Phospholipase and protease activities in clinical Candida isolates with reference to the sources of strains: Phospholipase‐ and Protease‐Aktivitat bei klinischen Candida‐Isolaten mit Bezug zur Herkunft der Stämme
Abstract
The present study was aimed at determining in vitro phospholipase and protease activities in 95 clinical isolates of various Candida species (C. albicans, C. glabrata, C. guilliermondii,C.kefyr, C. krusei, C. lipolytica, C. lusitaniae, C. parapsilosis, C.rugosa and C. tropicalis). 59 (62.1%) of isolates examined were phospholipase positive and 75 (78.9.9%) were protease positive. 56 (93.3%) of C.albicans isolates tested were phospholipase producers - however only a few strains of C. glabrata and C. kefyr behaved in the same way. Protease activity was detected in 57 (95%) of C. albicans strains tested and in a few strains of C. kefyr, C.lipolytica, C. parapsilosis and C. tropicalis- the remaining isolates were negative. 56 strains of C.albicans and 2 strains of C. kefyr tested produced both phospholipase and protease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Despite the lack of any secreted proteolytic activity, the C. glabrata genome contains eleven genes (CgYPS1-11) that code for a family of eleven putative GPI-anchored aspartyl proteases known as Yapsins.
“However, despite the lack of any secreted proteolytic activity [59], the C. glabrata genome contains eleven genes (CgYPS1-11) that code for a family of eleven putative GPI-anchored aspartyl proteases, known as Yapsins [60].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [59]
Cites
Yeasts : characteristics and identification
Barnett, J. A., Payne, R. W., Yarrow, D., & Barnett, L. (2000) · Cited by 1,870 · see citing works
Potential Role of Phospholipases in Virulence and Fungal Pathogenesis
Ghannoum, M. A. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.1.122-143.2000 · Cited by 814 · see citing works
Plate method for detection of phospholipase activity inCandida albicans
Price, M. F., Wilkinson, I. D., & Gentry, L. O. (1982) · Medical Mycology · doi:10.1080/00362178285380031 · Cited by 651 · see citing works
V., W. (1953) · Antonie van Leeuwenhoek · doi:10.1007/bf02594854 · Cited by 397 · see citing works
Evidence implicating phospholipase as a virulence factor of Candida albicans
Ibrahim, A. S., Mirbod, F., Filler, S. G., Banno, Y., Cole, G. T., Kitajima, Y., Edwards, J. E., Nozawa, Y., & Ghannoum, M. A. (1995) · Infection and Immunity · doi:10.1128/iai.63.5.1993-1998.1995 · Cited by 351 · see citing works
(1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-7-624_1 · Cited by 253 · see citing works
Factors affecting the phospholipase activity ofCandidaspeciesin vitro
Samaranayake, L. P., Raeside, J. M., & MacFarlane, T. W. (1984) · Medical Mycology · doi:10.1080/00362178485380331 · Cited by 247 · see citing works
Impact of the changing epidemiology of fungal infections in the 1990s
Pfaller, M. A., & Wenzel, R. P. (1992) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01962067 · Cited by 234 · see citing works
Candida albicans secreted aspartyl proteinases.
Hube, B. (1996) · PubMed · Cited by 159 · see citing works
Lee, K. S., Patton, J. L., Fido, M., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32081-1 · Cited by 149 · see citing works
Occurrence of yeast bloodstream infections between 1987 and 1995 in five Dutch university hospitals
Voss, A., Kluytmans, J. A. J. W., Koeleman, J. G. M., Spanjaard, L., Vandenbroucke-Grauls, C. M. J. E., Verbrugh, H. A., Vos, M. C., Weersink, A. Y. L., Hoogkamp-Korstanje, J. A. A., & Meis, J. F. G. M. (1996) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01690507 · Cited by 128 · see citing works
Schaller, M., Schackert, C., Korting, H. C., Januschke, E., & Hube, B. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00935.x · Cited by 110 · see citing works
Pathogenicity determinants of Candida
Ghannoum, M. A., & Abu‐Elteen, K. H. (1990) · Mycoses · doi:10.1111/myc.1990.33.6.265 · Cited by 109 · see citing works
Fu, Y., Ibrahim, A. S., Fonzi, W. A., Zhou, X., Ramos, C. F., & Ghannoum, M. A. (1997) · Microbiology · doi:10.1099/00221287-143-2-331 · Cited by 96 · see citing works
Sullivan, D. J., Henman, M. C., Moran, G. P., O'Neill, L. C., Bennett, D. E., Shanley, D. B., & Coleman, D. C. (1996) · Journal of Medical Microbiology · doi:10.1099/00222615-44-6-399 · Cited by 94 · see citing works
Biotyping and Virulence Properties of Skin Isolates of Candida parapsilosis
Bernardis, F. D., Mondello, F., Millàn, R. S., et al. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.11.3481-3486.1999 · Cited by 88 · see citing works
Regulation of extracellular protease production in Candida lipolytica
Ogrydziak, D. M., Demain, A. L., & Tannenbaum, S. R. (1977) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(77)90209-4 · Cited by 86 · see citing works
Swenson, C. E., Perkins, W. R., Roberts, P., Ahmad, I., Stevens, R., Stevens, D. A., & Janoff, A. S. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.4.767 · Cited by 82 · see citing works
Fungal virulence genes as targets for antifungal chemotherapy
Perfect, J. R. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.7.1577 · Cited by 80 · see citing works
Banno, Y., Yamada, T., & Nozawa, Y. (1985) · Medical Mycology · doi:10.1080/00362178585380081 · Cited by 79 · see citing works
