Cited by 132Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Insights into Candida tropicalis nosocomial infections and virulence factors

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Negri, M., Silva, S., Henriques, M., Oliveira, R.·2012·European Journal of Clinical Microbiology & Infectious Diseases

Abstract

Candida tropicalis is considered the first or the second non-Candida albicans Candida (NCAC) species most frequently isolated from candidosis, mainly in patients admitted in intensive care units (ICUs), especially with cancer, requiring prolonged catheterization, or receiving broad-spectrum antibiotics. The proportion of candiduria and candidemia caused by C. tropicalis varies widely with geographical area and patient group. Actually, in certain countries, C. tropicalis is more prevalent, even compared with C. albicans or other NCAC species. Although prophylactic treatments with fluconazole cause a decrease in the frequency of candidosis caused by C. tropicalis, it is increasingly showing a moderate level of fluconazole resistance. The propensity of C. tropicalis for dissemination and the high mortality associated with its infections might be strongly related to the potential of virulence factors exhibited by this species, such as adhesion to different host surfaces, biofilm formation, infection and dissemination, and enzymes secretion. Therefore, the aim of this review is to outline the present knowledge on all the above-mentioned C. tropicalis virulence traits.

Integrity signals

Registry

Crossref · 10.1007/s10096-011-1455-z

Cites

124 of 124 references verified0 citation errors · 0 not checkable

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  • Candida glabrata has high antifungal drug resistance.

    “In addition to the high antifungal drugs resistance and inability to form hyphae or secret hydrolases, C. glabrata retain many virulence factors”

    From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [39]

  • Candida glabrata retains many virulence factors that contribute to its extreme aggressiveness.

    “C. glabrata retain many virulence factors that contribute to its extreme aggressiveness and result in a low therapeutic response and serious recurrent candidiasis”

    From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [39]

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Authors
Negri, M., Silva, S., Henriques, M., & Oliveira, R.
Affiliations
Institute for Biotechnology and Bioengineering (PT)
Corresponding author
Henriques, M.
Venue
European Journal of Clinical Microbiology & Infectious Diseases
Published
2011-10-30
Volume
31
Issue
7
Pages
1399-1412
ISSN
  • 0934-9723 (ISSN-L)
  • 1435-4373
OpenAlex
W2105761493
Cited by
132
References
125
Citations by year
2026: 3 · 2025: 8 · 2024: 7 · 2023: 24 · 2022: 5 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 3
FWCI
4.06
Type
journal article
Language
en
Open access
Locations
  • European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida tropicalis, non-albicans Candida, nosocomial candidiasis, virulence factors, candidemia, candiduria, intensive care unit infections, fluconazole resistance, biofilm formation, adhesion, enzyme secretion, systemic candidiasis, antifungal prophylaxis
MeSH terms
Antifungal Agents, Candidiasis, Cross Infection, Humans, Fluconazole, Drug Resistance, Fungal, Virulence Factors, Candida tropicalis

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