Pages
- 643-655
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2130206397
- Cited by
- 537
- References
- 25
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- green
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