Ray, T. L., & Payne, C. D. (1990) · Infection and Immunity · doi:10.1128/iai.58.2.508-514.1990 · Cited by 76 · see citing works
Comparative Pathogenicity of a Wild-Type Strain and Respiratory Mutants of Candida albicans in Mice
Aoki, S., Ito-Kuwa, S., Nakamura, Y., & Masuhara, T. (1990) · Zentralblatt für Bakteriologie · doi:10.1016/s0934-8840(11)80437-8 · Cited by 71 · see citing works
Virulence of Candida albicans mutants
Polak, A. (1992) · Mycoses · doi:10.1111/j.1439-0507.1992.tb00813.x · Cited by 55 · see citing works
Phospholipase activity in Malassezia furfur pathogenic strains
Riciputo, R. M., Oliveri, S. M., Micali, G., et al. (1996) · Mycoses · doi:10.1111/j.1439-0507.1996.tb00131.x · Cited by 53 · see citing works
Togni, G., Sanglard, D., Quadroni, M., Foundling, S. I., & Monod, M. (1996) · Microbiology · doi:10.1099/13500872-142-3-493 · Cited by 51 · see citing works
Phospholipase activity in Cryptococcus neoformans
Vidotto, V., Sinicco, A., Fraia, D. D., Cardaropoli, S., Aoki, S., & Ito‐Kuwa, S. (1996) · Mycopathologia · doi:10.1007/bf00438916 · Cited by 49 · see citing works
Stimuli that induce production of Candida albicans extracellular aspartyl proteinase
Lerner, C. G., & Goldman, R. C. (1993) · Journal of General Microbiology · doi:10.1099/00221287-139-7-1643 · Cited by 46 · see citing works
Shimizu, M. T., Almeida, N. Q., Fantinato, V., et al. (1996) · Mycoses · doi:10.1111/j.1439-0507.1996.tb00120.x · Cited by 44 · see citing works
Purification and Characterization of Secretory Proteinase of Candida albicans
Yamamoto, T., Nohara, K., Uchida, K., et al. (1992) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1992.tb02064.x · Cited by 43 · see citing works
Extracellular Phospholipases as Universal Virulence Factor in Pathogenic Fungi.
Ghannoum, M. A. (1998) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.39.55 · Cited by 35 · see citing works
Detection of extracellular phospholipase activity inCandida albicans andRhodotorula rubra
Mayser, P., Laabs, S., Heuer, K.-U., et al. (1996) · Mycopathologia · doi:10.1007/bf00632336 · Cited by 30 · see citing works
Characterisation of yeasts implicated in vulvovaginal candidosis in Irish women.
Al-Rawi, N., & Kavanagh, K. A. (1999) · PubMed · Cited by 23 · see citing works
Vidotto, V., Koga‐Ito, C. Y., Canella, D., Sinicco, A., Perri, G. D., Aoki, S., & Ito‐Kuwa, S. (2000) · PubMed · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Silva, S., Negri, M., Henriques, M., Oliveira, R., Williams, D. W., & Azeredo, J. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00278.x · Cited by 969 · see citing works
Hydrolytic enzymes as virulence factors of <i>Candida albicans</i>
Schaller, M., Borelli, C., Korting, H. C., & Hube, B. (2005) · Mycoses · doi:10.1111/j.1439-0507.2005.01165.x · Cited by 506 · see citing works
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
Vermitsky, J.-P., & Edlind, T. D. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3773-3781.2004 · Cited by 285 · see citing works
A yeast by any other name: Candida glabrata and its interaction with the host
Kaur, R., Domergue, R., Zupancic, M. L., & Cormack, B. P. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.06.012 · Cited by 271 · see citing works
Seider, K., Brunke, S., Schild, L., Jablonowski, N., Wilson, D., Majer, O., Barz, D., Haas, A., Kuchler, K., Schaller, M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003730 · Cited by 220 · see citing works
Candida parapsilosis Is a Significant Neonatal Pathogen: A Systematic Review and Meta-analysis
Pammi, M., Holland, L., Butler, G., Gacser, A., & Bliss, J. M. (2013) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182863a1c · Cited by 206 · see citing works
Insights into Candida tropicalis nosocomial infections and virulence factors
Negri, M., Silva, S., Henriques, M., & Oliveira, R. (2012) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1455-z · Cited by 132 · see citing works
Candida glabrata: A Lot More Than Meets the Eye
Kumar, K., Askari, F., Sahu, M. S., & Kaur, R. (2019) · Microorganisms · doi:10.3390/microorganisms7020039 · Cited by 128 · see citing works
Esfahani, A., Omran, A. N., Salehi, Z., Shams-Ghahfarokhi, M., Ghane, M., Eybpoosh, S., & Razzaghi-Abyaneh, M. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105696 · Cited by 30 · see citing works
Oral epithelium–<i>Candida glabrata</i> interactions <i>in vitro</i>
Li, L., & Dongari‐Bagtzoglou, A. (2007) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00342.x · Cited by 29 · see citing works
- Authors
- Kantarcioǧlu, A. S., & Yücel, A.
- Affiliations
- Istanbul University-Cerrahpaşa (TR)
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2002-06
- Volume
- 45
- Issue
- 5-6
- Pages
- 160-165
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W1758436102
- Cited by
- 170
- References
- 33
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 8
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida, phospholipase activity, proteolytic activity, clinical isolates, Candida albicans, Candida kefyr, Candida tropicalis, Candida parapsilosis, Candida glabrata, Yarrowia lipolytica, Candida rugosa, Candida krusei, Candida guilliermondii, Candida lusitaniae, Candida species
- MeSH terms
- Blood, Candida, Candidiasis, Culture Media, Humans, Mouth, Endopeptidases, Phospholipases, Respiratory System, Urine, Virulence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review