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Cited by 239Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionAntioxidants, Aging, Portulaca oleracea

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

Yamada, Kiyofumi, Tanaka, Tomoko, Han, Daiken, Senzaki, Kouji, Kameyama, Tsutomu, Nabeshima, Toshitaka·1999·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.1999.00408.x
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Abstract

Amyloid β‐peptide (Aβ), the major constituent of the senile plaques in the brains of patients with Alzheimer's disease, is cytotoxic to neurons and has a central role in the pathogenesis of the disease. Previous studies have suggested that oxidative stress is involved in the mechanisms of Aβ‐induced neurotoxicity in vitro. In the present study, we examined whether oxidative stress contributes to learning and memory deficits caused by continuous intracerebroventricular infusion of Aβ‐(1–42). In the Aβ‐(1–42)‐infused rats, spontaneous alternation behaviour in a Y‐maze and spatial memory in a water maze task were significantly impaired, as compared with Aβ‐(40–1)‐infused control rats. The retention of passive avoidance learning was also significantly impaired by treatment with Aβ‐(1–42). Potent antioxidants idebenone and α‐tocopherol prevented the behavioural deficits in Y‐maze and water maze, but not passive avoidance, tasks in Aβ‐(1–42)‐infused rats when they were repeatedly administered by mouth once a day from 3 days before the start of Aβ infusion to the end of behavioural experiments. Lipid peroxide levels in the hippocampus and cerebral cortex of Aβ‐(1–42)‐infused rats did not differ from those in control animals, and neither idebenone nor α‐tocopherol affected the lipid peroxide levels. These results suggest that treatment with antioxidants such as idebenone and α‐tocopherol prevents learning and memory deficits caused by Aβ.

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  1. 10.1037/0735-7044.110.4.661 · DOI · Paper page
  2. 10.1037/0735-7044.98.6.946 · DOI

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Metadata

Authors
Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T., & Nabeshima, T.
Affiliations
  • Nagoya University Hospital (JP)
  • Meijo University (JP)
  • Nagoya University (JP)
Corresponding author
Nabeshima, Toshitaka
ORCID
Tanaka, Tomoko
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
1999-01
Volume
11
Issue
1
Pages
83-90
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.1999.00408.x
OpenAlex
W2038415004
Cited by
238
References
67
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 9
FWCI
9.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1088 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
idebenone, alpha-tocopherol, amyloid-beta 42, Alzheimer's disease, oxidative stress, learning and memory impairment, neuroprotection, antioxidants, lipid peroxidation, hippocampus, cerebral cortex, spatial memory, passive avoidance learning, intracerebroventricular infusion
MeSH terms
Alzheimer Disease, Animals, Antioxidants, Avoidance Learning, Brain Chemistry, Drug Interactions, Injections, Intraventricular, Locomotion, Male, Memory, Nerve Degeneration, Neurotoxins, Peptide Fragments, Ubiquinone, Vitamin E, Lipid Peroxidation, Benzoquinones, Amyloid beta-Peptides, Rats, Wistar, Oxidative Stress, Maze Learning, Rats

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