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Cited by 322

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Cell death induced by the Fas/Fas ligand pathway and its role in pathology

Open access
Waring, Paul, Müllbacher, Arno·1999·Immunology & Cell Biology

Abstract

Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via Fas/FasL interaction is important for homeostasis of cells in the immune system and for maintaining immune‐privileged sites in the body. Killing via the Fas/FasL pathway also constitutes an important pathway of killing for cytotoxic T cells. Fas ligand is induced in activated T cells, resulting in activation‐induced cell death by the Fas/FasL pathway. Recently it has been shown that the Fas receptor can also be up‐regulated following a lesion to the cell, particularly that induced by DNA‐damaging agents. This can then result in killing of the cell by a Fas/FasL‐dependent pathway. Up‐regulation of Fas receptor following DNA damage appears to be p53 dependent.

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Registry

Crossref · 10.1046/j.1440-1711.1999.00837.x

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Metadata

Authors
Waring, P., & Müllbacher, A.
Venue
Immunology & Cell Biology
Publisher
Wiley
Published
1999-08
Volume
77
Issue
4
Pages
312-317
ISSN
  • 0004-945X (ISSN-L)
  • 0818-9641
  • 1440-1711
OpenAlex
W1963673812
Cited by
322
References
4
FWCI
2.17
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.